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Protein

Regulator of G-protein signaling 8

Gene

Rgs8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 8
Short name:
RGS8
Gene namesi
Name:Rgs8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108408 Rgs8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042001 – 180Regulator of G-protein signaling 8Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BXT1
PRIDEiQ8BXT1

PTM databases

iPTMnetiQ8BXT1
PhosphoSitePlusiQ8BXT1
SwissPalmiQ8BXT1

Expressioni

Gene expression databases

BgeeiENSMUSG00000042671 Expressed in 113 organ(s), highest expression level in cerebellum
CleanExiMM_RGS8
ExpressionAtlasiQ8BXT1 baseline and differential
GenevisibleiQ8BXT1 MM

Interactioni

Subunit structurei

Interacts with GNAO1 and GNAI3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045715

Structurei

3D structure databases

ProteinModelPortaliQ8BXT1
SMRiQ8BXT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 171RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ8BXT1
KOiK16449
OrthoDBiEOG091G0BDG
PhylomeDBiQ8BXT1
TreeFamiTF315837

Family and domain databases

CDDicd08711 RGS_RGS8, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034948 RGS8
IPR034949 RGS_RGS8
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF147 PTHR10845:SF147, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8BXT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA
60 70 80 90 100
TRWAESFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK
110 120 130 140 150
LVTKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNMQEPSL TCFDQAQGKV
160 170 180
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
Length:180
Mass (Da):20,963
Last modified:March 1, 2003 - v1
Checksum:i00FC35E572785856
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z289D3Z289_MOUSE
Regulator of G-protein-signaling 8
Rgs8
178Annotation score:
D3YX00D3YX00_MOUSE
Regulator of G-protein-signaling 8
Rgs8
115Annotation score:
D3Z1V2D3Z1V2_MOUSE
Regulator of G-protein-signaling 8
Rgs8
137Annotation score:
D3YYE5D3YYE5_MOUSE
Regulator of G-protein-signaling 8
Rgs8
115Annotation score:
D3Z5I4D3Z5I4_MOUSE
Regulator of G-protein-signaling 8
Rgs8
98Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044337 mRNA Translation: BAC31874.1
AK142301 mRNA Translation: BAE25020.1
BC065056 mRNA Translation: AAH65056.1
BC094577 mRNA Translation: AAH94577.1
CCDSiCCDS15375.1
RefSeqiNP_080656.2, NM_026380.3
XP_006529881.1, XM_006529818.3
XP_006529882.1, XM_006529819.3
XP_006529883.1, XM_006529820.3
XP_006529884.1, XM_006529821.3
UniGeneiMm.379143

Genome annotation databases

EnsembliENSMUST00000041776; ENSMUSP00000045715; ENSMUSG00000042671
ENSMUST00000111810; ENSMUSP00000107441; ENSMUSG00000042671
ENSMUST00000111812; ENSMUSP00000107443; ENSMUSG00000042671
GeneIDi67792
KEGGimmu:67792
UCSCiuc007dad.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044337 mRNA Translation: BAC31874.1
AK142301 mRNA Translation: BAE25020.1
BC065056 mRNA Translation: AAH65056.1
BC094577 mRNA Translation: AAH94577.1
CCDSiCCDS15375.1
RefSeqiNP_080656.2, NM_026380.3
XP_006529881.1, XM_006529818.3
XP_006529882.1, XM_006529819.3
XP_006529883.1, XM_006529820.3
XP_006529884.1, XM_006529821.3
UniGeneiMm.379143

3D structure databases

ProteinModelPortaliQ8BXT1
SMRiQ8BXT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045715

PTM databases

iPTMnetiQ8BXT1
PhosphoSitePlusiQ8BXT1
SwissPalmiQ8BXT1

Proteomic databases

PaxDbiQ8BXT1
PRIDEiQ8BXT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041776; ENSMUSP00000045715; ENSMUSG00000042671
ENSMUST00000111810; ENSMUSP00000107441; ENSMUSG00000042671
ENSMUST00000111812; ENSMUSP00000107443; ENSMUSG00000042671
GeneIDi67792
KEGGimmu:67792
UCSCiuc007dad.1 mouse

Organism-specific databases

CTDi85397
MGIiMGI:108408 Rgs8

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ8BXT1
KOiK16449
OrthoDBiEOG091G0BDG
PhylomeDBiQ8BXT1
TreeFamiTF315837

Miscellaneous databases

ChiTaRSiRgs8 mouse
PROiPR:Q8BXT1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042671 Expressed in 113 organ(s), highest expression level in cerebellum
CleanExiMM_RGS8
ExpressionAtlasiQ8BXT1 baseline and differential
GenevisibleiQ8BXT1 MM

Family and domain databases

CDDicd08711 RGS_RGS8, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034948 RGS8
IPR034949 RGS_RGS8
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF147 PTHR10845:SF147, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS8_MOUSE
AccessioniPrimary (citable) accession number: Q8BXT1
Secondary accession number(s): Q505F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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