UniProtKB - Q8BXV2 (BRI3B_MOUSE)
Protein
BRI3-binding protein
Gene
Bri3bp
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in tumorigenesis and may function by stabilizing p53/TP53.1 Publication
Protein family/group databases
TCDBi | 1.A.74.2.1, the mitsugumin 23 (mg23) family |
Names & Taxonomyi
Protein namesi | Recommended name: BRI3-binding proteinShort name: I3-binding protein |
Gene namesi | Name:Bri3bpImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924059, Bri3bp |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
- mitochondrion Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 39 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 164 – 181 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 190 – 210 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000229748 | 1 – 253 | BRI3-binding proteinAdd BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 250 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8BXV2 |
MaxQBi | Q8BXV2 |
PaxDbi | Q8BXV2 |
PeptideAtlasi | Q8BXV2 |
PRIDEi | Q8BXV2 |
PTM databases
iPTMneti | Q8BXV2 |
PhosphoSitePlusi | Q8BXV2 |
SwissPalmi | Q8BXV2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037905, Expressed in primary visual cortex and 260 other tissues |
Genevisiblei | Q8BXV2, MM |
Interactioni
Subunit structurei
Interacts with LETMD1.
Interacts with BRI3.
By similarityProtein-protein interaction databases
BioGRIDi | 218329, 2 interactors |
IntActi | Q8BXV2, 1 interactor |
STRINGi | 10090.ENSMUSP00000037609 |
Miscellaneous databases
RNActi | Q8BXV2, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 219 – 253 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRNV, Eukaryota |
GeneTreei | ENSGT00390000002024 |
HOGENOMi | CLU_095006_0_0_1 |
InParanoidi | Q8BXV2 |
OMAi | KFEGDPE |
OrthoDBi | 1317796at2759 |
PhylomeDBi | Q8BXV2 |
TreeFami | TF332238 |
Family and domain databases
InterProi | View protein in InterPro IPR033367, BRI3BP |
PANTHERi | PTHR31253, PTHR31253, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8BXV2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGARASQEPR TRVRAGLRVL LPVLLLALLL LALVAPGAQG ARGRGAADKN
60 70 80 90 100
SHRRATSSFS QSVSSLFGED NVRAAQKLLS RLTERFVQGV DMFLETLWKV
110 120 130 140 150
WMELLEVLGL DVSNLSQYFS PASVSNSPTR ALVLVGVVLL AYWFLSLTLG
160 170 180 190 200
FTFSLLHLVF GRFFWLVRVI LFSMSCVYIL HKYEGEPEHA VLPLCVVVAI
210 220 230 240 250
YFMTGPMGYW RGSPGGLCSP SVEEKLEHLE NQVRLLNIRL NRVLENLDRS
KDK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JGE0 | A0A0G2JGE0_MOUSE | BRI3-binding protein | Bri3bp | 150 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | Q → E in BAC31982 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 217 | L → F in BAB27196 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010810 mRNA Translation: BAB27196.1 AK043288 mRNA Translation: BAC31516.1 AK044565 mRNA Translation: BAC31982.1 AK143538 mRNA Translation: BAE25425.1 BC039941 mRNA Translation: AAH39941.1 |
CCDSi | CCDS19686.1 |
RefSeqi | NP_084028.1, NM_029752.2 |
Genome annotation databases
Ensembli | ENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905 |
GeneIDi | 76809 |
KEGGi | mmu:76809 |
UCSCi | uc008zrr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010810 mRNA Translation: BAB27196.1 AK043288 mRNA Translation: BAC31516.1 AK044565 mRNA Translation: BAC31982.1 AK143538 mRNA Translation: BAE25425.1 BC039941 mRNA Translation: AAH39941.1 |
CCDSi | CCDS19686.1 |
RefSeqi | NP_084028.1, NM_029752.2 |
3D structure databases
SMRi | Q8BXV2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 218329, 2 interactors |
IntActi | Q8BXV2, 1 interactor |
STRINGi | 10090.ENSMUSP00000037609 |
Protein family/group databases
TCDBi | 1.A.74.2.1, the mitsugumin 23 (mg23) family |
PTM databases
iPTMneti | Q8BXV2 |
PhosphoSitePlusi | Q8BXV2 |
SwissPalmi | Q8BXV2 |
Proteomic databases
EPDi | Q8BXV2 |
MaxQBi | Q8BXV2 |
PaxDbi | Q8BXV2 |
PeptideAtlasi | Q8BXV2 |
PRIDEi | Q8BXV2 |
Protocols and materials databases
Antibodypediai | 2692, 161 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905 |
GeneIDi | 76809 |
KEGGi | mmu:76809 |
UCSCi | uc008zrr.1, mouse |
Organism-specific databases
CTDi | 140707 |
MGIi | MGI:1924059, Bri3bp |
Phylogenomic databases
eggNOGi | ENOG502QRNV, Eukaryota |
GeneTreei | ENSGT00390000002024 |
HOGENOMi | CLU_095006_0_0_1 |
InParanoidi | Q8BXV2 |
OMAi | KFEGDPE |
OrthoDBi | 1317796at2759 |
PhylomeDBi | Q8BXV2 |
TreeFami | TF332238 |
Miscellaneous databases
BioGRID-ORCSi | 76809, 2 hits in 17 CRISPR screens |
ChiTaRSi | Bri3bp, mouse |
PROi | PR:Q8BXV2 |
RNActi | Q8BXV2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037905, Expressed in primary visual cortex and 260 other tissues |
Genevisiblei | Q8BXV2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR033367, BRI3BP |
PANTHERi | PTHR31253, PTHR31253, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BRI3B_MOUSE | |
Accessioni | Q8BXV2Primary (citable) accession number: Q8BXV2 Secondary accession number(s): Q8BXP1, Q9CWE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot