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Protein

Claudin-17

Gene

Cldn17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-17
Gene namesi
Name:Cldn17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2652030 Cldn17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 164ExtracellularSequence analysisAdd BLAST19
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 224CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447781 – 224Claudin-17Add BLAST224

Proteomic databases

PaxDbiQ8BXA6
PRIDEiQ8BXA6

PTM databases

PhosphoSitePlusiQ8BXA6

Expressioni

Tissue specificityi

Expressed at high levels in the kidney and at mucher lower levels in the brain. In the kidney, expression gradually decreases from the proximal tubule downstream to the distal convoluted tubule. Expressed in the thin ascending limb of Henle's loop, as well as in the thick ascending limb of Henle's loop. In the distal convoluted tubules, expressed only in a few tubules. Not detected in the collecting duct. In the brain, expressed in blood vessels (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000055811 Expressed in 12 organ(s), highest expression level in nose
CleanExiMM_CLDN17

Interactioni

Subunit structurei

Interacts with OCLN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066427

Structurei

3D structure databases

ProteinModelPortaliQ8BXA6
SMRiQ8BXA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJK4 Eukaryota
ENOG410YQQY LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ8BXA6
KOiK06087
OMAiARALMCV
OrthoDBiEOG091G0MX2
PhylomeDBiQ8BXA6
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BXA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFYPLQIAG LVLGFFGLVG TIGTTLLPQW RVSAFIGSNI IIFERIWEGL
60 70 80 90 100
WMNCIQQAMV TLQCKFYNSI LALPPVLEAA RALMCVAVAL ALVALIIGIC
110 120 130 140 150
GMKQLQCTGS SERVKAYLLG TSGVLFILTG IFVLIPVSWT ANIIIRDFYD
160 170 180 190 200
PTVHAGQKRE LGGALFLGWA TAAVLFIGGG LLCGYCCCNR KERWHRYPVP
210 220
AYRVPQKDNQ RNVTVPRKSS TSYV
Length:224
Mass (Da):24,653
Last modified:March 1, 2003 - v1
Checksum:i6E049CE63AB60A34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048287 mRNA Translation: BAC33296.1
CCDSiCCDS28295.1
RefSeqiNP_852467.1, NM_181490.3
UniGeneiMm.126860

Genome annotation databases

EnsembliENSMUST00000069549; ENSMUSP00000066427; ENSMUSG00000055811
GeneIDi239931
KEGGimmu:239931
UCSCiuc007zuy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048287 mRNA Translation: BAC33296.1
CCDSiCCDS28295.1
RefSeqiNP_852467.1, NM_181490.3
UniGeneiMm.126860

3D structure databases

ProteinModelPortaliQ8BXA6
SMRiQ8BXA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066427

PTM databases

PhosphoSitePlusiQ8BXA6

Proteomic databases

PaxDbiQ8BXA6
PRIDEiQ8BXA6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069549; ENSMUSP00000066427; ENSMUSG00000055811
GeneIDi239931
KEGGimmu:239931
UCSCiuc007zuy.1 mouse

Organism-specific databases

CTDi26285
MGIiMGI:2652030 Cldn17

Phylogenomic databases

eggNOGiENOG410IJK4 Eukaryota
ENOG410YQQY LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ8BXA6
KOiK06087
OMAiARALMCV
OrthoDBiEOG091G0MX2
PhylomeDBiQ8BXA6
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q8BXA6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055811 Expressed in 12 organ(s), highest expression level in nose
CleanExiMM_CLDN17

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD17_MOUSE
AccessioniPrimary (citable) accession number: Q8BXA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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