UniProtKB - Q8BVR6 (RSPRY_MOUSE)
Protein
RING finger and SPRY domain-containing protein 1
Gene
Rspry1
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 527 – 562 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-protein transferase activity Source: GO_Central
GO - Biological processi
- proteolysis involved in cellular protein catabolic process Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger and SPRY domain-containing protein 1 |
Gene namesi | Name:Rspry1 Synonyms:Kiaa1972 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914860, Rspry1 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000278788 | 17 – 576 | RING finger and SPRY domain-containing protein 1Add BLAST | 560 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 50 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8BVR6 |
jPOSTi | Q8BVR6 |
PaxDbi | Q8BVR6 |
PeptideAtlasi | Q8BVR6 |
PRIDEi | Q8BVR6 |
PTM databases
GlyGeni | Q8BVR6, 1 site |
iPTMneti | Q8BVR6 |
PhosphoSitePlusi | Q8BVR6 |
SwissPalmi | Q8BVR6 |
Expressioni
Tissue specificityi
Expressed in embryonic bone during primary endochondral ossification. Strong localization is observed in the perichondrium and periostium (at protein level). Also expressed in embryonic and postnatal brain and craniofacial tissues. Expressed in skeletal muscles (PubMed:26497270).2 Publications
Developmental stagei
Shows relatively low expression levels in proliferating myoblasts. Expression peaks at around day 1 of differentiation into myotubes and decreases again by day 10, when assayed in C2C12 cell line (at protein level).1 Publication
Inductioni
Up-regulated in response to denervation-induced skeletal muscle atrophy. Induced by MYOD1.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000050079, Expressed in supraoptic nucleus and 285 other tissues |
Genevisiblei | Q8BVR6, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q8BVR6, 1 interactor |
STRINGi | 10090.ENSMUSP00000057275 |
Miscellaneous databases
RNActi | Q8BVR6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 300 – 483 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 184 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 527 – 562 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
Keywords - Domaini
Signal, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2242, Eukaryota |
GeneTreei | ENSGT00940000157894 |
HOGENOMi | CLU_026400_0_0_1 |
InParanoidi | Q8BVR6 |
OrthoDBi | 1005747at2759 |
PhylomeDBi | Q8BVR6 |
TreeFami | TF313546 |
Family and domain databases
CDDi | cd12883, SPRY_RING, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR003877, SPRY_dom IPR035774, SPRY_RSPRY1 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00622, SPRY, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50089, ZF_RING_2, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8BVR6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIVFGWAVFL ASRSLGQGLL LTLEEHIAHL LGTTGATATM GNSCICRDDS
60 70 80 90 100
GAEDNVDTHQ QQAENSTVPT ADSRSQPRDP VRPPRRGRGP HEPRRKKQNV
110 120 130 140 150
DGLVLDTLAV IRTLVDNDQE PPYSMITLHE MAETDEGWLD VVQSLIRVIP
160 170 180 190 200
LEDPLGPAVI TLLLDECPLP TKDALQKLTE ILNLNGEVAC QDSGHPAKHR
210 220 230 240 250
NTSAVLGCLA EKLAGPASIG LLSPGILEYL LQCLKLQSHP TVMLFALIAL
260 270 280 290 300
EKFAQTSENK LTISESSISD RLVTLELWAD DPDYLKRQVG FCAQWSLDNL
310 320 330 340 350
FLKEGRQLTY EKVDLNNIRA MLNSNDVSEY LKISPHGLEA RCDASSFESV
360 370 380 390 400
RCTFCVDTGV WYYEVTVVTS GVMQIGWATR DSKFLNHEGY GIGDDEYSCA
410 420 430 440 450
YDGCRQLIWY NARSKPHVHP CWKEGDTVGF LLDLNEKQMI FFLNGNQLPP
460 470 480 490 500
EKQVFSSTVS GFFAAASFMS YQQCEFNFGA RPFKYPPSMK FSTFNDYAFL
510 520 530 540 550
TAEEKIILPR HRRLALLKQV SIRENCCSLC CDEVADTQLK PCGHSDLCMD
560 570
CALQLETCPL CRKEIVSRIR QISHIS
Sequence cautioni
The sequence BAE22177 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 54 | D → N in BAE43070 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 67 | T → A in BAE38607 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 250 | L → M in BAC27858 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 527 | C → Y in BAE22177 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023384 | 1 – 124 | Missing in isoform 3. 1 PublicationAdd BLAST | 124 | |
Alternative sequenceiVSP_023385 | 117 | N → K in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_023386 | 118 – 576 | Missing in isoform 2. 1 PublicationAdd BLAST | 459 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173313 mRNA Translation: BAD32591.1 AK013003 mRNA Translation: BAB28589.1 AK031153 mRNA Translation: BAC27283.1 AK032416 mRNA Translation: BAC27858.1 AK076799 mRNA Translation: BAC36485.1 AK134544 mRNA Translation: BAE22177.1 Frameshift. AK141443 mRNA Translation: BAE24686.1 AK146028 mRNA Translation: BAE26842.1 AK150941 mRNA Translation: BAE29976.1 AK152435 mRNA Translation: BAE31217.1 AK166167 mRNA Translation: BAE38607.1 AK172567 mRNA Translation: BAE43070.1 BC010833 mRNA Translation: AAH10833.2 BC054121 mRNA Translation: AAH54121.1 |
CCDSi | CCDS22544.1 [Q8BVR6-1] |
RefSeqi | NP_080550.3, NM_026274.4 [Q8BVR6-1] XP_006531376.1, XM_006531313.3 |
Genome annotation databases
Ensembli | ENSMUST00000060389; ENSMUSP00000057275; ENSMUSG00000050079 [Q8BVR6-1] ENSMUST00000121101; ENSMUSP00000112482; ENSMUSG00000050079 [Q8BVR6-2] ENSMUST00000211983; ENSMUSP00000148737; ENSMUSG00000050079 [Q8BVR6-1] ENSMUST00000212729; ENSMUSP00000148724; ENSMUSG00000050079 [Q8BVR6-3] |
GeneIDi | 67610 |
KEGGi | mmu:67610 |
UCSCi | uc009mwq.2, mouse [Q8BVR6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173313 mRNA Translation: BAD32591.1 AK013003 mRNA Translation: BAB28589.1 AK031153 mRNA Translation: BAC27283.1 AK032416 mRNA Translation: BAC27858.1 AK076799 mRNA Translation: BAC36485.1 AK134544 mRNA Translation: BAE22177.1 Frameshift. AK141443 mRNA Translation: BAE24686.1 AK146028 mRNA Translation: BAE26842.1 AK150941 mRNA Translation: BAE29976.1 AK152435 mRNA Translation: BAE31217.1 AK166167 mRNA Translation: BAE38607.1 AK172567 mRNA Translation: BAE43070.1 BC010833 mRNA Translation: AAH10833.2 BC054121 mRNA Translation: AAH54121.1 |
CCDSi | CCDS22544.1 [Q8BVR6-1] |
RefSeqi | NP_080550.3, NM_026274.4 [Q8BVR6-1] XP_006531376.1, XM_006531313.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8BVR6, 1 interactor |
STRINGi | 10090.ENSMUSP00000057275 |
PTM databases
GlyGeni | Q8BVR6, 1 site |
iPTMneti | Q8BVR6 |
PhosphoSitePlusi | Q8BVR6 |
SwissPalmi | Q8BVR6 |
Proteomic databases
EPDi | Q8BVR6 |
jPOSTi | Q8BVR6 |
PaxDbi | Q8BVR6 |
PeptideAtlasi | Q8BVR6 |
PRIDEi | Q8BVR6 |
Protocols and materials databases
Antibodypediai | 28826, 89 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000060389; ENSMUSP00000057275; ENSMUSG00000050079 [Q8BVR6-1] ENSMUST00000121101; ENSMUSP00000112482; ENSMUSG00000050079 [Q8BVR6-2] ENSMUST00000211983; ENSMUSP00000148737; ENSMUSG00000050079 [Q8BVR6-1] ENSMUST00000212729; ENSMUSP00000148724; ENSMUSG00000050079 [Q8BVR6-3] |
GeneIDi | 67610 |
KEGGi | mmu:67610 |
UCSCi | uc009mwq.2, mouse [Q8BVR6-1] |
Organism-specific databases
CTDi | 89970 |
MGIi | MGI:1914860, Rspry1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2242, Eukaryota |
GeneTreei | ENSGT00940000157894 |
HOGENOMi | CLU_026400_0_0_1 |
InParanoidi | Q8BVR6 |
OrthoDBi | 1005747at2759 |
PhylomeDBi | Q8BVR6 |
TreeFami | TF313546 |
Miscellaneous databases
BioGRID-ORCSi | 67610, 3 hits in 19 CRISPR screens |
ChiTaRSi | Rspry1, mouse |
PROi | PR:Q8BVR6 |
RNActi | Q8BVR6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000050079, Expressed in supraoptic nucleus and 285 other tissues |
Genevisiblei | Q8BVR6, MM |
Family and domain databases
CDDi | cd12883, SPRY_RING, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR003877, SPRY_dom IPR035774, SPRY_RSPRY1 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00622, SPRY, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSPRY_MOUSE | |
Accessioni | Q8BVR6Primary (citable) accession number: Q8BVR6 Secondary accession number(s): Q3T9F1 Q9CZ54 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot