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Protein

Glomulin

Gene

Glmn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1 (By similarity). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (PubMed:22405651). Essential for normal development of the vasculature (PubMed:22405651). Contributes to the regulation of RPS6KB1 phosphorylation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glomulin
Alternative name(s):
FK506-binding protein-associated protein
Short name:
FAP
FKBP-associated protein
Gene namesi
Name:Glmn
Synonyms:Fap48
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141180 Glmn

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Complete embryonic lethality. Embryos are present at the expected Mendelian rate at 10.5 dpc, but all are dead by 12.5 dpc. Mutant embryos display decreased growth, delayed neural tube closure, incomplete axial turning, pericardial effusion and a failure to form an organized, functional vascular network. Mutant embryos have reduced protein levels of FBXW7, RBX1, CUL1, CUL2, CUL3 and CUL4A, due to increased proteasome-mediated degradation, and increased levels of CCNE1 and MYC.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000875142 – 596GlomulinAdd BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BZM1
MaxQBiQ8BZM1
PaxDbiQ8BZM1
PRIDEiQ8BZM1

PTM databases

PhosphoSitePlusiQ8BZM1

Expressioni

Tissue specificityi

Ubiquitous. Detected in embryonic vasculature and embryonic perichondrium, and in adult eye, brain, heart, testis, kidney, smooth muscle and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000029276 Expressed in 274 organ(s), highest expression level in retina
CleanExiMM_GLMN
ExpressionAtlasiQ8BZM1 baseline and differential
GenevisibleiQ8BZM1 MM

Interactioni

Subunit structurei

Interacts with FKBP4 and FKBP1A. Interacts with RBX1 (via RING domain). Identified in complexes that contain RBX1 plus one of the cullins CUL1, CUL2, CUL3, and CUL4A. Identified in a SCF complex composed of CUL1, RBX1, SKP1, FBXW7 and GLMN. Component of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN. Interacts with unphosphorylated MET and is released upon MET phosphorylation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228459, 2 interactors
STRINGi10090.ENSMUSP00000077168

Structurei

3D structure databases

ProteinModelPortaliQ8BZM1
SMRiQ8BZM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 555Alpha-helical region with structural similarity to HEAT repeatsBy similarityAdd BLAST554
Regioni299 – 596Important for interaction with RBX1By similarityAdd BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Leu4
Compositional biasi272 – 277Poly-Glu6

Domaini

The C-terminal half of the protein is important for interaction with RBX1.By similarity

Phylogenomic databases

eggNOGiENOG410IG4H Eukaryota
ENOG410YJ4Z LUCA
GeneTreeiENSGT00390000018446
HOGENOMiHOG000043079
HOVERGENiHBG044811
InParanoidiQ8BZM1
OMAiYFLMLDL
OrthoDBiEOG091G054M
PhylomeDBiQ8BZM1
TreeFamiTF105319

Family and domain databases

InterProiView protein in InterPro
IPR019516 Glomulin/ALF4
IPR013877 YAP-bd/ALF4/Glomulin
PANTHERiPTHR15430 PTHR15430, 1 hit
PfamiView protein in Pfam
PF08568 Kinetochor_Ybp2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BZM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVEELQSII KRCQILEEHD FKEEDFGLFQ LAGQRCIEDG YINQLLEIIQ
60 70 80 90 100
DEKNKTIIKS MGWNLVGPVV RCLLRGREED KREECFLIFD LLVKLCNPKE
110 120 130 140 150
LLLGLLELIE EPSGKQISQI ILLLLQPLQT VIQKLPNNKA YSVGLALSTL
160 170 180 190 200
WSQLSLLPVP HSEEQIQADD YGLCQCCKAL IEFTKPFVEE VISDKENKEN
210 220 230 240 250
AKLKDELLKF CFKGLKCPLL TAQFLEQSED VGNDPFRCFA SEIIGFLSKI
260 270 280 290 300
GHPVPQIILN HGRKKRTWDY LEFEEEEDKQ LAESVASLTY LVFVQGIGID
310 320 330 340 350
QLPMVLSPSY LLQLNMEHIE VFLQRTEQSI YSKGLELLET SLLRLEDNSL
360 370 380 390 400
CYQYLEIKSF LAVPQGLVKV MTLCPIETLR KKGLSMLQLF IDKLDSQGKY
410 420 430 440 450
TLFRCLLNTS NHSGVEAFVI QNIKNQIDLS FKKTYNKWFA GAQLISLLDL
460 470 480 490 500
VLSLPEGAET DLLQNSDRIM ASLNLLRYLV IKDNEDDNQT GLWTELGKIE
510 520 530 540 550
NNFLKPLHIG LNMSKAHYEA EIKNSQQNNQ VASMCKGVCS VTVGGEEIPS
560 570 580 590
MPPEMQLKVL HSALFTFDLI ESVLARVEEL IEIKSKSTSE ENVGIK
Length:596
Mass (Da):67,756
Last modified:March 1, 2003 - v1
Checksum:i4C306B16F3C206DB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3T9A5Q3T9A5_MOUSE
Glomulin
Glmn
532Annotation score:
D3Z0L3D3Z0L3_MOUSE
Glomulin
Glmn
100Annotation score:
D6RGR3D6RGR3_MOUSE
Glomulin
Glmn
97Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270Y → S in AAH03446 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566083 mRNA Translation: CAD92739.1
AK034160 mRNA Translation: BAC28612.1
AK169045 mRNA Translation: BAE40833.1
BC003446 mRNA Translation: AAH03446.1
CCDSiCCDS19505.1
RefSeqiNP_001155210.1, NM_001161738.1
NP_001155211.1, NM_001161739.1
NP_573511.2, NM_133248.2
XP_006534863.1, XM_006534800.3
UniGeneiMm.41417

Genome annotation databases

EnsembliENSMUST00000078021; ENSMUSP00000077168; ENSMUSG00000029276
ENSMUST00000082121; ENSMUSP00000080766; ENSMUSG00000029276
GeneIDi170823
KEGGimmu:170823
UCSCiuc008ymm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566083 mRNA Translation: CAD92739.1
AK034160 mRNA Translation: BAC28612.1
AK169045 mRNA Translation: BAE40833.1
BC003446 mRNA Translation: AAH03446.1
CCDSiCCDS19505.1
RefSeqiNP_001155210.1, NM_001161738.1
NP_001155211.1, NM_001161739.1
NP_573511.2, NM_133248.2
XP_006534863.1, XM_006534800.3
UniGeneiMm.41417

3D structure databases

ProteinModelPortaliQ8BZM1
SMRiQ8BZM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228459, 2 interactors
STRINGi10090.ENSMUSP00000077168

PTM databases

PhosphoSitePlusiQ8BZM1

Proteomic databases

EPDiQ8BZM1
MaxQBiQ8BZM1
PaxDbiQ8BZM1
PRIDEiQ8BZM1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078021; ENSMUSP00000077168; ENSMUSG00000029276
ENSMUST00000082121; ENSMUSP00000080766; ENSMUSG00000029276
GeneIDi170823
KEGGimmu:170823
UCSCiuc008ymm.2 mouse

Organism-specific databases

CTDi11146
MGIiMGI:2141180 Glmn

Phylogenomic databases

eggNOGiENOG410IG4H Eukaryota
ENOG410YJ4Z LUCA
GeneTreeiENSGT00390000018446
HOGENOMiHOG000043079
HOVERGENiHBG044811
InParanoidiQ8BZM1
OMAiYFLMLDL
OrthoDBiEOG091G054M
PhylomeDBiQ8BZM1
TreeFamiTF105319

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q8BZM1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029276 Expressed in 274 organ(s), highest expression level in retina
CleanExiMM_GLMN
ExpressionAtlasiQ8BZM1 baseline and differential
GenevisibleiQ8BZM1 MM

Family and domain databases

InterProiView protein in InterPro
IPR019516 Glomulin/ALF4
IPR013877 YAP-bd/ALF4/Glomulin
PANTHERiPTHR15430 PTHR15430, 1 hit
PfamiView protein in Pfam
PF08568 Kinetochor_Ybp2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLMN_MOUSE
AccessioniPrimary (citable) accession number: Q8BZM1
Secondary accession number(s): Q3TFR5, Q99LB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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