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Entry version 131 (08 May 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Lysophosphatidylcholine acyltransferase 2

Gene

Lpcat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:18156367). Activity is calcium-dependent (PubMed:17182612). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (PubMed:17182612, PubMed:18156367). Under resting conditions, acyltransferase activity is preferred (PubMed:17182612). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (PubMed:17182612). Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. Involved in the regulation of lipid droplet number and size (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=50.4 µM for acetyl-CoA1 Publication
  2. KM=21.1 µM for arachidonoyl-CoA1 Publication

    Temperature dependencei

    Optimum temperature is 7.4 degrees Celsius.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

    This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
    View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi404 – 4151PROSITE-ProRule annotationAdd BLAST12
    Calcium bindingi441 – 4522PROSITE-ProRule annotationAdd BLAST12

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase
    Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
    LigandCalcium, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.3.1.23 3474
    2.3.1.67 3474

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-1482788 Acyl chain remodelling of PC

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00085

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000293

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Lysophosphatidylcholine acyltransferase 2 (EC:2.3.1.23)
    Short name:
    LPC acyltransferase 2
    Short name:
    LPCAT-2
    Short name:
    LysoPC acyltransferase 2
    Alternative name(s):
    1-acylglycerol-3-phosphate O-acyltransferase 11 (EC:2.3.1.51)
    Short name:
    1-AGP acyltransferase 11
    Short name:
    1-AGPAT 11
    1-acylglycerophosphocholine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67)
    Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
    Short name:
    Acetyl-CoA:lyso-PAF acetyltransferase
    Short name:
    Lyso-PAF acetyltransferase
    Short name:
    LysoPAFAT
    Acyltransferase-like 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Lpcat2
    Synonyms:Aytl1, Aytl1a, Lpcat2a
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:3606214 Lpcat2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei59 – 79Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini80 – 544LumenalSequence analysisAdd BLAST465

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470591 – 544Lysophosphatidylcholine acyltransferase 2Add BLAST544

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8BYI6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8BYI6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8BYI6

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8BYI6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8BYI6

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q8BYI6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highest expression is found in resident macrophages and casein-induced neutrophils followed by skin, colon, spleen and thioglycollate-induced macrophages. Detected in erythroleukemic cells but not in reticulocytes.2 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By inflammatory stimulation by LPS and by ODN1826, a TLR9 ligand, but not by poly(I:C), a TLR3 ligand.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000033192 Expressed in 159 organ(s), highest expression level in utricle of membranous labyrinth

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8BYI6 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000049252

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8BYI6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini391 – 426EF-hand 1PROSITE-ProRule annotationAdd BLAST36
    Domaini428 – 463EF-hand 2PROSITE-ProRule annotationAdd BLAST36

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi146 – 151HXXXXD motif6
    Motifi220 – 223EGTC motif4

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The HXXXXD motif is essential for acyltransferase activity.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG4666 Eukaryota
    ENOG410XSIQ LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182744

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000234374

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8BYI6

    KEGG Orthology (KO)

    More...
    KOi
    K13510

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    THPITGW

    Database of Orthologous Groups

    More...
    OrthoDBi
    1266853at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8BYI6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323244

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00051 EFh, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011992 EF-hand-dom_pair
    IPR018247 EF_Hand_1_Ca_BS
    IPR002048 EF_hand_dom
    IPR002123 Plipid/glycerol_acylTrfase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01553 Acyltransferase, 1 hit
    PF13499 EF-hand_7, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00054 EFh, 2 hits
    SM00563 PlsC, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47473 SSF47473, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00018 EF_HAND_1, 2 hits
    PS50222 EF_HAND_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q8BYI6-1) [UniParc]FASTAAdd to basket
    Also known as: a, Aytl1_v1

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNRCAEAAAV AATVPGSGVG DAGLRPPMVP RQASFFPPPV PNPFVQQTTI
    60 70 80 90 100
    SASRRLQMFL LGIILLPVRA LLVGIILLLA WPFAVISTAC CPEKLTHPIS
    110 120 130 140 150
    NWRRKITRPA LTFLARAMFF SMGFTVTVKG KVASPLEAPI FVVAPHSTFF
    160 170 180 190 200
    DGIACVVAGL PSLVSRNENA QTPLVGRLLR ALQPVLVSRV DPDSRKNTIN
    210 220 230 240 250
    EIKKRATSGG EWPQILVFPE GTCTNRSCLI TFKPGAFIPG VPVQPVLLRY
    260 270 280 290 300
    PNKLDTVTWT WQGYTFLQLC VLTFCQLFTK VEIEFMPVQA PSEEEKNDPV
    310 320 330 340 350
    LFASRIRNLM AEALEIPVTD HTYEDCRLMI SAGQLTLPME AGLVEFSKIS
    360 370 380 390 400
    RKLKLDWDGI RKHLDEYASI ASSSKGGRIG IEEFAEYLKL PVSDVLRQLF
    410 420 430 440 450
    ALFDRNNDGS IDFREYVIGL AVLCNPANTE EIIQVAFKLF DVDEDGYITE
    460 470 480 490 500
    EEFCTILQAS LGVPDLNVSG LFREIAQRDS VSYEEFKSFA LKHPEYAKIF
    510 520 530 540
    TTYLDLQTCH VFSLPEEVQT APSVASNKVS PESQEEGTSD KKVD
    Length:544
    Mass (Da):60,254
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A790A4C71BB8898
    GO
    Isoform 2 (identifier: Q8BYI6-2) [UniParc]FASTAAdd to basket
    Also known as: b, Aytl1_v2

    The sequence of this isoform differs from the canonical sequence as follows:
         215-254: Missing.

    Show »
    Length:504
    Mass (Da):55,871
    Checksum:iA8F8F2F31006CAD9
    GO
    Isoform 3 (identifier: Q8BYI6-3) [UniParc]FASTAAdd to basket
    Also known as: c, Aytl1_v3

    The sequence of this isoform differs from the canonical sequence as follows:
         215-236: ILVFPEGTCTNRSCLITFKPGA → EPSSQEFQCSPSSSDTQTSWIL
         237-544: Missing.

    Show »
    Length:236
    Mass (Da):25,486
    Checksum:i51FA6EC5F42CC049
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037079215 – 254Missing in isoform 2. 1 PublicationAdd BLAST40
    Alternative sequenceiVSP_037080215 – 236ILVFP…FKPGA → EPSSQEFQCSPSSSDTQTSW IL in isoform 3. 1 PublicationAdd BLAST22
    Alternative sequenceiVSP_037081237 – 544Missing in isoform 3. 1 PublicationAdd BLAST308

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB244716 mRNA Translation: BAF47695.1
    AK039431 mRNA Translation: BAC30345.1
    EF442783 mRNA Translation: ABR20912.1
    EF442784 mRNA Translation: ABR20913.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS22524.1 [Q8BYI6-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_766602.1, NM_173014.1 [Q8BYI6-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000046290; ENSMUSP00000049252; ENSMUSG00000033192 [Q8BYI6-1]
    ENSMUST00000209265; ENSMUSP00000148089; ENSMUSG00000033192 [Q8BYI6-3]
    ENSMUST00000210099; ENSMUSP00000147941; ENSMUSG00000033192 [Q8BYI6-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    270084

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:270084

    UCSC genome browser

    More...
    UCSCi
    uc009muf.1 mouse [Q8BYI6-3]
    uc009mug.1 mouse [Q8BYI6-1]
    uc012gij.1 mouse [Q8BYI6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB244716 mRNA Translation: BAF47695.1
    AK039431 mRNA Translation: BAC30345.1
    EF442783 mRNA Translation: ABR20912.1
    EF442784 mRNA Translation: ABR20913.1
    CCDSiCCDS22524.1 [Q8BYI6-1]
    RefSeqiNP_766602.1, NM_173014.1 [Q8BYI6-1]

    3D structure databases

    SMRiQ8BYI6
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000049252

    Chemistry databases

    SwissLipidsiSLP:000000293

    PTM databases

    iPTMnetiQ8BYI6
    PhosphoSitePlusiQ8BYI6
    SwissPalmiQ8BYI6

    Proteomic databases

    PaxDbiQ8BYI6
    PeptideAtlasiQ8BYI6
    PRIDEiQ8BYI6

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    270084
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000046290; ENSMUSP00000049252; ENSMUSG00000033192 [Q8BYI6-1]
    ENSMUST00000209265; ENSMUSP00000148089; ENSMUSG00000033192 [Q8BYI6-3]
    ENSMUST00000210099; ENSMUSP00000147941; ENSMUSG00000033192 [Q8BYI6-2]
    GeneIDi270084
    KEGGimmu:270084
    UCSCiuc009muf.1 mouse [Q8BYI6-3]
    uc009mug.1 mouse [Q8BYI6-1]
    uc012gij.1 mouse [Q8BYI6-2]

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    54947
    MGIiMGI:3606214 Lpcat2

    Phylogenomic databases

    eggNOGiKOG4666 Eukaryota
    ENOG410XSIQ LUCA
    GeneTreeiENSGT00950000182744
    HOGENOMiHOG000234374
    InParanoidiQ8BYI6
    KOiK13510
    OMAiTHPITGW
    OrthoDBi1266853at2759
    PhylomeDBiQ8BYI6
    TreeFamiTF323244

    Enzyme and pathway databases

    UniPathwayiUPA00085
    BRENDAi2.3.1.23 3474
    2.3.1.67 3474
    ReactomeiR-MMU-1482788 Acyl chain remodelling of PC

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    Lpcat2 mouse

    Protein Ontology

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    PROi
    PR:Q8BYI6

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000033192 Expressed in 159 organ(s), highest expression level in utricle of membranous labyrinth
    GenevisibleiQ8BYI6 MM

    Family and domain databases

    CDDicd00051 EFh, 1 hit
    InterProiView protein in InterPro
    IPR011992 EF-hand-dom_pair
    IPR018247 EF_Hand_1_Ca_BS
    IPR002048 EF_hand_dom
    IPR002123 Plipid/glycerol_acylTrfase
    PfamiView protein in Pfam
    PF01553 Acyltransferase, 1 hit
    PF13499 EF-hand_7, 1 hit
    SMARTiView protein in SMART
    SM00054 EFh, 2 hits
    SM00563 PlsC, 1 hit
    SUPFAMiSSF47473 SSF47473, 1 hit
    PROSITEiView protein in PROSITE
    PS00018 EF_HAND_1, 2 hits
    PS50222 EF_HAND_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCAT2_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BYI6
    Secondary accession number(s): A3KBM0, A9Q1G2, A9Q1G3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 1, 2003
    Last modified: May 8, 2019
    This is version 131 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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