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Protein

Rho guanine nucleotide exchange factor 10

Gene

Arhgef10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in developmental myelination of peripheral nerves.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10
Gene namesi
Name:Arhgef10
Synonyms:Kiaa0294
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2444453 Arhgef10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809271 – 1345Rho guanine nucleotide exchange factor 10Add BLAST1345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157PhosphoserineCombined sources1
Modified residuei355PhosphoserineBy similarity1
Modified residuei1262PhosphoserineCombined sources1
Modified residuei1314N5-methylglutamineBy similarity1

Post-translational modificationi

Methylated at Gln-1314 by N6AMT1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8C033
PRIDEiQ8C033

PTM databases

iPTMnetiQ8C033
PhosphoSitePlusiQ8C033

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Found in the neuroepithelium of the meninges at E8.5, and in the roof plate of the rhombencephalon at E9.5. In E12.5 embryos, it is ubiquitously expressed, with a pronounced expression in the neuroepithelium of brain vesicles, the neural tube, the ganglia and the neural layer of the retina.1 Publication

Gene expression databases

BgeeiENSMUSG00000071176 Expressed in 251 organ(s), highest expression level in sciatic nerve
CleanExiMM_ARHGEF10
ExpressionAtlasiQ8C033 baseline and differential
GenevisibleiQ8C033 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8C033, 1 interactor
MINTiQ8C033
STRINGi10090.ENSMUSP00000081225

Structurei

3D structure databases

ProteinModelPortaliQ8C033
SMRiQ8C033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini397 – 584DHPROSITE-ProRule annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili307 – 335Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00670000097546
HOGENOMiHOG000232060
HOVERGENiHBG050570
InParanoidiQ8C033
KOiK16727
OMAiCHGLLMV
OrthoDBiEOG091G0A3T
PhylomeDBiQ8C033
TreeFamiTF331430

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030632 ARHGEF10
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877:SF14 PTHR12877:SF14, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C033-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQGEASPPV PAEHEAKCDT SNNEEEGELF DFDSGDEVPE ADRQVPSADD
60 70 80 90 100
RTRGAEAGGA DENTCPAGNG TGAEPAPEAE PAKLVVPTKV NPYSVIDITP
110 120 130 140 150
LQEDQPSSPD ANTEEEGVGL RVPSGYSVPV PCGYAVPSNL PLLLPAYSSP
160 170 180 190 200
VIIRAESVEE EEAAETVGDG QCNSLSSEDL PHSSEQGSQE GSALARWAAD
210 220 230 240 250
PANTAWMENP EEAIYDDVPR ENSDSEPDEM IYDDVENGEE GGNSSPEYGW
260 270 280 290 300
SSSEFESYEE PSDSEGKNGI PRSFLRSSHK KQLSHDLTRF KAHCEEKMRG
310 320 330 340 350
LVASTVGAME IQQAKQRQER KMQKLMKAAK EGTKDGLEKT KAAVKRGGSF
360 370 380 390 400
IRTRSLVSQD HRCYFEEEQN LFIDVDCKHP EAVLTPMPEG LSQQQVVRRY
410 420 430 440 450
ILGSIVESEK NYVDALRRIL EQYEKPLSEM EPRLLSDRKL RMVFYRVKEI
460 470 480 490 500
LQCHSMFQIA LASRVSEWDV VETIGDVFVA SFSKSMVLDA YSEYVNNFST
510 520 530 540 550
AVAVLKKTCA TKPAFLEFLK LSQDSSPDRV TLHSLMMRPI QRFPQFILLL
560 570 580 590 600
QDMLKNTAKG HPDRLPLQMA LTELETLAEK LNERKRDADQ RCEIKQIAKA
610 620 630 640 650
INERYLNKLL SSGNRYLVRS DDVIETVYND RGEIVKTKQR RIFMLNDVLM
660 670 680 690 700
CATASSRNSH ESHAVMSQRY LLKWSVPLGH VDVIQYNGGS GAGEHCRHHA
710 720 730 740 750
AHSPESLAVV ANAKPHKVYM GPGQLYQDLQ NLLHDLNVVG QISQLIGNLR
760 770 780 790 800
GSYQNLNQSV AHDWTSGLQR LILRKEDAIR AADRCRIQLQ LPGKQDKSGR
810 820 830 840 850
PTFFTAVFNT LTPAIKESWV SSLQMAKLAL EEENHMGWFC VDDDGNLAKK
860 870 880 890 900
ETHPLLVGHM PVMVAKQPEF KIECAAYNPE PYLSNESQPA SPSTARGFLW
910 920 930 940 950
IGSCSNQMGQ VAIVSFQGSN PKVIECFNVE SRILCMVYIP AEESKPQETT
960 970 980 990 1000
ETKDPEATAS RAPHVPTICL GTEEGSISIY KSSQGCKKVR LQHFYAPDKS
1010 1020 1030 1040 1050
TVMSLACSPQ GLYAGLVNGS VASYTKAPDG SWNSEPQQVI KLGVLPVRSL
1060 1070 1080 1090 1100
LLVEGALWAA SGGQVFMASV ETHTIENQLE AHQDEGMVIS HMAVAGVGIW
1110 1120 1130 1140 1150
IAFTSGSTLR LFHTETLKHL QDVNIDAPVH SMLPGHQRLS VTSLLVCHGL
1160 1170 1180 1190 1200
LMVGTSLGVV VALPVPRLQG IPKVTGRGMV SYHAHNGPVK FIVSATAFQN
1210 1220 1230 1240 1250
KDRARDSPRS GSELQDEDPK DLLCSEEGPS CPGQPDTYTS VWLGDSLGLP
1260 1270 1280 1290 1300
TQKNDLSSSS GSLNLSHGSS SLEHRSVDSS LCDLLRDPSA SPRSRPQGSR
1310 1320 1330 1340
RARASSALVV CGGQGHRRVH RKARQPSQED LVSSVMVWQI PLLGM
Length:1,345
Mass (Da):147,946
Last modified:June 27, 2006 - v2
Checksum:i8583299B5A4C5835
GO
Isoform 2 (identifier: Q8C033-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-321: Missing.

Show »
Length:1,306
Mass (Da):143,451
Checksum:iD7C283159543F50E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BCP8F7BCP8_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10
579Annotation score:
F7BQE4F7BQE4_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10
988Annotation score:

Sequence cautioni

The sequence AAH59212 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH66074 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27875 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD90400 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184Missing in BAC35629 (PubMed:16141072).Curated1
Sequence conflicti196R → Q in BAC27875 (PubMed:16141072).Curated1
Sequence conflicti207M → I in BAD90400 (Ref. 2) Curated1
Sequence conflicti348G → R in BAD90400 (Ref. 2) Curated1
Sequence conflicti528D → Y in BAC27875 (PubMed:16141072).Curated1
Sequence conflicti581L → R in BAC35629 (PubMed:16141072).Curated1
Sequence conflicti1332V → F in AAH06842 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010707283 – 321Missing in isoform 2. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032452 mRNA Translation: BAC27875.1 Different initiation.
AK054038 mRNA Translation: BAC35629.2
AK220332 mRNA Translation: BAD90400.1 Different initiation.
BC006842 mRNA Translation: AAH06842.1
BC047430 mRNA Translation: AAH47430.1
BC059212 mRNA Translation: AAH59212.1 Different initiation.
BC066074 mRNA Translation: AAH66074.1 Different initiation.
CCDSiCCDS40240.1 [Q8C033-1]
CCDS40241.1 [Q8C033-2]
RefSeqiNP_001032825.1, NM_001037736.2 [Q8C033-2]
NP_766339.2, NM_172751.3 [Q8C033-1]
UniGeneiMm.240298

Genome annotation databases

EnsembliENSMUST00000084207; ENSMUSP00000081225; ENSMUSG00000071176 [Q8C033-1]
ENSMUST00000110800; ENSMUSP00000106424; ENSMUSG00000071176 [Q8C033-2]
GeneIDi234094
KEGGimmu:234094
UCSCiuc009kzg.2 mouse [Q8C033-1]
uc009kzh.2 mouse [Q8C033-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032452 mRNA Translation: BAC27875.1 Different initiation.
AK054038 mRNA Translation: BAC35629.2
AK220332 mRNA Translation: BAD90400.1 Different initiation.
BC006842 mRNA Translation: AAH06842.1
BC047430 mRNA Translation: AAH47430.1
BC059212 mRNA Translation: AAH59212.1 Different initiation.
BC066074 mRNA Translation: AAH66074.1 Different initiation.
CCDSiCCDS40240.1 [Q8C033-1]
CCDS40241.1 [Q8C033-2]
RefSeqiNP_001032825.1, NM_001037736.2 [Q8C033-2]
NP_766339.2, NM_172751.3 [Q8C033-1]
UniGeneiMm.240298

3D structure databases

ProteinModelPortaliQ8C033
SMRiQ8C033
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C033, 1 interactor
MINTiQ8C033
STRINGi10090.ENSMUSP00000081225

PTM databases

iPTMnetiQ8C033
PhosphoSitePlusiQ8C033

Proteomic databases

PaxDbiQ8C033
PRIDEiQ8C033

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084207; ENSMUSP00000081225; ENSMUSG00000071176 [Q8C033-1]
ENSMUST00000110800; ENSMUSP00000106424; ENSMUSG00000071176 [Q8C033-2]
GeneIDi234094
KEGGimmu:234094
UCSCiuc009kzg.2 mouse [Q8C033-1]
uc009kzh.2 mouse [Q8C033-2]

Organism-specific databases

CTDi9639
MGIiMGI:2444453 Arhgef10
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00670000097546
HOGENOMiHOG000232060
HOVERGENiHBG050570
InParanoidiQ8C033
KOiK16727
OMAiCHGLLMV
OrthoDBiEOG091G0A3T
PhylomeDBiQ8C033
TreeFamiTF331430

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRSiArhgef10 mouse
PROiPR:Q8C033
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071176 Expressed in 251 organ(s), highest expression level in sciatic nerve
CleanExiMM_ARHGEF10
ExpressionAtlasiQ8C033 baseline and differential
GenevisibleiQ8C033 MM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030632 ARHGEF10
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877:SF14 PTHR12877:SF14, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARHGA_MOUSE
AccessioniPrimary (citable) accession number: Q8C033
Secondary accession number(s): Q5DU38
, Q80VH8, Q8BW76, Q922S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 27, 2006
Last modified: October 10, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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