UniProtKB - Q8BYI9 (TENR_MOUSE)
Tenascin-R
Tnr
Functioni
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
By similarity4 PublicationsMiscellaneous
GO - Molecular functioni
- integrin binding Source: MGI
- signaling receptor binding Source: GO_Central
- sphingolipid binding Source: MGI
GO - Biological processi
- associative learning Source: MGI
- cell adhesion Source: GO_Central
- extracellular matrix organization Source: MGI
- locomotory exploration behavior Source: MGI
- long-term synaptic potentiation Source: MGI
- modulation of chemical synaptic transmission Source: MGI
- negative regulation of axon extension Source: MGI
- negative regulation of axon extension involved in regeneration Source: MGI
- negative regulation of cell adhesion Source: MGI
- negative regulation of cell-cell adhesion Source: MGI
- negative regulation of neuron projection development Source: ComplexPortal
- negative regulation of synaptic transmission Source: MGI
- neuromuscular process controlling balance Source: MGI
- neuron cell-cell adhesion Source: MGI
- positive regulation of synaptic transmission, glutamatergic Source: MGI
- positive regulation of transmission of nerve impulse Source: MGI
- regulation of cell adhesion Source: ComplexPortal
- regulation of cell differentiation Source: ComplexPortal
- regulation of cell migration Source: ComplexPortal
- synapse organization Source: MGI
- telencephalon cell migration Source: MGI
Keywordsi
Biological process | Cell adhesion |
Ligand | Sialic acid |
Enzyme and pathway databases
Reactomei | R-MMU-3000178, ECM proteoglycans |
Names & Taxonomyi
Protein namesi | Recommended name: Tenascin-RShort name: TN-R Alternative name(s): Janusin Neural recognition molecule J1-160/180 Restrictin |
Gene namesi | Name:Tnr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99516, Tnr |
VEuPathDBi | HostDB:ENSMUSG00000015829 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cell surface Source: MGI
- collagen-containing extracellular matrix Source: ComplexPortal
- extracellular matrix Source: MGI
- glutamatergic synapse Source: SynGO
- hippocampal mossy fiber to CA3 synapse Source: MGI
- membrane raft Source: MGI
- perineuronal net Source: MGI
- perisynaptic extracellular matrix Source: MGI
- Schaffer collateral - CA1 synapse Source: SynGO
- tenascin complex Source: ComplexPortal
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000007748 | 32 – 1358 | Tenascin-RAdd BLAST | 1327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 198 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 278 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 297 ↔ 307 | PROSITE-ProRule annotation | ||
Disulfide bondi | 314 ↔ 323 | PROSITE-ProRule annotation | ||
Glycosylationi | 392 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 470 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 581 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 724 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 791 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 869 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 874 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1036 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1046 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1261 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, ProteoglycanProteomic databases
MaxQBi | Q8BYI9 |
PaxDbi | Q8BYI9 |
PeptideAtlasi | Q8BYI9 |
PRIDEi | Q8BYI9 |
ProteomicsDBi | 263275 [Q8BYI9-1] 263276 [Q8BYI9-2] |
PTM databases
GlyConnecti | 590, 25 N-Linked glycans (5 sites), 2 O-Linked glycans |
GlyGeni | Q8BYI9, 14 sites, 36 N-linked glycans (6 sites), 3 O-linked glycans (1 site) |
iPTMneti | Q8BYI9 |
PhosphoSitePlusi | Q8BYI9 |
SwissPalmi | Q8BYI9 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000015829, Expressed in cerebral cortex and 134 other tissues |
Genevisiblei | Q8BYI9, MM |
Interactioni
Subunit structurei
Interacts with BCAN and ACAN in a calcium-dependent manner.
Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity). Forms oligomers. Isoforms 1 and 2 form respectively trimeric (tribrachion) and dimeric kink-armed rodlike structures, which are linked by disulfide bridges.
Interacts with CNTN1, TNC and FN1.
