Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor-related protein 1

Gene

Arfrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi75 – 79GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • gastrulation Source: MGI
  • Golgi to plasma membrane protein transport Source: MGI
  • intracellular protein transport Source: GO_Central
  • protein localization to Golgi apparatus Source: MGI
  • protein localization to organelle Source: GO_Central
  • retrograde transport, endosome to Golgi Source: MGI

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-related protein 1
Short name:
ARF-related protein 1
Gene namesi
Name:Arfrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923938 Arfrp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Disruption phenotypei

Disruption of the gene leads to embryonic lethality during early gastrulation. Intestine-specific knockout mice display severe growth retardation due to reduced fat absorption and decrease in lipid release from the intestinal epithelium to the lymph and blood. Liver-specific knockout mice display impaired VLDL lipidation leading to reduced plasma triglyceride levels in the fasted state. Liver-specific knockout mice also display a disturbed glucose metabolism caused by a reduced plasma membrane localization of the glucose transporter GLUT2.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002074881 – 201ADP-ribosylation factor-related protein 1Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BXL7
MaxQBiQ8BXL7
PaxDbiQ8BXL7
PeptideAtlasiQ8BXL7
PRIDEiQ8BXL7

PTM databases

PhosphoSitePlusiQ8BXL7

Expressioni

Gene expression databases

BgeeiENSMUSG00000038671 Expressed in 282 organ(s), highest expression level in ear vesicle
CleanExiMM_ARFRP1
ExpressionAtlasiQ8BXL7 baseline and differential
GenevisibleiQ8BXL7 MM

Interactioni

Subunit structurei

Interacts with SYS1.By similarity

Protein-protein interaction databases

BioGridi218262, 2 interactors
STRINGi10090.ENSMUSP00000104436

Structurei

3D structure databases

ProteinModelPortaliQ8BXL7
SMRiQ8BXL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0076 Eukaryota
ENOG410ZMDV LUCA
GeneTreeiENSGT00550000074639
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ8BXL7
KOiK07952
OMAiGVRLNFW
OrthoDBiEOG091G0Z6O
PhylomeDBiQ8BXL7
TreeFamiTF105788

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BXL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL
60 70 80 90 100
SKITTTVGLN IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI
110 120 130 140 150
DSTDEERLSE SKEAFEKVVS SEALDGVPIL VLANKQDVET CLSIPDIKTA
160 170 180 190 200
FSDCTCKIGR RDCLTQACSA LTGKGVREGI EWMVKCVVRN VHRPPRQRDI

T
Length:201
Mass (Da):22,659
Last modified:May 10, 2004 - v2
Checksum:i7BB6D213946F597E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZK7E9PZK7_MOUSE
ADP-ribosylation factor-related pro...
Arfrp1
154Annotation score:
Q80SX7Q80SX7_MOUSE
ADP-ribosylation factor-related pro...
Arfrp1
121Annotation score:
V9GX20V9GX20_MOUSE
ADP-ribosylation factor-related pro...
Arfrp1
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41F → L in BAC32069 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ413952 Genomic DNA Translation: CAC88691.1
AJ413953 mRNA Translation: CAC88692.1
AK005174 mRNA Translation: BAB23861.1
AK044759 mRNA Translation: BAC32069.1
BC010713 mRNA Translation: AAH10713.1
CCDSiCCDS17209.1
RefSeqiNP_001159463.1, NM_001165991.1
NP_001159464.1, NM_001165992.1
NP_083978.3, NM_029702.4
XP_011238267.1, XM_011239965.2
UniGeneiMm.87720

Genome annotation databases

EnsembliENSMUST00000108808; ENSMUSP00000104436; ENSMUSG00000038671
ENSMUST00000127988; ENSMUSP00000122066; ENSMUSG00000038671
GeneIDi76688
KEGGimmu:76688
UCSCiuc008oly.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ413952 Genomic DNA Translation: CAC88691.1
AJ413953 mRNA Translation: CAC88692.1
AK005174 mRNA Translation: BAB23861.1
AK044759 mRNA Translation: BAC32069.1
BC010713 mRNA Translation: AAH10713.1
CCDSiCCDS17209.1
RefSeqiNP_001159463.1, NM_001165991.1
NP_001159464.1, NM_001165992.1
NP_083978.3, NM_029702.4
XP_011238267.1, XM_011239965.2
UniGeneiMm.87720

3D structure databases

ProteinModelPortaliQ8BXL7
SMRiQ8BXL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218262, 2 interactors
STRINGi10090.ENSMUSP00000104436

PTM databases

PhosphoSitePlusiQ8BXL7

Proteomic databases

EPDiQ8BXL7
MaxQBiQ8BXL7
PaxDbiQ8BXL7
PeptideAtlasiQ8BXL7
PRIDEiQ8BXL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108808; ENSMUSP00000104436; ENSMUSG00000038671
ENSMUST00000127988; ENSMUSP00000122066; ENSMUSG00000038671
GeneIDi76688
KEGGimmu:76688
UCSCiuc008oly.2 mouse

Organism-specific databases

CTDi10139
MGIiMGI:1923938 Arfrp1

Phylogenomic databases

eggNOGiKOG0076 Eukaryota
ENOG410ZMDV LUCA
GeneTreeiENSGT00550000074639
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ8BXL7
KOiK07952
OMAiGVRLNFW
OrthoDBiEOG091G0Z6O
PhylomeDBiQ8BXL7
TreeFamiTF105788

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

PROiPR:Q8BXL7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038671 Expressed in 282 organ(s), highest expression level in ear vesicle
CleanExiMM_ARFRP1
ExpressionAtlasiQ8BXL7 baseline and differential
GenevisibleiQ8BXL7 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARFRP_MOUSE
AccessioniPrimary (citable) accession number: Q8BXL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again