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Protein

UPF0505 protein C16orf62 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0505 protein C16orf62 homolog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1918767 9030624J02Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei699 – 719HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113531 – 963UPF0505 protein C16orf62 homologAdd BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BWQ6
PaxDbiQ8BWQ6
PeptideAtlasiQ8BWQ6
PRIDEiQ8BWQ6

PTM databases

iPTMnetiQ8BWQ6
PhosphoSitePlusiQ8BWQ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000030982 Expressed in 269 organ(s), highest expression level in fibroblast
CleanExiMM_9030624J02RIK
ExpressionAtlasiQ8BWQ6 baseline and differential
GenevisibleiQ8BWQ6 MM

Interactioni

Subunit structurei

Interacts with COMMD1, CCDC93 and CCDC22; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62 homolog. Interacts with WASHC1 and WASHC2.By similarity

Protein-protein interaction databases

BioGridi214753, 1 interactor
STRINGi10090.ENSMUSP00000051263

Structurei

3D structure databases

ProteinModelPortaliQ8BWQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 71Ser-richAdd BLAST23

Sequence similaritiesi

Belongs to the UPF0505 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3682 Eukaryota
ENOG410XQR5 LUCA
GeneTreeiENSGT00390000011343
HOVERGENiHBG107748
InParanoidiQ8BWQ6
PhylomeDBiQ8BWQ6

Family and domain databases

InterProiView protein in InterPro
IPR029705 UPF0505
PANTHERiPTHR13673 PTHR13673, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BWQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVFPWHSRN RNYKAELASC RLETVPLECG DYHPLKPITV TESKTKKVSR
60 70 80 90 100
KGSTSSTSSS SSSSVIDPLS SVLDGTDPLS MFAATSDPAA TGTVTDSSRK
110 120 130 140 150
KRDKDENSFV GPDFEPWANK RVEILARYTT TEKLSINLFM GSEKGRGGAA
160 170 180 190 200
ASAMSEKVRT RLEELDDFEE GSQKELLNLT QQDYVNRIEE LNQSLKDAWA
210 220 230 240 250
SDQKVKALKI VIQCSKLLSD TSVIQFYPSK FVLITDILDT FGKLVYERIS
260 270 280 290 300
SMCVDSRSAL PDHFSPENVN DTAKETCLNW FFKIASIREL IPRFYVEASI
310 320 330 340 350
LKCNKFLSKT GISECLPRLT CMIRGIGDPL VSVYARAYLC RVGIEVAPHL
360 370 380 390 400
KESLNKNFFD FLLTFKQIHG DTVQNQLVAQ GVELLSYLPL YSPAMGWIFQ
410 420 430 440 450
CVSYHAPEAL LTEMMERCKK LGNNALLLNS VMSAFRAEFV ATRSMDFIGM
460 470 480 490 500
IKECDESGFP KHLLFRSLGL NLALADPPEN DRLQILNEAW KVITKLKSPQ
510 520 530 540 550
DYINCAEVWV EYTCRHFTKR EVNTVLADVI KHMTPDRAFE DSYPQLQSII
560 570 580 590 600
QKVIAHFHDF SVLFSVEKFL PFLDMFQKES VRVEVCKCIM EAFIKHQQEP
610 620 630 640 650
TKDPVILNAL LHICKTMHDS VNALTLEDEK RTLAHLINGF IKMVSFGRDF
660 670 680 690 700
EQQLSFYVES RSMFCNLEPV LVQLIHSVNR LAMETRKVMK GNHSRKTAAF
710 720 730 740 750
VRACVAYCFI TIPSLVGIFT RLNLYLHSGQ VALANQCLSQ ADAFFKAAIG
760 770 780 790 800
LVPEVPKTIS IDGKLRPSEP FLLEFLCNFF STLLIVPDHP EHGVLFLVRE
810 820 830 840 850
LLNVIQDYTW EDSSDDKIRI YTSVLHLLSA MSQDTYLYHI DKVDSNDSLY
860 870 880 890 900
GGDSKFLAEN SKLCEAVMAQ ILEHLKTLAK DEALKRQSLL GLSFFNSILA
910 920 930 940 950
HGDLRNNKLN QLSVNLWHLA QRHGCADTRT MVKTLDYIKK RSKQPDMNHL
960
SELALRLPLQ TRT
Length:963
Mass (Da):109,077
Last modified:November 13, 2007 - v2
Checksum:i0A7A7A73FDBDF740
GO
Isoform 2 (identifier: Q8BWQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     409-434: ALLTEMMERCKKLGNNALLLNSVMSA → CALSSLPSLLSELRGLSHLWRCAEAV
     435-963: Missing.

