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Protein

Zeta-sarcoglycan

Gene

Sgcz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability.

GO - Biological processi

  • heart contraction Source: GO_Central
  • membrane organization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Zeta-sarcoglycan
Short name:
Zeta-SG
Alternative name(s):
ZSG1
Gene namesi
Name:Sgcz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2388820 Sgcz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50CytoplasmicSequence analysisAdd BLAST50
Transmembranei51 – 71Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini72 – 311ExtracellularSequence analysisAdd BLAST240

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000316791 – 311Zeta-sarcoglycanAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi285 ↔ 301Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BX51
PRIDEiQ8BX51

PTM databases

PhosphoSitePlusiQ8BX51

Expressioni

Tissue specificityi

Expressed in the heart, skeletal muscle and arterial vascular smooth muscle.

Gene expression databases

BgeeiENSMUSG00000039539 Expressed in 5 organ(s), highest expression level in brain
CleanExiMM_SGCZ
ExpressionAtlasiQ8BX51 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi232651, 2 interactors
CORUMiQ8BX51
STRINGi10090.ENSMUSP00000113912

Structurei

3D structure databases

SMRiQ8BX51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3950 Eukaryota
ENOG4111GCH LUCA
GeneTreeiENSGT00390000017950
HOGENOMiHOG000007853
HOVERGENiHBG008669
InParanoidiQ8BX51
OMAiYILAAQP
OrthoDBiEOG091G11VY
PhylomeDBiQ8BX51
TreeFamiTF313538

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR039972 Sarcoglycan_gamma/delta/zeta
IPR027662 Sgcz
PANTHERiPTHR12939 PTHR12939, 1 hit
PTHR12939:SF5 PTHR12939:SF5, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BX51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRSTDLDIQ ELKMTREQYI LATQQNNLPR PENAQLYPVG IYGWRKRCLY
60 70 80 90 100
FFVLLLLVTM IVNLAMTIWI LKVMNFTVDG MGNLRVTKKG IRLEGISEFL
110 120 130 140 150
LPLYVKEIHS RKDSPLVLQS DRNVTVNARN HMGQLTGQLT VGAEAVEAQC
160 170 180 190 200
KRFEVRASED GRVLFSADED EITIGAEKLK VTGTEGAVFG HSVETPHIRA
210 220 230 240 250
EPSQDLRLES PTRSLKMEAP RGVQVSAAAG DFKATCRKEL HLQSTEGEIF
260 270 280 290 300
LNADSIRLGN LPIGSFSSST SSSNSRQTVY ELCVCPNGKL YLSPAGVGST
310
CQSSSSICLW N
Length:311
Mass (Da):34,461
Last modified:March 1, 2003 - v1
Checksum:i1F85C0B347810E2B
GO
Isoform 2 (identifier: Q8BX51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:298
Mass (Da):32,916
Checksum:i22E72618F0472BB3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFA5D6RFA5_MOUSE
Zeta-sarcoglycan
Sgcz
209Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274N → D in AAM23275 (PubMed:12189167).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188851 – 13Missing in isoform 2. 3 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY095374 mRNA Translation: AAM23275.1
AY250713 mRNA Translation: AAP76378.1
AK048960 mRNA Translation: BAC33500.1
AK136779 mRNA Translation: BAE23127.1
CCDSiCCDS22251.2 [Q8BX51-1]
RefSeqiNP_665840.2, NM_145841.2 [Q8BX51-1]
XP_006509183.1, XM_006509120.3 [Q8BX51-1]
XP_011240440.1, XM_011242138.1 [Q8BX51-2]
UniGeneiMm.210388

Genome annotation databases

EnsembliENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539 [Q8BX51-1]
GeneIDi244431
KEGGimmu:244431
UCSCiuc009lme.2 mouse [Q8BX51-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY095374 mRNA Translation: AAM23275.1
AY250713 mRNA Translation: AAP76378.1
AK048960 mRNA Translation: BAC33500.1
AK136779 mRNA Translation: BAE23127.1
CCDSiCCDS22251.2 [Q8BX51-1]
RefSeqiNP_665840.2, NM_145841.2 [Q8BX51-1]
XP_006509183.1, XM_006509120.3 [Q8BX51-1]
XP_011240440.1, XM_011242138.1 [Q8BX51-2]
UniGeneiMm.210388

3D structure databases

SMRiQ8BX51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232651, 2 interactors
CORUMiQ8BX51
STRINGi10090.ENSMUSP00000113912

PTM databases

PhosphoSitePlusiQ8BX51

Proteomic databases

PaxDbiQ8BX51
PRIDEiQ8BX51

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539 [Q8BX51-1]
GeneIDi244431
KEGGimmu:244431
UCSCiuc009lme.2 mouse [Q8BX51-1]

Organism-specific databases

CTDi137868
MGIiMGI:2388820 Sgcz

Phylogenomic databases

eggNOGiKOG3950 Eukaryota
ENOG4111GCH LUCA
GeneTreeiENSGT00390000017950
HOGENOMiHOG000007853
HOVERGENiHBG008669
InParanoidiQ8BX51
OMAiYILAAQP
OrthoDBiEOG091G11VY
PhylomeDBiQ8BX51
TreeFamiTF313538

Miscellaneous databases

ChiTaRSiSgcz mouse
PROiPR:Q8BX51
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039539 Expressed in 5 organ(s), highest expression level in brain
CleanExiMM_SGCZ
ExpressionAtlasiQ8BX51 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR039972 Sarcoglycan_gamma/delta/zeta
IPR027662 Sgcz
PANTHERiPTHR12939 PTHR12939, 1 hit
PTHR12939:SF5 PTHR12939:SF5, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGCZ_MOUSE
AccessioniPrimary (citable) accession number: Q8BX51
Secondary accession number(s): Q3UVZ2, Q8K1E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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