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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Gene

Arap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri698 – 721C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Alternative name(s):
Centaurin-delta-1
Short name:
Cnt-d1
Gene namesi
Name:Arap2
Synonyms:Centd1, Gm148, Kiaa0580
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2684416 Arap2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742131 – 1703Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2Add BLAST1703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphotyrosineCombined sources1
Modified residuei1627PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BZ05
PaxDbiQ8BZ05
PRIDEiQ8BZ05

PTM databases

iPTMnetiQ8BZ05
PhosphoSitePlusiQ8BZ05

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075924

Structurei

3D structure databases

ProteinModelPortaliQ8BZ05
SMRiQ8BZ05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 70SAMPROSITE-ProRule annotationAdd BLAST65
Domaini480 – 572PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini585 – 677PH 2PROSITE-ProRule annotationAdd BLAST93
Domaini674 – 809Arf-GAPPROSITE-ProRule annotationAdd BLAST136
Domaini899 – 1001PH 3PROSITE-ProRule annotationAdd BLAST103
Domaini1012 – 1110PH 4PROSITE-ProRule annotationAdd BLAST99
Domaini1114 – 1295Rho-GAPPROSITE-ProRule annotationAdd BLAST182
Domaini1324 – 1418Ras-associatingPROSITE-ProRule annotationAdd BLAST95
Domaini1428 – 1531PH 5PROSITE-ProRule annotationAdd BLAST104

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri698 – 721C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
HOGENOMiHOG000246988
HOVERGENiHBG095947
InParanoidiQ8BZ05
PhylomeDBiQ8BZ05

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 5 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 4 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BZ05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSVSEVNAD IRDFLMSINL EQYLLHFREF GFYTVRDCTS INDSVLHQIG
60 70 80 90 100
ISPTGHRRRI LKQLQMIFSK MQDFPIYANV HKAKNGSTTK EQQHSDPSSS
110 120 130 140 150
THTGIECSDS ITVHRPGPAP SEMVTTSTLS EGNCQSPKSH DKLCLSSHDL
160 170 180 190 200
LCPEEELHQN VDSSKDSLFG GVNVKIDPLI TKRAVEYTAG EEHTEKGNLT
210 220 230 240 250
SEDSSKALST NTECLPSGDC PTSGTHSGNG TNGVLESFPP TPFFQFQGEM
260 270 280 290 300
VVNELYVPSS PVHGPMRSRS KLVSRPSRSF LLRHRPVPEI PGSTKSIPGS
310 320 330 340 350
YFRDRRSNTT SAGKSLTLKN SNEDNSTSIF PYGETFLFQR LESSKKRSIK
360 370 380 390 400
NEFWPHENTV KEEAATTRNS ILTQSSIYDN RKEKVSEDKV EDIWIPREDK
410 420 430 440 450
NNLAQDSASE SEYSTVEECF QSLRRKNSKA SKSRTQKAFY LDPFNRHSYP
460 470 480 490 500
LSSTSGNTEP SSTISNAISP YACFYGSSAA KEKCGWLDKL SPQGKRMFQK
510 520 530 540 550
RWVKFDGLSI SHYNNDREMY SKGIIPLTAI STVRAQGDNK FEIVTTQRTF
560 570 580 590 600
VFRVEKEEER NDWISILLSA LKSPSLASQL QAAVAPEKCG YLELRGYKAK
610 620 630 640 650
IFTVLRGNSV WLCKNEQDFK SGLGITIIPM NVANVKQVDR AVKQSFEIIT
660 670 680 690 700
PYRSFSFTAD SEREKQEWIE AVQQSIAETL SDYEVAEKIW FNESNRSCAD
710 720 730 740 750
CKAPDPDWAS INLCVVICKK CAGQHRSLGP KDCKVRSLKM DASIWSNELI
760 770 780 790 800
ELFIVIGNKR ANDFWAGNLQ KDEELQVDSP VEKRKNFITQ KYKEGKFRKT
810 820 830 840 850
LLASLTKEEL NKALCAAVVK PDVLETMALL FSGADVMCAT GDPVHSTPYL
860 870 880 890 900
LAKKAGQSLQ MEFLYHNKFS DFPQYDAHFE GGSSQDAAQS SFLCDFLYQT
910 920 930 940 950
AAAASRVSSE KKLLEDTNKK WCVLEGGFLS YYENDRCTTP NGTINISEVI
960 970 980 990 1000
CLAVHKEDFY LNTGPIFVFE IYLPSERVFL FGAETSQIQR KWTETIAKRF
1010 1020 1030 1040 1050
VPFVAENLTE ADYDLIGQLF YKDCHALDQW RKGWFAMDKS SLCFCLQTQE
1060 1070 1080 1090 1100
AQEERMNLRR LQELTISTMV QNGEKVDVLL LVEKGRTLYI HGHTKLDFTV
1110 1120 1130 1140 1150
WHTAIEKAAG TDGNALQDQQ LCKNDVPIIV NSCIAFVTQY GLGCKYIYQK
1160 1170 1180 1190 1200
DGDPLHISEL LESFKKDARS VKLRAGKHQL EDVTGVLKSF LSDIDDALLT
1210 1220 1230 1240 1250
KELYPYWVSA LDTQDEKERT SKYRAFIRSL PGVNRATLAA LIEHLYRVQK
1260 1270 1280 1290 1300
CSEINHMNAH NLAMVFSSCL FQTKGQTSEE VNVIEDLINN YVEIFEVKED
1310 1320 1330 1340 1350
QVKQMDIENS FITKWKDTQV SQAGDLLIEV FVERKEPDCS IIIRISPVME
1360 1370 1380 1390 1400
AEELTNDILA IKNIIPMKGD IWATFEVIEN EELERPLHYT ENVLEQVLQW
1410 1420 1430 1440 1450
SSLAEPGSAY LVVKRFLTVD SIKQCREKSI KEGILKLKEE PSKILSGNKF
1460 1470 1480 1490 1500
QDRCVVLRDG HLFIYKDPKS SKHDKMFPLR AMKFYLGVKK KMKPPTSWGL
1510 1520 1530 1540 1550
TVYSEKHHWH LCCDSLQAQM EWMASIFIAQ HENDIWPPAG KERKRSITKN
1560 1570 1580 1590 1600
PKIGGLPLIP IQHERNATQA RKNIETARAE LERLRLSEKH DPRDFTDSSL
1610 1620 1630 1640 1650
KDRASLIAHC LEHKDEKLRN RARKHRSFNC LEDTEAEGPH GLPKAYKGPK
1660 1670 1680 1690 1700
TLKKTEERNS KATLDADPKL PSKVIEELSV VLQRSRPLHK ELPDEQTLQK

