UniProtKB - Q8BWY9 (CIP2A_MOUSE)
Protein
Protein CIP2A
Gene
Cip2a
Organism
Mus musculus (Mouse)
Status
Functioni
Promotes anchorage-independent cell growth and tumor formation.By similarity
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- positive regulation of neural precursor cell proliferation Source: MGI
- spermatogenesis Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Protein CIP2AAlternative name(s): Cancerous inhibitor of PP2A p90 autoantigen homolog |
Gene namesi | Name:Cip2a Synonyms:Kiaa1524 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2146335, Cip2a |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
- Cytoplasm By similarity
Note: Slightly concentrates in the perinuclear region.By similarity
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 194 – 214 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287142 | 1 – 907 | Protein CIP2AAdd BLAST | 907 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 906 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8BWY9 |
MaxQBi | Q8BWY9 |
PaxDbi | Q8BWY9 |
PRIDEi | Q8BWY9 |
PTM databases
iPTMneti | Q8BWY9 |
PhosphoSitePlusi | Q8BWY9 |
Expressioni
Tissue specificityi
Highly expressed in E17.5 and E18.5 liver but not pexpressed in adult liver. Expressed at moderate level in embryonic brain, muscle and epidermal layers.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000033031, Expressed in cumulus cell and 234 other tissues |
ExpressionAtlasi | Q8BWY9, baseline and differential |
Genevisiblei | Q8BWY9, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with MYC.
Interacts with PPP2R5C; this interaction stabilizes CIP2A.
Interacts with PPP2R1A; this interaction stabilizes CIP2A.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 230256, 1 interactor |
IntActi | Q8BWY9, 1 interactor |
STRINGi | 10090.ENSMUSP00000113075 |
Miscellaneous databases
RNActi | Q8BWY9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 161 – 247 | Required for interaction with PPP2R5CBy similarityAdd BLAST | 87 | |
Regioni | 389 – 559 | Required for homodimerizationBy similarityAdd BLAST | 171 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 639 – 887 | Sequence analysisAdd BLAST | 249 |
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTAP, Eukaryota |
GeneTreei | ENSGT00940000153251 |
HOGENOMi | CLU_014754_0_0_1 |
InParanoidi | Q8BWY9 |
OMAi | AYKMLII |
OrthoDBi | 188665at2759 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR042510, CIP2A |
PANTHERi | PTHR23161, PTHR23161, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8BWY9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSTACLKSL LLSISQYKAV KSEANATQLL RHLEVVSGQK LTRLFTSHQI
60 70 80 90 100
LPSECLSCLV ELLEDPNISA SLILSIISLL SQLAIDNETR DCLQNIYNLN
110 120 130 140 150
SVLSGVVCRS SACHNDSVFL QCIQLLQRLT YNAKFFHSGA HIDDLITFLI
160 170 180 190 200
GHVQSSEDEL TMPCLGLLAN LCRHNLSVQT QIKTLSNVKS FYRTLISFLA
210 220 230 240 250
HSSLTVVVFA LSILSSLTLN EEVGEKLFHA RNIHQTFQLI FNILINGDGT
260 270 280 290 300
LTRKYSVDLL MDLLKNPKIA DYLTRYEHFS SCLSQVLGLL NAKDPDSSSK
310 320 330 340 350
VLELLLAFCA VTQLRHVLSQ MMFEQSPSGN ILGSRPKSLE PTAALLRWLS
360 370 380 390 400
QPLDGAENCS VLALELFKEI FEDVIDTGNC SSTDHFVTLL LPTILDQLQF
410 420 430 440 450
KEQNLDETLV RNKCERMVKA IEVLLTLCGD DSLKMHVVKI LTTLKCTTLI
460 470 480 490 500
