UniProtKB - Q8BX02 (KANK2_MOUSE)
KN motif and ankyrin repeat domain-containing protein 2
Kank2
Functioni
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- glomerular visceral epithelial cell migration Source: UniProtKB
- kidney epithelium development Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
- negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
- negative regulation of programmed cell death Source: UniProtKB
- negative regulation of stress fiber assembly Source: MGI
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of vitamin D receptor signaling pathway Source: UniProtKB
- regulation of Rho protein signal transduction Source: UniProtKB
Keywordsi
Biological process | Apoptosis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: KN motif and ankyrin repeat domain-containing protein 2Alternative name(s): Ankyrin repeat domain-containing protein 25 |
Gene namesi | Name:Kank2 Synonyms:Ankrd25 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384568, Kank2 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Other locations
- Cytoplasm By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240841 | 1 – 843 | KN motif and ankyrin repeat domain-containing protein 2Add BLAST | 843 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineBy similarity | 1 | |
Modified residuei | 83 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 89 | PhosphoserineCombined sources | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
Modified residuei | 105 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 170 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 331 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 358 | PhosphoserineBy similarity | 1 | |
Modified residuei | 532 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | Q8BX02 |
PaxDbi | Q8BX02 |
PeptideAtlasi | Q8BX02 |
PRIDEi | Q8BX02 |
PTM databases
iPTMneti | Q8BX02 |
PhosphoSitePlusi | Q8BX02 |
SwissPalmi | Q8BX02 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000032194, Expressed in dorsal pancreas and 260 other tissues |
ExpressionAtlasi | Q8BX02, baseline and differential |
Genevisiblei | Q8BX02, MM |
Interactioni
Subunit structurei
Interacts (non-phosphorylated form) with NCOA1; NCOA2 AND NCOA3 (By similarity).
Interacts with AIFM1 (By similarity).
Interacts with ARHGDIA; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 231612, 7 interactors |
IntActi | Q8BX02, 4 interactors |
MINTi | Q8BX02 |
STRINGi | 10090.ENSMUSP00000034717 |
Miscellaneous databases
RNActi | Q8BX02, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 673 – 703 | ANK 1Add BLAST | 31 | |
Repeati | 707 – 740 | ANK 2Add BLAST | 34 | |
Repeati | 745 – 774 | ANK 3Add BLAST | 30 | |
Repeati | 778 – 808 | ANK 4Add BLAST | 31 | |
Repeati | 812 – 842 | ANK 5Add BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | Interaction with AIFM1By similarityAdd BLAST | 72 | |
Regioni | 661 – 827 | Interaction with NCOA1By similarityAdd BLAST | 167 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 183 – 234 | Sequence analysisAdd BLAST | 52 | |
Coiled coili | 282 – 313 | Sequence analysisAdd BLAST | 32 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000161012 |
HOGENOMi | CLU_004269_2_0_1 |
InParanoidi | Q8BX02 |
OMAi | GYHTSQR |
OrthoDBi | 98668at2759 |
PhylomeDBi | Q8BX02 |
TreeFami | TF324499 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF12075, KN_motif, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQVLHVPAP FPGTPGQASP AAFPSKEPDP PYSVETPYGY RLDLDFLKYV
60 70 80 90 100
DDIEKGHTLR RVAVQRRPRL GSLPRGPGSW WTSTESLCSD ASGDSRHSAY
110 120 130 140 150
SYCGRGFYPQ YGALETRIGS NPRVERTLLD ARRRLEDQAA APSSGGLGSL
160 170 180 190 200
TPSAAGSTSS LAGVGLLPPT PRSSGLSTPV APSAGHLAHV REQMAGALRK
210 220 230 240 250
LRQLEEQVKL IPVLQVKLSV LQEEKRQLTV QLKSQKFLGH PSGTRSRSEL