EVK
Length:1,703
Mass (Da):193,398
Last modified:August 16, 2005 - v2
Checksum:i0D99E59D35E0ABEB
GO
Isoform 2 (identifier: Q8BZ05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1519: Missing.
     1531-1575: Missing.

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):16,063
Checksum:iBD062C4BFD0425F4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QP44E9QP44_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap2
1,703Annotation score:
E0CXD0E0CXD0_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap2
126Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0149961 – 1519Missing in isoform 2. 1 PublicationAdd BLAST1519
Alternative sequenceiVSP_0149971531 – 1575Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037027 mRNA Translation: BAC29675.1
AK084988 mRNA Translation: BAC39331.1
AK122316 mRNA Translation: BAC65598.1
BC018234 mRNA Translation: AAH18234.1
CCDSiCCDS51506.1 [Q8BZ05-1]
UniGeneiMm.244403

Genome annotation databases

UCSCiuc008xlz.2 mouse [Q8BZ05-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037027 mRNA Translation: BAC29675.1
AK084988 mRNA Translation: BAC39331.1
AK122316 mRNA Translation: BAC65598.1
BC018234 mRNA Translation: AAH18234.1
CCDSiCCDS51506.1 [Q8BZ05-1]
UniGeneiMm.244403

3D structure databases

ProteinModelPortaliQ8BZ05
SMRiQ8BZ05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075924

PTM databases

iPTMnetiQ8BZ05
PhosphoSitePlusiQ8BZ05

Proteomic databases

EPDiQ8BZ05
PaxDbiQ8BZ05
PRIDEiQ8BZ05

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008xlz.2 mouse [Q8BZ05-2]

Organism-specific databases

MGIiMGI:2684416 Arap2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
HOGENOMiHOG000246988
HOVERGENiHBG095947
InParanoidiQ8BZ05
PhylomeDBiQ8BZ05

Miscellaneous databases

ChiTaRSiArap2 mouse
PROiPR:Q8BZ05
SOURCEiSearch...

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 5 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 4 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARAP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ05
Secondary accession number(s): Q80TX2, Q8C3T2, Q8VEL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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