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Protein

Transcription termination factor 4, mitochondrial

Gene

Mterf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S (By similarity). Targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: MGI
  • heart development Source: MGI
  • mitochondrial transcription Source: MGI
  • protein targeting to mitochondrion Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
  • ribosome assembly Source: MGI
  • RNA splicing Source: GO_Central
  • rRNA processing Source: UniProtKB-KW

Keywordsi

Molecular functionRNA-binding
Biological processrRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 4, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 4
mTERF domain-containing protein 2
Gene namesi
Name:Mterf4
Synonyms:Mterfd2
Ordered Locus Names:HSPC096
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1918355 Mterf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Ablation of the gene is not viable. At 8.5 dpc, mutant homozygous embryos exhibit much reduced size, lack of heart and no optic disks. Conditional knockout in heart leads to severe mitochondrial cardiomyopathy. Premature death occurs at about 21 weeks and decreased body weight is observed from 15 weeks until death.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionBy similarityAdd BLAST42
ChainiPRO_000025546243 – 346Transcription termination factor 4, mitochondrialAdd BLAST304

Proteomic databases

MaxQBiQ8BVN4
PaxDbiQ8BVN4
PeptideAtlasiQ8BVN4
PRIDEiQ8BVN4

PTM databases

iPTMnetiQ8BVN4
PhosphoSitePlusiQ8BVN4

Expressioni

Tissue specificityi

Widely expressed, with highest levels in liver, followed by testis, kidney and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000026273
CleanExiMM_MTERFD2
ExpressionAtlasiQ8BVN4 baseline and differential
GenevisibleiQ8BVN4 MM

Interactioni

Subunit structurei

Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027492

Structurei

3D structure databases

ProteinModelPortaliQ8BVN4
SMRiQ8BVN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati142 – 172MTERF 1Add BLAST31
Repeati177 – 204MTERF 2Add BLAST28
Repeati209 – 239MTERF 3Add BLAST31
Repeati245 – 270MTERF 4Add BLAST26
Repeati290 – 318MTERF 5Add BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni310 – 327Dimerization with NSUN4By similarityAdd BLAST18

Domaini

The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.By similarity

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiENOG410IK50 Eukaryota
ENOG410Y0Q1 LUCA
GeneTreeiENSGT00460000041648
HOGENOMiHOG000069984
HOVERGENiHBG081990
InParanoidiQ8BVN4
KOiK15032
OMAiLKRTPDK
OrthoDBiEOG091G0DPS
PhylomeDBiQ8BVN4
TreeFamiTF329452

Family and domain databases

Gene3Di1.25.70.10, 1 hit
InterProiView protein in InterPro
IPR003690 MTERF
IPR038538 MTERF_sf
PfamiView protein in Pfam
PF02536 mTERF, 1 hit
SMARTiView protein in SMART
SM00733 Mterf, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BVN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLGRQVPE WHRLLALSWA CLVRQTPHLR EQKQMSPSLS CKLTTVPGRG
60 70 80 90 100
SFQEFSSITP QKYMQEPENR TRLVQCLHEE QKPCVDPESL EPEKVIRSLQ
110 120 130 140 150
DMGFAEAHIH SLFSIQPSVH PQQLLGIVSE LLLLGLNPEP VFNALKKNPQ
160 170 180 190 200
LLKLSSMQMK RRSSYLRKLG LGEGKLKRVL SVCPEVFTMH QRDIDRVVKV
210 220 230 240 250
LREKCLFTAQ HITDVLHRCP TVLQEDPNEL EYKFQYAYFR MGLTHLDIVR
260 270 280 290 300
TNFLQYSITK IKQRHIYLER LGRYQTPDKK GQTQIPNPSL RNILRVSEAE
310 320 330 340
FLARTACSSV EEFQVFKKLL DQEEEEESES HASEEEEEEE EEEELL
Length:346
Mass (Da):40,249
Last modified:March 1, 2003 - v1
Checksum:iEA34F8129804CC07
GO

Sequence cautioni

The sequence AAH02280 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH55877 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156S → N in AAH02280 (PubMed:15489334).Curated1
Sequence conflicti156S → N in AAH55877 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077142 mRNA Translation: BAC36640.1
BC002280 mRNA Translation: AAH02280.1 Different initiation.
BC055877 mRNA Translation: AAH55877.1 Different initiation.
BC064709 mRNA Translation: AAH64709.1
CCDSiCCDS35671.1
RefSeqiNP_835152.1, NM_178051.4
UniGeneiMm.52809

Genome annotation databases

EnsembliENSMUST00000027492; ENSMUSP00000027492; ENSMUSG00000026273
GeneIDi69821
KEGGimmu:69821
UCSCiuc007cdo.1 mouse

Entry informationi

Entry nameiMTEF4_MOUSE
AccessioniPrimary (citable) accession number: Q8BVN4
Secondary accession number(s): Q99LQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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