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Protein

Ephrin type-A receptor 10

Gene

Epha10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 10 (EC:2.7.10.1)
Gene namesi
Name:Epha10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3586824 Epha10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 565ExtracellularSequence analysisAdd BLAST543
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 1007CytoplasmicSequence analysisAdd BLAST421

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000028044423 – 1007Ephrin type-A receptor 10Add BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiQ8BYG9
PRIDEiQ8BYG9

PTM databases

iPTMnetiQ8BYG9
PhosphoSitePlusiQ8BYG9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028876 Expressed in 94 organ(s), highest expression level in bone marrow
CleanExiMM_EPHA10
ExpressionAtlasiQ8BYG9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ8BYG9
SMRiQ8BYG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 216Eph LBDPROSITE-ProRule annotationAdd BLAST182
Domaini340 – 452Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST113
Domaini456 – 554Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini644 – 899Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini932 – 996SAMPROSITE-ProRule annotationAdd BLAST65

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00930000150909
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiQ8BYG9
KOiK08897
PhylomeDBiQ8BYG9

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BYG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METGAGPHPL RLFVCLIPLC LALLLGPGRP GTAEEVILLD SKASQAELGW
60 70 80 90 100
TALPSTGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR
110 120 130 140 150
IFVELQFTLR DCSSIPGATG TCKETFNAYY LETETDLGRG RPRLGGNRPR
160 170 180 190 200
KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRQGFHL AFQDVGACVA
210 220 230 240 250
LVSVRVYYKQ CRATVRGLAA FPATAAESAF STLVEVAGTC VAHSEGEPSS
260 270 280 290 300
PPRMHCGADG EWLVPVGRCS CSAGFQEHGD ICEACPPGFY KVSPRRPLCS
310 320 330 340 350
PCPEHSLALE NASTFCVCQD TYARSPTDPP SASCTRPPSA PRDLQYSLSR
360 370 380 390 400
SPLALRLRWL PPADSGGRSD VTYSLLCLRC GRDGPAGACQ PCGPRVAFVP
410 420 430 440 450
RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGA TYAQVTVSTG
460 470 480 490 500
PGAPWEEDEI RRDRVEPQSV SLSWREPVPA GAPGTNSTEY EIRYYEKGQS
510 520 530 540 550
EQTYSTVKTG APAVTVTNLK PATRYVFQIR AASPGPLWEA QSFSPSIEVQ
560 570 580 590 600
TPGEVAPGSR DQSPAVVVTV VTISALLVLG SVMSVLAIWR RPCDGKGSGN
610 620 630 640 650
AHDEEELYFH FKVPTRRTFL DPQSCGDPLQ AVHLFAKELD AKSVTLEKSL
660 670 680 690 700
GAGRFGTLCC GCLQLPGRQE LPVAVHTLRD GCSDSQRLSF LAEALTLGQF
710 720 730 740 750
DHSHIVRLEG VVTRGNPLMI VTEYMNLGAL DDFLRHHEGE LVAAQLMGLL
760 770 780 790 800
PGLASAMKYL SEMGYVHRGL AARRVLVSSG LLCKISGFGR GPRDRAEAVY
810 820 830 840 850
TTMSGRSPAL WAAPETLQFG HFSSASDVWS FGIVMWEVMA FGERPYWDMS
860 870 880 890 900
GQDVIKAVED GFRLPPPRNC PSQLHRLMLE CWQKDPSERP RFSQIHSILS
910 920 930 940 950
KMGQEPEPSK CASTTCLRPP TPLADRAFST FPSFGSVGAW LEALDLCRYK
960 970 980 990 1000
DNFSAAGYGS LEAVAEMTAQ DLGSLGISST EHRESLLSGI SALQTRVLQL

QGQGVQV
Length:1,007
Mass (Da):109,100
Last modified:March 20, 2007 - v2
Checksum:i157A0E17CDCB9ED9
GO
Isoform 2 (identifier: Q8BYG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-292: ACPPGFYKV → GIQGPRGMG
     293-1007: Missing.

Show »
Length:292
Mass (Da):31,593
Checksum:i4CA95ED12646A858
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WVB0F6WVB0_MOUSE
Ephrin type-A receptor 10
Epha10
862Annotation score:

Sequence cautioni

The sequence CAM16104 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156A → S in BAC30423 (PubMed:16141072).Curated1
Sequence conflicti657T → D in CAM16104 (PubMed:19468303).Curated1
Sequence conflicti980T → A in CAM16104 (PubMed:19468303).Curated1
Sequence conflicti985S → A in CAM16104 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023676284 – 292ACPPGFYKV → GIQGPRGMG in isoform 2. 2 Publications9
Alternative sequenceiVSP_023677293 – 1007Missing in isoform 2. 2 PublicationsAdd BLAST715

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039700 mRNA Translation: BAC30423.1
AK143168 mRNA Translation: BAE25289.1
AL606933 Genomic DNA Translation: CAM16103.1
AL606933 Genomic DNA Translation: CAM16104.1 Sequence problems.
BC116991 mRNA Translation: AAI16992.1
BC119084 mRNA Translation: AAI19085.1
CCDSiCCDS18630.1 [Q8BYG9-2]
RefSeqiNP_808339.2, NM_177671.5 [Q8BYG9-2]
UniGeneiMm.171490
Mm.491537

Genome annotation databases

EnsembliENSMUST00000059343; ENSMUSP00000050810; ENSMUSG00000028876 [Q8BYG9-2]
GeneIDi230735
KEGGimmu:230735
UCSCiuc008urh.2 mouse [Q8BYG9-2]
uc008uri.2 mouse [Q8BYG9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039700 mRNA Translation: BAC30423.1
AK143168 mRNA Translation: BAE25289.1
AL606933 Genomic DNA Translation: CAM16103.1
AL606933 Genomic DNA Translation: CAM16104.1 Sequence problems.
BC116991 mRNA Translation: AAI16992.1
BC119084 mRNA Translation: AAI19085.1
CCDSiCCDS18630.1 [Q8BYG9-2]
RefSeqiNP_808339.2, NM_177671.5 [Q8BYG9-2]
UniGeneiMm.171490
Mm.491537

3D structure databases

ProteinModelPortaliQ8BYG9
SMRiQ8BYG9
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BYG9
PhosphoSitePlusiQ8BYG9

Proteomic databases

PeptideAtlasiQ8BYG9
PRIDEiQ8BYG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059343; ENSMUSP00000050810; ENSMUSG00000028876 [Q8BYG9-2]
GeneIDi230735
KEGGimmu:230735
UCSCiuc008urh.2 mouse [Q8BYG9-2]
uc008uri.2 mouse [Q8BYG9-1]

Organism-specific databases

CTDi284656
MGIiMGI:3586824 Epha10

Phylogenomic databases

GeneTreeiENSGT00930000150909
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiQ8BYG9
KOiK08897
PhylomeDBiQ8BYG9

Enzyme and pathway databases

ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

PROiPR:Q8BYG9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028876 Expressed in 94 organ(s), highest expression level in bone marrow
CleanExiMM_EPHA10
ExpressionAtlasiQ8BYG9 baseline and differential

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEPHAA_MOUSE
AccessioniPrimary (citable) accession number: Q8BYG9
Secondary accession number(s): A2A7J5, Q3UPV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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