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Protein

Transcriptional-regulating factor 1

Gene

Trerf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri512 – 534C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1019 – 1043C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1092 – 1114C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional-regulating factor 1
Alternative name(s):
Transcriptional-regulating protein 132
Zinc finger transcription factor TReP-132
Gene namesi
Name:Trerf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442086 Trerf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971351 – 1205Transcriptional-regulating factor 1Add BLAST1205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei490PhosphoserineBy similarity1
Modified residuei639N6-acetyllysineCombined sources1
Modified residuei646N6-acetyllysineCombined sources1
Modified residuei773PhosphothreonineCombined sources1
Modified residuei960PhosphothreonineBy similarity1
Modified residuei961PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8BXJ2
PeptideAtlasiQ8BXJ2
PRIDEiQ8BXJ2

PTM databases

iPTMnetiQ8BXJ2
PhosphoSitePlusiQ8BXJ2

Expressioni

Tissue specificityi

Highly expressed in kidney, lung and brain. In the brain, expression was seen in the basal ganglia, hippocampus, piriform cortex, cerebral cortex, ventromedial nucleus of the hypothalamus and the dorsal and superior central nuclei of the raphe.1 Publication

Developmental stagei

At 15.5 dpc, highly expressed in brain, lung, adrenal, thymus and kidney. Expression was also seen in spinal cord, retina and snout.1 Publication

Gene expression databases

CleanExiMM_TRERF1

Interactioni

Subunit structurei

Interacts with CREBBP and EP300. Interacts with DNTTIP1 and DNTT.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230328, 2 interactors
IntActiQ8BXJ2, 2 interactors
STRINGi10090.ENSMUSP00000077103

Structurei

3D structure databases

ProteinModelPortaliQ8BXJ2
SMRiQ8BXJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini785 – 876ELM2PROSITE-ProRule annotationAdd BLAST92
Domaini891 – 942SANTPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi202 – 404Gln-richAdd BLAST203
Compositional biasi552 – 755Pro-richAdd BLAST204
Compositional biasi962 – 987Glu-richAdd BLAST26

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri512 – 534C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1019 – 1043C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1092 – 1114C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4167 Eukaryota
ENOG4110BKZ LUCA
HOGENOMiHOG000154675
HOVERGENiHBG082398
InParanoidiQ8BXJ2
PhylomeDBiQ8BXJ2
TreeFamiTF106431

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BXJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDQQLYKTN HVGHGGENLF YQQPPLGVHS GLGHSYGNTI SGAGMDAPQA
60 70 80 90 100
SPISPHFPQD TRDGLGLPIG SKNLGQMDTS RQGGWGSHAG PGNHVQLRSN
110 120 130 140 150
LANSNMMWGT PTQVEPADGY QYTYSQASEI RTQKLTSGVL HKLDSFTQVF
160 170 180 190 200
ANQNLRIQVN NMAQVLHTQS AVMDGASDSA LRQLLSQKPV EPSASAIASR
210 220 230 240 250
YQQVPQQPHP GFTGGLPKPA LPVGQHAPQG HLYYDYQQPL AQMSMQGGQP
260 270 280 290 300
LQAPQVLSGH MQQLQQHQYY PQPPPQQQQA GLQRISVQEM QQQQQPQQIR
310 320 330 340 350
PSPPQQQQQL QLQQRQSSLQ IPQYYQPQPM MQHLQEQQQP SMHLQPPSYH
360 370 380 390 400
RDPHQYTPEQ AHAVQLIQLG SMPQYYYQEP QQAYSHPLYP QSHLSQHQQR
410 420 430 440 450
EDGQLKTYSS DRQTPAMLSS HGDMGTSDTG VADPASSEMT RVTSTLPHQP
460 470 480 490 500
LLSPSGIHLN NMGSQHQQPP SPSAMWPQMH LPDGRAQSGS PESSSGQTKG
510 520 530 540 550
VFGEQFDAKN KLTCSICLKE FKSLPALNGH MRSHGGMRAS PSLKQEEGEK
560 570 580 590 600
APPPQPQPQP QPQQPLPPPP PPPPPPQLPP EAERLTPMVM PVSVPVKLIP
610 620 630 640 650
PKPSSQGFTN SVAATPAARD KPASSMSDDE MPVLEIPRKH PPIAAKVEEP
660 670 680 690 700
LKNLPEKKKF RHRPEPLFIP PPPSSYTPNP TSYSGATLYQ SQLRSPRILG
710 720 730 740 750
DHLLLDPAHE LPPYTPPPML SPVRQGSGLF SNVLISGHGP GVHPQLPLTP
760 770 780 790 800
LTPTPRVLLC RSSSIDGSNV TVTPGPGEQT VDVEPRINIG LRFQAEIPEL
810 820 830 840 850
QDVSALAQDT HRATLVWKPW PELENQALQQ QVENLLNLCC SSALPGGGTN
860 870 880 890 900
SEFALHSLFE AKGDVMATLE MLLLRKPVRL KCHPLANYHY AGSDKWTSLE
910 920 930 940 950
RKLFNKALAT YSKDFIFVQK MVKSKTVAQC VEYYYTWKKI MRLGRKHRTR
960 970 980 990 1000
LAEIIDDCMT SEEEEEAEEE EEDPEEDRKS IKEEESEVAK SPEPPPAPAL
1010 1020 1030 1040 1050
APTEGPPMQA VGQQPSGNFI CEMPNCGAVF SSRQALNGHA RIHGGTNQVA
1060 1070 1080 1090 1100
KTRGAIPSGK QKPGGTQSGY CSVKSSPSHS TTSGETDPTT IFPCKECGKV
1110 1120 1130 1140 1150
FFKIKSRNAH MKTHRQQEEQ QRQKAQKAAF AAEMAATIER TTGPVGAPEL
1160 1170 1180 1190 1200
LPLDQLSLMK PVKDVDILDD DVVQQLGVMD EAEVVGTDLL LDDQDSVLLQ

GDTEL
Length:1,205
Mass (Da):132,402
Last modified:March 1, 2003 - v1
Checksum:i322FCC31845A99E2
GO
Isoform 2 (identifier: Q8BXJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     634-634: L → LVRMTLSPPHSPQGAAPRAPA

Show »
Length:1,225
Mass (Da):134,425
Checksum:i22F54805CD234944
GO
Isoform 3 (identifier: Q8BXJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-493: Missing.
     546-565: EEGEKAPPPQPQPQPQPQQP → VSREPAPSFPGHVLLALLCC
     566-1205: Missing.

Show »
Length:564
Mass (Da):62,165
Checksum:iC9DD7CCAE3D300C8
GO
Isoform 4 (identifier: Q8BXJ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-493: Missing.
     1028-1028: A → ADCRCHVAPFLPQ

Show »
Length:1,216
Mass (Da):133,683
Checksum:iA2B68EE59AA97B1A
GO

Sequence cautioni

The sequence AAN02288 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89A → V in AAH59215 (PubMed:15489334).Curated1
Sequence conflicti112T → P in AAN02288 (PubMed:12556907).Curated1
Sequence conflicti308 – 309QQ → HR in AAN02288 (PubMed:12556907).Curated2
Sequence conflicti368 – 369QL → PA in AAN02288 (PubMed:12556907).Curated2
Sequence conflicti464S → T in AAN02288 (PubMed:12556907).Curated1
Sequence conflicti659K → E in AAN02288 (PubMed:12556907).Curated1
Sequence conflicti915F → L in AAN02288 (PubMed:12556907).Curated1
Sequence conflicti1159M → I in AAN02288 (PubMed:12556907).Curated1
Sequence conflicti1202D → V in AAN02288 (PubMed:12556907).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015647493Missing in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_015648546 – 565EEGEK…QPQQP → VSREPAPSFPGHVLLALLCC in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_015649566 – 1205Missing in isoform 3. 1 PublicationAdd BLAST640
Alternative sequenceiVSP_015650634L → LVRMTLSPPHSPQGAAPRAP A in isoform 2. 1 Publication1
Alternative sequenceiVSP_0156511028A → ADCRCHVAPFLPQ in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081774 mRNA Translation: AAN02288.1 Frameshift.
AK042320 mRNA Translation: BAC31222.1
AK046822 mRNA Translation: BAC32884.1
BC051645 mRNA Translation: AAH51645.1
BC059215 mRNA Translation: AAH59215.1
BC108416 mRNA Translation: AAI08417.1
RefSeqiNP_001091092.1, NM_001097623.2 [Q8BXJ2-2]
NP_766210.1, NM_172622.3 [Q8BXJ2-1]
UniGeneiMm.260989

Genome annotation databases

EnsembliENSMUST00000230465; ENSMUSP00000155434; ENSMUSG00000116235 [Q8BXJ2-1]
ENSMUST00000230995; ENSMUSP00000155047; ENSMUSG00000116235 [Q8BXJ2-1]
GeneIDi224829
KEGGimmu:224829
UCSCiuc008cur.1 mouse [Q8BXJ2-1]
uc008cus.1 mouse [Q8BXJ2-2]
uc008cut.1 mouse [Q8BXJ2-3]
uc008cuw.1 mouse [Q8BXJ2-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081774 mRNA Translation: AAN02288.1 Frameshift.
AK042320 mRNA Translation: BAC31222.1
AK046822 mRNA Translation: BAC32884.1
BC051645 mRNA Translation: AAH51645.1
BC059215 mRNA Translation: AAH59215.1
BC108416 mRNA Translation: AAI08417.1
RefSeqiNP_001091092.1, NM_001097623.2 [Q8BXJ2-2]
NP_766210.1, NM_172622.3 [Q8BXJ2-1]
UniGeneiMm.260989

3D structure databases

ProteinModelPortaliQ8BXJ2
SMRiQ8BXJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230328, 2 interactors
IntActiQ8BXJ2, 2 interactors
STRINGi10090.ENSMUSP00000077103

PTM databases

iPTMnetiQ8BXJ2
PhosphoSitePlusiQ8BXJ2

Proteomic databases

PaxDbiQ8BXJ2
PeptideAtlasiQ8BXJ2
PRIDEiQ8BXJ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000230465; ENSMUSP00000155434; ENSMUSG00000116235 [Q8BXJ2-1]
ENSMUST00000230995; ENSMUSP00000155047; ENSMUSG00000116235 [Q8BXJ2-1]
GeneIDi224829
KEGGimmu:224829
UCSCiuc008cur.1 mouse [Q8BXJ2-1]
uc008cus.1 mouse [Q8BXJ2-2]
uc008cut.1 mouse [Q8BXJ2-3]
uc008cuw.1 mouse [Q8BXJ2-4]

Organism-specific databases

CTDi55809
MGIiMGI:2442086 Trerf1

Phylogenomic databases

eggNOGiKOG4167 Eukaryota
ENOG4110BKZ LUCA
HOGENOMiHOG000154675
HOVERGENiHBG082398
InParanoidiQ8BXJ2
PhylomeDBiQ8BXJ2
TreeFamiTF106431

Miscellaneous databases

PROiPR:Q8BXJ2
SOURCEiSearch...

Gene expression databases

CleanExiMM_TRERF1

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTREF1_MOUSE
AccessioniPrimary (citable) accession number: Q8BXJ2
Secondary accession number(s): Q32NY5
, Q6PCQ4, Q80X25, Q810H8, Q8BY31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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