Clptm1l

Functionⁱ

Enhances cisplatin-mediated apoptosis, when overexpressed.By similarity

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cleft lip and palate transmembrane protein 1-like protein Short name: CLPTM1-like protein
Gene namesⁱ	Name:Clptm1l
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:2442892 Clptm1l

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 10	CytoplasmicSequence analysis	10
Transmembraneⁱ	11 – 31	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	32 – 285	ExtracellularSequence analysisAdd BLAST	254
Transmembraneⁱ	286 – 306	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	307 – 325	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	326 – 342	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	343 – 403	ExtracellularSequence analysisAdd BLAST	61
Transmembraneⁱ	404 – 424	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	425 – 429	CytoplasmicSequence analysis	5
Transmembraneⁱ	430 – 450	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	451 – 539	ExtracellularSequence analysisAdd BLAST	89

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000331301	1 – 539	Cleft lip and palate transmembrane protein 1-like proteinAdd BLAST		539

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	91	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	101	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q8BXA5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BXA5
PaxDbⁱ	Q8BXA5
PeptideAtlas More...PeptideAtlasⁱ	Q8BXA5
PRIDEⁱ	Q8BXA5

PTM databases

PhosphoSitePlusⁱ	Q8BXA5

PhosphoSitePlusⁱ

Q8BXA5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021610 Expressed in 291 organ(s), highest expression level in saliva-secreting gland
Genevisibleⁱ	Q8BXA5 MM

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8BXA5, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q8BXA5
STRINGⁱ	10090.ENSMUSP00000022102

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CLPTM1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2489 Eukaryota ENOG410XPEV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063461
HOGENOMⁱ	HOG000201405
HOVERGENⁱ	HBG057146
InParanoidⁱ	Q8BXA5
OMAⁱ	HMLFDFL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05EF
PhylomeDBⁱ	Q8BXA5
TreeFamⁱ	TF318501

Family and domain databases

InterProⁱ	View protein in InterPro IPR008429 CLPTM1 IPR030434 CLPTM1L
PANTHERⁱ	PTHR21347 PTHR21347, 1 hit PTHR21347:SF0 PTHR21347:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05602 CLPTM1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8BXA5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWSGRSSFTS LVVGVFLVYV VHTCWVMYGI VYTRPCSGDS NCIQPYLALR 
        60         70         80         90        100
PKLQLSVYTT TRSSLGAENN VDLILNVEDF DVDSKFERTV NVSVPKKTRN 
       110        120        130        140        150
NGTLYAYIFL HHAGILPWQD GKQVHVVSTL TTYMIPKPEE INLLTGESAT 
       160        170        180        190        200
QQQIEAEKKP SNALDEPVSH WRPRLTLNVM VDDFVFDGSS LPADVHRYMK 
       210        220        230        240        250
MIQLGKTVHY LPILFIDQLS NRVKDLMVIN RSTTELPLTV SYDKISLGRL 
       260        270        280        290        300
RFWIHMQDAV YSLQQFGFSE KDADELKGIF VDTNLYLLAL TFFVAAFHLL 
       310        320        330        340        350
FDFLAFKSDI SFWKKKKSMI GMSTKAVLWR CFSTVVIFLF LLDEQTSLLV 
       360        370        380        390        400
LIPAGVGAAI ELWKVKKALK ITVAWRGLRP VFQFGTHSES ERKTEKYDAQ 
       410        420        430        440        450
AMKYLSYLLY PLCVGGAVYS LLNIKYKSWY SWLINSFVNG VYAFGFLFML 
       460        470        480        490        500
PQLFVNYKMK SVAHLPWKAF TYKAFNTFID DVFAFIITMP TSHRLACFRD 
       510        520        530 
DVVFLVYLYQ RWLYPVDKSR VNEFGESYEE QPKRKPHPD

