UniProtKB - Q8BWW4 (LARP4_MOUSE)
Protein
La-related protein 4
Gene
Larp4
Organism
Mus musculus (Mouse)
Status
Functioni
RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization.By similarity
GO - Molecular functioni
- mRNA 3'-UTR binding Source: MGI
- poly(A) binding Source: MGI
GO - Biological processi
- cytoskeleton organization Source: UniProtKB
- positive regulation of translation Source: MGI
- posttranscriptional regulation of gene expression Source: MGI
- regulation of cell morphogenesis Source: UniProtKB
- translation Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein 4Alternative name(s): La ribonucleoprotein domain family member 4 |
Gene namesi | Name:Larp4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443114, Larp4 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Other locations
- Stress granule By similarity
Note: Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment.By similarity
Cytosol
- cytosol Source: MGI
Other locations
- cytoplasmic stress granule Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207612 | 1 – 719 | La-related protein 4Add BLAST | 719 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 363 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 387 | PhosphoserineBy similarity | 1 | |
Modified residuei | 396 | PhosphoserineCombined sources | 1 | |
Modified residuei | 500 | PhosphoserineBy similarity | 1 | |
Modified residuei | 578 | PhosphoserineBy similarity | 1 | |
Modified residuei | 592 | PhosphoserineBy similarity | 1 | |
Modified residuei | 642 | PhosphoserineBy similarity | 1 | |
Modified residuei | 644 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 681 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 717 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q8BWW4 |
jPOSTi | Q8BWW4 |
MaxQBi | Q8BWW4 |
PaxDbi | Q8BWW4 |
PRIDEi | Q8BWW4 |
ProteomicsDBi | 265042 |
PTM databases
iPTMneti | Q8BWW4 |
PhosphoSitePlusi | Q8BWW4 |
SwissPalmi | Q8BWW4 |
Interactioni
Subunit structurei
Interacts (via N-terminal region) with PABPC1.
Interacts with RACK1.
By similarityProtein-protein interaction databases
BioGRIDi | 228885, 4 interactors |
IntActi | Q8BWW4, 2 interactors |
MINTi | Q8BWW4 |
STRINGi | 10090.ENSMUSP00000097780 |
Miscellaneous databases
RNActi | Q8BWW4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 198 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 199 – 277 | RRMAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 21 | Interaction with PABPC1By similarity | 10 | |
Regioni | 107 – 299 | Interaction with the poly-A tract of mRNABy similarityAdd BLAST | 193 |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota KOG2591, Eukaryota |
InParanoidi | Q8BWW4 |
OrthoDBi | 263288at2759 |
PhylomeDBi | Q8BWW4 |
Family and domain databases
CDDi | cd12707, RRM_LARP4, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR034903, LARP4_RRM IPR035979, RBD_domain_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8BWW4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLFVEVTSK GTGLNPNAKV WQEIPSGNPD GTPVTEPSWH ETAATSGSHP
60 70 80 90 100
EGHTELSEDM CKEYEVMYSP SCETTRNTAD VEESADGMIL GPEDLSYQLY
110 120 130 140 150
DVSGESSSAI STEDLKECLK KQLEFCFSRE NLSKDLYLIS QMDSDQFVPI
160 170 180 190 200
WTVANMEEIK KLTTNTDLIL EVLRSSPMVQ VDEKGEKVRP SHKRCIVILR
