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Protein

Tumor necrosis factor receptor superfamily member 19L

Gene

Relt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed.By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19L
Gene namesi
Name:Relt
Synonyms:Tnfrsf19l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443373 Relt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 169ExtracellularSequence analysisAdd BLAST138
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 436CytoplasmicSequence analysisAdd BLAST246

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000003460132 – 436Tumor necrosis factor receptor superfamily member 19LAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 72By similarity
Disulfide bondi78 ↔ 97By similarity
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei230PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated in vitro by OXSR1. Phosphorylated by STK39.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BX43
PaxDbiQ8BX43
PRIDEiQ8BX43

PTM databases

iPTMnetiQ8BX43
PhosphoSitePlusiQ8BX43

Expressioni

Gene expression databases

BgeeiENSMUSG00000008318 Expressed in 23 organ(s), highest expression level in bone marrow
CleanExiMM_RELT
ExpressionAtlasiQ8BX43 baseline and differential
GenevisibleiQ8BX43 MM

Interactioni

Subunit structurei

Interacts with RELL1, RELL2, OXSR1, PLSCR1 and STK39.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008462

Structurei

3D structure databases

ProteinModelPortaliQ8BX43
SMRiQ8BX43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 97TNFR-CysAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi355 – 358RFRV motif; mediates interaction with STK39By similarity4

Sequence similaritiesi

Belongs to the RELT family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJV Eukaryota
ENOG410YDMP LUCA
GeneTreeiENSGT00530000063385
HOGENOMiHOG000134238
HOVERGENiHBG062274
InParanoidiQ8BX43
KOiK05156
OMAiCGDCQPG
OrthoDBiEOG091G0ADI
TreeFamiTF332339

Family and domain databases

CDDicd13419 TNFRSF19L, 1 hit
InterProiView protein in InterPro
IPR022248 TNF_rcpt_RELT
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022333 TNFR_19-like
IPR034048 TNFRSF19L_N
PANTHERiPTHR23097:SF37 PTHR23097:SF37, 1 hit
PfamiView protein in Pfam
PF12606 RELT, 1 hit
PF00020 TNFR_c6, 1 hit
PRINTSiPR01970 TNFACTORR19L
SMARTiView protein in SMART
SM00208 TNFR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8BX43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQGLMMKR TLLCWPLSCL FVLLPWPLAT PTPITPWLCP PGKEPDPDPG
60 70 80 90 100
QGTLCRTCPP GTFSASWNSY PCQPHYRCSL QKRLEAQAGT ATHDTMCGDC
110 120 130 140 150
QHGWFGPQGV PHVPCQPCSK APPSTGGCDE SGRRGRRGVE VAAGTSSNGE
160 170 180 190 200
PRQPGNGTRA GGPEETAAQY AVIAIVPVFC LMGLLGILVC NLLKRKGYHC
210 220 230 240 250
TAQKEVGPSP GGGGSGINPA YRTEDANEDT IGVLVRLITE KKENAAALEE
260 270 280 290 300
LLKEYHSKQL VQTSHRPVPR LLPASPSIPH ICPHHHHLHT VQGLASLSGP
310 320 330 340 350
CCSRCSQKWP EVLLSPEAAA ATTPAPTLLP TASRAPKASA KPGRQGEITI
360 370 380 390 400
LSVGRFRVAR IPEQRTSSLL SEVKTITEAG PSEGDLPDSP QPGLPPEQRA
410 420 430
LLGSGGSHTK WLKPPAENKA EENRYVVRLS ESNLVI
Length:436
Mass (Da):46,518
Last modified:July 27, 2011 - v2
Checksum:iE61304480DBA0815
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z306D3Z306_MOUSE
Tumor necrosis factor receptor supe...
Relt
119Annotation score:
D6RIM1D6RIM1_MOUSE
Tumor necrosis factor receptor supe...
Relt
119Annotation score:
D3YWL9D3YWL9_MOUSE
Tumor necrosis factor receptor supe...
Relt
123Annotation score:
D3YTN8D3YTN8_MOUSE
Tumor necrosis factor receptor supe...
Relt
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39C → G in BAC33534 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049073 mRNA Translation: BAC33534.1
AK088621 mRNA Translation: BAC40459.1
BC100310 mRNA Translation: AAI00311.1
BC131929 mRNA Translation: AAI31930.1
BC131931 mRNA Translation: AAI31932.1
BC145200 mRNA Translation: AAI45201.1
CCDSiCCDS21506.1
RefSeqiNP_796047.2, NM_177073.6
XP_006507994.1, XM_006507931.3
XP_006507995.1, XM_006507932.3
XP_006507996.1, XM_006507933.2
XP_006507997.1, XM_006507934.3
XP_006507998.1, XM_006507935.3
XP_006507999.1, XM_006507936.3
UniGeneiMm.40336

Genome annotation databases

EnsembliENSMUST00000008462; ENSMUSP00000008462; ENSMUSG00000008318
GeneIDi320100
KEGGimmu:320100
UCSCiuc009int.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049073 mRNA Translation: BAC33534.1
AK088621 mRNA Translation: BAC40459.1
BC100310 mRNA Translation: AAI00311.1
BC131929 mRNA Translation: AAI31930.1
BC131931 mRNA Translation: AAI31932.1
BC145200 mRNA Translation: AAI45201.1
CCDSiCCDS21506.1
RefSeqiNP_796047.2, NM_177073.6
XP_006507994.1, XM_006507931.3
XP_006507995.1, XM_006507932.3
XP_006507996.1, XM_006507933.2
XP_006507997.1, XM_006507934.3
XP_006507998.1, XM_006507935.3
XP_006507999.1, XM_006507936.3
UniGeneiMm.40336

3D structure databases

ProteinModelPortaliQ8BX43
SMRiQ8BX43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008462

PTM databases

iPTMnetiQ8BX43
PhosphoSitePlusiQ8BX43

Proteomic databases

MaxQBiQ8BX43
PaxDbiQ8BX43
PRIDEiQ8BX43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008462; ENSMUSP00000008462; ENSMUSG00000008318
GeneIDi320100
KEGGimmu:320100
UCSCiuc009int.2 mouse

Organism-specific databases

CTDi84957
MGIiMGI:2443373 Relt

Phylogenomic databases

eggNOGiENOG410IKJV Eukaryota
ENOG410YDMP LUCA
GeneTreeiENSGT00530000063385
HOGENOMiHOG000134238
HOVERGENiHBG062274
InParanoidiQ8BX43
KOiK05156
OMAiCGDCQPG
OrthoDBiEOG091G0ADI
TreeFamiTF332339

Miscellaneous databases

PROiPR:Q8BX43
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008318 Expressed in 23 organ(s), highest expression level in bone marrow
CleanExiMM_RELT
ExpressionAtlasiQ8BX43 baseline and differential
GenevisibleiQ8BX43 MM

Family and domain databases

CDDicd13419 TNFRSF19L, 1 hit
InterProiView protein in InterPro
IPR022248 TNF_rcpt_RELT
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022333 TNFR_19-like
IPR034048 TNFRSF19L_N
PANTHERiPTHR23097:SF37 PTHR23097:SF37, 1 hit
PfamiView protein in Pfam
PF12606 RELT, 1 hit
PF00020 TNFR_c6, 1 hit
PRINTSiPR01970 TNFACTORR19L
SMARTiView protein in SMART
SM00208 TNFR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTR19L_MOUSE
AccessioniPrimary (citable) accession number: Q8BX43
Secondary accession number(s): Q497Z8, Q8BTV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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