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Protein

BRI3-binding protein

Gene

Bri3bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function by stabilizing p53/TP53.1 Publication

Protein family/group databases

TCDBi1.A.74.2.1 the mitsugumin 23 (mg23) family

Names & Taxonomyi

Protein namesi
Recommended name:
BRI3-binding protein
Short name:
I3-binding protein
Gene namesi
Name:Bri3bpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924059 Bri3bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei164 – 181HelicalSequence analysisAdd BLAST18
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297481 – 253BRI3-binding proteinAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei250PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BXV2
MaxQBiQ8BXV2
PaxDbiQ8BXV2
PeptideAtlasiQ8BXV2
PRIDEiQ8BXV2

PTM databases

iPTMnetiQ8BXV2
PhosphoSitePlusiQ8BXV2
SwissPalmiQ8BXV2

Expressioni

Gene expression databases

BgeeiENSMUSG00000037905 Expressed in 245 organ(s), highest expression level in liver
CleanExiMM_BRI3BP
ExpressionAtlasiQ8BXV2 baseline and differential
GenevisibleiQ8BXV2 MM

Interactioni

Subunit structurei

Interacts with LETMD1. Interacts with BRI3.By similarity

Protein-protein interaction databases

BioGridi218329, 1 interactor
IntActiQ8BXV2, 1 interactor
STRINGi10090.ENSMUSP00000037609

Structurei

3D structure databases

SMRiQ8BXV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili219 – 253Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ5B Eukaryota
ENOG410ZDYG LUCA
GeneTreeiENSGT00390000002024
HOGENOMiHOG000285949
HOVERGENiHBG058925
InParanoidiQ8BXV2
OMAiSCLYILQ
OrthoDBiEOG091G0P3Q
PhylomeDBiQ8BXV2
TreeFamiTF332238

Family and domain databases

InterProiView protein in InterPro
IPR033367 BRI3BP
PANTHERiPTHR31253 PTHR31253, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8BXV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGARASQEPR TRVRAGLRVL LPVLLLALLL LALVAPGAQG ARGRGAADKN
60 70 80 90 100
SHRRATSSFS QSVSSLFGED NVRAAQKLLS RLTERFVQGV DMFLETLWKV
110 120 130 140 150
WMELLEVLGL DVSNLSQYFS PASVSNSPTR ALVLVGVVLL AYWFLSLTLG
160 170 180 190 200
FTFSLLHLVF GRFFWLVRVI LFSMSCVYIL HKYEGEPEHA VLPLCVVVAI
210 220 230 240 250
YFMTGPMGYW RGSPGGLCSP SVEEKLEHLE NQVRLLNIRL NRVLENLDRS

KDK
Length:253
Mass (Da):28,263
Last modified:March 1, 2003 - v1
Checksum:i9FEBE500086CAC68
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGE0A0A0G2JGE0_MOUSE
BRI3-binding protein
Bri3bp
150Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Q → E in BAC31982 (PubMed:16141072).Curated1
Sequence conflicti217L → F in BAB27196 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010810 mRNA Translation: BAB27196.1
AK043288 mRNA Translation: BAC31516.1
AK044565 mRNA Translation: BAC31982.1
AK143538 mRNA Translation: BAE25425.1
BC039941 mRNA Translation: AAH39941.1
CCDSiCCDS19686.1
RefSeqiNP_084028.1, NM_029752.2
UniGeneiMm.290720

Genome annotation databases

EnsembliENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905
GeneIDi76809
KEGGimmu:76809
UCSCiuc008zrr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010810 mRNA Translation: BAB27196.1
AK043288 mRNA Translation: BAC31516.1
AK044565 mRNA Translation: BAC31982.1
AK143538 mRNA Translation: BAE25425.1
BC039941 mRNA Translation: AAH39941.1
CCDSiCCDS19686.1
RefSeqiNP_084028.1, NM_029752.2
UniGeneiMm.290720

3D structure databases

SMRiQ8BXV2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218329, 1 interactor
IntActiQ8BXV2, 1 interactor
STRINGi10090.ENSMUSP00000037609

Protein family/group databases

TCDBi1.A.74.2.1 the mitsugumin 23 (mg23) family

PTM databases

iPTMnetiQ8BXV2
PhosphoSitePlusiQ8BXV2
SwissPalmiQ8BXV2

Proteomic databases

EPDiQ8BXV2
MaxQBiQ8BXV2
PaxDbiQ8BXV2
PeptideAtlasiQ8BXV2
PRIDEiQ8BXV2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905
GeneIDi76809
KEGGimmu:76809
UCSCiuc008zrr.1 mouse

Organism-specific databases

CTDi140707
MGIiMGI:1924059 Bri3bp

Phylogenomic databases

eggNOGiENOG410IJ5B Eukaryota
ENOG410ZDYG LUCA
GeneTreeiENSGT00390000002024
HOGENOMiHOG000285949
HOVERGENiHBG058925
InParanoidiQ8BXV2
OMAiSCLYILQ
OrthoDBiEOG091G0P3Q
PhylomeDBiQ8BXV2
TreeFamiTF332238

Miscellaneous databases

ChiTaRSiBri3bp mouse
PROiPR:Q8BXV2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037905 Expressed in 245 organ(s), highest expression level in liver
CleanExiMM_BRI3BP
ExpressionAtlasiQ8BXV2 baseline and differential
GenevisibleiQ8BXV2 MM

Family and domain databases

InterProiView protein in InterPro
IPR033367 BRI3BP
PANTHERiPTHR31253 PTHR31253, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRI3B_MOUSE
AccessioniPrimary (citable) accession number: Q8BXV2
Secondary accession number(s): Q8BXP1, Q9CWE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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