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Protein

Fibronectin type-III domain-containing protein 3A

Gene

Fndc3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates spermatid-Sertoli adhesion during spermatogenesis.1 Publication

GO - Biological processi

  • cell-cell adhesion Source: MGI
  • fertilization Source: MGI
  • Sertoli cell development Source: MGI
  • spermatid development Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type-III domain-containing protein 3A
Gene namesi
Name:Fndc3a
Synonyms:D14Ertd453e, Fndc3, Kiaa0970
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1196463 Fndc3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1177 – 1197HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873221 – 1198Fibronectin type-III domain-containing protein 3AAdd BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei384N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BX90
MaxQBiQ8BX90
PaxDbiQ8BX90
PRIDEiQ8BX90

PTM databases

iPTMnetiQ8BX90
PhosphoSitePlusiQ8BX90

Expressioni

Tissue specificityi

Testis. Localizes to the acrosome of spermatids, as well as to Leydig cells. Can be detected on the acrosome beginning at steps 2-3 and continuing until step 12 of spermiogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000033487 Expressed in 291 organ(s), highest expression level in islet of Langerhans
CleanExiMM_FNDC3A
ExpressionAtlasiQ8BX90 baseline and differential
GenevisibleiQ8BX90 MM

Interactioni

Protein-protein interaction databases

IntActiQ8BX90, 3 interactors
MINTiQ8BX90
STRINGi10090.ENSMUSP00000086411

Structurei

3D structure databases

ProteinModelPortaliQ8BX90
SMRiQ8BX90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 369Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini373 – 465Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini469 – 562Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini566 – 660Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini664 – 757Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST94
Domaini761 – 851Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini863 – 950Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST88
Domaini951 – 1045Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1049 – 1151Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 133Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the FNDC3 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8R Eukaryota
ENOG410XNUW LUCA
GeneTreeiENSGT00860000133770
HOVERGENiHBG100680
InParanoidiQ8BX90
OrthoDBiEOG091G047U
PhylomeDBiQ8BX90
TreeFamiTF316401

Family and domain databases

CDDicd00063 FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BX90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEHPPLLDT AQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE
60 70 80 90 100
DGQFQCITGP AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQS
110 120 130 140 150
PEFHPGGHTV IHRSPHPPLP GFIPVPTMMP PPPRHMYSPV TGAGDMATQY
160 170 180 190 200
MPQYQSSQVY ADVDAHSTHG RSNFRDERSS KTYERLQKKL KDRQGTQKDK
210 220 230 240 250
MSSPPPSPQK CPSPISEHNG LIKGQNASGG NTGSARNRSG RGRSCTQVDP
260 270 280 290 300
EMEEKDEETK AFEAFLSNIV KPVASDIQAR TVLLTWSPPS SFINGEVNET
310 320 330 340 350
AVPELFNYEV LVSSTGKEGK YRSVYIGEET SVTLNDLKPA TDYHAKVQAE
360 370 380 390 400
SNSIKGIPSE AESFTTLSCE PDPPNAPRIA NRTKNSLTLQ WKAPSDNGSK
410 420 430 440 450
IQSFILEWDE GKGNGEFCQC YMGSQKQFKI TKLSPAMGCK FRLSAKNDYG
460 470 480 490 500
VSDFSEEVLY YTSGCAPSVP ASPVLTKAGV TWLSLQWTKP SGTPSDEGIS
510 520 530 540 550
YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV IAYNSEGKSN
560 570 580 590 600
PSEVVEFSTC PDKPGVPVKP SVKGKIHSHG FKITWDPPKD NGGAPINKYV
610 620 630 640 650
VEMAEGSNGN KWDMIYSGTT REHLCDRLTP GCYYRLRVYC ISDGGQSAVS
660 670 680 690 700
ESLLVQTPAV PPGPCLPPRL QGRPKAKEIQ LRWGPPQVDG GSPISCYAVE
710 720 730 740 750
MTPADKDEPR DVYQGSEVEC TVGSLLPGKT YSFRLRAANR IGFGPFSEKY
760 770 780 790 800
DITTAPGPPD QCRPPQVTCR SATCAQVNWE IPLSNGTDVT EYRLEWGGVE
810 820 830 840 850
GSMQMCYCGP GLSCELKGLS PATTYYCRVQ AMSVVGAGPF SEVVACVTPP
860 870 880 890 900
SVPAIVTCLQ EISDDDIEYP HYSPSTCLAI SWKEPYDHGS EILAYSIDLG
910 920 930 940 950
DKQPLTVGKM TSYIIDSLQP DTTYRIRIQA LNSLGAGPFS HTIKLKTKPL
960 970 980 990 1000
PPDPPRLECV AFNHQNLKLK WGEGTPKTLS TDAVQYHLQM EDRNGRFVSL
1010 1020 1030 1040 1050
YRGPCHTYKV QRLSESTSYK FCIQACNEAG EGPLSQEYVF TTPKSLPAAL
1060 1070 1080 1090 1100
KAPKIEKIND HICEITWEYL QPMKGDPVIY NLQVMVGKDS EFKQIYKGPD
1110 1120 1130 1140 1150
TSFRYSSLQL NCEYRFRVCA IRQCQDPTGH QDLVGPYSTT VFFISQRTEP
1160 1170 1180 1190
PASSNKDSVD SARTRRTLSD EQCAAVILVV FAFFSILIAF IIQYFVIK
Length:1,198
Mass (Da):131,958
Last modified:July 28, 2009 - v3
Checksum:i700E545ED3D4A8F3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TLV3F6TLV3_MOUSE
Fibronectin type-III domain-contain...
Fndc3a
1,154Annotation score:
E0CXY0E0CXY0_MOUSE
Fibronectin type-III domain-contain...
Fndc3a
540Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249D → E in BAE43015 (PubMed:16141072).Curated1
Sequence conflicti620T → A in BAC28002 (PubMed:16141072).Curated1
Sequence conflicti788D → G in BAC33381 (PubMed:16141072).Curated1
Sequence conflicti1165R → Q in AAH47066 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ192036 mRNA Translation: ABA82149.1
AK032733 mRNA Translation: BAC28002.2
AK048586 mRNA Translation: BAC33381.1
AK172458 mRNA Translation: BAE43015.1
AK129250 mRNA Translation: BAC98060.1
BC047066 mRNA Translation: AAH47066.1
CCDSiCCDS27264.1
RefSeqiNP_997519.2, NM_207636.2
XP_006519178.2, XM_006519115.3
XP_006519179.1, XM_006519116.3
UniGeneiMm.205421
Mm.450820

Genome annotation databases

EnsembliENSMUST00000089017; ENSMUSP00000086411; ENSMUSG00000033487
GeneIDi319448
KEGGimmu:319448
UCSCiuc007upf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ192036 mRNA Translation: ABA82149.1
AK032733 mRNA Translation: BAC28002.2
AK048586 mRNA Translation: BAC33381.1
AK172458 mRNA Translation: BAE43015.1
AK129250 mRNA Translation: BAC98060.1
BC047066 mRNA Translation: AAH47066.1
CCDSiCCDS27264.1
RefSeqiNP_997519.2, NM_207636.2
XP_006519178.2, XM_006519115.3
XP_006519179.1, XM_006519116.3
UniGeneiMm.205421
Mm.450820

3D structure databases

ProteinModelPortaliQ8BX90
SMRiQ8BX90
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BX90, 3 interactors
MINTiQ8BX90
STRINGi10090.ENSMUSP00000086411

PTM databases

iPTMnetiQ8BX90
PhosphoSitePlusiQ8BX90

Proteomic databases

EPDiQ8BX90
MaxQBiQ8BX90
PaxDbiQ8BX90
PRIDEiQ8BX90

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089017; ENSMUSP00000086411; ENSMUSG00000033487
GeneIDi319448
KEGGimmu:319448
UCSCiuc007upf.1 mouse

Organism-specific databases

CTDi22862
MGIiMGI:1196463 Fndc3a
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IE8R Eukaryota
ENOG410XNUW LUCA
GeneTreeiENSGT00860000133770
HOVERGENiHBG100680
InParanoidiQ8BX90
OrthoDBiEOG091G047U
PhylomeDBiQ8BX90
TreeFamiTF316401

Miscellaneous databases

ChiTaRSiFndc3a mouse
PROiPR:Q8BX90
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033487 Expressed in 291 organ(s), highest expression level in islet of Langerhans
CleanExiMM_FNDC3A
ExpressionAtlasiQ8BX90 baseline and differential
GenevisibleiQ8BX90 MM

Family and domain databases

CDDicd00063 FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFND3A_MOUSE
AccessioniPrimary (citable) accession number: Q8BX90
Secondary accession number(s): Q2VEY7
, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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