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Entry version 101 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Magnesium transporter NIPA4

Gene

Nipal4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a Mg2+ transporter. Can also transport other divalent cations such as Ba2+, Mn2+, Sr2+ and Co2+ but to a much less extent than Mg2+. May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity).By similarity1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.36 mM for magnesium ions1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • magnesium ion transport Source: UniProtKB

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionReceptor
    Biological processIon transport, Transport
    LigandMagnesium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-5223345 Miscellaneous transport and binding events

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Magnesium transporter NIPA4
    Alternative name(s):
    Ichthyin
    NIPA-like protein 4
    Non-imprinted in Prader-Willi/Angelman syndrome region protein 4 homolog
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Nipal4
    Synonyms:Ichn, Nipa4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2444671 Nipal4

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
    Topological domaini79 – 126CytoplasmicSequence analysisAdd BLAST48
    Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
    Topological domaini148 – 155ExtracellularSequence analysis8
    Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
    Topological domaini177 – 197CytoplasmicSequence analysisAdd BLAST21
    Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
    Topological domaini219 – 225ExtracellularSequence analysis7
    Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
    Topological domaini247 – 263CytoplasmicSequence analysisAdd BLAST17
    Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
    Topological domaini285 – 295ExtracellularSequence analysisAdd BLAST11
    Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
    Topological domaini317 – 326CytoplasmicSequence analysis10
    Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
    Topological domaini348 – 406ExtracellularSequence analysisAdd BLAST59

    Keywords - Cellular componenti

    Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002844481 – 406Magnesium transporter NIPA4Add BLAST406

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8BZF2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8BZF2

    PTM databases

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8BZF2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by low magnesium ion levels.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000020411 Expressed in 162 organ(s), highest expression level in urinary bladder urothelium

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8BZF2 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000020679

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the NIPA family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2922 Eukaryota
    ENOG410XNR8 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159087

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000203962

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8BZF2

    KEGG Orthology (KO)

    More...
    KOi
    K22733

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    QVLCQIV

    Database of Orthologous Groups

    More...
    OrthoDBi
    754939at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8BZF2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313214

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR008521 Mg_trans_NIPA

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12570 PTHR12570, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF05653 Mg_trans_NIPA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8BZF2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MELRVANANG SCENGSIVSL YCSSQEVLCQ IVRGISPEEP YNATLITWQE
    60 70 80 90 100
    RVRKKYGFYI GVGLAFLSCF LIGTSVILKK KGLIRLVATG ATRAVNGGYG
    110 120 130 140 150
    YLKDPMWWAG MATMSAGEVA NFGAYAFAPA TVVTPLGALS VLISAIFSSY
    160 170 180 190 200
    CLGESLNLLG KLGCVICMAG STVMVIHAPK EEKVTTVAEM ASKMKDTGFI
    210 220 230 240 250
    VFAVLLVVSC LILIFIVAPR YGQRNILIYI IICSVIGSFS VTAVKGLGVT
    260 270 280 290 300
    IRNFFQGLPV VRHPLPYILS LILGLSIIIQ VNFLNRALDI FNTSLVFPIY
    310 320 330 340 350
    YVFFTTVVVA SSIVLFKEWY TMSAVDIVGT LSGFVTIILG VFMLHAFKDL
    360 370 380 390 400
    DINQISLPHT HKNPTPAPAP EPTVIKLEDK NVLVDNIELA STPSPQQKPK

    VFMTDS
    Length:406
    Mass (Da):44,059
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39548AF196CF41DF
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK035561 mRNA Translation: BAC29107.1
    AL663031 Genomic DNA No translation available.
    AL713958 Genomic DNA No translation available.
    CH466575 Genomic DNA Translation: EDL33826.1
    BC139819 mRNA Translation: AAI39820.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS24572.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_766112.1, NM_172524.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000020679; ENSMUSP00000020679; ENSMUSG00000020411

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    214112

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:214112

    UCSC genome browser

    More...
    UCSCi
    uc007ioa.1 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK035561 mRNA Translation: BAC29107.1
    AL663031 Genomic DNA No translation available.
    AL713958 Genomic DNA No translation available.
    CH466575 Genomic DNA Translation: EDL33826.1
    BC139819 mRNA Translation: AAI39820.1
    CCDSiCCDS24572.1
    RefSeqiNP_766112.1, NM_172524.3

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020679

    PTM databases

    PhosphoSitePlusiQ8BZF2

    Proteomic databases

    PaxDbiQ8BZF2
    PRIDEiQ8BZF2

    Genome annotation databases

    EnsembliENSMUST00000020679; ENSMUSP00000020679; ENSMUSG00000020411
    GeneIDi214112
    KEGGimmu:214112
    UCSCiuc007ioa.1 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    348938
    MGIiMGI:2444671 Nipal4

    Phylogenomic databases

    eggNOGiKOG2922 Eukaryota
    ENOG410XNR8 LUCA
    GeneTreeiENSGT00940000159087
    HOGENOMiHOG000203962
    InParanoidiQ8BZF2
    KOiK22733
    OMAiQVLCQIV
    OrthoDBi754939at2759
    PhylomeDBiQ8BZF2
    TreeFamiTF313214

    Enzyme and pathway databases

    ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q8BZF2

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000020411 Expressed in 162 organ(s), highest expression level in urinary bladder urothelium
    GenevisibleiQ8BZF2 MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR008521 Mg_trans_NIPA
    PANTHERiPTHR12570 PTHR12570, 1 hit
    PfamiView protein in Pfam
    PF05653 Mg_trans_NIPA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIPA4_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BZF2
    Secondary accession number(s): A4QPF8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: March 1, 2003
    Last modified: October 16, 2019
    This is version 101 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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