UniProtKB - Q8BWL5 (RBMS3_MOUSE)
Protein
RNA-binding motif, single-stranded-interacting protein 3
Gene
Rbms3
Organism
Mus musculus (Mouse)
Status
Functioni
Binds poly(A) and poly(U) oligoribonucleotides.By similarity
GO - Molecular functioni
- mRNA 3'-UTR AU-rich region binding Source: MGI
- mRNA 3'-UTR binding Source: MGI
- poly(A) binding Source: MGI
- poly(U) RNA binding Source: MGI
- RNA binding Source: GO_Central
GO - Biological processi
- defense response to tumor cell Source: MGI
- negative regulation of canonical Wnt signaling pathway Source: MGI
- negative regulation of gene expression Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of translation Source: MGI
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding motif, single-stranded-interacting protein 3 |
Gene namesi | Name:Rbms3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444477, Rbms3 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: MGI
- ribonucleoprotein complex Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274907 | 1 – 431 | RNA-binding motif, single-stranded-interacting protein 3Add BLAST | 431 |
Proteomic databases
PaxDbi | Q8BWL5 |
PRIDEi | Q8BWL5 |
PTM databases
iPTMneti | Q8BWL5 |
PhosphoSitePlusi | Q8BWL5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039607, Expressed in vas deferens and 249 other tissues |
ExpressionAtlasi | Q8BWL5, baseline and differential |
Genevisiblei | Q8BWL5, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107403 |
Miscellaneous databases
RNActi | Q8BWL5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 129 | RRM 1PROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 135 – 220 | RRM 2PROSITE-ProRule annotationAdd BLAST | 86 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4733, Eukaryota |
GeneTreei | ENSGT00940000157131 |
HOGENOMi | CLU_016278_2_0_1 |
InParanoidi | Q8BWL5 |
OMAi | HYLQTKX |
OrthoDBi | 810893at2759 |
PhylomeDBi | Q8BWL5 |
TreeFami | TF314644 |
Family and domain databases
CDDi | cd12475, RRM2_RBMS3, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR002343, Hud_Sxl_RNA IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034406, RBMS3_RRM2 IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
PRINTSi | PR00961, HUDSXLRNA |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8BWL5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKRLDQPQM YPQYTYYCPQ YLQTKQSYAP APHPMAPPSP STNSSSNSSG
60 70 80 90 100
EQLSKTNLYI RGLPPGTTDQ DLIKLCQPYG KIVSTKAILD KNTNQCKGYG
110 120 130 140 150
FVDFDSPAAA QKAVASLKAN GVQAQMAKQQ EQDPTNLYIS NLPISMDEQE
160 170 180 190 200
LENMLKPFGH VISTRILRDA NGVSRGVGFA RMESTEKCEV VIQHFNGKYL
210 220 230 240 250
KTPPGIPAPS EPLLCKFADG GQKKRQGQSK HTQNGRPWPR EGEAGMALTY
260 270 280 290 300
DPTAALQNGF YSSPYSLATN RMIPQTSITP FIAASPVSTY QVQSTSWTPH
310 320 330 340 350
LPYIMQPTGA VITPAVDHPM SMQPTNIVGP LTQQMNHLSL GTAGTIQSQD
360 370 380 390 400
RIMVLHQLLC QYMTAAPMQG TYIPQYTPVP PTAVSIEGVV ADTSPQTVAP
410 420 430
SSQDSSGQQQ QLAVDTPSEH APAYSFQQSK P
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8MX12 | A0A6I8MX12_MOUSE | RNA-binding motif, single-stranded-... | Rbms3 | 541 | Annotation score: | ||
G3UZJ9 | G3UZJ9_MOUSE | RNA-binding motif, single-stranded-... | Rbms3 | 206 | Annotation score: | ||
G3UY10 | G3UY10_MOUSE | RNA-binding motif, single-stranded-... | Rbms3 | 185 | Annotation score: | ||
G3UYP9 | G3UYP9_MOUSE | RNA-binding motif, single-stranded-... | Rbms3 | 195 | Annotation score: |
Sequence cautioni
The sequence BAC34878 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | M → I in BAC26980 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 20 | Q → H in BAC26980 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 309 | G → S in AAI08403 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022932 | 1 – 26 | MGKRL…LQTKQ → MEGGRLLIRSNANGVTQSNS TVRAYQSSKSRVTMSPGFSS QWSNSQPAWNTYSFPRASLH YQSHASYTYCTGHPV in isoform 5. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_022933 | 292 – 308 | Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_022934 | 346 – 361 | Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_022935 | 388 – 431 | GVVAD…QQSKP → TIDRSEDVCLNLYLQ in isoform 4 and isoform 6. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030478 mRNA Translation: BAC26980.1 AK030609 mRNA Translation: BAC27045.1 AK032938 mRNA Translation: BAC28091.1 AK033005 mRNA Translation: BAC28122.1 AK041098 mRNA Translation: BAC30820.1 AK046197 mRNA Translation: BAC32633.1 AK052196 mRNA Translation: BAC34878.1 Different initiation. BC108402 mRNA Translation: AAI08403.1 BC117841 mRNA Translation: AAI17842.1 |
CCDSi | CCDS40798.1 [Q8BWL5-3] CCDS52955.1 [Q8BWL5-2] CCDS52956.1 [Q8BWL5-6] CCDS52957.1 [Q8BWL5-1] CCDS57711.1 [Q8BWL5-4] CCDS57712.1 [Q8BWL5-5] |
RefSeqi | NP_001165592.1, NM_001172121.1 [Q8BWL5-5] NP_001165593.1, NM_001172122.1 [Q8BWL5-2] NP_001165594.1, NM_001172123.1 [Q8BWL5-1] NP_001165595.1, NM_001172124.1 [Q8BWL5-6] NP_001165597.1, NM_001172126.1 [Q8BWL5-4] NP_848775.2, NM_178660.4 [Q8BWL5-3] |
Genome annotation databases
Ensembli | ENSMUST00000044901; ENSMUSP00000039706; ENSMUSG00000039607 [Q8BWL5-4] ENSMUST00000068962; ENSMUSP00000066735; ENSMUSG00000039607 [Q8BWL5-3] ENSMUST00000111772; ENSMUSP00000107402; ENSMUSG00000039607 [Q8BWL5-2] ENSMUST00000111773; ENSMUSP00000107403; ENSMUSG00000039607 [Q8BWL5-1] ENSMUST00000164018; ENSMUSP00000131371; ENSMUSG00000039607 [Q8BWL5-5] ENSMUST00000174868; ENSMUSP00000133621; ENSMUSG00000039607 [Q8BWL5-6] |
GeneIDi | 207181 |
KEGGi | mmu:207181 |
UCSCi | uc009ryv.3, mouse [Q8BWL5-3] uc009ryw.3, mouse [Q8BWL5-1] uc009ryx.3, mouse [Q8BWL5-2] uc009ryy.3, mouse [Q8BWL5-6] uc009ryz.3, mouse [Q8BWL5-4] uc009rza.3, mouse [Q8BWL5-5] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030478 mRNA Translation: BAC26980.1 AK030609 mRNA Translation: BAC27045.1 AK032938 mRNA Translation: BAC28091.1 AK033005 mRNA Translation: BAC28122.1 AK041098 mRNA Translation: BAC30820.1 AK046197 mRNA Translation: BAC32633.1 AK052196 mRNA Translation: BAC34878.1 Different initiation. BC108402 mRNA Translation: AAI08403.1 BC117841 mRNA Translation: AAI17842.1 |
CCDSi | CCDS40798.1 [Q8BWL5-3] CCDS52955.1 [Q8BWL5-2] CCDS52956.1 [Q8BWL5-6] CCDS52957.1 [Q8BWL5-1] CCDS57711.1 [Q8BWL5-4] CCDS57712.1 [Q8BWL5-5] |
RefSeqi | NP_001165592.1, NM_001172121.1 [Q8BWL5-5] NP_001165593.1, NM_001172122.1 [Q8BWL5-2] NP_001165594.1, NM_001172123.1 [Q8BWL5-1] NP_001165595.1, NM_001172124.1 [Q8BWL5-6] NP_001165597.1, NM_001172126.1 [Q8BWL5-4] NP_848775.2, NM_178660.4 [Q8BWL5-3] |
3D structure databases
SMRi | Q8BWL5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107403 |
PTM databases
iPTMneti | Q8BWL5 |
PhosphoSitePlusi | Q8BWL5 |
Proteomic databases
PaxDbi | Q8BWL5 |
PRIDEi | Q8BWL5 |
Protocols and materials databases
Antibodypediai | 11544, 166 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000044901; ENSMUSP00000039706; ENSMUSG00000039607 [Q8BWL5-4] ENSMUST00000068962; ENSMUSP00000066735; ENSMUSG00000039607 [Q8BWL5-3] ENSMUST00000111772; ENSMUSP00000107402; ENSMUSG00000039607 [Q8BWL5-2] ENSMUST00000111773; ENSMUSP00000107403; ENSMUSG00000039607 [Q8BWL5-1] ENSMUST00000164018; ENSMUSP00000131371; ENSMUSG00000039607 [Q8BWL5-5] ENSMUST00000174868; ENSMUSP00000133621; ENSMUSG00000039607 [Q8BWL5-6] |
GeneIDi | 207181 |
KEGGi | mmu:207181 |
UCSCi | uc009ryv.3, mouse [Q8BWL5-3] uc009ryw.3, mouse [Q8BWL5-1] uc009ryx.3, mouse [Q8BWL5-2] uc009ryy.3, mouse [Q8BWL5-6] uc009ryz.3, mouse [Q8BWL5-4] uc009rza.3, mouse [Q8BWL5-5] |
Organism-specific databases
CTDi | 27303 |
MGIi | MGI:2444477, Rbms3 |
Phylogenomic databases
eggNOGi | KOG4733, Eukaryota |
GeneTreei | ENSGT00940000157131 |
HOGENOMi | CLU_016278_2_0_1 |
InParanoidi | Q8BWL5 |
OMAi | HYLQTKX |
OrthoDBi | 810893at2759 |
PhylomeDBi | Q8BWL5 |
TreeFami | TF314644 |
Miscellaneous databases
BioGRID-ORCSi | 207181, 4 hits in 18 CRISPR screens |
ChiTaRSi | Rbms3, mouse |
PROi | PR:Q8BWL5 |
RNActi | Q8BWL5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039607, Expressed in vas deferens and 249 other tissues |
ExpressionAtlasi | Q8BWL5, baseline and differential |
Genevisiblei | Q8BWL5, MM |
Family and domain databases
CDDi | cd12475, RRM2_RBMS3, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR002343, Hud_Sxl_RNA IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034406, RBMS3_RRM2 IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
PRINTSi | PR00961, HUDSXLRNA |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBMS3_MOUSE | |
Accessioni | Q8BWL5Primary (citable) accession number: Q8BWL5 Secondary accession number(s): Q2VPR0 Q8BMN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot