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Protein

Casein kinase I isoform gamma-2

Gene

Csnk1g2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Stimulated by estrogen.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75ATPPROSITE-ProRule annotation1
Active sitei165Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 60ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660661 Sphingolipid de novo biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-2 (EC:2.7.11.1)
Short name:
CKI-gamma 2
Gene namesi
Name:Csnk1g2
Synonyms:Ck1g2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1920014 Csnk1g2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928431 – 415Casein kinase I isoform gamma-2Add BLAST415

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVP5
MaxQBiQ8BVP5
PeptideAtlasiQ8BVP5
PRIDEiQ8BVP5

PTM databases

iPTMnetiQ8BVP5
PhosphoSitePlusiQ8BVP5
SwissPalmiQ8BVP5

Expressioni

Tissue specificityi

Expressed in both the striatum and the neocortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000003345
CleanExiMM_CSNK1G2
ExpressionAtlasiQ8BVP5 baseline and differential
GenevisibleiQ8BVP5 MM

Interactioni

Subunit structurei

Monomer. Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8BVP5
SMRiQ8BVP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 316Protein kinasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00920000148988
HOGENOMiHOG000182054
HOVERGENiHBG000176
InParanoidiQ8BVP5
KOiK08958
PhylomeDBiQ8BVP5

Family and domain databases

InterProiView protein in InterPro
IPR022247 Casein_kinase-1_gamma_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12605 CK1gamma_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BVP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFDKKGGKG ELEEGRRMSK TGTSRSNHGV RSSGTSSGVL MVGPNFRVGK
60 70 80 90 100
KIGCGNFGEL RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSTTE
110 120 130 140 150
GVPQVYYFGP CGKYNAMVLE LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI
160 170 180 190 200
TRMEYVHTKS LIYRDVKPEN FLVGRPGSKR QHSIHIIDFG LAKEYIDPET
210 220 230 240 250
KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH MFMYFLRGSL
260 270 280 290 300
PWQGLKADTL KERYQKIGDT KRATPIEVLC ESFPEEMATY LRYVRRLDFF
310 320 330 340 350
EKPDYDYLRK LFTDLFDRSG YVFDYEYDWA GKPLPTPIGT VHPDVPSQPP
360 370 380 390 400
HRDKAQLHTK NQALNSTNGE LNTDDPTAGH SNAPIAAPAE VEVADETKCC
410
CFFKRRKRKS LQRHK
Length:415
Mass (Da):47,582
Last modified:March 1, 2003 - v1
Checksum:iC5EE5AFCF2F44677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077076 mRNA Translation: BAC36596.1
AK132871 mRNA Translation: BAE21399.1
CCDSiCCDS48638.1
RefSeqiNP_001153063.1, NM_001159591.1
NP_598763.1, NM_134002.2
XP_006513074.1, XM_006513011.1
UniGeneiMm.29873

Genome annotation databases

EnsembliENSMUST00000085435; ENSMUSP00000082560; ENSMUSG00000003345
GeneIDi103236
KEGGimmu:103236
UCSCiuc007geb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKC1G2_MOUSE
AccessioniPrimary (citable) accession number: Q8BVP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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