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Protein

RAD50-interacting protein 1

Gene

Rint1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
RAD50-interacting protein 1
Alternative name(s):
RAD50 interactor 1
Short name:
RINT-1
Gene namesi
Name:Rint1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916233 Rint1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973501 – 792RAD50-interacting protein 1Add BLAST792

Proteomic databases

PaxDbiQ8BZ36
PeptideAtlasiQ8BZ36
PRIDEiQ8BZ36

PTM databases

iPTMnetiQ8BZ36
PhosphoSitePlusiQ8BZ36

Expressioni

Gene expression databases

BgeeiENSMUSG00000028999 Expressed in 221 organ(s), highest expression level in fibroblast
CleanExiMM_RINT1
ExpressionAtlasiQ8BZ36 baseline and differential
GenevisibleiQ8BZ36 MM

Interactioni

Subunit structurei

Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex). Interacts directly with BNIP1/SEC20L and ZW10. Interacts with RAD50 during late S and G2/M phases. Interacts with RBL2, preferentially with the active, hypophosphorylated form (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030852

Structurei

3D structure databases

ProteinModelPortaliQ8BZ36
SMRiQ8BZ36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 792RINT1/TIP20PROSITE-ProRule annotationAdd BLAST573

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili71 – 123Sequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the RINT1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2218 Eukaryota
ENOG410XZD1 LUCA
GeneTreeiENSGT00390000017006
HOGENOMiHOG000118368
HOVERGENiHBG057727
InParanoidiQ8BZ36
KOiK20474
OMAiWGENVHY
OrthoDBiEOG091G036T
PhylomeDBiQ8BZ36
TreeFamiTF324274

Family and domain databases

InterProiView protein in InterPro
IPR007528 RINT1_Tip20
PANTHERiPTHR13520 PTHR13520, 1 hit
PfamiView protein in Pfam
PF04437 RINT1_TIP1, 1 hit
PROSITEiView protein in PROSITE
PS51386 RINT1_TIP20, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BZ36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAADDIGEV PAAPCCPESG DETKNTDVKS DVNTAAPAGS EQLSQGGSDD
60 70 80 90 100
ALLSYVSAFI EKEVGSDLKS LKTLGKLIEQ MTESKVKLEE QVLTISSEIP
110 120 130 140 150
KRIQSALKDA EESKQLLDEF LEQEAPLFSS ISSHLLMAQP WMDDLGAMIT
160 170 180 190 200
QMEEIERHLA YLKWVSQTEE LSDNIQQYLM TNSVPEAASL LVTMTELDIQ
210 220 230 240 250
LQESSCTHLL SFMRATVKFW HKILKDKLTS DFEEVLAQLH WPFTSHTQSQ
260 270 280 290 300
TVGGSRPAGT PELYSSLDTL FCQLLKLQAS DELLTEPKQL PEKYCLPASP
310 320 330 340 350
PVTLPIQVML APLQKRFRYH FRGSRQTNVM SKPEWYLAQV LMWIGNHTQF
360 370 380 390 400
LDEKIQPILD KVGSAVNARL EFSRGLVMLI LEKLASDIPC LLYDDSLFCH
410 420 430 440 450
LVDEVLLFER ELHTVHGYPS TFASCMHILS EETCFQRWLT VERKFALQKM
460 470 480 490 500
DSMLSSEAAW VSQYKDISDV DEMKVPDCAE VFMTLLLVIT DRYKNLPTAS
510 520 530 540 550
RKLQFLELQK DLVDDFRIRL TQVMKEETRA ALGFRYCAIL NAVNYISAVL
560 570 580 590 600
ADWADNVFFL QLQQAALEVF AENNVLSKLQ LGQLASMESS VFDDMINLLE
610 620 630 640 650
RLKLDMLTRQ VDHVFREVKD SAKLYKKERW LSLPSQSEQA VMSLSSSACP
660 670 680 690 700
LLLTLRDRLL QLEQQLCFSL FRIFWQMLAE KLDLYIYQEI ILANHFNEGG
710 720 730 740 750
AAQLQFDMTR NLFPLFSHYC KRPENYFKHV KEACIILNLN IGSALLLKDV
760 770 780 790
LQSVSEHIPA TAALNEVGVY KLAQQDVEIL LNLRTNWPNT GK
Length:792
Mass (Da):90,094
Last modified:February 1, 2005 - v2
Checksum:iB1E104125538F6D1
GO
Isoform 2 (identifier: Q8BZ36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-229: Missing.