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):48,439
Checksum:iEB7571165ECAB71F
GO
Isoform 3 (identifier: Q8BWQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-235: Missing.
     236-241: DILDTF → MLLAGH

Note: No experimental confirmation available.
Show »
Length:728
Mass (Da):82,999
Checksum:i8ECCC39C174A83AD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RR19F6RR19_MOUSE
VPS35 endosomal protein sorting fac...
Vps35l 9030624J02Rik, Vsp35l
203Annotation score:
I1E4X5I1E4X5_MOUSE
VPS35 endosomal protein sorting fac...
Vps35l 9030624J02Rik, Vsp35l
991Annotation score:
H3BJE8H3BJE8_MOUSE
VPS35 endosomal protein sorting fac...
Vps35l 9030624J02Rik, Vsp35l
245Annotation score:
D3YW19D3YW19_MOUSE
VPS35 endosomal protein sorting fac...
Vps35l 9030624J02Rik, Vsp35l
940Annotation score:
D3YW20D3YW20_MOUSE
VPS35 endosomal protein sorting fac...
Vps35l 9030624J02Rik, Vsp35l
874Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208L → V in BAE22841 (PubMed:16141072).Curated1
Sequence conflicti632T → M in AAH07154 (PubMed:15489334).Curated1
Sequence conflicti632T → M in AAH25808 (PubMed:15489334).Curated1
Sequence conflicti759I → M in BAE22543 (PubMed:16141072).Curated1
Sequence conflicti781S → C in BAC34176 (PubMed:16141072).Curated1
Sequence conflicti785I → M in AAH25808 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0295391 – 235Missing in isoform 3. 1 PublicationAdd BLAST235
Alternative sequenceiVSP_029540236 – 241DILDTF → MLLAGH in isoform 3. 1 Publication6
Alternative sequenceiVSP_029541409 – 434ALLTE…SVMSA → CALSSLPSLLSELRGLSHLW RCAEAV in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_029542435 – 963Missing in isoform 2. 1 PublicationAdd BLAST529

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018573 mRNA Translation: BAB31285.1
AK050302 mRNA Translation: BAC34176.1
AK135468 mRNA Translation: BAE22543.1
AK136140 mRNA Translation: BAE22841.1
BC007154 mRNA Translation: AAH07154.1
BC025808 mRNA Translation: AAH25808.1
BC043674 mRNA Translation: AAH43674.1
BC054720 mRNA Translation: AAH54720.1
RefSeqiNP_082091.3, NM_027815.4
UniGeneiMm.213298

Genome annotation databases

EnsembliENSMUST00000033280; ENSMUSP00000033280; ENSMUSG00000030982 [Q8BWQ6-3]
GeneIDi71517
KEGGimmu:71517
UCSCiuc009jkp.2 mouse [Q8BWQ6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018573 mRNA Translation: BAB31285.1
AK050302 mRNA Translation: BAC34176.1
AK135468 mRNA Translation: BAE22543.1
AK136140 mRNA Translation: BAE22841.1
BC007154 mRNA Translation: AAH07154.1
BC025808 mRNA Translation: AAH25808.1
BC043674 mRNA Translation: AAH43674.1
BC054720 mRNA Translation: AAH54720.1
RefSeqiNP_082091.3, NM_027815.4
UniGeneiMm.213298

3D structure databases

ProteinModelPortaliQ8BWQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214753, 1 interactor
STRINGi10090.ENSMUSP00000051263

PTM databases

iPTMnetiQ8BWQ6
PhosphoSitePlusiQ8BWQ6

Proteomic databases

EPDiQ8BWQ6
PaxDbiQ8BWQ6
PeptideAtlasiQ8BWQ6
PRIDEiQ8BWQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033280; ENSMUSP00000033280; ENSMUSG00000030982 [Q8BWQ6-3]
GeneIDi71517
KEGGimmu:71517
UCSCiuc009jkp.2 mouse [Q8BWQ6-3]

Organism-specific databases

CTDi71517
MGIiMGI:1918767 9030624J02Rik

Phylogenomic databases

eggNOGiKOG3682 Eukaryota
ENOG410XQR5 LUCA
GeneTreeiENSGT00390000011343
HOVERGENiHBG107748
InParanoidiQ8BWQ6
PhylomeDBiQ8BWQ6

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q8BWQ6

Gene expression databases

BgeeiENSMUSG00000030982 Expressed in 269 organ(s), highest expression level in fibroblast
CleanExiMM_9030624J02RIK
ExpressionAtlasiQ8BWQ6 baseline and differential
GenevisibleiQ8BWQ6 MM

Family and domain databases

InterProiView protein in InterPro
IPR029705 UPF0505
PANTHERiPTHR13673 PTHR13673, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP062_MOUSE
AccessioniPrimary (citable) accession number: Q8BWQ6
Secondary accession number(s): Q3UWS3
, Q3UXM0, Q7TQF5, Q80XN3, Q8R3A8, Q91VY3, Q9D307
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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Main funding by: National Institutes of Health

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