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Protein

tRNA:m(4)X modification enzyme TRM13 homolog

Gene

Trmt13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

tRNA methylase which 2'-O-methylates cytidine4 in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine4 in tRNA(His).By similarity

Catalytic activityi

S-adenosyl-L-methionine + cytidine4 in tRNA(Pro) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Pro).By similarity
S-adenosyl-L-methionine + cytidine4 in tRNA(Gly)(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Gly)(GCC).By similarity
S-adenosyl-L-methionine + adenosine4 in tRNA(His) = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNA(His).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri56 – 83CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • tRNA 2'-O-methyltransferase activity Source: InterPro
  • tRNA methyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA:m(4)X modification enzyme TRM13 homolog (EC:2.1.1.225)
Alternative name(s):
Coiled-coil domain-containing protein 76
Gene namesi
Name:Trmt13
Synonyms:Ccdc76
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1925219 Trmt13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002366791 – 481tRNA:m(4)X modification enzyme TRM13 homologAdd BLAST481

Proteomic databases

MaxQBiQ8BYH3
PaxDbiQ8BYH3
PeptideAtlasiQ8BYH3
PRIDEiQ8BYH3

PTM databases

iPTMnetiQ8BYH3
PhosphoSitePlusiQ8BYH3

Expressioni

Gene expression databases

BgeeiENSMUSG00000033439 Expressed in 233 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CCDC76
ExpressionAtlasiQ8BYH3 baseline and differential
GenevisibleiQ8BYH3 MM

Structurei

3D structure databases

ProteinModelPortaliQ8BYH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili113 – 140Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the methyltransferase TRM13 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri56 – 83CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2811 Eukaryota
ENOG410Z6H8 LUCA
GeneTreeiENSGT00390000003182
HOGENOMiHOG000000772
HOVERGENiHBG054828
InParanoidiQ8BYH3
KOiK15446
OMAiLIALCCH
OrthoDBiEOG091G0B5L
PhylomeDBiQ8BYH3
TreeFamiTF317538

Family and domain databases

InterProiView protein in InterPro
IPR007871 Methyltransferase_TRM13
IPR039044 Trm13
IPR022776 TRM13/UPF0224_CHHC_Znf_dom
IPR021721 Znf_CCCH-type_TRM13
PANTHERiPTHR12998 PTHR12998, 1 hit
PfamiView protein in Pfam
PF05206 TRM13, 1 hit
PF11722 zf-TRM13_CCCH, 1 hit
PF05253 zf-U11-48K, 1 hit
PROSITEiView protein in PROSITE
PS51800 ZF_CHHC_U11_48K, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8BYH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPAATSPS IGFPIDGRCN YFVEKKKRFC RMVAAAGKRF CGEHAGSAEE
60 70 80 90 100
ENTRKRILCP LDPKHTVYED QLAKHLKKCN SREKPKPDFF IQDINAGLKD
110 120 130 140 150
ETEIPEQLVP FSSLSEEQLE NLIKKLRKAS EGLNSTHEDH IMSHPALHDA
160 170 180 190 200
LNDPRNGDCA VKHLKQQASI LGNIEKLKLL GPRRCFVEFG AGKGKLSHWV
210 220 230 240 250
DIALKDAENV HFILVERVTT RFKVDGKHRK KDSVFERLQI DIQHLCLNRV
260 270 280 290 300
PVLREGRLPV VGIGKHLCGV ATDVALRCLV ETYAASFEEK DEEPLAKRIK
310 320 330 340 350
NDKTEKESNT LAKEGSEKDV PETWTPVAGI VIALCCHHRC DWRHYVGKEY
360 370 380 390 400
FKALGLGAVE FYYFQRMSSW ATCGMRTSLE GSDVTPERKD AQRDENEEHD
410 420 430 440 450
DGGDRLTDGN TDSLPGILTV EEKKKIGHLC KLLIDQGRLQ YLQQKGFSPA
460 470 480
LQYYTDPLVS LENVLLTAVP AHPSSQEKHH Q
Length:481
Mass (Da):54,261
Last modified:March 1, 2003 - v1
Checksum:iA301831B337D62B2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXM2V9GXM2_MOUSE
tRNA:m(4)X modification enzyme TRM1...
Trmt13
176Annotation score:
V9GWW9V9GWW9_MOUSE
MCG2008, isoform CRA_b
Trmt13 mCG_2008
292Annotation score:
A0A0G2JGN8A0A0G2JGN8_MOUSE
tRNA:m(4)X modification enzyme TRM1...
Trmt13
179Annotation score:
S4R2S3S4R2S3_MOUSE
tRNA:m(4)X modification enzyme TRM1...
Trmt13
64Annotation score:
A0A0G2JDL0A0A0G2JDL0_MOUSE
tRNA:m(4)X modification enzyme TRM1...
Trmt13
145Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039588 mRNA Translation: BAC30394.1
CCDSiCCDS38612.1
RefSeqiNP_084292.1, NM_030016.2
UniGeneiMm.259648

Genome annotation databases

EnsembliENSMUST00000041524; ENSMUSP00000047320; ENSMUSG00000033439
GeneIDi229780
KEGGimmu:229780
UCSCiuc008rck.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039588 mRNA Translation: BAC30394.1
CCDSiCCDS38612.1
RefSeqiNP_084292.1, NM_030016.2
UniGeneiMm.259648

3D structure databases

ProteinModelPortaliQ8BYH3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BYH3
PhosphoSitePlusiQ8BYH3

Proteomic databases

MaxQBiQ8BYH3
PaxDbiQ8BYH3
PeptideAtlasiQ8BYH3
PRIDEiQ8BYH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041524; ENSMUSP00000047320; ENSMUSG00000033439
GeneIDi229780
KEGGimmu:229780
UCSCiuc008rck.1 mouse

Organism-specific databases

CTDi54482
MGIiMGI:1925219 Trmt13

Phylogenomic databases

eggNOGiKOG2811 Eukaryota
ENOG410Z6H8 LUCA
GeneTreeiENSGT00390000003182
HOGENOMiHOG000000772
HOVERGENiHBG054828
InParanoidiQ8BYH3
KOiK15446
OMAiLIALCCH
OrthoDBiEOG091G0B5L
PhylomeDBiQ8BYH3
TreeFamiTF317538

Miscellaneous databases

PROiPR:Q8BYH3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033439 Expressed in 233 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CCDC76
ExpressionAtlasiQ8BYH3 baseline and differential
GenevisibleiQ8BYH3 MM

Family and domain databases

InterProiView protein in InterPro
IPR007871 Methyltransferase_TRM13
IPR039044 Trm13
IPR022776 TRM13/UPF0224_CHHC_Znf_dom
IPR021721 Znf_CCCH-type_TRM13
PANTHERiPTHR12998 PTHR12998, 1 hit
PfamiView protein in Pfam
PF05206 TRM13, 1 hit
PF11722 zf-TRM13_CCCH, 1 hit
PF05253 zf-U11-48K, 1 hit
PROSITEiView protein in PROSITE
PS51800 ZF_CHHC_U11_48K, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRM13_MOUSE
AccessioniPrimary (citable) accession number: Q8BYH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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