260 270 280 290 300
CLDLPEAPDD PAALETRSVG TWVRERDLGI PDGEAALVAK VAVLETQLKK
310 320 330 340 350
ALQELRAAQT QQVDLQPQAW PPPDTQVRVD TVRVVEGPRE VEVAASTAAG
360 370 380 390 400
ALAQRAQSLE PYGTGLKALT TSGGPENTLV FRSHEVVETM CPLPTATTGN
410 420 430 440 450
VHTAKKISIT ERSCTGAPRM TEPSSVNPRP AAASVVQPEN PVPAAQDTTD
460 470 480 490 500
KKPTRPAAAS QDSQAADGAG RASLATKRKE DPADPEVNQR NLQFVGVNGG
510 520 530 540 550
YESPSEDSST AENSEHESTE NEGPEPPARV LSPAECPQLR PPGAAVATTS
560 570 580 590 600
LEGPQLSQES QRVPAPEVAS GPDPEEEIRM DLSPDLISAC LALEKYLENP
610 620 630 640 650
NALTERELKV AYTTVLQEWL RLACRSDAHP ELVRRHLVTF RAMSARLLDY
660 670 680 690 700
VVNIADSNGN TALHYSVSHA NFPVVRQLLD SGVCHVDKLN RAGYSPIMLT
710 720 730 740 750
ALATLKTQDD IETILQLFRL GNVNAKASQA GQTALMLAVS HGRVDVVRAL
760 770 780 790 800
LACEADVNIQ DEDGSTALMC ACEHGHKEIT GLLLAVPSCD ISLTDRDGST
810 820 830 840
ALMVALDAGQ SEIASMLYSR MNIKCSFAPM SDYESPASSS AEE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SUF5 | A0A1L1SUF5_MOUSE | KN motif and ankyrin repeat domain-... | Kank2 | 27 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 135 | L → V in BAC32392 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 139 | A → V in AAH10245 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019430 | 580 – 607 | MDLSP…LTERE → KWPIPQCFRSGCAWPAAVTH TLSLCGDI in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_019431 | 608 – 843 | Missing in isoform 2. 1 PublicationAdd BLAST | 236 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045492 mRNA Translation: BAC32392.1 AK049288 mRNA Translation: BAC33660.1 BC010245 mRNA Translation: AAH10245.1 |
CCDSi | CCDS22911.1 [Q8BX02-1] |
RefSeqi | NP_663586.3, NM_145611.4 [Q8BX02-1] |
Genome annotation databases
Ensembli | ENSMUST00000034717; ENSMUSP00000034717; ENSMUSG00000032194 [Q8BX02-1] ENSMUST00000216008; ENSMUSP00000151181; ENSMUSG00000032194 [Q8BX02-2] |
GeneIDi | 235041 |
KEGGi | mmu:235041 |
UCSCi | uc009omm.2, mouse [Q8BX02-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045492 mRNA Translation: BAC32392.1 AK049288 mRNA Translation: BAC33660.1 BC010245 mRNA Translation: AAH10245.1 |
CCDSi | CCDS22911.1 [Q8BX02-1] |
RefSeqi | NP_663586.3, NM_145611.4 [Q8BX02-1] |
3D structure databases
SMRi | Q8BX02 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231612, 7 interactors |
IntActi | Q8BX02, 4 interactors |
MINTi | Q8BX02 |
STRINGi | 10090.ENSMUSP00000034717 |
PTM databases
iPTMneti | Q8BX02 |
PhosphoSitePlusi | Q8BX02 |
SwissPalmi | Q8BX02 |
Proteomic databases
jPOSTi | Q8BX02 |
PaxDbi | Q8BX02 |
PeptideAtlasi | Q8BX02 |
PRIDEi | Q8BX02 |
Protocols and materials databases
Antibodypediai | 2885, 174 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034717; ENSMUSP00000034717; ENSMUSG00000032194 [Q8BX02-1] ENSMUST00000216008; ENSMUSP00000151181; ENSMUSG00000032194 [Q8BX02-2] |
GeneIDi | 235041 |
KEGGi | mmu:235041 |
UCSCi | uc009omm.2, mouse [Q8BX02-1] |
Organism-specific databases
CTDi | 25959 |
MGIi | MGI:2384568, Kank2 |
Phylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000161012 |
HOGENOMi | CLU_004269_2_0_1 |
InParanoidi | Q8BX02 |
OMAi | GYHTSQR |
OrthoDBi | 98668at2759 |
PhylomeDBi | Q8BX02 |
TreeFami | TF324499 |
Miscellaneous databases
BioGRID-ORCSi | 235041, 0 hits in 17 CRISPR screens |
ChiTaRSi | Kank2, mouse |
PROi | PR:Q8BX02 |
RNActi | Q8BX02, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032194, Expressed in dorsal pancreas and 260 other tissues |
ExpressionAtlasi | Q8BX02, baseline and differential |
Genevisiblei | Q8BX02, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF12075, KN_motif, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KANK2_MOUSE | |
Accessioni | Q8BX02Primary (citable) accession number: Q8BX02 Secondary accession number(s): Q8BLD5, Q91Z35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot