UniProtKB - Q8BYG9 (EPHAA_MOUSE)
Protein
Ephrin type-A receptor 10
Gene
Epha10
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 (By similarity).By similarity
Catalytic activityi
- EC:2.7.10.1
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane-ephrin receptor activity Source: MGI
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- multicellular organism development Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2682334, EPH-Ephrin signaling R-MMU-3928663, EPHA-mediated growth cone collapse R-MMU-3928665, EPH-ephrin mediated repulsion of cells |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Epha10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3586824, Epha10 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- neuron projection Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 565 | ExtracellularSequence analysisAdd BLAST | 543 | |
Transmembranei | 566 – 586 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 587 – 1007 | CytoplasmicSequence analysisAdd BLAST | 421 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000280444 | 23 – 1007 | Ephrin type-A receptor 10Add BLAST | 985 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 311 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 486 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q8BYG9 |
PeptideAtlasi | Q8BYG9 |
PRIDEi | Q8BYG9 |
ProteomicsDBi | 277886 [Q8BYG9-1] 277887 [Q8BYG9-2] |
PTM databases
GlyGeni | Q8BYG9, 2 sites |
iPTMneti | Q8BYG9 |
PhosphoSitePlusi | Q8BYG9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028876, Expressed in bone marrow and 117 other tissues |
ExpressionAtlasi | Q8BYG9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 216 | Eph LBDPROSITE-ProRule annotationAdd BLAST | 182 | |
Domaini | 340 – 452 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 456 – 554 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 644 – 899 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 256 | |
Domaini | 932 – 996 | SAMPROSITE-ProRule annotationAdd BLAST | 65 |
Domaini
The protein kinase domain is predicted to be catalytically inactive.
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000160752 |
HOGENOMi | CLU_000288_141_3_1 |
InParanoidi | Q8BYG9 |
OrthoDBi | 933071at2759 |
PhylomeDBi | Q8BYG9 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF07647, SAM_2, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8BYG9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METGAGPHPL RLFVCLIPLC LALLLGPGRP GTAEEVILLD SKASQAELGW
60 70 80 90 100
TALPSTGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR
110 120 130 140 150
IFVELQFTLR DCSSIPGATG TCKETFNAYY LETETDLGRG RPRLGGNRPR
160 170 180 190 200
KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRQGFHL AFQDVGACVA
210 220 230 240 250
LVSVRVYYKQ CRATVRGLAA FPATAAESAF STLVEVAGTC VAHSEGEPSS
260 270 280 290 300
PPRMHCGADG EWLVPVGRCS CSAGFQEHGD ICEACPPGFY KVSPRRPLCS
310 320 330 340 350
PCPEHSLALE NASTFCVCQD TYARSPTDPP SASCTRPPSA PRDLQYSLSR
360 370 380 390 400
SPLALRLRWL PPADSGGRSD VTYSLLCLRC GRDGPAGACQ PCGPRVAFVP
410 420 430 440 450
RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGA TYAQVTVSTG
460 470 480 490 500
PGAPWEEDEI RRDRVEPQSV SLSWREPVPA GAPGTNSTEY EIRYYEKGQS
510 520 530 540 550
EQTYSTVKTG APAVTVTNLK PATRYVFQIR AASPGPLWEA QSFSPSIEVQ
560 570 580 590 600
TPGEVAPGSR DQSPAVVVTV VTISALLVLG SVMSVLAIWR RPCDGKGSGN
610 620 630 640 650
AHDEEELYFH FKVPTRRTFL DPQSCGDPLQ AVHLFAKELD AKSVTLEKSL
660 670 680 690 700
GAGRFGTLCC GCLQLPGRQE LPVAVHTLRD GCSDSQRLSF LAEALTLGQF
710 720 730 740 750
DHSHIVRLEG VVTRGNPLMI VTEYMNLGAL DDFLRHHEGE LVAAQLMGLL
760 770 780 790 800
PGLASAMKYL SEMGYVHRGL AARRVLVSSG LLCKISGFGR GPRDRAEAVY
810 820 830 840 850
TTMSGRSPAL WAAPETLQFG HFSSASDVWS FGIVMWEVMA FGERPYWDMS
860 870 880 890 900
GQDVIKAVED GFRLPPPRNC PSQLHRLMLE CWQKDPSERP RFSQIHSILS
910 920 930 940 950
KMGQEPEPSK CASTTCLRPP TPLADRAFST FPSFGSVGAW LEALDLCRYK
960 970 980 990 1000
DNFSAAGYGS LEAVAEMTAQ DLGSLGISST EHRESLLSGI SALQTRVLQL
QGQGVQV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6WVB0 | F6WVB0_MOUSE | Ephrin type-A receptor 10 | Epha10 | 862 | Annotation score: |
Sequence cautioni
The sequence CAM16104 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 156 | A → S in BAC30423 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 657 | T → D in CAM16104 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 980 | T → A in CAM16104 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 985 | S → A in CAM16104 (PubMed:19468303).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023676 | 284 – 292 | ACPPGFYKV → GIQGPRGMG in isoform 2. 2 Publications | 9 | |
Alternative sequenceiVSP_023677 | 293 – 1007 | Missing in isoform 2. 2 PublicationsAdd BLAST | 715 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK039700 mRNA Translation: BAC30423.1 AK143168 mRNA Translation: BAE25289.1 AL606933 Genomic DNA Translation: CAM16103.1 AL606933 Genomic DNA Translation: CAM16104.1 Sequence problems. BC116991 mRNA Translation: AAI16992.1 BC119084 mRNA Translation: AAI19085.1 |
CCDSi | CCDS18630.1 [Q8BYG9-2] |
RefSeqi | NP_808339.2, NM_177671.5 [Q8BYG9-2] |
Genome annotation databases
Ensembli | ENSMUST00000059343; ENSMUSP00000050810; ENSMUSG00000028876 [Q8BYG9-2] |
GeneIDi | 230735 |
KEGGi | mmu:230735 |
UCSCi | uc008urh.2, mouse [Q8BYG9-2] uc008uri.2, mouse [Q8BYG9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK039700 mRNA Translation: BAC30423.1 AK143168 mRNA Translation: BAE25289.1 AL606933 Genomic DNA Translation: CAM16103.1 AL606933 Genomic DNA Translation: CAM16104.1 Sequence problems. BC116991 mRNA Translation: AAI16992.1 BC119084 mRNA Translation: AAI19085.1 |
CCDSi | CCDS18630.1 [Q8BYG9-2] |
RefSeqi | NP_808339.2, NM_177671.5 [Q8BYG9-2] |
3D structure databases
SMRi | Q8BYG9 |
ModBasei | Search... |
PTM databases
GlyGeni | Q8BYG9, 2 sites |
iPTMneti | Q8BYG9 |
PhosphoSitePlusi | Q8BYG9 |
Proteomic databases
jPOSTi | Q8BYG9 |
PeptideAtlasi | Q8BYG9 |
PRIDEi | Q8BYG9 |
ProteomicsDBi | 277886 [Q8BYG9-1] 277887 [Q8BYG9-2] |
Protocols and materials databases
Antibodypediai | 51311, 269 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000059343; ENSMUSP00000050810; ENSMUSG00000028876 [Q8BYG9-2] |
GeneIDi | 230735 |
KEGGi | mmu:230735 |
UCSCi | uc008urh.2, mouse [Q8BYG9-2] uc008uri.2, mouse [Q8BYG9-1] |
Organism-specific databases
CTDi | 284656 |
MGIi | MGI:3586824, Epha10 |
Phylogenomic databases
GeneTreei | ENSGT00940000160752 |
HOGENOMi | CLU_000288_141_3_1 |
InParanoidi | Q8BYG9 |
OrthoDBi | 933071at2759 |
PhylomeDBi | Q8BYG9 |
Enzyme and pathway databases
Reactomei | R-MMU-2682334, EPH-Ephrin signaling R-MMU-3928663, EPHA-mediated growth cone collapse R-MMU-3928665, EPH-ephrin mediated repulsion of cells |
Miscellaneous databases
BioGRID-ORCSi | 230735, 0 hits in 20 CRISPR screens |
ChiTaRSi | Epha10, mouse |
PROi | PR:Q8BYG9 |
RNActi | Q8BYG9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028876, Expressed in bone marrow and 117 other tissues |
ExpressionAtlasi | Q8BYG9, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF07647, SAM_2, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPHAA_MOUSE | |
Accessioni | Q8BYG9Primary (citable) accession number: Q8BYG9 Secondary accession number(s): A2A7J5, Q3UPV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families