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Protein

C-type lectin domain family 1 member A

Gene

Clec1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 1 member A
Gene namesi
Name:Clec1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444151 Clec1a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini73 – 269ExtracellularSequence analysisAdd BLAST197

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466101 – 269C-type lectin domain family 1 member AAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 256PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi235 ↔ 248PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BWY2
PaxDbiQ8BWY2
PRIDEiQ8BWY2

PTM databases

iPTMnetiQ8BWY2
PhosphoSitePlusiQ8BWY2

Expressioni

Gene expression databases

BgeeiENSMUSG00000033082 Expressed in 113 organ(s), highest expression level in lung
CleanExiMM_CLEC1A
ExpressionAtlasiQ8BWY2 baseline and differential
GenevisibleiQ8BWY2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047065

Structurei

3D structure databases

ProteinModelPortaliQ8BWY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 257C-type lectinPROSITE-ProRule annotationAdd BLAST115

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104266
HOGENOMiHOG000111777
HOVERGENiHBG103475
InParanoidiQ8BWY2
KOiK10069
OMAiKWHGDKC
OrthoDBiEOG091G0K57
PhylomeDBiQ8BWY2
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BWY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAKYSSTRD MLDDDDTTIS LYSGTSTVTR RAEPRHSENG TPSSVWRPVA
60 70 80 90 100
LTLLTLCLVL LVGLAALGLV FFQFYQLSNI QQDSITEKDE KLGNMSRQLQ
110 120 130 140 150
SLQAQNRKLI ETLQQVAVKL CRELYNKSGG HRCSPCPEKW KWYGDKCYQF
160 170 180 190 200
YKESKNWQSC EYFCLADNAT MLKISTQEEL DFAMPQSYSE FFYSYWTGLS
210 220 230 240 250
RNGSGKAWLW TDGTPYSFEL FEIIIDPTNL RNRDCMTIFN GKAYSKDCKE
260
LRRCACERIA GRVVPGELQ
Length:269
Mass (Da):30,958
Last modified:March 1, 2003 - v1
Checksum:iDEC53DB093451ED0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV03A0A0N4SV03_MOUSE
C-type lectin domain family 1 membe...
Clec1a
206Annotation score:
A0A0N4SVE6A0A0N4SVE6_MOUSE
C-type lectin domain family 1 membe...
Clec1a
164Annotation score:
A0A0N4SWF3A0A0N4SWF3_MOUSE
C-type lectin domain family 1 membe...
Clec1a
77Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6S → G in AAH52840 (PubMed:15489334).Curated1
Sequence conflicti222E → Q in BAC27264 (PubMed:16141072).Curated1
Sequence conflicti228T → N in BAC27264 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031121 mRNA Translation: BAC27264.1
AK049608 mRNA Translation: BAC33840.1
BC052840 mRNA Translation: AAH52840.1
CCDSiCCDS20587.1
RefSeqiNP_001334404.1, NM_001347475.1
NP_780735.2, NM_175526.3
UniGeneiMm.131289

Genome annotation databases

EnsembliENSMUST00000037481; ENSMUSP00000047065; ENSMUSG00000033082
GeneIDi243653
KEGGimmu:243653
UCSCiuc009eft.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031121 mRNA Translation: BAC27264.1
AK049608 mRNA Translation: BAC33840.1
BC052840 mRNA Translation: AAH52840.1
CCDSiCCDS20587.1
RefSeqiNP_001334404.1, NM_001347475.1
NP_780735.2, NM_175526.3
UniGeneiMm.131289

3D structure databases

ProteinModelPortaliQ8BWY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047065

PTM databases

iPTMnetiQ8BWY2
PhosphoSitePlusiQ8BWY2

Proteomic databases

MaxQBiQ8BWY2
PaxDbiQ8BWY2
PRIDEiQ8BWY2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037481; ENSMUSP00000047065; ENSMUSG00000033082
GeneIDi243653
KEGGimmu:243653
UCSCiuc009eft.2 mouse

Organism-specific databases

CTDi51267
MGIiMGI:2444151 Clec1a

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104266
HOGENOMiHOG000111777
HOVERGENiHBG103475
InParanoidiQ8BWY2
KOiK10069
OMAiKWHGDKC
OrthoDBiEOG091G0K57
PhylomeDBiQ8BWY2
TreeFamiTF336674

Miscellaneous databases

PROiPR:Q8BWY2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033082 Expressed in 113 organ(s), highest expression level in lung
CleanExiMM_CLEC1A
ExpressionAtlasiQ8BWY2 baseline and differential
GenevisibleiQ8BWY2 MM

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC1A_MOUSE
AccessioniPrimary (citable) accession number: Q8BWY2
Secondary accession number(s): Q7TPX7, Q8BMH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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