Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (29 Sep 2021)
Sequence version 2 (16 May 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Double zinc ribbon and ankyrin repeat-containing protein 1

Gene

Dzank1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri230 – 289DZANK-type 1Add BLAST60
Zinc fingeri359 – 407DZANK-type 2Add BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Double zinc ribbon and ankyrin repeat-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dzank1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2139080, Dzank1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000037259

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002359121 – 778Double zinc ribbon and ankyrin repeat-containing protein 1Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei179PhosphoserineCombined sources1
Modified residuei201PhosphoserineBy similarity1
Modified residuei768PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8C008

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C008

PRoteomics IDEntifications database

More...
PRIDEi
Q8C008

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
277429

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C008

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C008

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037259, Expressed in central gray substance of midbrain and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C008, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C008, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
232341, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8C008, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8C008

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000080643

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C008, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C008

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati631 – 662ANK 1Add BLAST32
Repeati666 – 695ANK 2Add BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri230 – 289DZANK-type 1Add BLAST60
Zinc fingeri359 – 407DZANK-type 2Add BLAST49

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTJR, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000549

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C008

Identification of Orthologs from Complete Genome Data

More...
OMAi
VECGSMV

TreeFam database of animal gene trees

More...
TreeFami
TF351270

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036770, Ankyrin_rpt-contain_sf
IPR025874, DZR
IPR026876, Fn3_assoc_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12773, DZR, 2 hits
PF13287, Fn3_assoc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C008-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAGSVCAPQ IIPLRVPQPG KANHEIDTNT LLEMKSDTPD VNIYYTLDGS
60 70 80 90 100
KPDFLKKVGS GENNTFKYVK PITLPDGKIQ VKAVAVSKDC RQSGIVTKVF
110 120 130 140 150
QVDYEPPKMV SSEDNVEDAL KGFSKQELKN GFVGPKLRKK YKNAENKSTW
160 170 180 190 200
NVNLRRLADL KVGERADPKT LKDLRFAESP LEIPAYHEGA SARLPTHQAQ
210 220 230 240 250
SPGFAHITGQ KSLTSTEIMR IQRETDFLKC AHCLASRPSD PFARFCHECG
260 270 280 290 300
APVPPIFGYR LPPPEGAQMG LCAECGSMVP MNTPICVVCE APLAPQLRPQ
310 320 330 340 350
ASLYLKERVI CRTCGTGNPA HLRYCVTCEG PLPPTQEQWL CNGDEVPHPP
360 370 380 390 400
ARNGETISCS RCGCQNLWEA SFCDWCGAML GISASHSVCP KCGASNHLTA
410 420 430 440 450
RFCGSCGIYV KSITRFRMHN SLAIVAGAPR PFPEPRSAWQ SLNVPLPTSA
460 470 480 490 500
SGSKKDTGTQ TSGLFYPSGK LLAKKELEAA SHRQRQEKMS DHRPVLTAVS
510 520 530 540 550
PGRGYWRKQL DHISAHLRSY AQNNPEFRAL IAEPRMGKLI SATVHEDGYE
560 570 580 590 600
VSIRLNYIQV SNKSLYFNKS VNLSDHFLSS VTEGGNGLYD SRSSLVSAYS
610 620 630 640 650
QSVSDTPESI KKMKNLKAKS FLVNPEPLTP ENKLLLEEVG SSGKGRLSVL
660 670 680 690 700
EQLLDEGADP NCCDSQGRPA VIVAVVNKHY EAIPVLAQRG ADIDQQWGPF
710 720 730 740 750
RNTALHEATL LGLEGRESIA TLLGCNANAQ KKNTRGQTAY DIALEMGDDL
760 770
TSSLFAAKFT QGLEDQLSPP GNRILGDS
Length:778
Mass (Da):85,025
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A3EDB966EC74AED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q4Z6E9Q4Z6_MOUSE
Double zinc ribbon and ankyrin repe...
Dzank1 6330439K17Rik
779Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC27747 differs from that shown. Reason: Frameshift.Curated
The sequence BAC27960 differs from that shown. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202P → H in BAC27960 (PubMed:16141072).Curated1
Sequence conflicti693I → N in BAC27747 (PubMed:16141072).Curated1
Sequence conflicti710L → Q in BAC27747 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK032182 mRNA Translation: BAC27747.1 Frameshift.
AK032632 mRNA Translation: BAC27960.1 Sequence problems.
AL808119 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38254.1

NCBI Reference Sequences

More...
RefSeqi
NP_766447.2, NM_172859.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000081982; ENSMUSP00000080643; ENSMUSG00000037259

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
241688

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:241688

UCSC genome browser

More...
UCSCi
uc008mrd.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032182 mRNA Translation: BAC27747.1 Frameshift.
AK032632 mRNA Translation: BAC27960.1 Sequence problems.
AL808119 Genomic DNA No translation available.
CCDSiCCDS38254.1
RefSeqiNP_766447.2, NM_172859.2

3D structure databases

SMRiQ8C008
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi232341, 5 interactors
IntActiQ8C008, 6 interactors
MINTiQ8C008
STRINGi10090.ENSMUSP00000080643

PTM databases

iPTMnetiQ8C008
PhosphoSitePlusiQ8C008

Proteomic databases

MaxQBiQ8C008
PaxDbiQ8C008
PRIDEiQ8C008
ProteomicsDBi277429

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
54096, 25 antibodies

The DNASU plasmid repository

More...
DNASUi
241688

Genome annotation databases

EnsembliENSMUST00000081982; ENSMUSP00000080643; ENSMUSG00000037259
GeneIDi241688
KEGGimmu:241688
UCSCiuc008mrd.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55184
MGIiMGI:2139080, Dzank1
VEuPathDBiHostDB:ENSMUSG00000037259

Phylogenomic databases

eggNOGiENOG502QTJR, Eukaryota
GeneTreeiENSGT00390000000549
InParanoidiQ8C008
OMAiVECGSMV
TreeFamiTF351270

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
241688, 0 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dzank1, mouse

Protein Ontology

More...
PROi
PR:Q8C008
RNActiQ8C008, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037259, Expressed in central gray substance of midbrain and 222 other tissues
ExpressionAtlasiQ8C008, baseline and differential
GenevisibleiQ8C008, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR036770, Ankyrin_rpt-contain_sf
IPR025874, DZR
IPR026876, Fn3_assoc_repeat
PfamiView protein in Pfam
PF12773, DZR, 2 hits
PF13287, Fn3_assoc, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDZAN1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C008
Secondary accession number(s): A2AN93, Q8C060
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 29, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again