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Protein

Tumor necrosis factor receptor superfamily member 27

Gene

Eda2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 27
Alternative name(s):
X-linked ectodysplasin-A2 receptor
Short name:
EDA-A2 receptor
Gene namesi
Name:Eda2r
Synonyms:Tnfrsf27, Xedar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442860 Eda2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 138ExtracellularSequence analysisAdd BLAST138
Transmembranei139 – 159Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini160 – 297CytoplasmicSequence analysisAdd BLAST138

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589391 – 297Tumor necrosis factor receptor superfamily member 27Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 15PROSITE-ProRule annotation
Disulfide bondi18 ↔ 31PROSITE-ProRule annotation
Disulfide bondi21 ↔ 41PROSITE-ProRule annotation
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi61 ↔ 75PROSITE-ProRule annotation
Disulfide bondi64 ↔ 83PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi86 ↔ 104PROSITE-ProRule annotation
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BX35
PaxDbiQ8BX35
PRIDEiQ8BX35

PTM databases

PhosphoSitePlusiQ8BX35

Expressioni

Gene expression databases

BgeeiENSMUSG00000034457
CleanExiMM_EDA2R
ExpressionAtlasiQ8BX35 baseline and differential
GenevisibleiQ8BX35 MM

Interactioni

Subunit structurei

Associates with TRAF1, TRAF3 and TRAF6.By similarity

Protein-protein interaction databases

BioGridi232789, 2 interactors
IntActiQ8BX35, 1 interactor
STRINGi10090.ENSMUSP00000041210

Structurei

3D structure databases

ProteinModelPortaliQ8BX35
SMRiQ8BX35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 41TNFR-Cys 1Add BLAST40
Repeati43 – 83TNFR-Cys 2Add BLAST41
Repeati85 – 118TNFR-Cys 3Add BLAST34

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IETX Eukaryota
ENOG41104RU LUCA
GeneTreeiENSGT00730000110978
HOGENOMiHOG000132464
HOVERGENiHBG059312
InParanoidiQ8BX35
KOiK05163
OMAiLPRFYRK
OrthoDBiEOG091G0ADI
PhylomeDBiQ8BX35
TreeFamiTF331385

Family and domain databases

CDDicd15838 TNFRSF27, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022319 TNFR_27
IPR034060 TNFRSF27_N
PANTHERiPTHR12120:SF8 PTHR12120:SF8, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01973 TNFACTORR27
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BX35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCQENEYRD QWGRCVTCQQ CGPGQELSKD CGYGEGGDAH CIVCPPRKYK
60 70 80 90 100
STWGHHRCQT CITCAVINRV QKANCTNTSN AICGDCLPRF YRKTRIGGLQ
110 120 130 140 150
DQECIPCTKQ TPSSEVQCTF QLSLVKVDAH TVPPREATLV ALVGSLLVVF
160 170 180 190 200
ALAFLGLFFL YCKQIFNRHC QCRDSLQYEA EKTVEEDSLF PVPPGQETSP
210 220 230 240 250
EFPANEGILE IKPLNSILDD DCSSTRGFPT QESFTMASCA SESHSQWVHT
260 270 280 290
PIECTELDLQ KFSSSIPSTG PETLRENTAE HSGDRLELYV PFEVPSL
Length:297
Mass (Da):33,066
Last modified:March 1, 2003 - v1
Checksum:i46FEFDDC51D739BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70V → A in BAC28879 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034909 mRNA Translation: BAC28879.1
AK049134 mRNA Translation: BAC33562.1
CCDSiCCDS30293.1
RefSeqiNP_001154904.1, NM_001161432.1
NP_001154905.1, NM_001161433.1
NP_780749.3, NM_175540.5
XP_006528088.1, XM_006528025.2
XP_006528089.1, XM_006528026.2
UniGeneiMm.189270

Genome annotation databases

EnsembliENSMUST00000037353; ENSMUSP00000041210; ENSMUSG00000034457
ENSMUST00000113832; ENSMUSP00000109463; ENSMUSG00000034457
GeneIDi245527
KEGGimmu:245527
UCSCiuc009tus.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTNR27_MOUSE
AccessioniPrimary (citable) accession number: Q8BX35
Secondary accession number(s): Q8BM50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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