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UniProtKB - Q8BYM7 (RSH4A_MOUSE)
Protein
Radial spoke head protein 4 homolog A
Gene
Rsph4a
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:32203505).
Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (PubMed:32203505).
1 PublicationGO - Biological processi
- axoneme assembly Source: MGI
- cilium movement Source: MGI
- cilium movement involved in cell motility Source: InterPro
- maintenance of ciliary planar beating movement pattern Source: MGI
- radial spoke assembly Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Radial spoke head protein 4 homolog AAlternative name(s): Radial spoke head-like protein 3 |
Gene namesi | Name:Rsph4a Synonyms:Rshl3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3027894, Rsph4a |
VEuPathDBi | HostDB:ENSMUSG00000039552 |
Subcellular locationi
Cytoskeleton
- cilium axoneme Curated
Other locations
- cilium 1 Publication
Note: Radial spoke.Curated
Cytoskeleton
- axoneme Source: MGI
- radial spoke Source: UniProtKB
- radial spoke head Source: MGI
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
Other locations
- cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313739 | 1 – 716 | Radial spoke head protein 4 homolog AAdd BLAST | 716 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 395 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q8BYM7 |
PaxDbi | Q8BYM7 |
PRIDEi | Q8BYM7 |
ProteomicsDBi | 256783 |
PTM databases
iPTMneti | Q8BYM7 |
PhosphoSitePlusi | Q8BYM7 |
Expressioni
Tissue specificityi
Expressed in the trachea, ependymal cells and oviduct (at protein level) (PubMed:32203505, PubMed:30239614). Expressed in brain, kidney and testis.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000039552, Expressed in choroid plexus epithelium and 91 other tissues |
Genevisiblei | Q8BYM7, MM |
Interactioni
Subunit structurei
Interacts with RSPH6A.
1 PublicationProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000131647 |
Miscellaneous databases
RNActi | Q8BYM7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q8BYM7 |
SMRi | Q8BYM7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 167 | DisorderedSequence analysisAdd BLAST | 167 | |
Regioni | 374 – 413 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 564 – 586 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 668 – 716 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 52 – 77 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 92 – 159 | Polar residuesSequence analysisAdd BLAST | 68 | |
Compositional biasi | 564 – 582 | Acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 702 – 716 | Acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the flagellar radial spoke RSP4/6 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QSU4, Eukaryota |
GeneTreei | ENSGT00500000044869 |
HOGENOMi | CLU_021526_1_0_1 |
InParanoidi | Q8BYM7 |
OMAi | AQFQKKM |
OrthoDBi | 619686at2759 |
PhylomeDBi | Q8BYM7 |
TreeFami | TF324531 |
Family and domain databases
InterProi | View protein in InterPro IPR006802, Radial_spoke |
PANTHERi | PTHR13159, PTHR13159, 1 hit |
Pfami | View protein in Pfam PF04712, Radial_spoke, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8BYM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENSTSLKQE KENQEPGEAE RLWQGESDVS PQEPGPPSPE YREEEQRTDT
60 70 80 90 100
EPAPRMSPSW SHQSRVSLST GDLTAGPEVS SSPPPPPLQF HSTPLNTETT
110 120 130 140 150
QDPVAASPTE KTANGIADTG TPYSDPWESS SAAKQSTSHY TSHAEESTFP
160 170 180 190 200
QSQTPQPDLC GLRDASRNKS KHKGLRFDLL QEEGSDSNCD PDQPEVGASE
210 220 230 240 250
AAQSMLEVAI QNAKAYLLST SSKSGLNLYD HLSKVLTKIL DERPADAVDI
260 270 280 290 300
IENISQDVKM AHFNKKLDTL HNEYEMLPAY EIAETQKALF LQGHLEGADS
310 320 330 340 350
ELEEEMAESS LPNVMESAYY FEQAGVGLGT DETYRVFLAL KQLTDTHPIQ
360 370 380 390 400
RCRFWGKILG LEMNYIVAEV EFRDGEDEEE VEEEGIAEER DNGGSEAGEE
410 420 430 440 450
EEEELPKSLY KAPQVIPKEE SRTGANKYVY FVCNVPGRPW VRLPSVTPAQ
460 470 480 490 500
IVTARKIKKF FTGRLDAAVI SYPPFPGNES NYLRAQIARI SAGTHVSPLG
510 520 530 540 550
FYQFGEEEGE EEEVEGGRDS YEENPDFEGI QVIDLVESLS NWVHHVQYIL
560 570 580 590 600
PQGRCNWFNP IQKDEDEEEE EEEDEEKGEE PDYIEQEVGP PLLTPISEDL
610 620 630 640 650
GIQNIPSWTT QLSSNLIPQY AIAVLRSNLW PGAYAFSNGK KFENFYIGWG
660 670 680 690 700
HKYCVENYTP PSPPPVYQEY PSGPEITEMN DPSVEEEQAF RMTQEPVALS
710
TEENEGTEDE DEDDED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC153961 Genomic DNA No translation available. BC138000 mRNA Translation: AAI38001.1 BC138001 mRNA Translation: AAI38002.1 AK038980 mRNA Translation: BAC30192.1 |
CCDSi | CCDS48534.1 |
RefSeqi | NP_001156429.1, NM_001162957.1 |
Genome annotation databases
Ensembli | ENSMUST00000169670; ENSMUSP00000131647; ENSMUSG00000039552 |
GeneIDi | 212892 |
KEGGi | mmu:212892 |
UCSCi | uc007euh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC153961 Genomic DNA No translation available. BC138000 mRNA Translation: AAI38001.1 BC138001 mRNA Translation: AAI38002.1 AK038980 mRNA Translation: BAC30192.1 |
CCDSi | CCDS48534.1 |
RefSeqi | NP_001156429.1, NM_001162957.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7DMP | electron microscopy | 3.20 | B/b | 1-716 | [»] | |
AlphaFoldDBi | Q8BYM7 | |||||
SMRi | Q8BYM7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000131647 |
PTM databases
iPTMneti | Q8BYM7 |
PhosphoSitePlusi | Q8BYM7 |
Proteomic databases
MaxQBi | Q8BYM7 |
PaxDbi | Q8BYM7 |
PRIDEi | Q8BYM7 |
ProteomicsDBi | 256783 |
Protocols and materials databases
Antibodypediai | 32513, 55 antibodies from 11 providers |
Genome annotation databases
Ensembli | ENSMUST00000169670; ENSMUSP00000131647; ENSMUSG00000039552 |
GeneIDi | 212892 |
KEGGi | mmu:212892 |
UCSCi | uc007euh.2, mouse |
Organism-specific databases
CTDi | 345895 |
MGIi | MGI:3027894, Rsph4a |
VEuPathDBi | HostDB:ENSMUSG00000039552 |
Phylogenomic databases
eggNOGi | ENOG502QSU4, Eukaryota |
GeneTreei | ENSGT00500000044869 |
HOGENOMi | CLU_021526_1_0_1 |
InParanoidi | Q8BYM7 |
OMAi | AQFQKKM |
OrthoDBi | 619686at2759 |
PhylomeDBi | Q8BYM7 |
TreeFami | TF324531 |
Miscellaneous databases
BioGRID-ORCSi | 212892, 0 hits in 70 CRISPR screens |
ChiTaRSi | Rsph4a, mouse |
PROi | PR:Q8BYM7 |
RNActi | Q8BYM7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039552, Expressed in choroid plexus epithelium and 91 other tissues |
Genevisiblei | Q8BYM7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR006802, Radial_spoke |
PANTHERi | PTHR13159, PTHR13159, 1 hit |
Pfami | View protein in Pfam PF04712, Radial_spoke, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RSH4A_MOUSE | |
Accessioni | Q8BYM7Primary (citable) accession number: Q8BYM7 Secondary accession number(s): B2RQN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | May 25, 2022 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families