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Protein

Oxysterol-binding protein-related protein 2

Gene

Osbpl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds 25-hydroxycholesterol.By similarity

GO - Molecular functioni

  • cholesterol binding Source: MGI
  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-192105 Synthesis of bile acids and bile salts

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 2
Short name:
ORP-2
Short name:
OSBP-related protein 2
Gene namesi
Name:Osbpl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442832 Osbpl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003701 – 484Oxysterol-binding protein-related protein 2Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei20PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BX94
MaxQBiQ8BX94
PaxDbiQ8BX94
PRIDEiQ8BX94

PTM databases

PhosphoSitePlusiQ8BX94

Expressioni

Gene expression databases

BgeeiENSMUSG00000039050 Expressed in 273 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_OSBPL2
GenevisibleiQ8BX94 MM

Interactioni

Subunit structurei

Interacts with DIAPH1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046538

Structurei

3D structure databases

ProteinModelPortaliQ8BX94
SMRiQ8BX94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
HOVERGENiHBG053374
InParanoidiQ8BX94
KOiK20174
OMAiEWRTRWF
OrthoDBiEOG091G07RK
PhylomeDBiQ8BX94

Family and domain databases

InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BX94-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGEEEFFDA VTGFDSDNSS IGEFSEANKI SGMIDLDTSK STRSGKNGEK
60 70 80 90 100
PQQENGIQKH RTALPAPMFT RSDFSVWSIL KKCIGLELSK ITMPIAFNEP
110 120 130 140 150
LSFLQRITEY MEHVYLIHKA SSQSQPLERM QSVAAFAVSA VASQWERTGK
160 170 180 190 200
PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFYSEGL NQDFRFHGSI
210 220 230 240 250
YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVILGQLWIE
260 270 280 290 300
QYGIVEIVNH RTGDKCILHF KPCGLFGKEL HRVEGYIQDK NRKKLFIMYG
310 320 330 340 350
KWTECLWGID PASYESFKKQ EKRGDQARKA KMDDGPEKAN SDVPGDVADD
360 370 380 390 400
VPVAQETVQV IPGSKLLWRI NSRPPNSAQM YNFTSFTVSL NELESGMEKT
410 420 430 440 450
LPPTDCRLRP DIRGMENGNM DLASQEKERL EEKQREARKE RAKEDAEWRT
460 470 480
RWFSPGNNPY TGAPDWLYAG HYFERNFSDC PDIY
Length:484
Mass (Da):55,384
Last modified:March 1, 2003 - v1
Checksum:iE67BCF2D0C413497
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21I → T in AAH26804 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048537 mRNA Translation: BAC33367.1
AK170669 mRNA Translation: BAE41948.1
BC026804 mRNA Translation: AAH26804.1
CCDSiCCDS17170.1
RefSeqiNP_653083.2, NM_144500.3
XP_017173482.1, XM_017317993.1
UniGeneiMm.253578

Genome annotation databases

EnsembliENSMUST00000040668; ENSMUSP00000046538; ENSMUSG00000039050
GeneIDi228983
KEGGimmu:228983
UCSCiuc008oik.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048537 mRNA Translation: BAC33367.1
AK170669 mRNA Translation: BAE41948.1
BC026804 mRNA Translation: AAH26804.1
CCDSiCCDS17170.1
RefSeqiNP_653083.2, NM_144500.3
XP_017173482.1, XM_017317993.1
UniGeneiMm.253578

3D structure databases

ProteinModelPortaliQ8BX94
SMRiQ8BX94
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046538

PTM databases

PhosphoSitePlusiQ8BX94

Proteomic databases

EPDiQ8BX94
MaxQBiQ8BX94
PaxDbiQ8BX94
PRIDEiQ8BX94

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040668; ENSMUSP00000046538; ENSMUSG00000039050
GeneIDi228983
KEGGimmu:228983
UCSCiuc008oik.1 mouse

Organism-specific databases

CTDi9885
MGIiMGI:2442832 Osbpl2

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
HOVERGENiHBG053374
InParanoidiQ8BX94
KOiK20174
OMAiEWRTRWF
OrthoDBiEOG091G07RK
PhylomeDBiQ8BX94

Enzyme and pathway databases

ReactomeiR-MMU-192105 Synthesis of bile acids and bile salts

Miscellaneous databases

PROiPR:Q8BX94
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039050 Expressed in 273 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_OSBPL2
GenevisibleiQ8BX94 MM

Family and domain databases

InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BX94
Secondary accession number(s): Q3TCK8, Q8R0H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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