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Protein

Splicing regulatory glutamine/lysine-rich protein 1

Gene

Srek1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing regulatory glutamine/lysine-rich protein 1
Alternative name(s):
Serine/arginine-rich-splicing regulatory protein 86
Short name:
SRrp86
Splicing factor, arginine/serine-rich 12
Gene namesi
Name:Srek1
Synonyms:Sfrs12, Srrp86
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145245 Srek1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819411 – 494Splicing regulatory glutamine/lysine-rich protein 1Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei348PhosphothreonineBy similarity1
Cross-linki490Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BZX4
PeptideAtlasiQ8BZX4
PRIDEiQ8BZX4

PTM databases

iPTMnetiQ8BZX4
PhosphoSitePlusiQ8BZX4

Expressioni

Gene expression databases

BgeeiENSMUSG00000032621 Expressed in 274 organ(s), highest expression level in rostral migratory stream
CleanExiMM_SFRS12
ExpressionAtlasiQ8BZX4 baseline and differential
GenevisibleiQ8BZX4 MM

Interactioni

Subunit structurei

Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome. Interacts with SREK1IP1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BZX4, 1 interactor
MINTiQ8BZX4
STRINGi10090.ENSMUSP00000074196

Structurei

3D structure databases

ProteinModelPortaliQ8BZX4
SMRiQ8BZX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 145RRMPROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi190 – 473Arg/Glu/Lys/Ser-richAdd BLAST284

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGiKOG4676 Eukaryota
ENOG410YYIR LUCA
GeneTreeiENSGT00730000110872
HOVERGENiHBG079174
InParanoidiQ8BZX4
KOiK13165
OMAiCYIKFRE
OrthoDBiEOG091G0QKH
PhylomeDBiQ8BZX4
TreeFamiTF106266

Family and domain databases

CDDicd12260 RRM2_SREK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033568 Srek1
IPR034192 SREK1_RRM2
PANTHERiPTHR32343:SF7 PTHR32343:SF7, 2 hits
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BZX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSLVPGAGL LPIPTSSPLT AVSSLGVSLS SLGAIPAAAL DPNITTLGEI
60 70 80 90 100
PQPPLMGNVD PSKIDEIRRT VYVGNLNSQT TTADQLLEFF KQVGEVKFVR
110 120 130 140 150
MAGDETQPTR FAFVEFADQN SVPRALAFNG VMFGDRPLKI NHSNNAIVKP
160 170 180 190 200
PEMTPQAAAK ELEEVMKRVR EAQSFISAAI EPESGKSNER KGGRSRSHTR
210 220 230 240 250
SKSRSSSKSH SRRKRSQSKH RSRSHNRSRS RQKDRRRSKS PHKKRSKSRE
260 270 280 290 300
RRKSRSRSRS RDKRKDTREK VKERVKEKER EKEREREKDR EKDKERGKNK
310 320 330 340 350
DKDREKEKDH EKERDKEKEK EQDKDKEREK DRSKETDEKR KKEKKSRTPP
360 370 380 390 400
RSYNASRRSR STSRERRRRR SRSSSRSPRT SKTVKRKSSR SPSPRGRNKK
410 420 430 440 450
EKKREKERDH ISDRRERERS TSTKKSSGDR DGKEKVEKST TPVKEKEHSK
460 470 480 490
ESDATVSKAA DEKGSPRTED EGKVQHNGNC QPNEESPCSK ADAV
Length:494
Mass (Da):56,763
Last modified:March 1, 2003 - v1
Checksum:i2451AD74522C7C5D
GO
Isoform 2 (identifier: Q8BZX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNSGGGFGLG...LSLLAPAPTM

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):69,121
Checksum:i54AA813A2FB27971
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSR3A0A1B0GSR3_MOUSE
Splicing regulatory glutamine/lysin...
Srek1
314Annotation score:
A0A1B0GSB4A0A1B0GSB4_MOUSE
Splicing regulatory glutamine/lysin...
Srek1
198Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401E → G in BAC29709 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0084001M → MNSGGGFGLGLGFGLFPTTV IQVTNLSSAVTSEQMRTLFS FLGEIEELRLYPPDNTPLAF SSKVCYIKFRDPSSVGVAQH LTNTVFIDRALIVVPCAEGK IPEEAKALSLLAPAPTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033354 mRNA Translation: BAC28243.1
AK037115 mRNA Translation: BAC29709.2
AK039311 mRNA Translation: BAC30314.1
AK044086 mRNA Translation: BAC31767.1
AK052265 mRNA Translation: BAC34905.2
BC070460 mRNA Translation: AAH70460.1
CCDSiCCDS26743.1 [Q8BZX4-1]
RefSeqiNP_766180.1, NM_172592.2 [Q8BZX4-1]
XP_006517669.1, XM_006517606.2
XP_006517670.1, XM_006517607.3 [Q8BZX4-1]
XP_017170986.1, XM_017315497.1 [Q8BZX4-1]
UniGeneiMm.458176
Mm.459433

Genome annotation databases

EnsembliENSMUST00000074616; ENSMUSP00000074196; ENSMUSG00000032621 [Q8BZX4-2]
ENSMUST00000210489; ENSMUSP00000147737; ENSMUSG00000032621 [Q8BZX4-1]
GeneIDi218543
KEGGimmu:218543
UCSCiuc007rsh.1 mouse [Q8BZX4-1]
uc007rsj.1 mouse [Q8BZX4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033354 mRNA Translation: BAC28243.1
AK037115 mRNA Translation: BAC29709.2
AK039311 mRNA Translation: BAC30314.1
AK044086 mRNA Translation: BAC31767.1
AK052265 mRNA Translation: BAC34905.2
BC070460 mRNA Translation: AAH70460.1
CCDSiCCDS26743.1 [Q8BZX4-1]
RefSeqiNP_766180.1, NM_172592.2 [Q8BZX4-1]
XP_006517669.1, XM_006517606.2
XP_006517670.1, XM_006517607.3 [Q8BZX4-1]
XP_017170986.1, XM_017315497.1 [Q8BZX4-1]
UniGeneiMm.458176
Mm.459433

3D structure databases

ProteinModelPortaliQ8BZX4
SMRiQ8BZX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BZX4, 1 interactor
MINTiQ8BZX4
STRINGi10090.ENSMUSP00000074196

PTM databases

iPTMnetiQ8BZX4
PhosphoSitePlusiQ8BZX4

Proteomic databases

PaxDbiQ8BZX4
PeptideAtlasiQ8BZX4
PRIDEiQ8BZX4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074616; ENSMUSP00000074196; ENSMUSG00000032621 [Q8BZX4-2]
ENSMUST00000210489; ENSMUSP00000147737; ENSMUSG00000032621 [Q8BZX4-1]
GeneIDi218543
KEGGimmu:218543
UCSCiuc007rsh.1 mouse [Q8BZX4-1]
uc007rsj.1 mouse [Q8BZX4-2]

Organism-specific databases

CTDi140890
MGIiMGI:2145245 Srek1

Phylogenomic databases

eggNOGiKOG4676 Eukaryota
ENOG410YYIR LUCA
GeneTreeiENSGT00730000110872
HOVERGENiHBG079174
InParanoidiQ8BZX4
KOiK13165
OMAiCYIKFRE
OrthoDBiEOG091G0QKH
PhylomeDBiQ8BZX4
TreeFamiTF106266

Miscellaneous databases

ChiTaRSiSrek1 mouse
PROiPR:Q8BZX4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032621 Expressed in 274 organ(s), highest expression level in rostral migratory stream
CleanExiMM_SFRS12
ExpressionAtlasiQ8BZX4 baseline and differential
GenevisibleiQ8BZX4 MM

Family and domain databases

CDDicd12260 RRM2_SREK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033568 Srek1
IPR034192 SREK1_RRM2
PANTHERiPTHR32343:SF7 PTHR32343:SF7, 2 hits
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSREK1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZX4
Secondary accession number(s): Q8BLM8
, Q8BWK7, Q8BYK0, Q8BYZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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