Length:539

Mass (Da):62,183

Last modified:March 1, 2003 - v1

Checksum:ⁱD08CF6B6E31B7AD9

GO

Sequence cautionⁱ

The sequence AAH26562 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAC27798 differs from that shown. Reason: Frameshift at position 335.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	212	P → L in BAE33624 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK032295 mRNA Translation: BAC27798.1 Frameshift. AK048357 mRNA Translation: BAC33311.1 AK156203 mRNA Translation: BAE33624.1 BC026562 mRNA Translation: AAH26562.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56894.1
NCBI Reference Sequences More...RefSeqⁱ	NP_666159.2, NM_146047.2
UniGeneⁱ	Mm.30099

Genome annotation databases

Ensemblⁱ	ENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610
GeneIDⁱ	218335
KEGGⁱ	mmu:218335
UCSC genome browser More...UCSCⁱ	uc007rdo.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BXA5	Cleft lip and palate transmembrane protein 1-like protein		HUMAN		538	UniRef90_Q96KA5
Cleft lip and palate transmembrane protein 1-like protein		PONAB		538
Cleft lip and palate transmembrane protein 1-like protein		BOVIN		538
cleft lip and palate transmembrane protein 1-like protein		BALAS		626
CLPTM1 like		LOXAF		541
+162

Protein	Similar proteins		Species	Score	Length	Source
Q8BXA5	Cleft lip and palate transmembrane protein 1-like protein		HUMAN		538	UniRef50_Q96KA5
Cleft lip and palate transmembrane protein 1-like protein		PONAB		538
Cleft lip and palate transmembrane protein 1-like protein		BOVIN		538
Cleft lip and palate transmembrane protein 1-like protein		DANRE		538
Cleft lip and palate transmembrane protein 1-like protein		CHICK		536
+489

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK032295 mRNA Translation: BAC27798.1 Frameshift. AK048357 mRNA Translation: BAC33311.1 AK156203 mRNA Translation: BAE33624.1 BC026562 mRNA Translation: AAH26562.1 Different initiation.
CCDSⁱ	CCDS56894.1
RefSeqⁱ	NP_666159.2, NM_146047.2
UniGeneⁱ	Mm.30099

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8BXA5, 1 interactor
MINTⁱ	Q8BXA5
STRINGⁱ	10090.ENSMUSP00000022102

PTM databases

PhosphoSitePlusⁱ	Q8BXA5

PhosphoSitePlusⁱ

Q8BXA5

Proteomic databases

EPDⁱ	Q8BXA5
MaxQBⁱ	Q8BXA5
PaxDbⁱ	Q8BXA5
PeptideAtlasⁱ	Q8BXA5
PRIDEⁱ	Q8BXA5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610
GeneIDⁱ	218335
KEGGⁱ	mmu:218335
UCSCⁱ	uc007rdo.2 mouse

Organism-specific databases

CTDⁱ	81037
MGIⁱ	MGI:2442892 Clptm1l

Phylogenomic databases

eggNOGⁱ	KOG2489 Eukaryota ENOG410XPEV LUCA
GeneTreeⁱ	ENSGT00530000063461
HOGENOMⁱ	HOG000201405
HOVERGENⁱ	HBG057146
InParanoidⁱ	Q8BXA5
OMAⁱ	HMLFDFL
OrthoDBⁱ	EOG091G05EF
PhylomeDBⁱ	Q8BXA5
TreeFamⁱ	TF318501

Miscellaneous databases

ChiTaRSⁱ	Clptm1l mouse
Protein Ontology More...PROⁱ	PR:Q8BXA5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021610 Expressed in 291 organ(s), highest expression level in saliva-secreting gland
Genevisibleⁱ	Q8BXA5 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR008429 CLPTM1 IPR030434 CLPTM1L
PANTHERⁱ	PTHR21347 PTHR21347, 1 hit PTHR21347:SF0 PTHR21347:SF0, 1 hit
Pfamⁱ	View protein in Pfam PF05602 CLPTM1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLP1L_MOUSE
Accessionⁱ	Q8BXA5Primary (citable) accession number: Q8BXA5 Secondary accession number(s): Q3U176, Q8C053, Q8R0P2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BXA5 (CLP1L_MOUSE)

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Cleft lip and palate transmembrane protein 1-like protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