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Protein

Neuromedin-U receptor 2

Gene

Nmur2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Gene namesi
Name:Nmur2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2441765 Nmur2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 74CytoplasmicSequence analysisAdd BLAST12
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 115ExtracellularSequence analysisAdd BLAST20
Transmembranei116 – 138Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 212ExtracellularSequence analysisAdd BLAST34
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 257CytoplasmicSequence analysisAdd BLAST24
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 293ExtracellularSequence analysisAdd BLAST15
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 395CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3351217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699111 – 395Neuromedin-U receptor 2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 196PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BZ39
PRIDEiQ8BZ39

PTM databases

PhosphoSitePlusiQ8BZ39

Expressioni

Tissue specificityi

Expressed primarily in brain tissues, more specifically in medulla and spinal cord. Widespread distribution in peripheral tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000037393
CleanExiMM_NMUR2
GenevisibleiQ8BZ39 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044718

Chemistry databases

BindingDBiQ8BZ39

Structurei

3D structure databases

ProteinModelPortaliQ8BZ39
SMRiQ8BZ39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiQ8BZ39
KOiK05053
OMAiSQYAMIN
OrthoDBiEOG091G0ZDG
PhylomeDBiQ8BZ39
TreeFamiTF318522

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005392 NeuromedU_rcpt_2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01567 NEUROMEDNU2R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BZ39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLENASWI HDSLMKYLNS TEEYLAYLCG PKRSDLSLPV SVVYALIFVV
60 70 80 90 100
GVIGNLLVCL VIARHQTLKT PTNYYLFSLA VSDLLVLLLG MPLEVYELWH
110 120 130 140 150
NYPFLFGPVG CYFKTALFET VCFASILSVT TVSIERYVAI VHPFRAKLES
160 170 180 190 200
TRRRALRILS LVWSFSVVFS LPNTSIHGIK FQQFPNGSSV PGSATCTVTK
210 220 230 240 250
PIWVYNFIIQ ATSFLFYILP MTLISVLYYL MGLRLKRDES LEADKVTVNI
260 270 280 290 300
HRPSRKSVTK MLFVLVLVFA ICWTPFHVDR LFFSFVDEWT ESLAAVFNLI
310 320 330 340 350
HVVSGVFFYL SSAVNPIIYN LLSRRFRAAF RNVVSPSCKW CHPQHRPQGP
360 370 380 390
PAQKVIFLTE CHLVELTEDA GPQFPCQSSI HNTQLTTVPC VEEVP
Length:395
Mass (Da):44,827
Last modified:March 1, 2003 - v1
Checksum:i0EA292C1947142FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202I → M in AAL26695 (PubMed:12217421).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057384 mRNA Translation: AAL26695.1
AK036756 mRNA Translation: BAC29564.1
AL671969 Genomic DNA No translation available.
CCDSiCCDS24716.1
RefSeqiNP_694719.2, NM_153079.4
UniGeneiMm.213205

Genome annotation databases

EnsembliENSMUST00000037682; ENSMUSP00000044718; ENSMUSG00000037393
GeneIDi216749
KEGGimmu:216749
UCSCiuc007izq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNMUR2_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ39
Secondary accession number(s): Q91Z76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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