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Entry version 153 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Sal-like protein 4

Gene

Sall4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri387 – 409C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri601 – 623C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri880 – 902C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri908 – 930C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8943724 Regulation of PTEN gene transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sal-like protein 4
Alternative name(s):
Zinc finger protein SALL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sall4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2139360 Sall4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002614161 – 1067Sal-like protein 4Add BLAST1067

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei308PhosphoserineBy similarity1
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki377Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki379Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki379Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki557Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki630Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei785PhosphoserineBy similarity1
Modified residuei798PhosphoserineBy similarity1
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki906Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki942Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki957Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1029PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BX22

PeptideAtlas

More...
PeptideAtlasi
Q8BX22

PRoteomics IDEntifications database

More...
PRIDEi
Q8BX22

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BX22

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BX22

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027547 Expressed in 128 organ(s), highest expression level in primary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BX22 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BX22 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POU5F1/OCT4 (By similarity).

Interacts with NANOG.

Interacts with BEND3.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
221236, 57 interactors

Database of interacting proteins

More...
DIPi
DIP-29926N

Protein interaction database and analysis system

More...
IntActi
Q8BX22, 44 interactors

Molecular INTeraction database

More...
MINTi
Q8BX22

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000029061

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi217 – 225Poly-Gln9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 409C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri601 – 623C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri880 – 902C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri908 – 930C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1074 Eukaryota
ENOG410ZE3Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231986

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8BX22

KEGG Orthology (KO)

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KOi
K19871

Identification of Orthologs from Complete Genome Data

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OMAi
KLPHANV

Database of Orthologous Groups

More...
OrthoDBi
244207at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317003

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BX22-1) [UniParc]FASTAAdd to basket
Also known as: Sall4a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRKQAKPQ HINWEEGQGE QPQQLPSPDL AEALAAEEPG APVNSPGNCD
60 70 80 90 100
EASEDSIPVK RPRREDTHIC NKCCAEFFSL SEFMEHKKSC TKTPPVLIMN
110 120 130 140 150
DSEGPVPSED FSRAALSHQL GSPSNKDSLQ ENGSSSGDLK KLGTDSILYL
160 170 180 190 200
KTEATQPSTP QDISYLPKGK VANTNVTLQA LRGTKVAVNQ RGAEAPMAPM
210 220 230 240 250
PAAQGIPWVL EQILCLQQQQ LQQIQLTEQI RVQVNMWAAH ALHSGVAGAD
260 270 280 290 300
TLKALSSHVS QQVSVSQQVS AAVALLSQKA SNPALSLDAL KQAKLPHASV
310 320 330 340 350
PSAASPLSSG LTSFTLKPDG TRVLPNFVSR LPSALLPQTP GSVLLQSPFS
360 370 380 390 400
AVTLDQSKKG KGKPQNLSAS ASVLDVKAKD EVVLGKHKCR YCPKVFGTDS
410 420 430 440 450
SLQIHLRSHT GERPYVCPIC GHRFTTKGNL KVHLQRHPEV KANPQLLAEF
460 470 480 490 500
QDKGAVSAAS HYALPVPVPA DESSLSVDAE PVPVTGTPSL GLPQKLTSGP
510 520 530 540 550
NSRDLMGGSL PNDMQPGPSP ESEAGLPLLG VGMIHNPPKA GGFQGTGAPE
560 570 580 590 600
SGSETLKLQQ LVENIDKATT DPNECLICHR VLSCQSSLKM HYRTHTGERP
610 620 630 640 650
FQCKICGRAF STKGNLKTHL GVHRTNTTVK TQHSCPICQK KFTNAVMLQQ
660 670 680 690 700
HIRMHMGGQI PNTPLPESPC DFTAPEPVAV SENGSASGVC QDDAAEGMEA
710 720 730 740 750
EEVCSQDVPS GPSTVSLPVP SAHLASPSLG FSVLASLDTQ GKGALPALAL
760 770 780 790 800
QRQSSRENSS LEGGDTGPAN DSSLLVGDQE CQSRSPDATE TMCYQAVSPA
810 820 830 840 850
NSQAGSVKSR SPEGHKAEGV ESCRVDTEGR TSLPPTFIRA QPTFVKVEVP
860 870 880 890 900
GTFVGPPSMP SGMPPLLASQ PQPRRQAKQH CCTRCGKNFS SASALQIHER
910 920 930 940 950
THTGEKPFVC NICGRAFTTK GNLKVHYMTH GANNNSARRG RKLAIENPMA
960 970 980 990 1000
ALSAEGKRAP EVFSKELLSP AVSVDPASWN QYTSVLNGGL AMKTNEISVI
1010 1020 1030 1040 1050
QSGGIPTLPV SLGASSVVSN GTISKLDGSQ TGVSMPMSGN GEKLAVPDGM
1060
AKHQFPHFLE ENKIAVS
Length:1,067
Mass (Da):113,110
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23B92F488AAF53E5
GO
Isoform 2 (identifier: Q8BX22-2) [UniParc]FASTAAdd to basket
Also known as: Sall4b

The sequence of this isoform differs from the canonical sequence as follows:
     386-829: Missing.

