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Protein

Pogo transposable element with ZNF domain

Gene

Pogz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 550C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri557 – 580C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri587 – 610C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri616 – 638C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri644 – 667C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri767 – 790C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri811 – 836C2H2-type 9PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • kinetochore assembly Source: UniProtKB
  • mitotic sister chromatid cohesion Source: UniProtKB
  • regulation of gene expression Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with ZNF domain
Gene namesi
Name:Pogz
Synonyms:Kiaa0461
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2442117 Pogz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472251 – 1409Pogo transposable element with ZNF domainAdd BLAST1409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei333PhosphoserineBy similarity1
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei360PhosphoserineBy similarity1
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei422PhosphoserineBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei442PhosphoserineBy similarity1
Cross-linki446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei460PhosphothreonineBy similarity1
Cross-linki486Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki626Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki674Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1334PhosphoserineBy similarity1
Modified residuei1360PhosphoserineBy similarity1
Modified residuei1366PhosphoserineBy similarity1
Modified residuei1391PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BZH4
MaxQBiQ8BZH4
PaxDbiQ8BZH4
PRIDEiQ8BZH4

PTM databases

iPTMnetiQ8BZH4
PhosphoSitePlusiQ8BZH4

Expressioni

Gene expression databases

BgeeiENSMUSG00000038902 Expressed in 247 organ(s), highest expression level in cardiac ventricle
CleanExiMM_POGZ
ExpressionAtlasiQ8BZH4 baseline and differential
GenevisibleiQ8BZH4 MM

Interactioni

Subunit structurei

Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230865, 6 interactors
IntActiQ8BZH4, 1 interactor
STRINGi10090.ENSMUSP00000102891

Structurei

3D structure databases

ProteinModelPortaliQ8BZH4
SMRiQ8BZH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1011 – 1081HTH CENPB-typePROSITE-ProRule annotationAdd BLAST71
Domaini1113 – 1319DDE-1Sequence analysisAdd BLAST207

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni806 – 846Required for interaction with CBX5By similarityAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1336 – 1364Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi872 – 927Pro-richAdd BLAST56

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 550C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri557 – 580C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri587 – 610C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri616 – 638C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri644 – 667C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri767 – 790C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri811 – 836C2H2-type 9PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG3105 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063300
HOGENOMiHOG000010309
HOVERGENiHBG049435
InParanoidiQ8BZH4
KOiK22594
OrthoDBiEOG091G01UE
PhylomeDBiQ8BZH4
TreeFamiTF331707

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8BZH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT SVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSNSGAQNSD STKKTLVTLI ANNNAGNTLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AGQPPGQSNQ TSNPKLAPSF PSPPAVSIAS
310 320 330 340 350
FVTVKRPGVT GENSNEVAKL VNTLNTVPSL GQSPGPVVVS NNSSAQRTSG
360 370 380 390 400
PESSVKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE
410 420 430 440 450
YQKKGKSLDA EPSVPSAAKP SSPEKTAPVT STPSSTPIPA LSPPTKVPEP
460 470 480 490 500
NENAGDAVQT KLIMLVDDFY YGRDGGKAAQ LTSFPKVATS FRCPHCTKRL
510 520 530 540 550
KNNIRFMNHM KHHVELDQQN GEVDGHTICQ HCYRQFSTPF QLQCHLENVH
560 570 580 590 600
SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ VCQYRSSLYS
610 620 630 640 650
EVDVHFRMIH EDTRHLLCPY CLKVFKNGNA FQQHYMRHQK RNVYHCNKCR
660 670 680 690 700
LQFLFAKDKI EHKLQHHKTF RKPKQLEGLK PGTKVTIRAS RGQPRTVPVS
710 720 730 740 750
SNDAPSGTLQ EAAALTSTDP LPVFLYPPVQ RNIQKRAVRK MSVMGRQTCL
760 770 780 790 800
ECSFEIPDFP NHFPTYVHCS LCRYSTCCSR AYANHMINNH VPRKSPKYLA
810 820 830 840 850
LFKNSVSGIK LACTSCTFAT SVGDAMAKHL VFNPSHRSSN ILPRGLSWMS
860 870 880 890 900
HLRPGQASER VFDWSMKNTY LPPPLVPNKA ATVKPVGVTP AEPQELAGPV
910 920 930 940 950
LQALPSPAST ATPPATPTHP QPSALPPSAT EGTECLNVSE QEEGSPVTQD
960 970 980 990 1000
PEPASGGGGG SGVGKKEQLS VKKLRVVLFA LCCNTEQAAE HFRNPQRRIR
1010 1020 1030 1040 1050
RWLRRFQASQ GENLEGKYLS FEAEEKLAEW VLIQREQQLP VNEETLFQKA
1060 1070 1080 1090 1100
TKIGRSLEGG FKISYEWAVR FMLRHHLTPH ARRAVAHTLP KHVAENAGLF
1110 1120 1130 1140 1150
IEFVQRQIHN QDLPLSMIVA IDEISLFLDT EVLSSDDRKE NALQTVGTGE
1160 1170 1180 1190 1200
PWCDVVLAIL ADGTVLPTLV FFRGQANRFA NVPDSILLEA KDSGYSDDEI
1210 1220 1230 1240 1250
MELWSTRVWK KHTACQHSKS MLVMDCHRTH LSEEVLALLS ASSTLPAVVP
1260 1270 1280 1290 1300
AGCSSKIQPL DVCIKRTVKN FLHKKWKEQA REMADAACDS DVLLQLVLVW
1310 1320 1330 1340 1350
LGEVLGVIGD SPELVQRSFL VASVLPGPDG NVNSPTRNAD MQEELIASLE
1360 1370 1380 1390 1400
EQLKLNGEQS EEHSASAPRP RSSPEETVEP ESLHQLFEGE SETESFYGFE

EADLDLMEI
Length:1,409
Mass (Da):154,910
Last modified:April 26, 2004 - v2
Checksum:iED08A5E2C1E719A5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUX1D3YUX1_MOUSE
Pogo transposable element with ZNF ...
Pogz
1,356Annotation score:
Q0VGT3Q0VGT3_MOUSE
Pogo transposable element with ZNF ...
Pogz mCG_13704
1,400Annotation score:
D3YUW8D3YUW8_MOUSE
Pogo transposable element with ZNF ...
Pogz
1,314Annotation score:
F7D0L1F7D0L1_MOUSE
Pogo transposable element with ZNF ...
Pogz
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti513 – 515HVE → TRP in AAH32176 (PubMed:15489334).Curated3
Sequence conflicti1342Q → E in BAC29003 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030880 mRNA Translation: BAC27169.1
AK035255 mRNA Translation: BAC29003.1
BC032176 mRNA Translation: AAH32176.1
BC096492 mRNA Translation: AAH96492.1
AK122288 mRNA Translation: BAC65570.1
CCDSiCCDS17596.1
RefSeqiNP_766271.2, NM_172683.3
XP_011238392.1, XM_011240090.2
UniGeneiMm.274787

Genome annotation databases

EnsembliENSMUST00000107270; ENSMUSP00000102891; ENSMUSG00000038902
GeneIDi229584
KEGGimmu:229584
UCSCiuc008qhc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030880 mRNA Translation: BAC27169.1
AK035255 mRNA Translation: BAC29003.1
BC032176 mRNA Translation: AAH32176.1
BC096492 mRNA Translation: AAH96492.1
AK122288 mRNA Translation: BAC65570.1
CCDSiCCDS17596.1
RefSeqiNP_766271.2, NM_172683.3
XP_011238392.1, XM_011240090.2
UniGeneiMm.274787

3D structure databases

ProteinModelPortaliQ8BZH4
SMRiQ8BZH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230865, 6 interactors
IntActiQ8BZH4, 1 interactor
STRINGi10090.ENSMUSP00000102891

PTM databases

iPTMnetiQ8BZH4
PhosphoSitePlusiQ8BZH4

Proteomic databases

EPDiQ8BZH4
MaxQBiQ8BZH4
PaxDbiQ8BZH4
PRIDEiQ8BZH4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107270; ENSMUSP00000102891; ENSMUSG00000038902
GeneIDi229584
KEGGimmu:229584
UCSCiuc008qhc.2 mouse

Organism-specific databases

CTDi23126
MGIiMGI:2442117 Pogz
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG3105 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063300
HOGENOMiHOG000010309
HOVERGENiHBG049435
InParanoidiQ8BZH4
KOiK22594
OrthoDBiEOG091G01UE
PhylomeDBiQ8BZH4
TreeFamiTF331707

Miscellaneous databases

ChiTaRSiPogz mouse
PROiPR:Q8BZH4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038902 Expressed in 247 organ(s), highest expression level in cardiac ventricle
CleanExiMM_POGZ
ExpressionAtlasiQ8BZH4 baseline and differential
GenevisibleiQ8BZH4 MM

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPOGZ_MOUSE
AccessioniPrimary (citable) accession number: Q8BZH4
Secondary accession number(s): Q4VA94
, Q80TZ8, Q8C0K1, Q8K294
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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