Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 120 (16 Oct 2019)
Sequence version 2 (28 Nov 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Vacuolar protein sorting-associated protein 13C

Gene

Vps13c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 13C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vps13cImported
Synonyms:Kiaa3021Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444207 Vps13c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002629501 – 3748Vacuolar protein sorting-associated protein 13CAdd BLAST3748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineCombined sources1
Modified residuei613PhosphothreonineBy similarity1
Modified residuei618PhosphoserineBy similarity1
Modified residuei623PhosphothreonineBy similarity1
Modified residuei736PhosphoserineCombined sources1
Modified residuei841PhosphoserineBy similarity1
Modified residuei871PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei1968PhosphothreonineCombined sources1
Modified residuei1974PhosphoserineCombined sources1
Modified residuei2442PhosphoserineCombined sources1
Modified residuei3514Omega-N-methylarginineCombined sources1
Modified residuei3521Omega-N-methylarginineBy similarity1
Modified residuei3533N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BX70

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BX70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BX70

PeptideAtlas

More...
PeptideAtlasi
Q8BX70

PRoteomics IDEntifications database

More...
PRIDEi
Q8BX70

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BX70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BX70

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BX70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035284 Expressed in 25 organ(s), highest expression level in Ammon's horn

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BX70 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
236091, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000077040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BX70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi145 – 179Lys-richSequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS13 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1809 Eukaryota
COG5043 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183083

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218634

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BX70

KEGG Orthology (KO)

More...
KOi
K19525

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGMYVKN

Database of Orthologous Groups

More...
OrthoDBi
4159at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BX70

TreeFam database of animal gene trees

More...
TreeFami
TF300316

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015412 Autophagy-rel_C
IPR009543 SHR-BD
IPR026847 VPS13
IPR031645 VPS13_C
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2

The PANTHER Classification System

More...
PANTHERi
PTHR16166 PTHR16166, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BX70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE
60 70 80 90 100
LDVPFKVKAG QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA
110 120 130 140 150
EKEEKSLQDI KQKELCRIEE ALQKAAEKGA HSGEFMYGLE NLLYKDVKPG
160 170 180 190 200
RKRKKHKKHF KKRFKGLDRS KDKPKEAKKD TFLEKLATQV IKNVQVKITD
210 220 230 240 250
IHIKYEDDIT DPERPLSFGV TLREFSLLTT NEHWTPCILN EAEKIIYKLV
260 270 280 290 300
KLDSLSAYWN VGCCMSYRGS REHILEQLKR EILTSTNIPP DHQYIFQPIS
310 320 330 340 350
ASAKLYMNPG AESELKTPKL DGNVEVQNIA IELTKPQYLS MIDFLESLDY
360 370 380 390 400
MVRNAPYRKY KPCLPLHTNC RQWWKYAIDS VLEVHIRRYT QPWSWSNIKN
410 420 430 440 450
HRQLLKSYKM AYKTKLTQAK VSEEIQKQIQ DLEKSLDVFN IILVRQQAQV
460 470 480 490 500
EVIHSGQKLR KKSAEAGEKR GWFSGFWGKK ESKKRDEESS VPETIDDLMT
510 520 530 540 550
PEEKDKLFTA IGYSENAYNL ALPKQYVAHI LTLKLVSTSI IIRENRNVPE
560 570 580 590 600
ILRVQIIGLG TQVSQRPGAQ ALKIEAKLEH WYVTGLRQQD IVPSLVASIG
610 620 630 640 650
DTTSSLLKIE FETNPENSPA DQTLIVQSQP VEVIYDAKTI NAVVEFFQSN
660 670 680 690 700
KGLDLEQITS ATLMKLEEIK ERTATGLTHI IETRKVLDLR INLKPSYLII
710 720 730 740 750
PQTGFHHEKS NLLILDFGTF QLNSKDQGAQ KTANASLEEI IDKAYDKFDV
760 770 780 790 800
EIRSVQLLFA KAEENWKKCR FQHPSTMHIL QPMDIHVELA KAMVEKDVRM
810 820 830 840 850
AKFKVSGGLP LMHVRISDQK IKDALCLINS IPLPQKSSTP SPERQVASIP
860 870 880 890 900
VLSGGTKALL GTSLLLDGVE SESDEEFFDA EDGDSQAART VKASELKKAA
910 920 930 940 950
EVPNEELVSL LLKFEIKEVV LELTKQQKEE ETILVFNVTQ LGTEATMRTF
960 970 980 990 1000
DLTAVSYLRK ISLDYHDIKG SRKKPIHLIS SSDRPGLDLL KVEYIKVDRN
1010 1020 1030 1040 1050
GPSFQTTFEK TEQTVKVAFS SLNLLLQTQA LLSSLNYLTT VIPSDSQNTG
1060 1070 1080 1090 1100
VAKEVQAMPE KQKNSPLQKV MVPSRDSDVI GFRLFAKLNA FCVTVCDEKS
1110 1120 1130 1140 1150
NIAEIKIQGL DSSLSLQSKK QSLFARLENI IVTDVDPKTI HKKAVSIVGN
1160 1170 1180 1190 1200
EVFRFNLDLY PDATEGDSYT DMSTVDGVVA LHVGCIQIVY LHKFLMSLLS
1210 1220 1230 1240 1250
FLNNFQVAKE ALSAATAQAA EKAATSVKDL AQRSFRVSVD IDLKAPVIVI
1260 1270 1280 1290 1300
PQSSLSTNAV VVDLGLIRVH NRFSLVSGED TANPPVIDKM EVQLTKLKLS
1310 1320 1330 1340 1350
RTAIQPGTSH PDIQLLHPIN LEFFVSRNLA ANWYHKVPVV EIKGRLDSMN
1360 1370 1380 1390 1400
VSLNQEDLNL LFRILAENLG EATEDLDKGK PRIQERGETK ACREVSTPQD
1410 1420 1430 1440 1450
VHTTQGVPAA RVEETRPVDI INVLLNFEIK EVVVTLMKKA ERKGSPFHEL
1460 1470 1480 1490 1500
KILHLGMEAK VKAHDMTAAA YLRNISMRCF HFPDSKGEPL RIVNTSDVSD
1510 1520 1530 1540 1550
GILLKLLFIK ADSDGPDFKT IHDNTKQKLK VSFSSLDLVL HLEALLSLMD
1560 1570 1580 1590 1600
FLSSAIPSSD SSSSEKEPEL KPLVGESRSL AIRAVPSSYE GDAFDLKITA
1610 1620 1630 1640 1650
ELNAFNIFIC DQKSNIAEIK IHGMDASISV KPKQTDVFAR LKNIIVMNVD
1660 1670 1680 1690 1700
SLSIHKKAVS ILGDEVFRFQ MSLYPDATEG ENYGDMSKVD GRLSLKVGCI
1710 1720 1730 1740 1750
QIVYVHKFFM SLLSFLNNFQ AAKEALSTAT VQAAERAASS VKDLAQKSFR
1760 1770 1780 1790 1800
LLMDIDLKAP VITIPQSSVS PNVVIADLGL IRVENKFSLV SVEQLALPPV
1810 1820 1830 1840 1850
ADEMSIQLTQ LKLARTVLQA DSPQHDVEIL KPVNMLLCIQ RNLSAAWYTQ
1860 1870 1880 1890 1900
IPGMEIKGEL KPMQVALSQD DLTVLMKILL ENLGEASSQP SPTQYAQEAA
1910 1920 1930 1940 1950
RVKRDTRSGP DYLKEQELAD PKPPGDQTVT LQFDFHFDSL SIILYNSDSS
1960 1970 1980 1990 2000
QEPRLSFHND SFRLGELTLH LMASAGKMFK DGSMNVSLKL KTCTLDDLRE
2010 2020 2030 2040 2050
GIERATSRMI DKKNDQDNNS SMIDISYSQD KNGSQVDAVL DKLYVCASVE
2060 2070 2080 2090 2100
FLMTVADFFI KAMPQSPENI AKEIQIPSRQ TAAGRVKMEK DDSVRPNMTL
2110 2120 2130 2140 2150
KAMITDPEVV FVASLTKADA PALTASFQCN LSLSTSKLEQ MMEASVRDLK
2160 2170 2180 2190 2200
VLACPFLRER RGKSITTVLQ PCSLFMEKCT WASGKQNINI VVKEFVIKIS
2210 2220 2230 2240 2250
PIILNTVMTI MAAMSPKTKE DEWKDTPKET DNLWAVKSIT DYNSWFLGVD
2260 2270 2280 2290 2300
MATEVTENFR DSEHPSIEEN CVVAVESVQV TLECGLGHRT VPLLLAESKF
2310 2320 2330 2340 2350
SGNIKNWTSL MAAAADMTLE VHYYNETHAV WEPLIERVEG NKPWSLKLNV
2360 2370 2380 2390 2400
KKNPIQDKSL MPGDDFIPEP QTAVHISSGA TMNITISKSC LNVFSNLAKG
2410 2420 2430 2440 2450
FSEGAASTFD YSLKDRAPFT VKNALGVPMK VQPNRNLKVM GSPEKSDIYD
2460 2470 2480 2490 2500
VGAGQHLELD YASLEPSRQG KLSILSRQES SLFTLTFVPY GYTEVASVPV
2510 2520 2530 2540 2550
ARPGRRLYNV RNPSASHSDS VLVQIDATEG NKVVTLRSPL QIKNHFSIAF
2560 2570 2580 2590 2600
IIYKFVKNVK LLERIGIARP EEEFHVPLDS YRCQLYVQPA GGLEQQYTHS
2610 2620 2630 2640 2650
STYISWKEEL HRSREVRCML QCPAVEVSFL PLIVNTVALP DELSYIGAHG
2660 2670 2680 2690 2700
EDWDPAYVIH LYPPLTLRNL LPYSLRYLLE GTAETHELAE GSSADVLHSR
2710 2720 2730 2740 2750
ISGEIIELVL VKYLGKNWNG HFRICDTLPE FFLVCFSSDT AEVMTVDLSV
2760 2770 2780 2790 2800
HVRRIGCRME LSVFSPYWLI NKTSRVLQYR SEEIHVKHPA DFRDIILFSF
2810 2820 2830 2840 2850
KKKNIFSKNK VQLKISTSAW SNGFSLDTVG SYGCVKCPAT NMEYLVGVSI
2860 2870 2880 2890 2900
KMSSFNLSRV VTLTPFCTVA NKSSLDLEVG EIASDGSIPT NKWHYVASSE
2910 2920 2930 2940 2950
CIPFWPENLS GKLCVRVVGY EGSSKPFFYN RQDNGTLLSL EDLNGGILVD
2960 2970 2980 2990 3000
INTAEHSTVI TFSDYHEGSA PALIMNHTQW DVLTYKQSGS QEELVLLPGE
3010 3020 3030 3040 3050
TRLFAWADPT GIRKLTWNYA ANFGEHDLLK DECGQFPYDA NIQIHWVSFL
3060 3070 3080 3090 3100
DGRQRVLLFT DDVALVSKAL QAEEMEQADH EVALSLHSLG LSLVNNENKQ
3110 3120 3130 3140 3150
EVSYVGITSS GVVWEMKPKQ KWKPFSQKQI MSLEQAYSKR LASQDRGWVK
3160 3170 3180 3190 3200
LDSNFEVNFD KVPMEMRLPI RCPIKRDFLS GIQVEFKQSP HQRSLRARLY
3210 3220 3230 3240 3250
WLQVDNQLPG TMFPVVFHPV APPKSIALDS EPKPFIDVSV ITRFNEYSKV
3260 3270 3280 3290 3300
LQFKYFMVLI QEMALKVDQG FLGAVISLFT PTTDPEAERK RTKLIQQDID
3310 3320 3330 3340 3350
ALNTELMESS MTDMSILSFF EHFHISPVKL HLSLSLGSGG EESDKEKQEM
3360 3370 3380 3390 3400
IAIHSVNLLL KSIGATLTDV DDLIFKLAYY EIRYQFYKRD QLMWSVVRHY
3410 3420 3430 3440 3450
SEQFLKQMYV LVLGLDVLGN PFGLIRGLSE GVEALFYEPF QGAVQGPEEF
3460 3470 3480 3490 3500
AEGLVIGVRS LVGHTVGGAA GVVSRITGSV GKGLAAITMD KEYQQKRREE
3510 3520 3530 3540 3550
MGRQPKDFGD SLARGGKGFL RGVVGGVTGI ITKPVEGAKK EGAAGFFKGI
3560 3570 3580 3590 3600
GKGLVGAVAR PTGGIIDMAS STFQGIQRVA ESTEEVSSLR PPRLIHEDGI
3610 3620 3630 3640 3650
IRPYDRQESE GSDLLENHIK KLEGEAYQFH CAVPGNKRAV LMITNRRALF
3660 3670 3680 3690 3700
IKEVEILGHM SVDWQCLFED FVCPPEVSEN LLKISVKEQG LFHKKDSANI
3710 3720 3730 3740
GHLRKIYLKD PITAKRAFDA IESAQSARQQ QKLMRQSSVK LLRPQGPS
Length:3,748
Mass (Da):420,089
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57F0943B89B7A087
GO
Isoform 21 Publication (identifier: Q8BX70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3617-3623: NHIKKLE → QEMGTQE
     3624-3748: Missing.

Show »
Length:3,623
Mass (Da):405,827
Checksum:i1111D28941C7116A
GO
Isoform 31 Publication (identifier: Q8BX70-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-802: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:3,708
Mass (Da):415,300
Checksum:i4916DC5EAF3BAE31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SS63A0A1L1SS63_MOUSE
Vacuolar protein sorting-associated...
Vps13c
757Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SSJ3A0A1L1SSJ3_MOUSE
Vacuolar protein sorting-associated...
Vps13c
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SUY8A0A1L1SUY8_MOUSE
Vacuolar protein sorting-associated...
Vps13c
771Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC33451 differs from that shown. Reason: Frameshift.Curated
The sequence BAC33809 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE20465 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1759A → S in BAC33809 (PubMed:16141072).Curated1
Sequence conflicti2868T → P in BAC98296 (PubMed:14621295).Curated1
Sequence conflicti2916R → G in BAC98296 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052246763 – 802Missing in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0522473617 – 3623NHIKKLE → QEMGTQE in isoform 2. 1 Publication7
Alternative sequenceiVSP_0522483624 – 3748Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC156799 Genomic DNA No translation available.
AK030931 mRNA Translation: BAE20465.1 Different initiation.
AK045749 mRNA Translation: BAC32479.2
AK048766 mRNA Translation: BAC33451.1 Frameshift.
AK049557 mRNA Translation: BAC33809.1 Different initiation.
AK129486 mRNA Translation: BAC98296.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40676.1 [Q8BX70-1]

NCBI Reference Sequences

More...
RefSeqi
NP_796158.2, NM_177184.3 [Q8BX70-1]
XP_006511289.1, XM_006511226.1 [Q8BX70-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000077879; ENSMUSP00000077040; ENSMUSG00000035284 [Q8BX70-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
320528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:320528

UCSC genome browser

More...
UCSCi
uc009qms.1 mouse [Q8BX70-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156799 Genomic DNA No translation available.
AK030931 mRNA Translation: BAE20465.1 Different initiation.
AK045749 mRNA Translation: BAC32479.2
AK048766 mRNA Translation: BAC33451.1 Frameshift.
AK049557 mRNA Translation: BAC33809.1 Different initiation.
AK129486 mRNA Translation: BAC98296.1
CCDSiCCDS40676.1 [Q8BX70-1]
RefSeqiNP_796158.2, NM_177184.3 [Q8BX70-1]
XP_006511289.1, XM_006511226.1 [Q8BX70-2]

3D structure databases

SMRiQ8BX70
ModBaseiSearch...

Protein-protein interaction databases

BioGridi236091, 3 interactors
STRINGi10090.ENSMUSP00000077040

PTM databases

iPTMnetiQ8BX70
PhosphoSitePlusiQ8BX70
SwissPalmiQ8BX70

Proteomic databases

EPDiQ8BX70
jPOSTiQ8BX70
PaxDbiQ8BX70
PeptideAtlasiQ8BX70
PRIDEiQ8BX70

Genome annotation databases

EnsembliENSMUST00000077879; ENSMUSP00000077040; ENSMUSG00000035284 [Q8BX70-1]
GeneIDi320528
KEGGimmu:320528
UCSCiuc009qms.1 mouse [Q8BX70-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54832
MGIiMGI:2444207 Vps13c

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1809 Eukaryota
COG5043 LUCA
GeneTreeiENSGT00950000183083
HOGENOMiHOG000218634
InParanoidiQ8BX70
KOiK19525
OMAiLGMYVKN
OrthoDBi4159at2759
PhylomeDBiQ8BX70
TreeFamiTF300316

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Vps13c mouse

Protein Ontology

More...
PROi
PR:Q8BX70

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035284 Expressed in 25 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiQ8BX70 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR015412 Autophagy-rel_C
IPR009543 SHR-BD
IPR026847 VPS13
IPR031645 VPS13_C
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2
PANTHERiPTHR16166 PTHR16166, 3 hits
PfamiView protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP13C_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BX70
Secondary accession number(s): Q3V3W5
, Q6ZPE1, Q8BLB1, Q8BQI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 16, 2019
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again