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Protein

RNA-binding protein NOB1

Gene

Nob1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mRNA degradation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi261Zinc1
Metal bindingi264Zinc1
Metal bindingi276Zinc1
Metal bindingi279Zinc1

GO - Molecular functioni

GO - Biological processi

  • cleavage involved in rRNA processing Source: InterPro
  • maturation of SSU-rRNA Source: MGI
  • ribosomal small subunit biogenesis Source: MGI
  • visual perception Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein NOB1
Gene namesi
Name:Nob1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914869 Nob1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332671 – 403RNA-binding protein NOB1Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BW10
MaxQBiQ8BW10
PaxDbiQ8BW10
PRIDEiQ8BW10

PTM databases

iPTMnetiQ8BW10
PhosphoSitePlusiQ8BW10

Expressioni

Gene expression databases

BgeeiENSMUSG00000003848 Expressed in 240 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ8BW10 baseline and differential
GenevisibleiQ8BW10 MM

Interactioni

Subunit structurei

May interact with UPF2.1 Publication

Protein-protein interaction databases

IntActiQ8BW10, 3 interactors
MINTiQ8BW10
STRINGi10090.ENSMUSP00000003946

Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8BW10
SMRiQ8BW10
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BW10

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 108PINcAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 190Poly-Glu10

Sequence similaritiesi

Belongs to the NOB1 family.Curated

Phylogenomic databases

eggNOGiKOG2463 Eukaryota
COG1439 LUCA
GeneTreeiENSGT00390000015857
HOGENOMiHOG000159692
HOVERGENiHBG057385
InParanoidiQ8BW10
KOiK11883
OMAiKVISLTY
OrthoDBiEOG091G0C8H
PhylomeDBiQ8BW10
TreeFamiTF105838

Family and domain databases

CDDicd09876 PIN_Nob1, 1 hit
Gene3Di3.30.40.120, 1 hit
InterProiView protein in InterPro
IPR039907 NOB1
IPR017117 Nob1_euk
IPR036283 NOB1_Zf-like_sf
IPR014881 NOB1_Zn-bd
IPR002716 PIN_dom
IPR039909 PIN_NOB1
IPR033411 Ribonuclease_PIN
IPR033461 WRNPLPNID
PANTHERiPTHR12814 PTHR12814, 1 hit
PfamiView protein in Pfam
PF08772 NOB1_Zn_bind, 1 hit
PF17146 PIN_6, 1 hit
PF15017 WRNPLPNID, 1 hit
PIRSFiPIRSF037125 D-site_20S_pre-rRNA_nuclease, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF144206 SSF144206, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BW10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVEHVVAD AGAFLRDAPL QDIGKNIYTI REVVREIRDK ATRRRLAVLP
60 70 80 90 100
YQLRFKEPLP EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV
110 120 130 140 150
SHLKKEPEKA KVSSSIQHPE TALHISGFHL PSKSKPLQEA VDRGHAADGP
160 170 180 190 200
ENLEFSSFMF WRTPLPNIDR ELQELLIDGR EEEEEEEECE DSDDDGGGWI
210 220 230 240 250
TPSNIKQIQQ ELEQCDTPED VQVGCVTTDF AMQNVLLQMG LHVLAVNGML
260 270 280 290 300
VREARSYILR CHGCFKTTSD MNRVFCGHCG NKTLKKVSVT INDDGTLHMH
310 320 330 340 350
FSRNPKVLNP RGLRYSLPTP KGGKYAINPH LTEDQRFPQL RLSQKARQKT
360 370 380 390 400
DVFAPDYIAG VSPFAENDIS SRSAILQVRD GMLGAGRRRL NPNASRKKFV

KKR
Length:403
Mass (Da):45,464
Last modified:March 1, 2003 - v1
Checksum:i923A88BF2B2275FF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PW56E9PW56_MOUSE
RNA-binding protein NOB1
Nob1
159Annotation score:
F6YBB8F6YBB8_MOUSE
RNA-binding protein NOB1
Nob1
62Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075755 mRNA Translation: BAC35933.1
AK021194 mRNA Translation: BAB32325.1
BC054835 mRNA Translation: AAH54835.1
BC103793 mRNA Translation: AAI03794.1
CCDSiCCDS22649.1
RefSeqiNP_080553.1, NM_026277.3
UniGeneiMm.334793

Genome annotation databases

EnsembliENSMUST00000003946; ENSMUSP00000003946; ENSMUSG00000003848
GeneIDi67619
KEGGimmu:67619
UCSCiuc009nhr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075755 mRNA Translation: BAC35933.1
AK021194 mRNA Translation: BAB32325.1
BC054835 mRNA Translation: AAH54835.1
BC103793 mRNA Translation: AAI03794.1
CCDSiCCDS22649.1
RefSeqiNP_080553.1, NM_026277.3
UniGeneiMm.334793

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CONNMR-A251-316[»]
ProteinModelPortaliQ8BW10
SMRiQ8BW10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BW10, 3 interactors
MINTiQ8BW10
STRINGi10090.ENSMUSP00000003946

PTM databases

iPTMnetiQ8BW10
PhosphoSitePlusiQ8BW10

Proteomic databases

EPDiQ8BW10
MaxQBiQ8BW10
PaxDbiQ8BW10
PRIDEiQ8BW10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003946; ENSMUSP00000003946; ENSMUSG00000003848
GeneIDi67619
KEGGimmu:67619
UCSCiuc009nhr.1 mouse

Organism-specific databases

CTDi28987
MGIiMGI:1914869 Nob1

Phylogenomic databases

eggNOGiKOG2463 Eukaryota
COG1439 LUCA
GeneTreeiENSGT00390000015857
HOGENOMiHOG000159692
HOVERGENiHBG057385
InParanoidiQ8BW10
KOiK11883
OMAiKVISLTY
OrthoDBiEOG091G0C8H
PhylomeDBiQ8BW10
TreeFamiTF105838

Miscellaneous databases

ChiTaRSiNob1 mouse
EvolutionaryTraceiQ8BW10
PROiPR:Q8BW10
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003848 Expressed in 240 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ8BW10 baseline and differential
GenevisibleiQ8BW10 MM

Family and domain databases

CDDicd09876 PIN_Nob1, 1 hit
Gene3Di3.30.40.120, 1 hit
InterProiView protein in InterPro
IPR039907 NOB1
IPR017117 Nob1_euk
IPR036283 NOB1_Zf-like_sf
IPR014881 NOB1_Zn-bd
IPR002716 PIN_dom
IPR039909 PIN_NOB1
IPR033411 Ribonuclease_PIN
IPR033461 WRNPLPNID
PANTHERiPTHR12814 PTHR12814, 1 hit
PfamiView protein in Pfam
PF08772 NOB1_Zn_bind, 1 hit
PF17146 PIN_6, 1 hit
PF15017 WRNPLPNID, 1 hit
PIRSFiPIRSF037125 D-site_20S_pre-rRNA_nuclease, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF144206 SSF144206, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOB1_MOUSE
AccessioniPrimary (citable) accession number: Q8BW10
Secondary accession number(s): Q7TPR3, Q9CRD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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