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Entry version 101 (07 Apr 2021)
Sequence version 2 (15 Jan 2008)
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Protein

Radial spoke head protein 4 homolog A

Gene

Rsph4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:32203505). Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (PubMed:32203505).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Radial spoke head protein 4 homolog A
Alternative name(s):
Radial spoke head-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rsph4a
Synonyms:Rshl3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3027894, Rsph4a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show hydrocephalus and the tracheal and ependymal cell cilia show clockwise rotation motion instead of planar beating (PubMed:32203505). All three types of radial spoke heads (RS1, RS2 and RS3) are missing in the tracheal cilia (PubMed:32203505).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003137391 – 716Radial spoke head protein 4 homolog AAdd BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BYM7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BYM7

PRoteomics IDEntifications database

More...
PRIDEi
Q8BYM7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
256783

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BYM7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BYM7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the trachea, ependymal cells and oviduct (at protein level) (PubMed:32203505, PubMed:30239614). Expressed in brain, kidney and testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039552, Expressed in choroid plexus epithelium and 81 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BYM7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RSPH6A.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000131647

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BYM7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BYM7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi83 – 87Poly-Pro5
Compositional biasi369 – 404Glu-richAdd BLAST36
Compositional biasi506 – 587Glu-richAdd BLAST82

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSU4, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021526_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BYM7

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQCGFSI

Database of Orthologous Groups

More...
OrthoDBi
619686at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324531

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006802, Radial_spoke

The PANTHER Classification System

More...
PANTHERi
PTHR13159, PTHR13159, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04712, Radial_spoke, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BYM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSTSLKQE KENQEPGEAE RLWQGESDVS PQEPGPPSPE YREEEQRTDT
60 70 80 90 100
EPAPRMSPSW SHQSRVSLST GDLTAGPEVS SSPPPPPLQF HSTPLNTETT
110 120 130 140 150
QDPVAASPTE KTANGIADTG TPYSDPWESS SAAKQSTSHY TSHAEESTFP
160 170 180 190 200
QSQTPQPDLC GLRDASRNKS KHKGLRFDLL QEEGSDSNCD PDQPEVGASE
210 220 230 240 250
AAQSMLEVAI QNAKAYLLST SSKSGLNLYD HLSKVLTKIL DERPADAVDI
260 270 280 290 300
IENISQDVKM AHFNKKLDTL HNEYEMLPAY EIAETQKALF LQGHLEGADS
310 320 330 340 350
ELEEEMAESS LPNVMESAYY FEQAGVGLGT DETYRVFLAL KQLTDTHPIQ
360 370 380 390 400
RCRFWGKILG LEMNYIVAEV EFRDGEDEEE VEEEGIAEER DNGGSEAGEE
410 420 430 440 450
EEEELPKSLY KAPQVIPKEE SRTGANKYVY FVCNVPGRPW VRLPSVTPAQ
460 470 480 490 500
IVTARKIKKF FTGRLDAAVI SYPPFPGNES NYLRAQIARI SAGTHVSPLG
510 520 530 540 550
FYQFGEEEGE EEEVEGGRDS YEENPDFEGI QVIDLVESLS NWVHHVQYIL
560 570 580 590 600
PQGRCNWFNP IQKDEDEEEE EEEDEEKGEE PDYIEQEVGP PLLTPISEDL
610 620 630 640 650
GIQNIPSWTT QLSSNLIPQY AIAVLRSNLW PGAYAFSNGK KFENFYIGWG
660 670 680 690 700
HKYCVENYTP PSPPPVYQEY PSGPEITEMN DPSVEEEQAF RMTQEPVALS
710
TEENEGTEDE DEDDED
Length:716
Mass (Da):80,146
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7C76BEFB1DDEAB8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC153961 Genomic DNA No translation available.
BC138000 mRNA Translation: AAI38001.1
BC138001 mRNA Translation: AAI38002.1
AK038980 mRNA Translation: BAC30192.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48534.1

NCBI Reference Sequences

More...
RefSeqi
NP_001156429.1, NM_001162957.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000169670; ENSMUSP00000131647; ENSMUSG00000039552

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
212892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:212892

UCSC genome browser

More...
UCSCi
uc007euh.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153961 Genomic DNA No translation available.
BC138000 mRNA Translation: AAI38001.1
BC138001 mRNA Translation: AAI38002.1
AK038980 mRNA Translation: BAC30192.1
CCDSiCCDS48534.1
RefSeqiNP_001156429.1, NM_001162957.1

3D structure databases

SMRiQ8BYM7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131647

PTM databases

iPTMnetiQ8BYM7
PhosphoSitePlusiQ8BYM7

Proteomic databases

MaxQBiQ8BYM7
PaxDbiQ8BYM7
PRIDEiQ8BYM7
ProteomicsDBi256783

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32513, 56 antibodies

Genome annotation databases

EnsembliENSMUST00000169670; ENSMUSP00000131647; ENSMUSG00000039552
GeneIDi212892
KEGGimmu:212892
UCSCiuc007euh.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
345895
MGIiMGI:3027894, Rsph4a

Phylogenomic databases

eggNOGiENOG502QSU4, Eukaryota
GeneTreeiENSGT00500000044869
HOGENOMiCLU_021526_1_0_1
InParanoidiQ8BYM7
OMAiNQCGFSI
OrthoDBi619686at2759
TreeFamiTF324531

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
212892, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rsph4a, mouse

Protein Ontology

More...
PROi
PR:Q8BYM7
RNActiQ8BYM7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039552, Expressed in choroid plexus epithelium and 81 other tissues
GenevisibleiQ8BYM7, MM

Family and domain databases

InterProiView protein in InterPro
IPR006802, Radial_spoke
PANTHERiPTHR13159, PTHR13159, 1 hit
PfamiView protein in Pfam
PF04712, Radial_spoke, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSH4A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BYM7
Secondary accession number(s): B2RQN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 7, 2021
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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