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Entry version 148 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

RING finger and SPRY domain-containing protein 1

Gene

Rspry1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri527 – 562RING-typePROSITE-ProRule annotationAdd BLAST36

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING finger and SPRY domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rspry1
Synonyms:Kiaa1972
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914860, Rspry1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027878817 – 576RING finger and SPRY domain-containing protein 1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BVR6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BVR6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BVR6

PeptideAtlas

More...
PeptideAtlasi
Q8BVR6

PRoteomics IDEntifications database

More...
PRIDEi
Q8BVR6

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8BVR6, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BVR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BVR6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BVR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryonic bone during primary endochondral ossification. Strong localization is observed in the perichondrium and periostium (at protein level). Also expressed in embryonic and postnatal brain and craniofacial tissues. Expressed in skeletal muscles (PubMed:26497270).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Shows relatively low expression levels in proliferating myoblasts. Expression peaks at around day 1 of differentiation into myotubes and decreases again by day 10, when assayed in C2C12 cell line (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to denervation-induced skeletal muscle atrophy. Induced by MYOD1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000050079, Expressed in supraoptic nucleus and 285 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BVR6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8BVR6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000057275

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BVR6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 483B30.2/SPRYPROSITE-ProRule annotationAdd BLAST184

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri527 – 562RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Signal, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2242, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026400_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BVR6

KEGG Orthology (KO)

More...
KOi
K23332

Database of Orthologous Groups

More...
OrthoDBi
1005747at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BVR6

TreeFam database of animal gene trees

More...
TreeFami
TF313546

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12883, SPRY_RING, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR003877, SPRY_dom
IPR035774, SPRY_RSPRY1
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00622, SPRY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BVR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIVFGWAVFL ASRSLGQGLL LTLEEHIAHL LGTTGATATM GNSCICRDDS
60 70 80 90 100
GAEDNVDTHQ QQAENSTVPT ADSRSQPRDP VRPPRRGRGP HEPRRKKQNV
110 120 130 140 150
DGLVLDTLAV IRTLVDNDQE PPYSMITLHE MAETDEGWLD VVQSLIRVIP
160 170 180 190 200
LEDPLGPAVI TLLLDECPLP TKDALQKLTE ILNLNGEVAC QDSGHPAKHR
210 220 230 240 250
NTSAVLGCLA EKLAGPASIG LLSPGILEYL LQCLKLQSHP TVMLFALIAL
260 270 280 290 300
EKFAQTSENK LTISESSISD RLVTLELWAD DPDYLKRQVG FCAQWSLDNL
310 320 330 340 350
FLKEGRQLTY EKVDLNNIRA MLNSNDVSEY LKISPHGLEA RCDASSFESV
360 370 380 390 400
RCTFCVDTGV WYYEVTVVTS GVMQIGWATR DSKFLNHEGY GIGDDEYSCA
410 420 430 440 450
YDGCRQLIWY NARSKPHVHP CWKEGDTVGF LLDLNEKQMI FFLNGNQLPP
460 470 480 490 500
EKQVFSSTVS GFFAAASFMS YQQCEFNFGA RPFKYPPSMK FSTFNDYAFL
510 520 530 540 550
TAEEKIILPR HRRLALLKQV SIRENCCSLC CDEVADTQLK PCGHSDLCMD
560 570
CALQLETCPL CRKEIVSRIR QISHIS
Length:576
Mass (Da):64,322
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i823C3532FCE18387
GO
Isoform 2 (identifier: Q8BVR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-117: N → K
     118-576: Missing.

Show »
Length:117
Mass (Da):12,738
Checksum:iD3FEC471ABD55D3C
GO
Isoform 3 (identifier: Q8BVR6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Show »
Length:452
Mass (Da):50,799
Checksum:i6D5BBCA25ED5731A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE22177 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54D → N in BAE43070 (PubMed:16141072).Curated1
Sequence conflicti67T → A in BAE38607 (PubMed:16141072).Curated1
Sequence conflicti250L → M in BAC27858 (PubMed:16141072).Curated1
Sequence conflicti527C → Y in BAE22177 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0233841 – 124Missing in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_023385117N → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_023386118 – 576Missing in isoform 2. 1 PublicationAdd BLAST459

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173313 mRNA Translation: BAD32591.1
AK013003 mRNA Translation: BAB28589.1
AK031153 mRNA Translation: BAC27283.1
AK032416 mRNA Translation: BAC27858.1
AK076799 mRNA Translation: BAC36485.1
AK134544 mRNA Translation: BAE22177.1 Frameshift.
AK141443 mRNA Translation: BAE24686.1
AK146028 mRNA Translation: BAE26842.1
AK150941 mRNA Translation: BAE29976.1
AK152435 mRNA Translation: BAE31217.1
AK166167 mRNA Translation: BAE38607.1
AK172567 mRNA Translation: BAE43070.1
BC010833 mRNA Translation: AAH10833.2
BC054121 mRNA Translation: AAH54121.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22544.1 [Q8BVR6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_080550.3, NM_026274.4 [Q8BVR6-1]
XP_006531376.1, XM_006531313.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000060389; ENSMUSP00000057275; ENSMUSG00000050079 [Q8BVR6-1]
ENSMUST00000121101; ENSMUSP00000112482; ENSMUSG00000050079 [Q8BVR6-2]
ENSMUST00000211983; ENSMUSP00000148737; ENSMUSG00000050079 [Q8BVR6-1]
ENSMUST00000212729; ENSMUSP00000148724; ENSMUSG00000050079 [Q8BVR6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
67610

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67610

UCSC genome browser

More...
UCSCi
uc009mwq.2, mouse [Q8BVR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173313 mRNA Translation: BAD32591.1
AK013003 mRNA Translation: BAB28589.1
AK031153 mRNA Translation: BAC27283.1
AK032416 mRNA Translation: BAC27858.1
AK076799 mRNA Translation: BAC36485.1
AK134544 mRNA Translation: BAE22177.1 Frameshift.
AK141443 mRNA Translation: BAE24686.1
AK146028 mRNA Translation: BAE26842.1
AK150941 mRNA Translation: BAE29976.1
AK152435 mRNA Translation: BAE31217.1
AK166167 mRNA Translation: BAE38607.1
AK172567 mRNA Translation: BAE43070.1
BC010833 mRNA Translation: AAH10833.2
BC054121 mRNA Translation: AAH54121.1
CCDSiCCDS22544.1 [Q8BVR6-1]
RefSeqiNP_080550.3, NM_026274.4 [Q8BVR6-1]
XP_006531376.1, XM_006531313.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8BVR6, 1 interactor
STRINGi10090.ENSMUSP00000057275

PTM databases

GlyGeniQ8BVR6, 1 site
iPTMnetiQ8BVR6
PhosphoSitePlusiQ8BVR6
SwissPalmiQ8BVR6

Proteomic databases

EPDiQ8BVR6
jPOSTiQ8BVR6
PaxDbiQ8BVR6
PeptideAtlasiQ8BVR6
PRIDEiQ8BVR6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28826, 89 antibodies

Genome annotation databases

EnsembliENSMUST00000060389; ENSMUSP00000057275; ENSMUSG00000050079 [Q8BVR6-1]
ENSMUST00000121101; ENSMUSP00000112482; ENSMUSG00000050079 [Q8BVR6-2]
ENSMUST00000211983; ENSMUSP00000148737; ENSMUSG00000050079 [Q8BVR6-1]
ENSMUST00000212729; ENSMUSP00000148724; ENSMUSG00000050079 [Q8BVR6-3]
GeneIDi67610
KEGGimmu:67610
UCSCiuc009mwq.2, mouse [Q8BVR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89970
MGIiMGI:1914860, Rspry1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2242, Eukaryota
GeneTreeiENSGT00940000157894
HOGENOMiCLU_026400_0_0_1
InParanoidiQ8BVR6
KOiK23332
OrthoDBi1005747at2759
PhylomeDBiQ8BVR6
TreeFamiTF313546

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67610, 3 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rspry1, mouse

Protein Ontology

More...
PROi
PR:Q8BVR6
RNActiQ8BVR6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000050079, Expressed in supraoptic nucleus and 285 other tissues
GenevisibleiQ8BVR6, MM

Family and domain databases

CDDicd12883, SPRY_RING, 1 hit
Gene3Di2.60.120.920, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR003877, SPRY_dom
IPR035774, SPRY_RSPRY1
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00622, SPRY, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSPRY_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BVR6
Secondary accession number(s): Q3T9F1
, Q3TM35, Q3U802, Q3UKF9, Q3UYN5, Q8BMH0, Q8C039, Q9CZ54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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