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UniProtKB - Q8BXA5 (CLP1L_MOUSE)

Entry version 114 (25 May 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

Clptm1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances cisplatin-mediated apoptosis, when overexpressed.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1-like protein
Short name:
CLPTM1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Clptm1l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2442892, Clptm1l

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000021610

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 285ExtracellularSequence analysisAdd BLAST254
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 325CytoplasmicSequence analysisAdd BLAST19
Transmembranei326 – 342HelicalSequence analysisAdd BLAST17
Topological domaini343 – 403ExtracellularSequence analysisAdd BLAST61
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 429CytoplasmicSequence analysis5
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 539ExtracellularSequence analysisAdd BLAST89

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003313011 – 539Cleft lip and palate transmembrane protein 1-like proteinAdd BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8BXA5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8BXA5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8BXA5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8BXA5

PeptideAtlas

More...PeptideAtlasi		Q8BXA5

PRoteomics IDEntifications database

More...PRIDEi		Q8BXA5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		283313

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2219, 7 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8BXA5, 3 sites, 7 N-linked glycans (3 sites)

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8BXA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000021610, Expressed in saliva-secreting gland and 313 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8BXA5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000022102

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8BXA5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8BXA5

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2489, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063461

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019907_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8BXA5

Identification of Orthologs from Complete Genome Data

More...OMAi		QFDRQGM

Database of Orthologous Groups

More...OrthoDBi		1106937at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8BXA5

TreeFam database of animal gene trees

More...TreeFami		TF318501

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008429, CLPTM1
IPR030434, CLPTM1L

The PANTHER Classification System

More...PANTHERi		PTHR21347, PTHR21347, 1 hit
PTHR21347:SF12, PTHR21347:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05602, CLPTM1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BXA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWSGRSSFTS LVVGVFLVYV VHTCWVMYGI VYTRPCSGDS NCIQPYLALR 
        60         70         80         90        100
PKLQLSVYTT TRSSLGAENN VDLILNVEDF DVDSKFERTV NVSVPKKTRN 
       110        120        130        140        150
NGTLYAYIFL HHAGILPWQD GKQVHVVSTL TTYMIPKPEE INLLTGESAT 
       160        170        180        190        200
QQQIEAEKKP SNALDEPVSH WRPRLTLNVM VDDFVFDGSS LPADVHRYMK 
       210        220        230        240        250
MIQLGKTVHY LPILFIDQLS NRVKDLMVIN RSTTELPLTV SYDKISLGRL 
       260        270        280        290        300
RFWIHMQDAV YSLQQFGFSE KDADELKGIF VDTNLYLLAL TFFVAAFHLL 
       310        320        330        340        350
FDFLAFKSDI SFWKKKKSMI GMSTKAVLWR CFSTVVIFLF LLDEQTSLLV 
       360        370        380        390        400
LIPAGVGAAI ELWKVKKALK ITVAWRGLRP VFQFGTHSES ERKTEKYDAQ 
       410        420        430        440        450
AMKYLSYLLY PLCVGGAVYS LLNIKYKSWY SWLINSFVNG VYAFGFLFML 
       460        470        480        490        500
PQLFVNYKMK SVAHLPWKAF TYKAFNTFID DVFAFIITMP TSHRLACFRD 
       510        520        530 
DVVFLVYLYQ RWLYPVDKSR VNEFGESYEE QPKRKPHPD
Length:539
Mass (Da):62,183
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD08CF6B6E31B7AD9
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26562 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27798 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti212P → L in BAE33624 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK032295 mRNA Translation: BAC27798.1 Frameshift.
AK048357 mRNA Translation: BAC33311.1
AK156203 mRNA Translation: BAE33624.1
BC026562 mRNA Translation: AAH26562.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56894.1

NCBI Reference Sequences

More...RefSeqi		NP_666159.2, NM_146047.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610

Database of genes from NCBI RefSeq genomes

More...GeneIDi		218335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:218335

UCSC genome browser

More...UCSCi		uc007rdo.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032295 mRNA Translation: BAC27798.1 Frameshift.
AK048357 mRNA Translation: BAC33311.1
AK156203 mRNA Translation: BAE33624.1
BC026562 mRNA Translation: AAH26562.1 Different initiation.
CCDSiCCDS56894.1
RefSeqiNP_666159.2, NM_146047.2

3D structure databases

AlphaFoldDBiQ8BXA5
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022102

PTM databases

GlyConnecti2219, 7 N-Linked glycans (3 sites)
GlyGeniQ8BXA5, 3 sites, 7 N-linked glycans (3 sites)
PhosphoSitePlusiQ8BXA5

Proteomic databases

EPDiQ8BXA5
jPOSTiQ8BXA5
MaxQBiQ8BXA5
PaxDbiQ8BXA5
PeptideAtlasiQ8BXA5
PRIDEiQ8BXA5
ProteomicsDBi283313

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3079, 213 antibodies from 22 providers

Genome annotation databases

EnsembliENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610
GeneIDi218335
KEGGimmu:218335
UCSCiuc007rdo.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81037
MGIiMGI:2442892, Clptm1l
VEuPathDBiHostDB:ENSMUSG00000021610

Phylogenomic databases

eggNOGiKOG2489, Eukaryota
GeneTreeiENSGT00530000063461
HOGENOMiCLU_019907_4_1_1
InParanoidiQ8BXA5
OMAiQFDRQGM
OrthoDBi1106937at2759
PhylomeDBiQ8BXA5
TreeFamiTF318501

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		218335, 1 hit in 72 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Clptm1l, mouse

Protein Ontology

More...PROi		PR:Q8BXA5
RNActiQ8BXA5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000021610, Expressed in saliva-secreting gland and 313 other tissues
GenevisibleiQ8BXA5, MM

Family and domain databases

InterProiView protein in InterPro
IPR008429, CLPTM1
IPR030434, CLPTM1L
PANTHERiPTHR21347, PTHR21347, 1 hit
PTHR21347:SF12, PTHR21347:SF12, 1 hit
PfamiView protein in Pfam
PF05602, CLPTM1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLP1L_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BXA5
Secondary accession number(s): Q3U176, Q8C053, Q8R0P2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: May 25, 2022
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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