By similarity2 PublicationsGO - Molecular functioni
- integrin binding Source: MGI
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 204272, 25 interactors |
ComplexPortali | CPX-1033, Tenascin-R complex |
IntActi | Q8BYI9, 14 interactors |
MINTi | Q8BYI9 |
STRINGi | 10090.ENSMUSP00000107298 |
Miscellaneous databases
RNActi | Q8BYI9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 188 – 199 | EGF-like 1Add BLAST | 12 | |
Domaini | 219 – 230 | EGF-like 2Add BLAST | 12 | |
Domaini | 250 – 261 | EGF-like 3Add BLAST | 12 | |
Domaini | 281 – 292 | EGF-like 4Add BLAST | 12 | |
Domaini | 312 – 323 | EGF-like 5Add BLAST | 12 | |
Domaini | 328 – 420 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 421 – 505 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 506 – 597 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 598 – 687 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 688 – 777 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 778 – 865 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 866 – 955 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 956 – 1042 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 1043 – 1131 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 1129 – 1344 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 216 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 37 – 58 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 127 – 157 | Sequence analysisAdd BLAST | 31 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG1225, Eukaryota KOG2579, Eukaryota |
GeneTreei | ENSGT00940000157761 |
HOGENOMi | CLU_001162_0_0_1 |
InParanoidi | Q8BYI9 |
OMAi | RPYNHRP |
OrthoDBi | 18592at2759 |
PhylomeDBi | Q8BYI9 |
TreeFami | TF329915 |
Family and domain databases
CDDi | cd00063, FN3, 9 hits cd00087, FReD, 1 hit |
Gene3Di | 2.60.40.10, 9 hits 3.90.215.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR041161, EGF_Tenascin IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR002181, Fibrinogen_a/b/g_C_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR033079, TNR |
PANTHERi | PTHR19143:SF254, PTHR19143:SF254, 3 hits |
Pfami | View protein in Pfam PF18720, EGF_Tenascin, 4 hits PF00147, Fibrinogen_C, 1 hit PF00041, fn3, 9 hits |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00186, FBG, 1 hit SM00060, FN3, 9 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 5 hits PS01186, EGF_2, 4 hits PS51406, FIBRINOGEN_C_2, 1 hit PS50853, FN3, 9 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGIDGETVVL KNMLIGVNLI LLGSMLKPSE CRLEVTTERA QRQTVEEEGG
60 70 80 90 100
ASSYNTSSKE QPMVFNHVYN INVPLESLCS SGLEASAEQD MSAEDDTLAE
110 120 130 140 150
YIGQTSDHES QVTFTHKINL PKKACPCASS SQVLQELLSR IEMLEREVSL
160 170 180 190 200
LRDQCNTNCC QESAATGQLD YVPHCSGHGN FSFESCGCIC NEGWFGKNCS
210 220 230 240 250
EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS SRGLCVDGEC
260 270 280 290 300