Note: No experimental confirmation available.
Show »
Length:623
Mass (Da):66,215
Checksum:i8C762461A0483EF7
GO
Isoform 3 (identifier: Q8BX22-3) [UniParc]FASTAAdd to basket
Also known as: Sall4c

The sequence of this isoform differs from the canonical sequence as follows:
     40-828: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):29,725
Checksum:iD8DCBBFE0618EF02
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AUZ6A2AUZ6_MOUSE
Sal-like protein 4
Sall4
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AUZ7A2AUZ7_MOUSE
Sal-like protein 4
Sall4
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti865P → H in AAR91797 (Ref. 1) Curated1
Sequence conflicti950A → V in AAR91797 (Ref. 1) Curated1
Sequence conflicti950A → V in CAD32912 (Ref. 5) Curated1
Sequence conflicti969S → Y in AAR91796 (Ref. 1) Curated1
Sequence conflicti969S → Y in AAR91798 (Ref. 1) Curated1
Sequence conflicti969S → Y in BAC33598 (PubMed:16141072).Curated1
Sequence conflicti997I → T in AAR91797 (Ref. 1) Curated1
Sequence conflicti1022T → M in AAR91797 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02168640 – 828Missing in isoform 3. 1 PublicationAdd BLAST789
Alternative sequenceiVSP_021687386 – 829Missing in isoform 2. 1 PublicationAdd BLAST444

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY463371 mRNA Translation: AAR91796.1
AY463372 mRNA Translation: AAR91797.1
AY463373 mRNA Translation: AAR91798.1
AK049188 mRNA Translation: BAC33598.1
AL929248 Genomic DNA No translation available.
CH466551 Genomic DNA Translation: EDL06559.1
AJ488904 Genomic DNA Translation: CAD32912.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17115.1 [Q8BX22-1]
CCDS17116.1 [Q8BX22-2]
CCDS17117.1 [Q8BX22-3]

NCBI Reference Sequences

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RefSeqi
NP_780512.2, NM_175303.4 [Q8BX22-1]
NP_958797.2, NM_201395.3 [Q8BX22-2]
NP_958798.2, NM_201396.3 [Q8BX22-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000029061; ENSMUSP00000029061; ENSMUSG00000027547 [Q8BX22-1]
ENSMUST00000075044; ENSMUSP00000074556; ENSMUSG00000027547 [Q8BX22-3]
ENSMUST00000103074; ENSMUSP00000099363; ENSMUSG00000027547 [Q8BX22-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
99377

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:99377

UCSC genome browser

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UCSCi
uc008obf.1 mouse [Q8BX22-1]
uc008obg.1 mouse [Q8BX22-2]
uc008obh.1 mouse [Q8BX22-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY463371 mRNA Translation: AAR91796.1
AY463372 mRNA Translation: AAR91797.1
AY463373 mRNA Translation: AAR91798.1
AK049188 mRNA Translation: BAC33598.1
AL929248 Genomic DNA No translation available.
CH466551 Genomic DNA Translation: EDL06559.1
AJ488904 Genomic DNA Translation: CAD32912.1
CCDSiCCDS17115.1 [Q8BX22-1]
CCDS17116.1 [Q8BX22-2]
CCDS17117.1 [Q8BX22-3]
RefSeqiNP_780512.2, NM_175303.4 [Q8BX22-1]
NP_958797.2, NM_201395.3 [Q8BX22-2]
NP_958798.2, NM_201396.3 [Q8BX22-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi221236, 57 interactors
DIPiDIP-29926N
IntActiQ8BX22, 44 interactors
MINTiQ8BX22
STRINGi10090.ENSMUSP00000029061

PTM databases

iPTMnetiQ8BX22
PhosphoSitePlusiQ8BX22

Proteomic databases

PaxDbiQ8BX22
PeptideAtlasiQ8BX22
PRIDEiQ8BX22

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
99377

Genome annotation databases

EnsembliENSMUST00000029061; ENSMUSP00000029061; ENSMUSG00000027547 [Q8BX22-1]
ENSMUST00000075044; ENSMUSP00000074556; ENSMUSG00000027547 [Q8BX22-3]
ENSMUST00000103074; ENSMUSP00000099363; ENSMUSG00000027547 [Q8BX22-2]
GeneIDi99377
KEGGimmu:99377
UCSCiuc008obf.1 mouse [Q8BX22-1]
uc008obg.1 mouse [Q8BX22-2]
uc008obh.1 mouse [Q8BX22-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57167
MGIiMGI:2139360 Sall4

Phylogenomic databases

eggNOGiKOG1074 Eukaryota
ENOG410ZE3Z LUCA
GeneTreeiENSGT00940000155384
HOGENOMiHOG000231986
InParanoidiQ8BX22
KOiK19871
OMAiKLPHANV
OrthoDBi244207at2759
TreeFamiTF317003

Enzyme and pathway databases

ReactomeiR-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8BX22

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027547 Expressed in 128 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ8BX22 baseline and differential
GenevisibleiQ8BX22 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSALL4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BX22
Secondary accession number(s): A2AV00
, Q6S7E8, Q6S7E9, Q7TST6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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