210 220 230 240 250
EIPETTPVEE VKALFKNENC PKVISCEFAH NSNWYITFQS DTDAQQAFKY
260 270 280 290 300
LREEVKTFQG KPIMARIKAI NTFFAKNGYR LMDSSMYTQP IQTPTQYPSP
310 320 330 340 350
VFMQPVYNPQ QYSVYSLVPQ SWSPSPAPYF ETPLAPFPNG SFVDGFSSPG
360 370 380 390 400
SYKTNAAAMN MGRPFPKNRV KPHFRSSSGS EHSTEGSVSL GDGPLSRSSS
410 420 430 440 450
RIFLSERHNP TVTGQQEQTY LPKEAPILQM EQNGDFGRGR RTLFRGRRRR
460 470 480 490 500
DDDRIPRPQP AATEAKAPTP KFDLLATNFP PLPGSSSRVP DELGLENRMS
510 520 530 540 550
DVVKGVCREK DSEDVRVSCP VPAEDGQTDC TSAPLSISPS PPCTAEPPVL
560 570 580 590 600
STTQQEQDQM EDSAVPKDTL NPVAVPVSSP TATKPSPANT ASPCTSNINP
610 620 630 640 650
PRAVALQEPR KLSYAEVCQK PPKEPSPVLV QPLRELRSNA VSPTRNEENG
660 670 680 690 700
APEKPVEKPH EKPETRASKD HSGFRGNTIP RGAAGKIREQ RRQFSHRATP
710
QGVTRRNGKE QYVPPRSPK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3X9Q6 | G3X9Q6_MOUSE | La-related protein 4 | Larp4 | 719 | Annotation score: | ||
E9Q066 | E9Q066_MOUSE | La-related protein 4 | Larp4 | 718 | Annotation score: | ||
A0A2R8VKL5 | A0A2R8VKL5_MOUSE | La-related protein 4 | Larp4 | 660 | Annotation score: | ||
A0A2R8W6Y5 | A0A2R8W6Y5_MOUSE | La-related protein 4 | Larp4 | 610 | Annotation score: | ||
A0A2R8VHW8 | A0A2R8VHW8_MOUSE | La-related protein 4 | Larp4 | 107 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049756 mRNA Translation: BAC33905.2 AK141743 mRNA Translation: BAE24819.1 |
CCDSi | CCDS37208.1 |
RefSeqi | NP_001019697.2, NM_001024526.2 NP_001074417.1, NM_001080948.2 NP_001271450.1, NM_001284521.1 NP_001271451.1, NM_001284522.1 NP_001271452.1, NM_001284523.1 |
Genome annotation databases
GeneIDi | 207214 |
KEGGi | mmu:207214 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049756 mRNA Translation: BAC33905.2 AK141743 mRNA Translation: BAE24819.1 |
CCDSi | CCDS37208.1 |
RefSeqi | NP_001019697.2, NM_001024526.2 NP_001074417.1, NM_001080948.2 NP_001271450.1, NM_001284521.1 NP_001271451.1, NM_001284522.1 NP_001271452.1, NM_001284523.1 |
3D structure databases
SMRi | Q8BWW4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228885, 4 interactors |
IntActi | Q8BWW4, 2 interactors |
MINTi | Q8BWW4 |
STRINGi | 10090.ENSMUSP00000097780 |
PTM databases
iPTMneti | Q8BWW4 |
PhosphoSitePlusi | Q8BWW4 |
SwissPalmi | Q8BWW4 |
Proteomic databases
EPDi | Q8BWW4 |
jPOSTi | Q8BWW4 |
MaxQBi | Q8BWW4 |
PaxDbi | Q8BWW4 |
PRIDEi | Q8BWW4 |
ProteomicsDBi | 265042 |
Genome annotation databases
GeneIDi | 207214 |
KEGGi | mmu:207214 |
Organism-specific databases
CTDi | 113251 |
MGIi | MGI:2443114, Larp4 |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota KOG2591, Eukaryota |
InParanoidi | Q8BWW4 |
OrthoDBi | 263288at2759 |
PhylomeDBi | Q8BWW4 |
Miscellaneous databases
BioGRID-ORCSi | 207214, 14 hits in 54 CRISPR screens |
ChiTaRSi | Larp4, mouse |
PROi | PR:Q8BWW4 |
RNActi | Q8BWW4, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd12707, RRM_LARP4, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR034903, LARP4_RRM IPR035979, RBD_domain_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP4_MOUSE | |
Accessioni | Q8BWW4Primary (citable) accession number: Q8BWW4 Secondary accession number(s): Q3UR69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | May 16, 2006 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot