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Protein

Neuroligin-3

Gene

Nlgn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.1 Publication

GO - Molecular functioni

GO - Biological processi

  • adult behavior Source: MGI
  • axon extension Source: BHF-UCL
  • excitatory postsynaptic potential Source: BHF-UCL
  • inhibitory postsynaptic potential Source: BHF-UCL
  • learning Source: MGI
  • long-term synaptic potentiation Source: CACAO
  • modulation of chemical synaptic transmission Source: MGI
  • negative regulation of dendritic spine morphogenesis Source: CACAO
  • negative regulation of excitatory postsynaptic potential Source: CACAO
  • neuron cell-cell adhesion Source: BHF-UCL
  • oligodendrocyte differentiation Source: MGI
  • positive regulation of AMPA receptor activity Source: BHF-UCL
  • positive regulation of dendritic spine development Source: MGI
  • positive regulation of excitatory postsynaptic potential Source: BHF-UCL
  • positive regulation of inhibitory postsynaptic potential Source: MGI
  • positive regulation of protein localization to synapse Source: MGI
  • positive regulation of synapse assembly Source: CACAO
  • positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  • positive regulation of synaptic vesicle clustering Source: CACAO
  • postsynaptic membrane assembly Source: BHF-UCL
  • presynaptic membrane assembly Source: BHF-UCL
  • receptor-mediated endocytosis Source: BHF-UCL
  • regulation of AMPA receptor activity Source: BHF-UCL
  • regulation of dendritic spine morphogenesis Source: BHF-UCL
  • regulation of long-term synaptic potentiation Source: BHF-UCL
  • regulation of NMDA receptor activity Source: BHF-UCL
  • regulation of respiratory gaseous exchange by neurological system process Source: MGI
  • regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  • regulation of terminal button organization Source: BHF-UCL
  • rhythmic synaptic transmission Source: BHF-UCL
  • social behavior Source: BHF-UCL
  • synapse assembly Source: MGI
  • synapse organization Source: MGI
  • synaptic vesicle endocytosis Source: GO_Central
  • visual learning Source: MGI
  • vocalization behavior Source: MGI

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Protein family/group databases

ESTHERimouse-3neur Neuroligin
MEROPSiS09.987

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-3
Alternative name(s):
Gliotactin homolog
Gene namesi
Name:Nlgn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2444609 Nlgn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 686ExtracellularSequence analysisAdd BLAST652
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 825CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

No obvious phenotype, but mice present subtle behavorial changes with reduced ultrasound vocalization and impaired response to olfactory cues. In addition, mice have reduced brain volume. Mice lacking both NLGN1 and NLGN3, or NLGN2 and NLGN3, are viable, but have impaired breathing, drastically reduced reproduction rates and striking deficits in raising their offspring. Mice lacking NLGN1, NLGN2 and NLGN3 are born at the expected Mendelian rate, but die shortly after birth due to respiratory failure. They do not show a significant change in the number of synapses, but synapse function is strongly impaired.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000000864635 – 825Neuroligin-3Add BLAST791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 138By similarity
Disulfide bondi317 ↔ 328By similarity
Disulfide bondi487 ↔ 521By similarity
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei722PhosphoserineBy similarity1
Modified residuei769PhosphotyrosineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BYM5
PaxDbiQ8BYM5
PRIDEiQ8BYM5

PTM databases

iPTMnetiQ8BYM5
PhosphoSitePlusiQ8BYM5

Expressioni

Tissue specificityi

Brain and arteries (at protein level). Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Expressed in olfactory bulb and olfactory epithelium. Found in olfactory ensheathing glia but not in olfactory neurons, and in developing peripheral glia.5 Publications

Developmental stagei

Detected at embryonic day E17 and postnatal day P1 in retinal astrocytes, spinal chord astrocytes and Schwann cells of the dorsal root ganglion.1 Publication

Gene expression databases

BgeeiENSMUSG00000031302
CleanExiMM_NLGN3
ExpressionAtlasiQ8BYM5 baseline and differential
GenevisibleiQ8BYM5 MM

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity). Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232793, 4 interactors
IntActiQ8BYM5, 4 interactors
MINTiQ8BYM5
STRINGi10090.ENSMUSP00000066304

Structurei

3D structure databases

ProteinModelPortaliQ8BYM5
SMRiQ8BYM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000231424
HOVERGENiHBG008839
InParanoidiQ8BYM5
KOiK07378
TreeFamiTF326187

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030024 NLGN3
PANTHERiPTHR43903:SF4 PTHR43903:SF4, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR01090 NEUROLIGIN
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BYM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLQPSLSLS PTPTVGRSLC LTLGFLSLVL RASTQAPAPT VNTHFGKLRG
60 70 80 90 100
ARVPLPSEIL GPVDQYLGVP YAAPPIGEKR FLPPEPPPSW SGIRNATHFP
110 120 130 140 150
PVCPQNIHTA VPEVMLPVWF TANLDIVATY IQEPNEDCLY LNVYVPTEDG
160 170 180 190 200
SGAKKQGEDL ADNDGDEDED IRDSGAKPVM VYIHGGSYME GTGNMIDGSV
210 220 230 240 250
LASYGNVIVI TLNYRVGVLG FLSTGDQAAK GNYGLLDQIQ ALRWVSENIA
260 270 280 290 300
FFGGDPRRIT VFGSGIGASC VSLLTLSHHS EGLFQRAIIQ SGSALSSWAV
310 320 330 340 350
NYQPVKYTSL LADKVGCNVL DTVDMVDCLR QKSAKELVEQ DIQPARYHVA
360 370 380 390 400
FGPVIDGDVI PDDPEILMEQ GEFLNYDIML GVNQGEGLKF VEGVVDPEDG
410 420 430 440 450
VSGTDFDYSV SNFVDNLYGY PEGKDTLRET IKFMYTDWAD RDNPETRRKT
460 470 480 490 500
LVALFTDHQW VEPSVVTADL HARYGSPTYF YAFYHHCQSL MKPAWSDAAH
510 520 530 540 550
GDEVPYVFGV PMVGPTDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNKP
560 570 580 590 600
VPQDTKFIHT KANRFEEVAW SKYNPRDQLY LHIGLKPRVR DHYRATKVAF
610 620 630 640 650
WKHLVPHLYN LHDMFHYTST TTKVPPPDTT HSSHITRRPN GKTWSTKRPA
660 670 680 690 700
ISPAYSNENA PGSWNGDQDA GPLLVENPRD YSTELSVTIA VGASLLFLNV
710 720 730 740 750
LAFAALYYRK DKRRQEPLRQ PSPQRGTGAP ELGTAPEEEL AALQLGPTHH
760 770 780 790 800
ECEAGPPHDT LRLTALPDYT LTLRRSPDDI PLMTPNTITM IPNSLVGLQT
810 820
LHPYNTFAAG FNSTGLPHSH STTRV
Length:825
Mass (Da):91,162
Last modified:July 27, 2011 - v2
Checksum:iCEF160C63E0A71A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64D → E in BAC30207 (PubMed:16141072).Curated1
Sequence conflicti459Q → K in BAC31918 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039018 mRNA Translation: BAC30207.1
AK044438 mRNA Translation: BAC31918.1
AL683892 Genomic DNA No translation available.
CCDSiCCDS30313.1
RefSeqiNP_766520.2, NM_172932.4
UniGeneiMm.121508

Genome annotation databases

EnsembliENSMUST00000065858; ENSMUSP00000066304; ENSMUSG00000031302
GeneIDi245537
KEGGimmu:245537
UCSCiuc009txj.3 mouse

Similar proteinsi

Entry informationi

Entry nameiNLGN3_MOUSE
AccessioniPrimary (citable) accession number: Q8BYM5
Secondary accession number(s): A2AGI1, Q8BXR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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