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Protein

Zinc finger CCCH domain-containing protein 6

Gene

Zc3h6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 297C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri299 – 326C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri327 – 350C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 6
Gene namesi
Name:Zc3h6
Synonyms:Zc3hdc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926001 Zc3h6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139021 – 1177Zinc finger CCCH domain-containing protein 6Add BLAST1177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1150PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BYK8
PRIDEiQ8BYK8

PTM databases

iPTMnetiQ8BYK8
PhosphoSitePlusiQ8BYK8

Expressioni

Gene expression databases

BgeeiENSMUSG00000042851 Expressed in 225 organ(s), highest expression level in primary oocyte
CleanExiMM_ZC3H6
ExpressionAtlasiQ8BYK8 baseline and differential
GenevisibleiQ8BYK8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105949

Structurei

3D structure databases

ProteinModelPortaliQ8BYK8
SMRiQ8BYK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 73Sequence analysisAdd BLAST47
Coiled coili347 – 383Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi386 – 518Pro-richAdd BLAST133

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 297C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri299 – 326C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri327 – 350C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040 Eukaryota
COG5084 LUCA
GeneTreeiENSGT00530000063288
HOGENOMiHOG000231733
HOVERGENiHBG063914
InParanoidiQ8BYK8
PhylomeDBiQ8BYK8

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 2 hits
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
SUPFAMiSSF90229 SSF90229, 3 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BYK8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDSEHAGHD REDGELEDGE IDDAGFEETQ DQEAKENEKQ KNEKAYRKSR
60 70 80 90 100
KKHKKEREKK KSKRRKHEKH KHNSPSGDDS SDYSLDSDVE RMQSSRKKRT
110 120 130 140 150
SSYRDYDVPF SQHRRISGSY MTSKKSQHNK KTNSKEYAES SFYSDDYFGN
160 170 180 190 200
YSDDNFGNYS NQEGEEDFSS QLKYYRQSQE SSGSSFSKES GKKLRSKGSP
210 220 230 240 250
PGTEYRIKSF DVSHGHLLPK KIRRKEHCGA RVIKGPYVFS GMDDFQEYSK
260 270 280 290 300
PGKKWKVMTQ EFINQHTVEH KGKQICKYFL EGRCIKGDHC KFNHDAELEK
310 320 330 340 350
KKEVCKYYLQ GYCTKGENCI YMHSEFPCKF YHSGAKCYQG DKCKFSHDDL
360 370 380 390 400
TKETRKLLDK VLNADEELVN EDERELEELR KRGITPLPKP PPGVGLLPTP
410 420 430 440 450
SEHFPFSDPE DDFETDLSDD MKKIPSLFEI VVKPTVDLAH KIGKKPPAFY
460 470 480 490 500
NSTSPPGPQF EESSHCPQRM YSSESSPGPG SKVPQGCESP VRHPGSPGHH
510 520 530 540 550
PCVGPPGPPM QENPSLLPSS SEIVGPHSQA GGLVQLDTLP SMGGAYHSPG
560 570 580 590 600
FPGHSVKVPR ESHSSPASLY QQMPSEMQRS ADSESMQGSA EFYDDYYPQH
610 620 630 640 650
AAHNFQPPDN SADEMWHEEF AQQQPPIARD TAHLGSGPNS SSRMTSHCPL
660 670 680 690 700
SASGLPPAVQ RALFIPLTQR YQEDEEPAGT QPHRASSKEE DDTANWYSSS
710 720 730 740 750
EEEEGSGVKS ILRTLQKQTG TLRNQQLPPT ELSVPTDPRL AKEKRKRNQV
760 770 780 790 800
VDPRLRTVPR QDIKKPHESV PVDLRLVWDP KKLRGNGGAP GGSSARGAEF
810 820 830 840 850
DLRHTNAGAN HKSKRREDDD EDSERELREK AFLIPLDSSP GIVLQDPRSQ
860 870 880 890 900
LRQFSHIKMD IILNKPNFAK HIVWAPEDLL PVPLPKPDPV SSINLPLPPL
910 920 930 940 950
IADQRLNRLW NTKSDHQGAL SLDPTSAAKA KLSLTHREGC LEQSGDLHSS
960 970 980 990 1000
GGKLGDPRLQ KNFDPRLHRL PNTESHQVTA KDSHSSRSAL PLARWNPALS
1010 1020 1030 1040 1050
QPSTAAPINV ASVTPPLYAP KLSSEGLPPG TSSSVLSGIS LYDPRDKGSL
1060 1070 1080 1090 1100
SATELSTISS GENTESQKKS GLKNSDKNQP SPGEVTVPQN TTADMEVPVD
1110 1120 1130 1140 1150
GPVDMQTDIL RSADKVQVPA VHSLPIQALT GLLRPPYSDP RQAREPGQAS
1160 1170
PTPDEETDDK PLKEVFKTFD PTASPFC
Length:1,177
Mass (Da):131,250
Last modified:May 10, 2004 - v2
Checksum:i6476FBE426823394
GO
Isoform 2 (identifier: Q8BYK8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-151: HRRISGSYMT...FYSDDYFGNY → NSAITVVHLQ...PLTAVLTFCL
     152-1177: Missing.

Show »
Length:151
Mass (Da):17,568
Checksum:i4FF97971AE87A53F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AP88A2AP88_MOUSE
Zinc finger CCCH domain-containing ...
Zc3h6 mCG_20994
1,177Annotation score:

Sequence cautioni

The sequence AAH43311 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti469R → H in AAH43311 (PubMed:15489334).Curated1
Sequence conflicti482K → N in AAH43311 (PubMed:15489334).Curated1
Sequence conflicti556V → M in AAH43311 (PubMed:15489334).Curated1
Sequence conflicti629R → H in AAH43311 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010212113 – 151HRRIS…YFGNY → NSAITVVHLQNLIHLTQKFC TSEADLLRSPLTAVLTFCL in isoform 2. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_010213152 – 1177Missing in isoform 2. 2 PublicationsAdd BLAST1026

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014766 mRNA Translation: BAB29540.1
AK039171 mRNA Translation: BAC30264.1
AL833780 Genomic DNA No translation available.
BC043311 mRNA Translation: AAH43311.1 Different initiation.
BC058173 mRNA Translation: AAH58173.1
CCDSiCCDS50707.1 [Q8BYK8-1]
UniGeneiMm.26377

Genome annotation databases

EnsembliENSMUST00000110319; ENSMUSP00000105948; ENSMUSG00000042851 [Q8BYK8-2]
UCSCiuc008mha.2 mouse [Q8BYK8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014766 mRNA Translation: BAB29540.1
AK039171 mRNA Translation: BAC30264.1
AL833780 Genomic DNA No translation available.
BC043311 mRNA Translation: AAH43311.1 Different initiation.
BC058173 mRNA Translation: AAH58173.1
CCDSiCCDS50707.1 [Q8BYK8-1]
UniGeneiMm.26377

3D structure databases

ProteinModelPortaliQ8BYK8
SMRiQ8BYK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105949

PTM databases

iPTMnetiQ8BYK8
PhosphoSitePlusiQ8BYK8

Proteomic databases

PaxDbiQ8BYK8
PRIDEiQ8BYK8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110319; ENSMUSP00000105948; ENSMUSG00000042851 [Q8BYK8-2]
UCSCiuc008mha.2 mouse [Q8BYK8-2]

Organism-specific databases

MGIiMGI:1926001 Zc3h6

Phylogenomic databases

eggNOGiKOG1040 Eukaryota
COG5084 LUCA
GeneTreeiENSGT00530000063288
HOGENOMiHOG000231733
HOVERGENiHBG063914
InParanoidiQ8BYK8
PhylomeDBiQ8BYK8

Miscellaneous databases

PROiPR:Q8BYK8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042851 Expressed in 225 organ(s), highest expression level in primary oocyte
CleanExiMM_ZC3H6
ExpressionAtlasiQ8BYK8 baseline and differential
GenevisibleiQ8BYK8 MM

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 2 hits
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
SUPFAMiSSF90229 SSF90229, 3 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZC3H6_MOUSE
AccessioniPrimary (citable) accession number: Q8BYK8
Secondary accession number(s): A2AP87
, Q80UK3, Q8C1H1, Q9D604
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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