Note: No experimental confirmation available.
Show »
Length:734
Mass (Da):83,442
Checksum:iBAFBA6FB872719C6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YU54D3YU54_MOUSE
RAD50 interactor 1, isoform CRA_e
Rint1 mCG_114470
36Annotation score:
D3YU07D3YU07_MOUSE
RAD50 interactor 1, isoform CRA_f
Rint1 mCG_114470
60Annotation score:

Sequence cautioni

The sequence BAC29582 differs from that shown. Reason: Frameshift at position 772.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24K → N in BAC29582 (PubMed:16141072).Curated1
Sequence conflicti569V → D in BAC26077 (PubMed:16141072).Curated1
Sequence conflicti743S → C in BAC29582 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012658172 – 229Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028707 mRNA Translation: BAC26077.1
AK036805 mRNA Translation: BAC29582.1 Frameshift.
AK135334 mRNA Translation: BAE22492.1
BC065059 mRNA Translation: AAH65059.2
CCDSiCCDS39025.1 [Q8BZ36-1]
CCDS80220.1 [Q8BZ36-2]
RefSeqiNP_001297396.1, NM_001310467.1 [Q8BZ36-2]
NP_796297.2, NM_177323.4 [Q8BZ36-1]
UniGeneiMm.133300

Genome annotation databases

EnsembliENSMUST00000030852; ENSMUSP00000030852; ENSMUSG00000028999 [Q8BZ36-1]
ENSMUST00000115113; ENSMUSP00000110766; ENSMUSG00000028999 [Q8BZ36-2]
GeneIDi72772
KEGGimmu:72772
UCSCiuc008wqq.1 mouse [Q8BZ36-1]
uc012dsx.1 mouse [Q8BZ36-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028707 mRNA Translation: BAC26077.1
AK036805 mRNA Translation: BAC29582.1 Frameshift.
AK135334 mRNA Translation: BAE22492.1
BC065059 mRNA Translation: AAH65059.2
CCDSiCCDS39025.1 [Q8BZ36-1]
CCDS80220.1 [Q8BZ36-2]
RefSeqiNP_001297396.1, NM_001310467.1 [Q8BZ36-2]
NP_796297.2, NM_177323.4 [Q8BZ36-1]
UniGeneiMm.133300

3D structure databases

ProteinModelPortaliQ8BZ36
SMRiQ8BZ36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030852

PTM databases

iPTMnetiQ8BZ36
PhosphoSitePlusiQ8BZ36

Proteomic databases

PaxDbiQ8BZ36
PeptideAtlasiQ8BZ36
PRIDEiQ8BZ36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030852; ENSMUSP00000030852; ENSMUSG00000028999 [Q8BZ36-1]
ENSMUST00000115113; ENSMUSP00000110766; ENSMUSG00000028999 [Q8BZ36-2]
GeneIDi72772
KEGGimmu:72772
UCSCiuc008wqq.1 mouse [Q8BZ36-1]
uc012dsx.1 mouse [Q8BZ36-2]

Organism-specific databases

CTDi60561
MGIiMGI:1916233 Rint1

Phylogenomic databases

eggNOGiKOG2218 Eukaryota
ENOG410XZD1 LUCA
GeneTreeiENSGT00390000017006
HOGENOMiHOG000118368
HOVERGENiHBG057727
InParanoidiQ8BZ36
KOiK20474
OMAiWGENVHY
OrthoDBiEOG091G036T
PhylomeDBiQ8BZ36
TreeFamiTF324274

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:Q8BZ36
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028999 Expressed in 221 organ(s), highest expression level in fibroblast
CleanExiMM_RINT1
ExpressionAtlasiQ8BZ36 baseline and differential
GenevisibleiQ8BZ36 MM

Family and domain databases

InterProiView protein in InterPro
IPR007528 RINT1_Tip20
PANTHERiPTHR13520 PTHR13520, 1 hit
PfamiView protein in Pfam
PF04437 RINT1_TIP1, 1 hit
PROSITEiView protein in PROSITE
PS51386 RINT1_TIP20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRINT1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ36
Secondary accession number(s): Q3UXS1, Q6P1I2, Q8C193
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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