Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (17 Jun 2020)
Sequence version 2 (02 May 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Chromodomain-helicase-DNA-binding protein 9

Gene

Chd9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA (By similarity). Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi884 – 891ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-400206 Regulation of lipid metabolism by PPARalpha

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 9 (EC:3.6.4.12)
Short name:
CHD-9
Alternative name(s):
ATP-dependent helicase CHD9
PPAR-alpha-interacting complex protein 320 kDa
Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chd9
Synonyms:Kiaa0308, Pric320
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924001 Chd9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331731 – 2885Chromodomain-helicase-DNA-binding protein 9Add BLAST2885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei498N6-acetyllysineBy similarity1
Modified residuei549PhosphoserineBy similarity1
Cross-linki595Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei610PhosphoserineBy similarity1
Modified residuei1467PhosphoserineBy similarity1
Modified residuei1471PhosphoserineBy similarity1
Cross-linki1587Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1737Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2025PhosphoserineBy similarity1
Cross-linki2037Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2057PhosphoserineBy similarity1
Modified residuei2058PhosphoserineBy similarity1
Cross-linki2073Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2074PhosphoserineBy similarity1
Modified residuei2078PhosphoserineBy similarity1
Cross-linki2349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki2355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki2360Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki2833Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BYH8

PeptideAtlas

More...
PeptideAtlasi
Q8BYH8

PRoteomics IDEntifications database

More...
PRIDEi
Q8BYH8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BYH8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BYH8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in osteoprogenitor cells during development and in mature bone (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from embryonic day 16.5 dpc in mesenchymal cartilage surrounding bone cartilage and newly formed bone trabecular spicules. Detected in bone sections of 4-day-old newborn and 3-week-old mice.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000056608 Expressed in manus and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BYH8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BYH8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPARA. Probably interacts with ESR1 and NR1I3 (By similarity).

By similarity

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8BYH8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105243

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BYH8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BYH8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini689 – 760Chromo 1PROSITE-ProRule annotationAdd BLAST72
Domaini772 – 838Chromo 2PROSITE-ProRule annotationAdd BLAST67
Domaini871 – 1045Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini1185 – 1336Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2331 – 2471Binds A/T-rich DNABy similarityAdd BLAST141
Regioni2428 – 2435A.T hook-like8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi867 – 871LXXLL motif 15
Motifi996 – 999DEAH box4
Motifi1035 – 1039LXXLL motif 25
Motifi2030 – 2034LXXLL motif 35
Motifi2710 – 2714LXXLL motif 45
Motifi2782 – 2787LXXLL motif 56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0384 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000315_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BYH8

KEGG Orthology (KO)

More...
KOi
K14438

Identification of Orthologs from Complete Genome Data

More...
OMAi
VKEEYDQ

Database of Orthologous Groups

More...
OrthoDBi
7181at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BYH8

TreeFam database of animal gene trees

More...
TreeFami
TF313572

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.28.130, 2 hits
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR042850 CHD9
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

The PANTHER Classification System

More...
PANTHERi
PTHR46850 PTHR46850, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07533 BRK, 2 hits
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00592 BRK, 2 hits
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160481 SSF160481, 2 hits
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50013 CHROMO_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BYH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDPMMDFFD DANLFGETLE GLSDDTFVQP GPVSLVDELN LGAEFEPLHI
60 70 80 90 100
DSLNHVQGTP THQKMADFEQ LSQFDSMKFH PVNQSFGSPV EHVLSPHSQF
110 120 130 140 150
NCSPIHPPNQ PNGLFQDVAD GSPMWGHQTA TGLANQNGSP FHQPGHSHSL
160 170 180 190 200
HQNKSFVAHP DFALFQASEH QTQCSSLHSQ QSRSNLNPGQ NSLGQAKNFL
210 220 230 240 250
DANVSGAHRV NVNHLATAPS SQQTLPVQFS PTANPPAHFL KCSSHQEGNY
260 270 280 290 300
NRPSPSMTSC SVSNSQQFPS HYSFSSGHVS PSSLLQSSAG LAPGHTNQAL
310 320 330 340 350
SDFAGSNSFS PHRGMKQEPT QHLLNPTPSL NSNNFQILHS SHPQGNYSNS
360 370 380 390 400
KLSPVHMNFP DPVDAGPPVG HFNDHAETNG FSSLEENLLH HVDSHAEPFA
410 420 430 440 450
GLDPEDLLQE GLLPQFDESP FGQDNSNHVL DHDLDRQFTS HLVSRPSDMA
460 470 480 490 500
QTQLQYQARG WPSPLSTNHQ HLHSRNHLCL QRQPPSSKKS DGSGTYTKLQ
510 520 530 540 550
NTQVRVMSEK KPRKRVESES KQEKANRIIS EAIARAKERG ERNIPRVMSP
560 570 580 590 600
ENFPSASVEG KEEKRGRRMK SKPKDRDNKK PKTYSKLKEK TKIGKLIITL
610 620 630 640 650
GKKHKRRNES SDELSDAEQR SQHTFKEQHS QKRRSNRQIK RKKYAEDAEG
660 670 680 690 700
KQSEEEVKGS LRVKRNSAPP PGEQPLQLFV ENPSEEDAAI VDKILACRTV
710 720 730 740 750
KKEVSPGVML DIEEFFVKYK NYSYLHCEWA TEQQLLKDKR IQQKIKRFKL
760 770 780 790 800
RQAQRAHFLA DMEEEPFNPD YVEVDRILEV SFCEDKDTGE SVIYYLVKWC
810 820 830 840 850
SLPYEDSTWE LKEDVDLAKI EEFEQLQASR PDTRHLDRPP SNIWKKIEQS
860 870 880 890 900
REYKNGNQLR EYQLEGLNWL LFNWYNRRNC ILADEMGLGK TIQSITFLYE
910 920 930 940 950
ILLTGIRGPF LIIAPLSTIA NWEREFRTWT DINVVVYHGS LISRQMIQQY
960 970 980 990 1000
EMYFRDSQGR IIRGAYRFQA IITTFEMILG GCGELNAIDW RCVIIDEAHR
1010 1020 1030 1040 1050
LKNKNCKLLE GLKLMNLEHK VLLTGTPLQN TVEELFSLLH FLEPLRFPSE
1060 1070 1080 1090 1100
STFMQEFGDL KTEEQVQKLQ AILKPMMLRR LKEDVEKKLA PKEETIIEVE
1110 1120 1130 1140 1150
LTNIQKKYYR AILEKNFSFL SKGAGQTNVP NLVNTMMELR KCCNHPYLIK
1160 1170 1180 1190 1200
GAEEKILGEF RDTYNPSASD FHLQAMIQSA GKLVLIDKLL PKMKAGGHKV
1210 1220 1230 1240 1250
LIFSQMVRCL DILEDYLIHK RYLYERIDGR VRGNLRQAAI DRFSKPDSDR
1260 1270 1280 1290 1300
FVFLLCTRAG GLGINLTAAD TCIIFDSDWN PQNDLQAQAR CHRIGQNKAV
1310 1320 1330 1340 1350
KVYRLVTRNS YEREMFDRAS LKLGLDKAVL QSMSGRDSNV SGIQQLSKKE
1360 1370 1380 1390 1400
IEDLLRRGAY GAIMEEEDEG SKFCEEDIDQ ILLRRTKTIT IESEGRGSTF
1410 1420 1430 1440 1450
AKASFVASGN RTDISLDDPN FWQKWAKKAE LDIDTISGRN SLVIDTPRIR
1460 1470 1480 1490 1500
KQTRPFSATK DELAELSEAE SEGEEKPKLR RPCDRSGGYG RTECFRVEKN
1510 1520 1530 1540 1550
LLVYGWGRWR EILSHGRFKR QLNEHDVEVI CRALLAYCLI HYRGDEKIKG
1560 1570 1580 1590 1600
FIWDLITPTE DGQTRELQNH LGLSAPVPRG RKGKKVKTQT SSFDIQKAEW
1610 1620 1630 1640 1650
LRKYNPEQLL QDEGYKKHVK HHCNKVLLRV RMLYYLKQEV IGNESQKVFD
1660 1670 1680 1690 1700
GVDASDIDVW VPEPDHSEVP AAWWDFDADK SLLIGVFKHG YEKYNTIRAD
1710 1720 1730 1740 1750
PALCFLERVG KPDDKAVAAE QRANDYMDGD VEDPEYKPAP AIFKDDIEDD
1760 1770 1780 1790 1800
VSSPGDLVIA DGEGQLMEGD KVYWPTPSAL TTRLRRLITA YQRTNKNRHI
1810 1820 1830 1840 1850
QQMQPTFSLP ANAMQPLYEE ATLNPKMAAK IERQQRWTRR EEADFYRVVS
1860 1870 1880 1890 1900
TFGVVFDPDR GQFDWTKFRA LARLHKKTDN SLEKYLCAFM SMCRRVCRLP
1910 1920 1930 1940 1950
SKEELVDPNI FIQPITEERA SRTLYRIELL RKVREQALRH PQLFERLKLC
1960 1970 1980 1990 2000
HPNPDLPIWW ECGSHDRDLL IGAAKHGVSR TDYHILRDPE LSFMAAQRNY
2010 2020 2030 2040 2050
NQSKAAHSRT SAPLLQQYQV ALSASPLTSL PRLLGAKGTL LEDMKVKSES
2060 2070 2080 2090 2100
LTEEPQSSEE ESMSSMETRT RVKSEPVSPK NGVLSQATGD QKSGGKSETD
2110 2120 2130 2140 2150
RRMVAARTEP LTPNPASKKP RVHKRGSQSS SDSDSDSARS SCSSRSSSSS
2160 2170 2180 2190 2200
SSSSSCSHSR SGSSSSSSSS CSSASSSSSS SSSSSSSSSS SSSEESDSEE
2210 2220 2230 2240 2250
DVQKREGTPH RKAYDEESVA SLSTTQDETQ DSFQANNGTP ESAYLLQGGY
2260 2270 2280 2290 2300
MLAASYWPKD RVMINRLDSI CQTVLKGKWP SARRHYDANT VASFYTTKLL
2310 2320 2330 2340 2350
DSPGAATERG EPSVPTPPAV AVREEHEQSA QMSKVKKHVR EKEFTVKIKD
2360 2370 2380 2390 2400
EGGLKLTFQK QGLAQKRPFD GEDGALGQQQ YLTRLRELQS TSETSLVNLP
2410 2420 2430 2440 2450
KAVPASGTSI QPTLGANGAI LDSQPIVKKR RGRRRNVEGA DILFLNRNKP
2460 2470 2480 2490 2500
PNHIPTGMNP ALSYPQPQRI PDTESPVPVI NLKDGTRLAG DDAPKRKDLD
2510 2520 2530 2540 2550
RWLKEHPGYV EDLGAFIPRV QLHEGRPKQK RHRCRNPNKL DINSLTGEER
2560 2570 2580 2590 2600
VQLINRRNAR KVGGAFAPPL KDLCRFLKEN SEYGVAPEWG DVVKQSGFLP
2610 2620 2630 2640 2650
ESMFERILTG PVVREEVSRR GRRPKSGIAK ATTAAAVPAG SVPGNPLLAN
2660 2670 2680 2690 2700
GLLPGVDLTA LQALQQNLQN LQSLQVTAGL MGMPAGLSSG GETKNMAAMF
2710 2720 2730 2740 2750
PMLFSGMAGL PNLLGMGGLL SKTAESGAEE KRGNDSKELE GKKERTESQS
2760 2770 2780 2790 2800
PENGGERCVP GSPSTSSTAA LSSAAAAKPI ALNPLLLSNI LYPGMLLTPG
2810 2820 2830 2840 2850
LNLHLPTLSQ SNAFDVQKNK SDDLDSSKSV EIKEENSRVR DQEEKGGTEP
2860 2870 2880
SPLNENSTDE GSERASSGSD SSSSSSEDSD SSNED
Length:2,885
Mass (Da):323,860
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB820BE8EA9CC2915
GO
Isoform 2 (identifier: Q8BYH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2335-2350: Missing.

Show »
Length:2,869
Mass (Da):321,894
Checksum:iA684A06A35C83F91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GR76A0A1B0GR76_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd9
1,853Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GS03A0A1B0GS03_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd9
874Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GS89A0A1B0GS89_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd9
641Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GQX8A0A1B0GQX8_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd9
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52896 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101N → I in BAC39090 (PubMed:16141072).Curated1
Sequence conflicti584Y → D in BAC28711 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0180872335 – 2350Missing in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ127229 mRNA Translation: AAZ73184.2
AK034446 mRNA Translation: BAC28711.1
AK039562 mRNA Translation: BAC30385.1
AK084000 mRNA Translation: BAC39090.1
AB093226 mRNA Translation: BAC41410.3
BC052896 mRNA Translation: AAH52896.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22517.1 [Q8BYH8-2]
CCDS80912.1 [Q8BYH8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001297459.1, NM_001310530.1 [Q8BYH8-1]
NP_796198.1, NM_177224.2 [Q8BYH8-2]
XP_006530632.1, XM_006530569.2 [Q8BYH8-1]
XP_011246574.1, XM_011248272.2 [Q8BYH8-1]
XP_011246575.1, XM_011248273.2 [Q8BYH8-1]
XP_011246576.1, XM_011248274.2 [Q8BYH8-1]
XP_011246577.1, XM_011248275.2 [Q8BYH8-1]
XP_017168006.1, XM_017312517.1 [Q8BYH8-1]
XP_017168007.1, XM_017312518.1 [Q8BYH8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000048665; ENSMUSP00000046356; ENSMUSG00000056608 [Q8BYH8-2]
ENSMUST00000109614; ENSMUSP00000105243; ENSMUSG00000056608 [Q8BYH8-1]
ENSMUST00000209423; ENSMUSP00000148088; ENSMUSG00000056608 [Q8BYH8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109151

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:109151

UCSC genome browser

More...
UCSCi
uc009msf.2 mouse [Q8BYH8-2]
uc009msi.2 mouse [Q8BYH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ127229 mRNA Translation: AAZ73184.2
AK034446 mRNA Translation: BAC28711.1
AK039562 mRNA Translation: BAC30385.1
AK084000 mRNA Translation: BAC39090.1
AB093226 mRNA Translation: BAC41410.3
BC052896 mRNA Translation: AAH52896.1 Different initiation.
CCDSiCCDS22517.1 [Q8BYH8-2]
CCDS80912.1 [Q8BYH8-1]
RefSeqiNP_001297459.1, NM_001310530.1 [Q8BYH8-1]
NP_796198.1, NM_177224.2 [Q8BYH8-2]
XP_006530632.1, XM_006530569.2 [Q8BYH8-1]
XP_011246574.1, XM_011248272.2 [Q8BYH8-1]
XP_011246575.1, XM_011248273.2 [Q8BYH8-1]
XP_011246576.1, XM_011248274.2 [Q8BYH8-1]
XP_011246577.1, XM_011248275.2 [Q8BYH8-1]
XP_017168006.1, XM_017312517.1 [Q8BYH8-1]
XP_017168007.1, XM_017312518.1 [Q8BYH8-1]

3D structure databases

SMRiQ8BYH8
ModBaseiSearch...

Protein-protein interaction databases

CORUMiQ8BYH8
STRINGi10090.ENSMUSP00000105243

PTM databases

iPTMnetiQ8BYH8
PhosphoSitePlusiQ8BYH8

Proteomic databases

PaxDbiQ8BYH8
PeptideAtlasiQ8BYH8
PRIDEiQ8BYH8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28339 61 antibodies

Genome annotation databases

EnsembliENSMUST00000048665; ENSMUSP00000046356; ENSMUSG00000056608 [Q8BYH8-2]
ENSMUST00000109614; ENSMUSP00000105243; ENSMUSG00000056608 [Q8BYH8-1]
ENSMUST00000209423; ENSMUSP00000148088; ENSMUSG00000056608 [Q8BYH8-1]
GeneIDi109151
KEGGimmu:109151
UCSCiuc009msf.2 mouse [Q8BYH8-2]
uc009msi.2 mouse [Q8BYH8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80205
MGIiMGI:1924001 Chd9

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0384 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000155706
HOGENOMiCLU_000315_5_1_1
InParanoidiQ8BYH8
KOiK14438
OMAiVKEEYDQ
OrthoDBi7181at2759
PhylomeDBiQ8BYH8
TreeFamiTF313572

Enzyme and pathway databases

ReactomeiR-MMU-400206 Regulation of lipid metabolism by PPARalpha

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
109151 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Chd9 mouse

Protein Ontology

More...
PROi
PR:Q8BYH8
RNActiQ8BYH8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000056608 Expressed in manus and 234 other tissues
ExpressionAtlasiQ8BYH8 baseline and differential
GenevisibleiQ8BYH8 MM

Family and domain databases

Gene3Di2.20.28.130, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR042850 CHD9
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR46850 PTHR46850, 1 hit
PfamiView protein in Pfam
PF07533 BRK, 2 hits
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592 BRK, 2 hits
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF160481 SSF160481, 2 hits
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BYH8
Secondary accession number(s): Q7TMV5
, Q8BJG8, Q8BZJ2, Q8CHG8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: June 17, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again