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Entry version 106 (11 Dec 2019)
Sequence version 1 (01 Mar 2003)
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Protein

G protein-regulated inducer of neurite outgrowth 3

Gene

Gprin3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neurite outgrowth.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 3
Short name:
GRIN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gprin3
Synonyms:Kiaa2027
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924785 Gprin3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002519511 – 763G protein-regulated inducer of neurite outgrowth 3Add BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei323PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BWS5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BWS5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BWS5

PRoteomics IDEntifications database

More...
PRIDEi
Q8BWS5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BWS5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BWS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045441 Expressed in 163 organ(s), highest expression level in caudate-putamen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BWS5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BWS5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000051805

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BWS5 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVMU Eukaryota
ENOG4111KRR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00570000079168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060135

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BWS5

Identification of Orthologs from Complete Genome Data

More...
OMAi
VFQSMLQ

Database of Orthologous Groups

More...
OrthoDBi
612273at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BWS5

TreeFam database of animal gene trees

More...
TreeFami
TF337047

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C

The PANTHER Classification System

More...
PANTHERi
PTHR15718 PTHR15718, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15235 GRIN_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BWS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTVPDPLRV TKASIVAASG KEESRGESQS VSPQPAQPDN NASGIGNVPA
60 70 80 90 100
ELSLQLSAAA QALMQACVSE SSQQDMASPG VFSEGEPVSP KQKTPDDFLL
110 120 130 140 150
HGSKESAAPG LNATAQKELI SAPCLISVVQ HTHHAIQRDA PNTSTCAVPE
160 170 180 190 200
GSLVKSEANS NGENPEKPGC PARVTCCSSK NQEGLCDFPS PENSQGILQT
210 220 230 240 250
PDIASPSADR PEGEGQKVIN NITAVSSEPP VREGCSENKQ PSATALNTTA
260 270 280 290 300
ERSENPPPSH LTSKGATCSS EARQALLPAQ YPVSRFKEAS TMTCQAESGA
310 320 330 340 350
KEVSGRAWQD AEVQAVASVE SRSVSTSPSI LPAYLKENPA PELENGQEQL
360 370 380 390 400
RVICHGKGSG NHLLELSNSM VDSQESRQCP SIVPQVHIQA ATATPAAFKG
410 420 430 440 450
GCKPANQPAE GLKSPLIHVT SSQNTETEED LRLSASKEAT SRQPEGTNPD
460 470 480 490 500
FQKANAIGQI SLPAGSQAEI NQGLWNSGPR EPEIVVKTAK DHKAESSCKP
510 520 530 540 550
SNSGGGANKD YPPESLDPTD KKGAKDKKPA SPLIVKDHAP GATSTLDAKT
560 570 580 590 600
LLLNPKSQVK EGEGPEVSPA PSPGRKSQQN TLEELRQPKT VMSLSLPSDG
610 620 630 640 650
TGDSSPGSGK RTPSLSVKAS PRRGSRVSEF LKELSVTAAA AQVGLTPGEK
660 670 680 690 700
KKQLGADSKL HLKQSKRVRD VVWDDQGMTW EVYGASLDPE SLGVAIQNHL
710 720 730 740 750
QRQIREHEKI VKTQSGQTRR SISSDSSSSK KLKGRQHGVL QSMLQNFRRP
760
NCCVRPAPSS VLD
Length:763
Mass (Da):80,485
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34972AE1BF6CA09B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32614 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173336 mRNA Translation: BAD32614.1 Different initiation.
AK050148 mRNA Translation: BAC34093.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20199.1

NCBI Reference Sequences

More...
RefSeqi
NP_899006.1, NM_183183.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000051065; ENSMUSP00000051805; ENSMUSG00000045441

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
243385

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:243385

UCSC genome browser

More...
UCSCi
uc009cdk.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173336 mRNA Translation: BAD32614.1 Different initiation.
AK050148 mRNA Translation: BAC34093.1
CCDSiCCDS20199.1
RefSeqiNP_899006.1, NM_183183.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051805

PTM databases

iPTMnetiQ8BWS5
PhosphoSitePlusiQ8BWS5

Proteomic databases

EPDiQ8BWS5
MaxQBiQ8BWS5
PaxDbiQ8BWS5
PRIDEiQ8BWS5

Genome annotation databases

EnsembliENSMUST00000051065; ENSMUSP00000051805; ENSMUSG00000045441
GeneIDi243385
KEGGimmu:243385
UCSCiuc009cdk.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285513
MGIiMGI:1924785 Gprin3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IVMU Eukaryota
ENOG4111KRR LUCA
GeneTreeiENSGT00570000079168
HOGENOMiHOG000060135
InParanoidiQ8BWS5
OMAiVFQSMLQ
OrthoDBi612273at2759
PhylomeDBiQ8BWS5
TreeFamiTF337047

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8BWS5
RNActiQ8BWS5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045441 Expressed in 163 organ(s), highest expression level in caudate-putamen
ExpressionAtlasiQ8BWS5 baseline and differential
GenevisibleiQ8BWS5 MM

Family and domain databases

InterProiView protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C
PANTHERiPTHR15718 PTHR15718, 1 hit
PfamiView protein in Pfam
PF15235 GRIN_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRIN3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BWS5
Secondary accession number(s): Q69Z30
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: December 11, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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