UniProtKB - Q8BVQ9 (Q8BVQ9_MOUSE)
26S proteasome regulatory subunit 7
Psmc2
Functioni
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
ARBA annotationGO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- proteasome-activating activity Source: Ensembl
GO - Biological processi
- ubiquitin-dependent protein catabolic process Source: Ensembl
Keywordsi
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 5.6.1.5, 3474 |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit 7ARBA annotationAlternative name(s): 26S proteasome AAA-ATPase subunit RPT1ARBA annotation Proteasome 26S subunit ATPase 2ARBA annotation |
Gene namesi | Name:Psmc2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109555, Psmc2 |
VEuPathDBi | HostDB:ENSMUSG00000028932 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Cytosol
- cytosol Source: Ensembl
Other locations
- cytoplasmic ribonucleoprotein granule Source: Ensembl
- proteasome complex Source: UniProtKB-KW
Keywords - Cellular componenti
ProteasomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000028932, Expressed in respiratory primordium and 313 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 250 – 389 | AAAInterPro annotationAdd BLAST | 140 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 80 – 107 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 48 – 62 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT01020000230346 |
HOGENOMi | CLU_000688_6_1_1 |
OrthoDBi | 571919at2759 |
TreeFami | TF105661 |
Family and domain databases
Gene3Di | 2.40.50.140, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase IPR035245, PSMC2 |
PANTHERi | PTHR23073:SF13, PTHR23073:SF13, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSREPAPGRG ATSGGEEKGK TPAEAGKVLC NHRDAEALAA SKMPDYLGAD
60 70 80 90 100
QRKTKEEEKD DKPIRALDEG DIALLKTYGQ STYSRQIKQV EDDIQQLLKK
110 120 130 140 150
INELTGIKES DTGLAPPALW DLAADKQTLQ SEQPLQVARC TKIINADSED
160 170 180 190 200
PKYIINVKQF AKFVVDLSDQ VAPTDIEEGM RVGVDRNKYQ IHIPLPPKID
210 220 230 240 250
PTVTMMQVEE KPDVTYSDVG GCKEQIEKLR EVVETPLLHP ERFVNLGIEP
260 270 280 290 300
PKGVLLFGPP GTGKTLCARA VANRTDACFI RVIGSELVQK YVGEGARMVR
310 320 330 340 350
ELFEMARTKK ACLIFFDEID AIGGARFDDG AGGDNEVQRT MLELINQLDG
360 370 380 390 400
FDPRGNIKVL MATNRPDTLD PALMRPGRLD RKIEFSLPDL EGRTHIFKIH
410 420 430 440 450
ARSMSVERDI RFELLARLCP NSTGAEIRSV CTEAGMFAIR ARRKIATEKD
460 470
FLEAVNKVIK SYAKFSATPR YMTYN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP46471 | PRS7_MOUSE | 26S proteasome regulatory subunit 7 | Psmc2 Mss1 | 433 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC125313 Genomic DNA No translation available. AK076874 mRNA Translation: BAC36516.1 |
RefSeqi | NP_035318.1, NM_011188.3 |
Genome annotation databases
Ensembli | ENSMUST00000030769; ENSMUSP00000030769; ENSMUSG00000028932 ENSMUST00000239497.2; ENSMUSP00000159299.2; ENSMUSG00000028932.9 |
GeneIDi | 19181 |
KEGGi | mmu:19181 |
UCSCi | uc008wpd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC125313 Genomic DNA No translation available. AK076874 mRNA Translation: BAC36516.1 |
RefSeqi | NP_035318.1, NM_011188.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8BVQ9, 1 interactor |
Proteomic databases
ProteomicsDBi | 337176 |
Protocols and materials databases
Antibodypediai | 16901, 361 antibodies from 34 providers |
DNASUi | 19181 |
Genome annotation databases
Ensembli | ENSMUST00000030769; ENSMUSP00000030769; ENSMUSG00000028932 ENSMUST00000239497.2; ENSMUSP00000159299.2; ENSMUSG00000028932.9 |
GeneIDi | 19181 |
KEGGi | mmu:19181 |
UCSCi | uc008wpd.1, mouse |
Organism-specific databases
CTDi | 5701 |
MGIi | MGI:109555, Psmc2 |
VEuPathDBi | HostDB:ENSMUSG00000028932 |
Phylogenomic databases
GeneTreei | ENSGT01020000230346 |
HOGENOMi | CLU_000688_6_1_1 |
OrthoDBi | 571919at2759 |
TreeFami | TF105661 |
Enzyme and pathway databases
BRENDAi | 5.6.1.5, 3474 |
Miscellaneous databases
BioGRID-ORCSi | 19181, 26 hits in 74 CRISPR screens |
ChiTaRSi | Psmc2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028932, Expressed in respiratory primordium and 313 other tissues |
Family and domain databases
Gene3Di | 2.40.50.140, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase IPR035245, PSMC2 |
PANTHERi | PTHR23073:SF13, PTHR23073:SF13, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8BVQ9_MOUSE | |
Accessioni | Q8BVQ9Primary (citable) accession number: Q8BVQ9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |