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Entry version 121 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Solute carrier family 41 member 2

Gene

Slc41a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a plasma-membrane magnesium transporter.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport
LigandMagnesium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-425410, Metal ion SLC transporters

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 41 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc41a2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442940, Slc41a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 162ExtracellularSequence analysisAdd BLAST162
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 195CytoplasmicBy similarityAdd BLAST12
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 245ExtracellularBy similarityAdd BLAST29
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 282CytoplasmicBy similarityAdd BLAST16
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 313ExtracellularBy similarity10
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 347CytoplasmicBy similarityAdd BLAST13
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 376ExtracellularBy similarity8
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 406CytoplasmicBy similarity9
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 469ExtracellularBy similarityAdd BLAST42
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 498CytoplasmicBy similarity8
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Topological domaini520 – 543ExtracellularBy similarityAdd BLAST24
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 573CytoplasmicBy similarity9

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002950421 – 573Solute carrier family 41 member 2Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei137PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BYR8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BYR8

PRoteomics IDEntifications database

More...
PRIDEi
Q8BYR8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BYR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BYR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034591, Expressed in lacrimal gland and 231 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BYR8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036690

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BYR8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BYR8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3788, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183042

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018207_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BYR8

KEGG Orthology (KO)

More...
KOi
K15122

Identification of Orthologs from Complete Genome Data

More...
OMAi
DRHKKTN

Database of Orthologous Groups

More...
OrthoDBi
1059294at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BYR8

TreeFam database of animal gene trees

More...
TreeFami
TF313647

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006667, SLC41_membr_dom
IPR036739, SLC41_membr_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01769, MgtE, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161093, SSF161093, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BYR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHSKGRPVT YKTSASPESG GGFVDWTLNL NTIQSDKFLN LLLSMVPVIY
60 70 80 90 100
QKNQEDRHKK VNGIWQDGLS GAAQTFSKRS EPHLDYHEFS EQAFHSSSSG
110 120 130 140 150
HTPASCSPKY DDYAGYNYCD GREASETTAM LQDEDLSSEG DDVIVETSQR
160 170 180 190 200
IPKESSGVMA LQILVPFLLA GFGTVSAGMV LDIVQHWEVF KNVTEVFILV
210 220 230 240 250
PALLGLKGNL EMTLASRLST AVNVGKMDSP IEKWNLIIGN LALKQVQATV
260 270 280 290 300
VGFLAAVAAI ILGWIPEGKY YLSHSILLCS SSVATAFIAS LLQGIIMVGV
310 320 330 340 350
IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYS CLETYYYISP
360 370 380 390 400
LVCAFFLALT PIWIIIAAKH PATRTVLHSG WEPVITAMVI SSIGGLILDT
410 420 430 440 450
TVSDPNLVGI VVYTPVINGI GGNLVAIQAS RISTYLHLHS IPGELPEEPK
460 470 480 490 500
GCSYPFRTFF GSGVNNKSAQ VLLLFVIPGH LIFLYTIHLM KSGHTSLTVV
510 520 530 540 550
FVVVYLFAAV LQVFTLLWIA DWMVHRFWRK GKDPDSFSIP YLTALGDLLG
560 570
TALLALSFHF LWLIGDRDGD VGD
Length:573
Mass (Da):62,305
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4EAE989C4309B9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWW0D3YWW0_MOUSE
Solute carrier family 41 member 2
Slc41a2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYW2D3YYW2_MOUSE
Solute carrier family 41 member 2
Slc41a2
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5A5D3Z5A5_MOUSE
Solute carrier family 41 member 2
Slc41a2
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK038549 mRNA Translation: BAC30038.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24075.1

NCBI Reference Sequences

More...
RefSeqi
NP_796362.1, NM_177388.3
XP_006513874.1, XM_006513811.3
XP_011241800.1, XM_011243498.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000039956; ENSMUSP00000036690; ENSMUSG00000034591

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
338365

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:338365

UCSC genome browser

More...
UCSCi
uc007gkf.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038549 mRNA Translation: BAC30038.1
CCDSiCCDS24075.1
RefSeqiNP_796362.1, NM_177388.3
XP_006513874.1, XM_006513811.3
XP_011241800.1, XM_011243498.2

3D structure databases

SMRiQ8BYR8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036690

PTM databases

iPTMnetiQ8BYR8
PhosphoSitePlusiQ8BYR8

Proteomic databases

MaxQBiQ8BYR8
PaxDbiQ8BYR8
PRIDEiQ8BYR8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30606, 136 antibodies

Genome annotation databases

EnsembliENSMUST00000039956; ENSMUSP00000036690; ENSMUSG00000034591
GeneIDi338365
KEGGimmu:338365
UCSCiuc007gkf.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84102
MGIiMGI:2442940, Slc41a2

Phylogenomic databases

eggNOGiKOG3788, Eukaryota
GeneTreeiENSGT00950000183042
HOGENOMiCLU_018207_3_0_1
InParanoidiQ8BYR8
KOiK15122
OMAiDRHKKTN
OrthoDBi1059294at2759
PhylomeDBiQ8BYR8
TreeFamiTF313647

Enzyme and pathway databases

ReactomeiR-MMU-425410, Metal ion SLC transporters

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
338365, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slc41a2, mouse

Protein Ontology

More...
PROi
PR:Q8BYR8
RNActiQ8BYR8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034591, Expressed in lacrimal gland and 231 other tissues
GenevisibleiQ8BYR8, MM

Family and domain databases

InterProiView protein in InterPro
IPR006667, SLC41_membr_dom
IPR036739, SLC41_membr_dom_sf
PfamiView protein in Pfam
PF01769, MgtE, 2 hits
SUPFAMiSSF161093, SSF161093, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS41A2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BYR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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