EQQFTYGKID LGFGTKVADS ELCKLAADVI LKTLTLMNKL KQLVPGMEVS
510 520 530 540 550
FYKILQDPRL ITPLAFALTS DNREQVQSGL GILLEASPLP DFPAFVLGES
560 570 580 590 600
IAANNVYRQQ ETEHLPRKMT FQPLNHGFST SAKCLTPPPS KDNAPALNIE
610 620 630 640 650
DLIEKLQAGV MVKDQISDIR ISDIMDVYEM KLSTLASKES RLQDLLEAKA
660 670 680 690 700
LALAQADRLI AQYRCQRTQA ETEARTLAGM LREVERKNEE LSVLLKSQQL
710 720 730 740 750
ESERAQNDIE HLFQHSKKLE SVAAEHEILT KSYMELVQRN EATEKKNTDL
760 770 780 790 800
QTTCESLNKH IETMKKLNEA LKQQNEKTIA QLIEKEEQRK EVQSQLADRE
810 820 830 840 850
CKLSNLHKIA KSQEEKLNVL QKEKEDKQET IDILRKELSR TEQIRKELSI
860 870 880 890 900
KASSLEMHKA QLEGRLEEKE SLLKLQQEEL NKHSHMIAMI HSLSGGKISP
ETVNLSI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z7B5 | D3Z7B5_MOUSE | Protein CIP2A | Cip2a C330027C09Rik | 907 | Annotation score: |
Sequence cautioni
The sequence BAC33705 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | S → R in BAC33705 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 413 – 415 | KCE → EVI in AAH52662 (PubMed:15489334).Curated | 3 | |
Sequence conflicti | 699 | Q → K in BAC33705 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049356 mRNA Translation: BAC33705.1 Different initiation. BC137719 mRNA Translation: AAI37720.1 BC052662 mRNA Translation: AAH52662.1 AK173190 mRNA Translation: BAD32468.1 |
CCDSi | CCDS49867.1 |
RefSeqi | NP_766204.2, NM_172616.2 |
Genome annotation databases
Ensembli | ENSMUST00000048374; ENSMUSP00000044714; ENSMUSG00000033031 |
GeneIDi | 224171 |
KEGGi | mmu:224171 |
UCSCi | uc007zkb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049356 mRNA Translation: BAC33705.1 Different initiation. BC137719 mRNA Translation: AAI37720.1 BC052662 mRNA Translation: AAH52662.1 AK173190 mRNA Translation: BAD32468.1 |
CCDSi | CCDS49867.1 |
RefSeqi | NP_766204.2, NM_172616.2 |
3D structure databases
SMRi | Q8BWY9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230256, 1 interactor |
IntActi | Q8BWY9, 1 interactor |
STRINGi | 10090.ENSMUSP00000113075 |
PTM databases
iPTMneti | Q8BWY9 |
PhosphoSitePlusi | Q8BWY9 |
Proteomic databases
EPDi | Q8BWY9 |
MaxQBi | Q8BWY9 |
PaxDbi | Q8BWY9 |
PRIDEi | Q8BWY9 |
Protocols and materials databases
Antibodypediai | 32380, 243 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000048374; ENSMUSP00000044714; ENSMUSG00000033031 |
GeneIDi | 224171 |
KEGGi | mmu:224171 |
UCSCi | uc007zkb.1, mouse |
Organism-specific databases
CTDi | 57650 |
MGIi | MGI:2146335, Cip2a |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTAP, Eukaryota |
GeneTreei | ENSGT00940000153251 |
HOGENOMi | CLU_014754_0_0_1 |
InParanoidi | Q8BWY9 |
OMAi | AYKMLII |
OrthoDBi | 188665at2759 |
Miscellaneous databases
BioGRID-ORCSi | 224171, 7 hits in 18 CRISPR screens |
ChiTaRSi | Cip2a, mouse |
PROi | PR:Q8BWY9 |
RNActi | Q8BWY9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033031, Expressed in cumulus cell and 234 other tissues |
ExpressionAtlasi | Q8BWY9, baseline and differential |
Genevisiblei | Q8BWY9, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR042510, CIP2A |
PANTHERi | PTHR23161, PTHR23161, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CIP2A_MOUSE | |
Accessioni | Q8BWY9Primary (citable) accession number: Q8BWY9 Secondary accession number(s): B2RQ25, Q69ZH6, Q7TPZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot