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Protein

Ribosomal L1 domain-containing protein 1

Gene

Rsl1d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.By similarity

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: MGI
  • mRNA 5'-UTR binding Source: MGI
  • RNA binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal L1 domain-containing protein 1
Gene namesi
Name:Rsl1d1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913659 Rsl1d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004306291 – 452Ribosomal L1 domain-containing protein 1Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei334PhosphothreonineBy similarity1
Modified residuei344PhosphothreonineBy similarity1
Modified residuei360PhosphothreonineBy similarity1
Modified residuei399PhosphothreonineCombined sources1
Modified residuei407PhosphothreonineBy similarity1
Modified residuei429PhosphothreonineBy similarity1
Modified residuei432N6-acetyllysineBy similarity1
Modified residuei433PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8BVY0
PaxDbiQ8BVY0
PRIDEiQ8BVY0

PTM databases

iPTMnetiQ8BVY0
PhosphoSitePlusiQ8BVY0
SwissPalmiQ8BVY0

Expressioni

Gene expression databases

BgeeiENSMUSG00000005846 Expressed in 296 organ(s), highest expression level in embryo
GenevisibleiQ8BVY0 MM

Interactioni

Subunit structurei

Interacts with ING1.By similarity

Protein-protein interaction databases

BioGridi211453, 3 interactors
IntActiQ8BVY0, 2 interactors
MINTiQ8BVY0
STRINGi10090.ENSMUSP00000113431

Structurei

3D structure databases

ProteinModelPortaliQ8BVY0
SMRiQ8BVY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili277 – 350Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi282 – 447Lys-richPROSITE-ProRule annotationAdd BLAST166

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1685 Eukaryota
ENOG4111W39 LUCA
GeneTreeiENSGT00440000038603
HOGENOMiHOG000133021
HOVERGENiHBG054786
InParanoidiQ8BVY0
KOiK14775
OMAiNENFFLM
OrthoDBiEOG091G0MY8
TreeFamiTF354254

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BVY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGSASESPS ASVAEATTTD VQVTPTALLQ LDREQIRKAV EVISNRSKSK
60 70 80 90 100
KNNNELLLSG SENLFLMVIL WKIPEKELRV KVPLPHSILS ESSDVCLFTK
110 120 130 140 150
DEFDSPEQTE GFYKKLLKKH GVNTISQIIP FKTLKTEYKA YEAKLRLLGS
160 170 180 190 200
FEVFITDARI RRHLPSHIGR HFYQRKKVPV SVNLLAKNLS KEINRCITGT
210 220 230 240 250
VLNISKRGSC STIRIGHTGM ETEHIVDNIL AVSEMLSEKL PEKWQSVKLL
260 270 280 290 300
FLKTEKSVSL PIFSSFVTSQ DENAVSLRSL RKQELKKRKR ENAKLKKESK
310 320 330 340 350
MLRKKSKKAT SLLTQSGLAS SAPAKSPGAQ KKKTNKAHKK QKVTEECEEA
360 370 380 390 400
IPQLVPIGET PDKENVKMQE NITGKTPKSK SDPSTPKGKK RKALLATETP
410 420 430 440 450
EASAPGTSGK KQKKDVQEFR KPEASSFSTP RKSGKKASNT PRDKKTKAAH

SN
Length:452
Mass (Da):50,421
Last modified:March 1, 2003 - v1
Checksum:iD40EA836C21D6B48
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHW2A0A2R8VHW2_MOUSE
Ribosomal L1 domain-containing prot...
Rsl1d1
238Annotation score:
A0A2R8VK65A0A2R8VK65_MOUSE
Ribosomal L1 domain-containing prot...
Rsl1d1
33Annotation score:

Sequence cautioni

The sequence AAH34355 differs from that shown. Reason: Frameshift at position 445.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075933 mRNA Translation: BAC36063.1
AK136025 mRNA Translation: BAE22779.1
AK166579 mRNA Translation: BAE38868.1
BC034355 mRNA Translation: AAH34355.1 Frameshift.
AC087541 Genomic DNA No translation available.
CCDSiCCDS49763.1
RefSeqiNP_079822.1, NM_025546.2
UniGeneiMm.28291

Genome annotation databases

EnsembliENSMUST00000119953; ENSMUSP00000113431; ENSMUSG00000005846
GeneIDi66409
KEGGimmu:66409
UCSCiuc007yfb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075933 mRNA Translation: BAC36063.1
AK136025 mRNA Translation: BAE22779.1
AK166579 mRNA Translation: BAE38868.1
BC034355 mRNA Translation: AAH34355.1 Frameshift.
AC087541 Genomic DNA No translation available.
CCDSiCCDS49763.1
RefSeqiNP_079822.1, NM_025546.2
UniGeneiMm.28291

3D structure databases

ProteinModelPortaliQ8BVY0
SMRiQ8BVY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211453, 3 interactors
IntActiQ8BVY0, 2 interactors
MINTiQ8BVY0
STRINGi10090.ENSMUSP00000113431

PTM databases

iPTMnetiQ8BVY0
PhosphoSitePlusiQ8BVY0
SwissPalmiQ8BVY0

Proteomic databases

MaxQBiQ8BVY0
PaxDbiQ8BVY0
PRIDEiQ8BVY0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119953; ENSMUSP00000113431; ENSMUSG00000005846
GeneIDi66409
KEGGimmu:66409
UCSCiuc007yfb.1 mouse

Organism-specific databases

CTDi26156
MGIiMGI:1913659 Rsl1d1

Phylogenomic databases

eggNOGiKOG1685 Eukaryota
ENOG4111W39 LUCA
GeneTreeiENSGT00440000038603
HOGENOMiHOG000133021
HOVERGENiHBG054786
InParanoidiQ8BVY0
KOiK14775
OMAiNENFFLM
OrthoDBiEOG091G0MY8
TreeFamiTF354254

Miscellaneous databases

ChiTaRSiRsl1d1 mouse
PROiPR:Q8BVY0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005846 Expressed in 296 organ(s), highest expression level in embryo
GenevisibleiQ8BVY0 MM

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL1D1_MOUSE
AccessioniPrimary (citable) accession number: Q8BVY0
Secondary accession number(s): Q8K235
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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