Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tensin-4

Gene

Tns4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-8875513 MET interacts with TNS proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-4
Gene namesi
Name:Tns4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144377 Tns4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14By similarityAdd BLAST14
ChainiPRO_000024821415 – 696Tensin-4Add BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.By similarity
Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BZ33
PaxDbiQ8BZ33
PeptideAtlasiQ8BZ33
PRIDEiQ8BZ33

PTM databases

iPTMnetiQ8BZ33
PhosphoSitePlusiQ8BZ33

Expressioni

Gene expression databases

BgeeiENSMUSG00000017607 Expressed in 71 organ(s), highest expression level in cornea
CleanExiMM_TNS4
GenevisibleiQ8BZ33 MM

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8BZ33
SMRiQ8BZ33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini429 – 536SH2PROSITE-ProRule annotationAdd BLAST108
Domaini528 – 695Phosphatase tensin-typeAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi174 – 299Ser-richAdd BLAST126

Keywords - Domaini

SH2 domain, Signal

Phylogenomic databases

eggNOGiENOG410IUIK Eukaryota
ENOG41125SH LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000230981
HOVERGENiHBG080039
InParanoidiQ8BZ33
KOiK18080
OMAiGPQRCSS
OrthoDBiEOG091G0G8Y
TreeFamiTF315996

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR033929 Tensin_PTB
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BZ33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSLLAGGH MVSLTPCEES RMALHPTPSP GLPALCPYYT TESWGTQPLM
60 70 80 90 100
APTLRKGSSD RLQQAQQAEA RAHCLLQGPG EQASGASQDL ESCIDFSLEA
110 120 130 140 150
LNQMILEIDP TFQLLPSGTA GPQAESTNSI MSRNKKEEPE ALDIKYIEVT
160 170 180 190 200
STRSRYLDGP QRCSSPCATP PFGSPRSGSL FLSRDIPRET RSSSNESLIF
210 220 230 240 250
SGNQGRGPSP LTPSSLSNAI PCRESRTSGS PLATPPGWEK GLRAPQRGSR
260 270 280 290 300
VSILSASPVS DVSYVFGSNQ SLPHSSLSSY PSSSRSLGSP ASSSSSLHSL
310 320 330 340 350
DRGSQCGRPS DAQAPSNPIL GMGQPQAVQS TPVAKEQASS CPASVTNSMA
360 370 380 390 400
DIPIVLINGS PEPQSPPAQR TPGHQDSVQS RVTSPSHLCQ AIKSPSKTLP
410 420 430 440 450
DVPLPASPDG PAKDMQPTMK FVMDTSKYWF KPSITREQAI NLLRTEKPGA
460 470 480 490 500
FVIRDSSSYR GSFGLALKVQ ETSASAPNRP GEDSSDLIRH FLIESSAKGV
510 520 530 540 550
HLKGADEEPY FGSLSSFVCQ HSIMALALPC KLTIPQKELG GAEPASDSPT
560 570 580 590 600
HGQTSCLKIS AGCHTLYLSS VSVETLSGAL AVQKAISVTL ERDVLPTPTV
610 620 630 640 650
VHFKVTEQGI TLTDVQRKVF FRRHYPLSAL RFCGMDPEQR KWQKYCKPSR
660 670 680 690
IFGFVAKSQT EPQENVCHLF AEYDAVQPAS QVISLVTALL QDTERM
Length:696
Mass (Da):74,622
Last modified:July 27, 2011 - v2
Checksum:iE2EB3F1D4DBFD079
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268S → I in BAC29598 (PubMed:16141072).Curated1
Sequence conflicti490H → D in BAE41928 (PubMed:16141072).Curated1
Sequence conflicti507E → K in BAE41928 (PubMed:16141072).Curated1
Sequence conflicti589T → I in AAH55820 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591366 Genomic DNA Translation: CAM26976.1
CH466556 Genomic DNA Translation: EDL16179.1
AK036834 mRNA Translation: BAC29598.1
AK170638 mRNA Translation: BAE41928.1
BC055820 mRNA Translation: AAH55820.1
CCDSiCCDS25372.1
RefSeqiNP_766152.2, NM_172564.3
UniGeneiMm.262067

Genome annotation databases

EnsembliENSMUST00000017751; ENSMUSP00000017751; ENSMUSG00000017607
GeneIDi217169
KEGGimmu:217169
UCSCiuc007lig.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591366 Genomic DNA Translation: CAM26976.1
CH466556 Genomic DNA Translation: EDL16179.1
AK036834 mRNA Translation: BAC29598.1
AK170638 mRNA Translation: BAE41928.1
BC055820 mRNA Translation: AAH55820.1
CCDSiCCDS25372.1
RefSeqiNP_766152.2, NM_172564.3
UniGeneiMm.262067

3D structure databases

ProteinModelPortaliQ8BZ33
SMRiQ8BZ33
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BZ33
PhosphoSitePlusiQ8BZ33

Proteomic databases

MaxQBiQ8BZ33
PaxDbiQ8BZ33
PeptideAtlasiQ8BZ33
PRIDEiQ8BZ33

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017751; ENSMUSP00000017751; ENSMUSG00000017607
GeneIDi217169
KEGGimmu:217169
UCSCiuc007lig.2 mouse

Organism-specific databases

CTDi84951
MGIiMGI:2144377 Tns4

Phylogenomic databases

eggNOGiENOG410IUIK Eukaryota
ENOG41125SH LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000230981
HOVERGENiHBG080039
InParanoidiQ8BZ33
KOiK18080
OMAiGPQRCSS
OrthoDBiEOG091G0G8Y
TreeFamiTF315996

Enzyme and pathway databases

ReactomeiR-MMU-8875513 MET interacts with TNS proteins

Miscellaneous databases

PROiPR:Q8BZ33
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017607 Expressed in 71 organ(s), highest expression level in cornea
CleanExiMM_TNS4
GenevisibleiQ8BZ33 MM

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR033929 Tensin_PTB
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTENS4_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ33
Secondary accession number(s): A2A552, Q3TCM8, Q7TNR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again