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Protein

Radial spoke head protein 4 homolog A

Gene

Rsph4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Radial spoke head protein 4 homolog A
Alternative name(s):
Radial spoke head-like protein 3
Gene namesi
Name:Rsph4a
Synonyms:Rshl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3027894 Rsph4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137391 – 716Radial spoke head protein 4 homolog AAdd BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BYM7
PaxDbiQ8BYM7
PRIDEiQ8BYM7

PTM databases

iPTMnetiQ8BYM7
PhosphoSitePlusiQ8BYM7

Expressioni

Gene expression databases

BgeeiENSMUSG00000039552 Expressed in 57 organ(s), highest expression level in choroid plexus epithelium
CleanExiMM_RSHL3
GenevisibleiQ8BYM7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131647

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 87Poly-Pro5
Compositional biasi369 – 404Glu-richAdd BLAST36
Compositional biasi506 – 587Glu-richAdd BLAST82

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF1Z Eukaryota
ENOG410XQP5 LUCA
GeneTreeiENSGT00500000044869
HOGENOMiHOG000006653
InParanoidiQ8BYM7
KOiK19756
OMAiYYRRMTK
OrthoDBiEOG091G0FGU
TreeFamiTF324531

Family and domain databases

InterProiView protein in InterPro
IPR006802 Radial_spoke
PANTHERiPTHR13159 PTHR13159, 1 hit
PfamiView protein in Pfam
PF04712 Radial_spoke, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BYM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSTSLKQE KENQEPGEAE RLWQGESDVS PQEPGPPSPE YREEEQRTDT
60 70 80 90 100
EPAPRMSPSW SHQSRVSLST GDLTAGPEVS SSPPPPPLQF HSTPLNTETT
110 120 130 140 150
QDPVAASPTE KTANGIADTG TPYSDPWESS SAAKQSTSHY TSHAEESTFP
160 170 180 190 200
QSQTPQPDLC GLRDASRNKS KHKGLRFDLL QEEGSDSNCD PDQPEVGASE
210 220 230 240 250
AAQSMLEVAI QNAKAYLLST SSKSGLNLYD HLSKVLTKIL DERPADAVDI
260 270 280 290 300
IENISQDVKM AHFNKKLDTL HNEYEMLPAY EIAETQKALF LQGHLEGADS
310 320 330 340 350
ELEEEMAESS LPNVMESAYY FEQAGVGLGT DETYRVFLAL KQLTDTHPIQ
360 370 380 390 400
RCRFWGKILG LEMNYIVAEV EFRDGEDEEE VEEEGIAEER DNGGSEAGEE
410 420 430 440 450
EEEELPKSLY KAPQVIPKEE SRTGANKYVY FVCNVPGRPW VRLPSVTPAQ
460 470 480 490 500
IVTARKIKKF FTGRLDAAVI SYPPFPGNES NYLRAQIARI SAGTHVSPLG
510 520 530 540 550
FYQFGEEEGE EEEVEGGRDS YEENPDFEGI QVIDLVESLS NWVHHVQYIL
560 570 580 590 600
PQGRCNWFNP IQKDEDEEEE EEEDEEKGEE PDYIEQEVGP PLLTPISEDL
610 620 630 640 650
GIQNIPSWTT QLSSNLIPQY AIAVLRSNLW PGAYAFSNGK KFENFYIGWG
660 670 680 690 700
HKYCVENYTP PSPPPVYQEY PSGPEITEMN DPSVEEEQAF RMTQEPVALS
710
TEENEGTEDE DEDDED
Length:716
Mass (Da):80,146
Last modified:January 15, 2008 - v2
Checksum:iF7C76BEFB1DDEAB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153961 Genomic DNA No translation available.
BC138000 mRNA Translation: AAI38001.1
BC138001 mRNA Translation: AAI38002.1
AK038980 mRNA Translation: BAC30192.1
CCDSiCCDS48534.1
RefSeqiNP_001156429.1, NM_001162957.1
UniGeneiMm.131949

Genome annotation databases

EnsembliENSMUST00000169670; ENSMUSP00000131647; ENSMUSG00000039552
GeneIDi212892
KEGGimmu:212892
UCSCiuc007euh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153961 Genomic DNA No translation available.
BC138000 mRNA Translation: AAI38001.1
BC138001 mRNA Translation: AAI38002.1
AK038980 mRNA Translation: BAC30192.1
CCDSiCCDS48534.1
RefSeqiNP_001156429.1, NM_001162957.1
UniGeneiMm.131949

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131647

PTM databases

iPTMnetiQ8BYM7
PhosphoSitePlusiQ8BYM7

Proteomic databases

MaxQBiQ8BYM7
PaxDbiQ8BYM7
PRIDEiQ8BYM7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169670; ENSMUSP00000131647; ENSMUSG00000039552
GeneIDi212892
KEGGimmu:212892
UCSCiuc007euh.2 mouse

Organism-specific databases

CTDi345895
MGIiMGI:3027894 Rsph4a

Phylogenomic databases

eggNOGiENOG410IF1Z Eukaryota
ENOG410XQP5 LUCA
GeneTreeiENSGT00500000044869
HOGENOMiHOG000006653
InParanoidiQ8BYM7
KOiK19756
OMAiYYRRMTK
OrthoDBiEOG091G0FGU
TreeFamiTF324531

Miscellaneous databases

PROiPR:Q8BYM7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039552 Expressed in 57 organ(s), highest expression level in choroid plexus epithelium
CleanExiMM_RSHL3
GenevisibleiQ8BYM7 MM

Family and domain databases

InterProiView protein in InterPro
IPR006802 Radial_spoke
PANTHERiPTHR13159 PTHR13159, 1 hit
PfamiView protein in Pfam
PF04712 Radial_spoke, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSH4A_MOUSE
AccessioniPrimary (citable) accession number: Q8BYM7
Secondary accession number(s): B2RQN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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