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UniProtKB - Q8BXA5 (CLP1L_MOUSE)
Protein
Cleft lip and palate transmembrane protein 1-like protein
Gene
Clptm1l
Organism
Mus musculus (Mouse)
Status
Functioni
Enhances cisplatin-mediated apoptosis, when overexpressed.
By similarityGO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Cleft lip and palate transmembrane protein 1-like proteinShort name: CLPTM1-like protein |
Gene namesi | Name:Clptm1l |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442892, Clptm1l |
VEuPathDBi | HostDB:ENSMUSG00000021610 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 11 – 31 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 32 – 285 | ExtracellularSequence analysisAdd BLAST | 254 | |
Transmembranei | 286 – 306 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 307 – 325 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 326 – 342 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 343 – 403 | ExtracellularSequence analysisAdd BLAST | 61 | |
Transmembranei | 404 – 424 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 425 – 429 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 430 – 450 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 451 – 539 | ExtracellularSequence analysisAdd BLAST | 89 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331301 | 1 – 539 | Cleft lip and palate transmembrane protein 1-like proteinAdd BLAST | 539 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8BXA5 |
jPOSTi | Q8BXA5 |
MaxQBi | Q8BXA5 |
PaxDbi | Q8BXA5 |
PeptideAtlasi | Q8BXA5 |
PRIDEi | Q8BXA5 |
ProteomicsDBi | 283313 |
PTM databases
GlyConnecti | 2219, 7 N-Linked glycans (3 sites) |
GlyGeni | Q8BXA5, 3 sites, 7 N-linked glycans (3 sites) |
PhosphoSitePlusi | Q8BXA5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021610, Expressed in saliva-secreting gland and 313 other tissues |
Genevisiblei | Q8BXA5, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022102 |
Miscellaneous databases
RNActi | Q8BXA5, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8BXA5 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the CLPTM1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2489, Eukaryota |
GeneTreei | ENSGT00530000063461 |
HOGENOMi | CLU_019907_4_1_1 |
InParanoidi | Q8BXA5 |
OMAi | QFDRQGM |
OrthoDBi | 1106937at2759 |
PhylomeDBi | Q8BXA5 |
TreeFami | TF318501 |
Family and domain databases
InterProi | View protein in InterPro IPR008429, CLPTM1 IPR030434, CLPTM1L |
PANTHERi | PTHR21347, PTHR21347, 1 hit PTHR21347:SF12, PTHR21347:SF12, 1 hit |
Pfami | View protein in Pfam PF05602, CLPTM1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8BXA5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWSGRSSFTS LVVGVFLVYV VHTCWVMYGI VYTRPCSGDS NCIQPYLALR
60 70 80 90 100
PKLQLSVYTT TRSSLGAENN VDLILNVEDF DVDSKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGILPWQD GKQVHVVSTL TTYMIPKPEE INLLTGESAT
160 170 180 190 200
QQQIEAEKKP SNALDEPVSH WRPRLTLNVM VDDFVFDGSS LPADVHRYMK
210 220 230 240 250
MIQLGKTVHY LPILFIDQLS NRVKDLMVIN RSTTELPLTV SYDKISLGRL
260 270 280 290 300
RFWIHMQDAV YSLQQFGFSE KDADELKGIF VDTNLYLLAL TFFVAAFHLL
310 320 330 340 350
FDFLAFKSDI SFWKKKKSMI GMSTKAVLWR CFSTVVIFLF LLDEQTSLLV
360 370 380 390 400
LIPAGVGAAI ELWKVKKALK ITVAWRGLRP VFQFGTHSES ERKTEKYDAQ
410 420 430 440 450
AMKYLSYLLY PLCVGGAVYS LLNIKYKSWY SWLINSFVNG VYAFGFLFML
460 470 480 490 500
PQLFVNYKMK SVAHLPWKAF TYKAFNTFID DVFAFIITMP TSHRLACFRD
510 520 530
DVVFLVYLYQ RWLYPVDKSR VNEFGESYEE QPKRKPHPD
Sequence cautioni
The sequence AAH26562 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27798 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 212 | P → L in BAE33624 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032295 mRNA Translation: BAC27798.1 Frameshift. AK048357 mRNA Translation: BAC33311.1 AK156203 mRNA Translation: BAE33624.1 BC026562 mRNA Translation: AAH26562.1 Different initiation. |
CCDSi | CCDS56894.1 |
RefSeqi | NP_666159.2, NM_146047.2 |
Genome annotation databases
Ensembli | ENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610 |
GeneIDi | 218335 |
KEGGi | mmu:218335 |
UCSCi | uc007rdo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032295 mRNA Translation: BAC27798.1 Frameshift. AK048357 mRNA Translation: BAC33311.1 AK156203 mRNA Translation: BAE33624.1 BC026562 mRNA Translation: AAH26562.1 Different initiation. |
CCDSi | CCDS56894.1 |
RefSeqi | NP_666159.2, NM_146047.2 |
3D structure databases
AlphaFoldDBi | Q8BXA5 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022102 |
PTM databases
GlyConnecti | 2219, 7 N-Linked glycans (3 sites) |
GlyGeni | Q8BXA5, 3 sites, 7 N-linked glycans (3 sites) |
PhosphoSitePlusi | Q8BXA5 |
Proteomic databases
EPDi | Q8BXA5 |
jPOSTi | Q8BXA5 |
MaxQBi | Q8BXA5 |
PaxDbi | Q8BXA5 |
PeptideAtlasi | Q8BXA5 |
PRIDEi | Q8BXA5 |
ProteomicsDBi | 283313 |
Protocols and materials databases
Antibodypediai | 3079, 213 antibodies from 22 providers |
Genome annotation databases
Ensembli | ENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610 |
GeneIDi | 218335 |
KEGGi | mmu:218335 |
UCSCi | uc007rdo.2, mouse |
Organism-specific databases
CTDi | 81037 |
MGIi | MGI:2442892, Clptm1l |
VEuPathDBi | HostDB:ENSMUSG00000021610 |
Phylogenomic databases
eggNOGi | KOG2489, Eukaryota |
GeneTreei | ENSGT00530000063461 |
HOGENOMi | CLU_019907_4_1_1 |
InParanoidi | Q8BXA5 |
OMAi | QFDRQGM |
OrthoDBi | 1106937at2759 |
PhylomeDBi | Q8BXA5 |
TreeFami | TF318501 |
Miscellaneous databases
BioGRID-ORCSi | 218335, 1 hit in 72 CRISPR screens |
ChiTaRSi | Clptm1l, mouse |
PROi | PR:Q8BXA5 |
RNActi | Q8BXA5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021610, Expressed in saliva-secreting gland and 313 other tissues |
Genevisiblei | Q8BXA5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008429, CLPTM1 IPR030434, CLPTM1L |
PANTHERi | PTHR21347, PTHR21347, 1 hit PTHR21347:SF12, PTHR21347:SF12, 1 hit |
Pfami | View protein in Pfam PF05602, CLPTM1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLP1L_MOUSE | |
Accessioni | Q8BXA5Primary (citable) accession number: Q8BXA5 Secondary accession number(s): Q3U176, Q8C053, Q8R0P2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families