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Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

Clptm1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances cisplatin-mediated apoptosis, when overexpressed.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1-like protein
Short name:
CLPTM1-like protein
Gene namesi
Name:Clptm1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442892 Clptm1l

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 285ExtracellularSequence analysisAdd BLAST254
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 325CytoplasmicSequence analysisAdd BLAST19
Transmembranei326 – 342HelicalSequence analysisAdd BLAST17
Topological domaini343 – 403ExtracellularSequence analysisAdd BLAST61
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 429CytoplasmicSequence analysis5
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 539ExtracellularSequence analysisAdd BLAST89

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313011 – 539Cleft lip and palate transmembrane protein 1-like proteinAdd BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8BXA5
MaxQBiQ8BXA5
PaxDbiQ8BXA5
PeptideAtlasiQ8BXA5
PRIDEiQ8BXA5

PTM databases

PhosphoSitePlusiQ8BXA5

Expressioni

Gene expression databases

BgeeiENSMUSG00000021610 Expressed in 291 organ(s), highest expression level in saliva-secreting gland
GenevisibleiQ8BXA5 MM

Interactioni

Protein-protein interaction databases

IntActiQ8BXA5, 1 interactor
MINTiQ8BXA5
STRINGi10090.ENSMUSP00000022102

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2489 Eukaryota
ENOG410XPEV LUCA
GeneTreeiENSGT00530000063461
HOGENOMiHOG000201405
HOVERGENiHBG057146
InParanoidiQ8BXA5
OMAiHMLFDFL
OrthoDBiEOG091G05EF
PhylomeDBiQ8BXA5
TreeFamiTF318501

Family and domain databases

InterProiView protein in InterPro
IPR008429 CLPTM1
IPR030434 CLPTM1L
PANTHERiPTHR21347 PTHR21347, 1 hit
PTHR21347:SF0 PTHR21347:SF0, 1 hit
PfamiView protein in Pfam
PF05602 CLPTM1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BXA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWSGRSSFTS LVVGVFLVYV VHTCWVMYGI VYTRPCSGDS NCIQPYLALR
60 70 80 90 100
PKLQLSVYTT TRSSLGAENN VDLILNVEDF DVDSKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGILPWQD GKQVHVVSTL TTYMIPKPEE INLLTGESAT
160 170 180 190 200
QQQIEAEKKP SNALDEPVSH WRPRLTLNVM VDDFVFDGSS LPADVHRYMK
210 220 230 240 250
MIQLGKTVHY LPILFIDQLS NRVKDLMVIN RSTTELPLTV SYDKISLGRL
260 270 280 290 300
RFWIHMQDAV YSLQQFGFSE KDADELKGIF VDTNLYLLAL TFFVAAFHLL
310 320 330 340 350
FDFLAFKSDI SFWKKKKSMI GMSTKAVLWR CFSTVVIFLF LLDEQTSLLV
360 370 380 390 400
LIPAGVGAAI ELWKVKKALK ITVAWRGLRP VFQFGTHSES ERKTEKYDAQ
410 420 430 440 450
AMKYLSYLLY PLCVGGAVYS LLNIKYKSWY SWLINSFVNG VYAFGFLFML
460 470 480 490 500
PQLFVNYKMK SVAHLPWKAF TYKAFNTFID DVFAFIITMP TSHRLACFRD
510 520 530
DVVFLVYLYQ RWLYPVDKSR VNEFGESYEE QPKRKPHPD
Length:539
Mass (Da):62,183
Last modified:March 1, 2003 - v1
Checksum:iD08CF6B6E31B7AD9
GO

Sequence cautioni

The sequence AAH26562 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27798 differs from that shown. Reason: Frameshift at position 335.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212P → L in BAE33624 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032295 mRNA Translation: BAC27798.1 Frameshift.
AK048357 mRNA Translation: BAC33311.1
AK156203 mRNA Translation: BAE33624.1
BC026562 mRNA Translation: AAH26562.1 Different initiation.
CCDSiCCDS56894.1
RefSeqiNP_666159.2, NM_146047.2
UniGeneiMm.30099

Genome annotation databases

EnsembliENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610
GeneIDi218335
KEGGimmu:218335
UCSCiuc007rdo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032295 mRNA Translation: BAC27798.1 Frameshift.
AK048357 mRNA Translation: BAC33311.1
AK156203 mRNA Translation: BAE33624.1
BC026562 mRNA Translation: AAH26562.1 Different initiation.
CCDSiCCDS56894.1
RefSeqiNP_666159.2, NM_146047.2
UniGeneiMm.30099

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BXA5, 1 interactor
MINTiQ8BXA5
STRINGi10090.ENSMUSP00000022102

PTM databases

PhosphoSitePlusiQ8BXA5

Proteomic databases

EPDiQ8BXA5
MaxQBiQ8BXA5
PaxDbiQ8BXA5
PeptideAtlasiQ8BXA5
PRIDEiQ8BXA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610
GeneIDi218335
KEGGimmu:218335
UCSCiuc007rdo.2 mouse

Organism-specific databases

CTDi81037
MGIiMGI:2442892 Clptm1l

Phylogenomic databases

eggNOGiKOG2489 Eukaryota
ENOG410XPEV LUCA
GeneTreeiENSGT00530000063461
HOGENOMiHOG000201405
HOVERGENiHBG057146
InParanoidiQ8BXA5
OMAiHMLFDFL
OrthoDBiEOG091G05EF
PhylomeDBiQ8BXA5
TreeFamiTF318501

Miscellaneous databases

ChiTaRSiClptm1l mouse
PROiPR:Q8BXA5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021610 Expressed in 291 organ(s), highest expression level in saliva-secreting gland
GenevisibleiQ8BXA5 MM

Family and domain databases

InterProiView protein in InterPro
IPR008429 CLPTM1
IPR030434 CLPTM1L
PANTHERiPTHR21347 PTHR21347, 1 hit
PTHR21347:SF0 PTHR21347:SF0, 1 hit
PfamiView protein in Pfam
PF05602 CLPTM1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLP1L_MOUSE
AccessioniPrimary (citable) accession number: Q8BXA5
Secondary accession number(s): Q3U176, Q8C053, Q8R0P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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