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Protein

Probable cationic amino acid transporter

Gene

Slc7a14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in arginine transport.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cationic amino acid transporter
Alternative name(s):
Solute carrier family 7 member 14
Gene namesi
Name:Slc7a14
Synonyms:Kiaa1613
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3040688 Slc7a14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei119 – 141HelicalSequence analysisAdd BLAST23
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice exhibit slightly thinner retina, including outer retinal layer, and abnormal electroretinography at 2 and 6 months of age compared to wild-type animals. They are viable and fertile. They do not show any noticeable physical abnormalities.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073611 – 771Probable cationic amino acid transporterAdd BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei465PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei757PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BXR1
PaxDbiQ8BXR1
PeptideAtlasiQ8BXR1
PRIDEiQ8BXR1

PTM databases

iPTMnetiQ8BXR1
PhosphoSitePlusiQ8BXR1

Expressioni

Tissue specificityi

Expressed in retina, brain and spinal cord. In the retina, expressed in the inner nuclear layer and photoreceptor layer (at protein level).1 Publication

Developmental stagei

Detected in the eyeball at 18.5 dpc. Expression increases in the retina after birth from P4 to P90.

Gene expression databases

BgeeiENSMUSG00000069072 Expressed in 111 organ(s), highest expression level in superior cervical ganglion
ExpressionAtlasiQ8BXR1 baseline and differential
GenevisibleiQ8BXR1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088803

Structurei

3D structure databases

ProteinModelPortaliQ8BXR1
SMRiQ8BXR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119151
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiQ8BXR1
KOiK13871
OrthoDBiEOG091G05NM
PhylomeDBiQ8BXR1
TreeFamiTF315212

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BXR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGFLASLDP RRVQWGAAWY AMHSRILRTK PVESMLEGTG TTSAHGTKLA
60 70 80 90 100
QVLTTVDLIS LGVGSCVGTG MYVVSGLVAK EMAGPGVIVS FIIAAVASIL
110 120 130 140 150
SGVCYAEFGV RVPKTTGSAY TYSYVTVGEF VAFFIGWNLI LEYLIGTAAG
160 170 180 190 200
ASALSSMFDS LANHSISRWM VDTVGTLNGL GKGEESYPDL LALVIAVIVT
210 220 230 240 250
IIVALGVKNS VGFNNVLNVL NLAVWVFIMI AGLFFINGKY WAEGQFLPHG
260 270 280 290 300
WSGVLQGAAT CFYAFIGFDI IATTGEEAKN PNTSIPYAIT ASLVICLTAY
310 320 330 340 350
VSVSMILTLM VPYYAIDTES PLMEMFVAHG FYAAKFVVAI GSVAGLTVSL
360 370 380 390 400
LGSLFPMPRV IYAMAGDGLL FRFLAHVSSY TETPVVACIV SGFLAALLSL
410 420 430 440 450
LVSLRDLIEM MSIGTLLAYT LVSVCVLLLR YQPESDIDGF VKFLSEEHTK
460 470 480 490 500
KKEGILADCE KETCSPVSEG EEFSSPATNT CGAKNLPSLG DNEMLIGKSD
510 520 530 540 550
KSAYNVNHPN YGTVDMTTGI EADESENIYL IKLKKLIGPR YYTMRIRLGL
560 570 580 590 600
PGKMDRPTAA TGHTVTICVL LLFILMFIFC SFIIFGSEYI SGQSWWAILL
610 620 630 640 650
VVLMMLLISV LVFVILQQPE NPKKLPYMAP CLPFVPAFAM LVNIYLMLKL
660 670 680 690 700
STITWIRFAV WCFVGMLIYF GYGIWNSTLE ISAREQALHQ STYQRYDVDD
710 720 730 740 750
PFSVEEGFSY ATEGESQEDW GGPAEDKGFY YQQMSDAKAN SRTSSKAKSK
760 770
SKHKQNSEAL IANDELDCSP E
Length:771
Mass (Da):83,984
Last modified:March 1, 2003 - v1
Checksum:i52381841C32BC848
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YY38D3YY38_MOUSE
Probable cationic amino acid transp...
Slc7a14
677Annotation score:

Sequence cautioni

The sequence BAD32495 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173217 mRNA Translation: BAD32495.1 Different initiation.
AK044448 mRNA Translation: BAC31925.1
BC061928 mRNA Translation: AAH61928.1
CCDSiCCDS17291.1
RefSeqiNP_766449.1, NM_172861.3
XP_006535535.1, XM_006535472.3
UniGeneiMm.285366

Genome annotation databases

EnsembliENSMUST00000091259; ENSMUSP00000088803; ENSMUSG00000069072
GeneIDi241919
KEGGimmu:241919
UCSCiuc008ovx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173217 mRNA Translation: BAD32495.1 Different initiation.
AK044448 mRNA Translation: BAC31925.1
BC061928 mRNA Translation: AAH61928.1
CCDSiCCDS17291.1
RefSeqiNP_766449.1, NM_172861.3
XP_006535535.1, XM_006535472.3
UniGeneiMm.285366

3D structure databases

ProteinModelPortaliQ8BXR1
SMRiQ8BXR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088803

PTM databases

iPTMnetiQ8BXR1
PhosphoSitePlusiQ8BXR1

Proteomic databases

MaxQBiQ8BXR1
PaxDbiQ8BXR1
PeptideAtlasiQ8BXR1
PRIDEiQ8BXR1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091259; ENSMUSP00000088803; ENSMUSG00000069072
GeneIDi241919
KEGGimmu:241919
UCSCiuc008ovx.2 mouse

Organism-specific databases

CTDi57709
MGIiMGI:3040688 Slc7a14
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119151
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiQ8BXR1
KOiK13871
OrthoDBiEOG091G05NM
PhylomeDBiQ8BXR1
TreeFamiTF315212

Miscellaneous databases

PROiPR:Q8BXR1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069072 Expressed in 111 organ(s), highest expression level in superior cervical ganglion
ExpressionAtlasiQ8BXR1 baseline and differential
GenevisibleiQ8BXR1 MM

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS7A14_MOUSE
AccessioniPrimary (citable) accession number: Q8BXR1
Secondary accession number(s): Q69ZE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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