UniProtKB - Q8BWD8 (CDK19_MOUSE)
Protein
Cyclin-dependent kinase 19
Gene
Cdk19
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 52 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 151 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 27 – 35 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: GO_Central
GO - Biological processi
- cellular response to lipopolysaccharide Source: Ensembl
- positive regulation of apoptotic process Source: MGI
- positive regulation of inflammatory response Source: MGI
- protein phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 19 (EC:2.7.11.22)Alternative name(s): CDC2-related protein kinase 6 Cell division cycle 2-like protein kinase 6 Cell division protein kinase 19 |
Gene namesi | Name:Cdk19 Synonyms:Cdc2l6, Kiaa1028 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1925584, Cdk19 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- mediator complex Source: GO_Central
- nucleus Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085714 | 1 – 501 | Cyclin-dependent kinase 19Add BLAST | 501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 449 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8BWD8 |
MaxQBi | Q8BWD8 |
PaxDbi | Q8BWD8 |
PRIDEi | Q8BWD8 |
PTM databases
PhosphoSitePlusi | Q8BWD8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038481, Expressed in utricle of membranous labyrinth and 251 other tissues |
Genevisiblei | Q8BWD8, MM |
Interactioni
Protein-protein interaction databases
ComplexPortali | CPX-3267, CKM complex variant 2 |
IntActi | Q8BWD8, 1 interactor |
MINTi | Q8BWD8 |
STRINGi | 10090.ENSMUSP00000040936 |
Miscellaneous databases
RNActi | Q8BWD8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 335 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 315 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 372 – 404 | Gln-richAdd BLAST | 33 | |
Compositional biasi | 415 – 422 | Poly-Gly | 8 | |
Compositional biasi | 461 – 495 | Ser-richAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0666, Eukaryota |
GeneTreei | ENSGT00940000158213 |
HOGENOMi | CLU_000288_181_6_1 |
InParanoidi | Q8BWD8 |
OMAi | VTERYRI |
OrthoDBi | 642369at2759 |
PhylomeDBi | Q8BWD8 |
TreeFami | TF101025 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8BWD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA
60 70 80 90 100
LKQIEGTGIS MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA
110 120 130 140 150
EHDLWHIIKF HRASKANKKP MQLPRSMVKS LLYQILDGIH YLHANWVLHR
160 170 180 190 200
DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR
210 220 230 240 250
APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPFHHD
260 270 280 290 300
QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH
310 320 330 340 350
KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ
360 370 380 390 400
IPYPKREFLN EDEPEEKGDK NQPQQQNPHQ QPAAPAQQTA APPQAPPPQQ
410 420 430 440 450
SSAQTNGTAG GATAGGGGAG AGLQHSQDPG LNQVPPNKKP RIGPSGANSG
460 470 480 490 500
GPVMPSDYQH SSSRLNYQSS VQGSSQSQST LGYSSSQQST QYHSSHQTHR
Y
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E8L1 | G5E8L1_MOUSE | Cyclin-dependent kinase 19 | Cdk19 | 457 | Annotation score: | ||
A0A1L1SRF1 | A0A1L1SRF1_MOUSE | Cyclin-dependent kinase 19 | Cdk19 | 164 | Annotation score: | ||
A0A1L1SSW8 | A0A1L1SSW8_MOUSE | Cyclin-dependent kinase 19 | Cdk19 | 44 | Annotation score: |
Sequence cautioni
The sequence BAC65703 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052818 mRNA Translation: BAC35159.1 AK122421 mRNA Translation: BAC65703.1 Different initiation. |
CCDSi | CCDS48545.1 |
RefSeqi | NP_001161776.1, NM_001168304.1 |
Genome annotation databases
Ensembli | ENSMUST00000044672; ENSMUSP00000040936; ENSMUSG00000038481 |
GeneIDi | 78334 |
KEGGi | mmu:78334 |
UCSCi | uc007ewt.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052818 mRNA Translation: BAC35159.1 AK122421 mRNA Translation: BAC65703.1 Different initiation. |
CCDSi | CCDS48545.1 |
RefSeqi | NP_001161776.1, NM_001168304.1 |
3D structure databases
SMRi | Q8BWD8 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-3267, CKM complex variant 2 |
IntActi | Q8BWD8, 1 interactor |
MINTi | Q8BWD8 |
STRINGi | 10090.ENSMUSP00000040936 |
PTM databases
PhosphoSitePlusi | Q8BWD8 |
Proteomic databases
EPDi | Q8BWD8 |
MaxQBi | Q8BWD8 |
PaxDbi | Q8BWD8 |
PRIDEi | Q8BWD8 |
Protocols and materials databases
Antibodypediai | 2087, 191 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000044672; ENSMUSP00000040936; ENSMUSG00000038481 |
GeneIDi | 78334 |
KEGGi | mmu:78334 |
UCSCi | uc007ewt.2, mouse |
Organism-specific databases
CTDi | 23097 |
MGIi | MGI:1925584, Cdk19 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0666, Eukaryota |
GeneTreei | ENSGT00940000158213 |
HOGENOMi | CLU_000288_181_6_1 |
InParanoidi | Q8BWD8 |
OMAi | VTERYRI |
OrthoDBi | 642369at2759 |
PhylomeDBi | Q8BWD8 |
TreeFami | TF101025 |
Miscellaneous databases
BioGRID-ORCSi | 78334, 0 hits in 16 CRISPR screens |
ChiTaRSi | Cdk19, mouse |
PROi | PR:Q8BWD8 |
RNActi | Q8BWD8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038481, Expressed in utricle of membranous labyrinth and 251 other tissues |
Genevisiblei | Q8BWD8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK19_MOUSE | |
Accessioni | Q8BWD8Primary (citable) accession number: Q8BWD8 Secondary accession number(s): Q80TM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index