VCEEPYTGED CRELRCPGDC SGKGQCANGT CLCQEGYAGE DCSQRRCLNA
310 320 330 340 350
CSGRGHCQEG LCICEEGYQG PDCSAVAPPE DLRVAGISDR SIELEWDGPM
360 370 380 390 400
AVTEYVISYQ PTALGGLQLQ QRVPGDWSGV TIMELEPGLT YNISVYAVIS
410 420 430 440 450
NILSLPITAK VATHLSTPQG LQFKTITETT VEVQWEPFSF SFDGWEISFI
460 470 480 490 500
PKNNEGGVIA QLPSDVTSFN QTGLKPGEEY IVNVVALKEQ ARSPPTSASV
510 520 530 540 550
STVIDGPTQI LVRDVSDTVA FVEWTPPRAK VDFILLKYGL VGGEGGKTTF
560 570 580 590 600
RLQPPLSQYS VQALRPGSRY EVSISAVRGT NESEASSTQF TTEIDAPKNL
610 620 630 640 650
RVGSRTATSL DLEWDNSEAE AQEYKVVYST LAGEQYHEVL VPKGIGPTTK
660 670 680 690 700
TTLTDLVPGT EYGVGISAVM NSKQSIPATM NARTELDSPR DLMVTASSET
710 720 730 740 750
SISLIWTKAS GPIDHYRITF TPSSGISSEV TVPRDRTSYT LTDLEPGAEY
760 770 780 790 800
IISITAERGR QQSLESTVDA FTGFRPISHL HFSHVTSSSV NITWSDPSPP
810 820 830 840 850
ADRLILNYSP RDKEEDMLEV LLDATKRHAV LMGLQPATEY IVNLVAVHGT
860 870 880 890 900
VTSEPIVGSI TTGIDPPKNI TISNVTKDSL TVSWSSPVAP FDYYRVSYRP
910 920 930 940 950
TQVGRLDSSV VPNTVTEFAI TRLYPATEYE ISLNSVRGRE ESERICTLVH
960 970 980 990 1000
TAMDSPMDLI ATNITPTEAL LQWKAPMGEV ENYVIVLTHF AIAGETILVD
1010 1020 1030 1040 1050
GVSEEFQLVD LLPSTHYTVT MYATSGPLMS GTIATNFSTL LDPPDNLTAS
1060 1070 1080 1090 1100
EVTRQSALIS WQPPRAAIEN YVLTYKSTDG SRKELIVDAE DTWIRLEGLS
1110 1120 1130 1140 1150
ENTDYTVLLQ AAQEATRSSL TSTVFTTGGR VFSHPQDCAQ HLMNGDTLSG
1160 1170 1180 1190 1200
VYTIFLNGEL SHKLQVYCDM TTDGGGWIVF QRRQNGQTDF FRKWADYRVG
1210 1220 1230 1240 1250
FGNLEDEFWL GLDNIHRITA QGRYELRVDM RDGQEAVFAY YDKFAVEDSR
1260 1270 1280 1290 1300
SLYKIRIGSY NGTAGDSLSY HQGRPFSTED RDNDVAVTNC AMSYKGAWWY
1310 1320 1330 1340 1350
KNCHRTNLNG KYGESRHSQG INWYHWKGHE FSIPFVEMKM RPYIHRLTAG
RKRRALKF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YWD9 | A0A0A6YWD9_MOUSE | Tenascin-R | Tnr | 181 | Annotation score: | ||
A0A0A6YWY3 | A0A0A6YWY3_MOUSE | Tenascin-R | Tnr | 98 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 54 | Y → H in BAC30335 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012994 | 773 – 862 | Missing in isoform 2. CuratedAdd BLAST | 90 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK039390 mRNA Translation: BAC30335.1 BC132392 mRNA Translation: AAI32393.1 BC138043 mRNA Translation: AAI38044.1 AJ005844 mRNA Translation: CAA06739.1 |
CCDSi | CCDS15403.1 [Q8BYI9-1] |
RefSeqi | NP_071707.2, NM_022312.3 [Q8BYI9-1] XP_006496805.1, XM_006496742.3 [Q8BYI9-1] XP_006496806.1, XM_006496743.2 [Q8BYI9-1] XP_006496807.1, XM_006496744.3 [Q8BYI9-1] |
Genome annotation databases
Ensembli | ENSMUST00000111669; ENSMUSP00000107298; ENSMUSG00000015829 [Q8BYI9-1] ENSMUST00000192069; ENSMUSP00000141553; ENSMUSG00000015829 [Q8BYI9-1] |
GeneIDi | 21960 |
KEGGi | mmu:21960 |
UCSCi | uc007dea.2, mouse [Q8BYI9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK039390 mRNA Translation: BAC30335.1 BC132392 mRNA Translation: AAI32393.1 BC138043 mRNA Translation: AAI38044.1 AJ005844 mRNA Translation: CAA06739.1 |
CCDSi | CCDS15403.1 [Q8BYI9-1] |
RefSeqi | NP_071707.2, NM_022312.3 [Q8BYI9-1] XP_006496805.1, XM_006496742.3 [Q8BYI9-1] XP_006496806.1, XM_006496743.2 [Q8BYI9-1] XP_006496807.1, XM_006496744.3 [Q8BYI9-1] |
3D structure databases
SMRi | Q8BYI9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204272, 25 interactors |
ComplexPortali | CPX-1033, Tenascin-R complex |
IntActi | Q8BYI9, 14 interactors |
MINTi | Q8BYI9 |
STRINGi | 10090.ENSMUSP00000107298 |
PTM databases
GlyConnecti | 590, 25 N-Linked glycans (5 sites), 2 O-Linked glycans |
GlyGeni | Q8BYI9, 14 sites, 36 N-linked glycans (6 sites), 3 O-linked glycans (1 site) |
iPTMneti | Q8BYI9 |
PhosphoSitePlusi | Q8BYI9 |
SwissPalmi | Q8BYI9 |
Proteomic databases
MaxQBi | Q8BYI9 |
PaxDbi | Q8BYI9 |
PeptideAtlasi | Q8BYI9 |
PRIDEi | Q8BYI9 |
ProteomicsDBi | 263275 [Q8BYI9-1] 263276 [Q8BYI9-2] |
Protocols and materials databases
Antibodypediai | 20571, 138 antibodies from 25 providers |
DNASUi | 21960 |
Genome annotation databases
Ensembli | ENSMUST00000111669; ENSMUSP00000107298; ENSMUSG00000015829 [Q8BYI9-1] ENSMUST00000192069; ENSMUSP00000141553; ENSMUSG00000015829 [Q8BYI9-1] |
GeneIDi | 21960 |
KEGGi | mmu:21960 |
UCSCi | uc007dea.2, mouse [Q8BYI9-1] |
Organism-specific databases
CTDi | 7143 |
MGIi | MGI:99516, Tnr |
VEuPathDBi | HostDB:ENSMUSG00000015829 |
Phylogenomic databases
eggNOGi | KOG1225, Eukaryota KOG2579, Eukaryota |
GeneTreei | ENSGT00940000157761 |
HOGENOMi | CLU_001162_0_0_1 |
InParanoidi | Q8BYI9 |
OMAi | RPYNHRP |
OrthoDBi | 18592at2759 |
PhylomeDBi | Q8BYI9 |
TreeFami | TF329915 |
Enzyme and pathway databases
Reactomei | R-MMU-3000178, ECM proteoglycans |
Miscellaneous databases
BioGRID-ORCSi | 21960, 1 hit in 65 CRISPR screens |
ChiTaRSi | Tnr, mouse |
PROi | PR:Q8BYI9 |
RNActi | Q8BYI9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015829, Expressed in cerebral cortex and 134 other tissues |
Genevisiblei | Q8BYI9, MM |
Family and domain databases
CDDi | cd00063, FN3, 9 hits cd00087, FReD, 1 hit |
Gene3Di | 2.60.40.10, 9 hits 3.90.215.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR041161, EGF_Tenascin IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR002181, Fibrinogen_a/b/g_C_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR033079, TNR |
PANTHERi | PTHR19143:SF254, PTHR19143:SF254, 3 hits |
Pfami | View protein in Pfam PF18720, EGF_Tenascin, 4 hits PF00147, Fibrinogen_C, 1 hit PF00041, fn3, 9 hits |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00186, FBG, 1 hit SM00060, FN3, 9 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 5 hits PS01186, EGF_2, 4 hits PS51406, FIBRINOGEN_C_2, 1 hit PS50853, FN3, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TENR_MOUSE | |
Accessioni | Q8BYI9Primary (citable) accession number: Q8BYI9 Secondary accession number(s): A2RT70, O88717 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families