Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cation channel sperm-associated protein 4

Gene

Catsper4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.2 Publications

Activity regulationi

In contrast to the human ortholog, not activated by progesterone.1 Publication

GO - Molecular functioni

  • calcium activated cation channel activity Source: InterPro
  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Developmental protein, Ion channel, Voltage-gated channel
Biological processCalcium transport, Differentiation, Ion transport, Spermatogenesis, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-1300642 Sperm Motility And Taxes

Protein family/group databases

TCDBi1.A.1.19.3 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein 4
Short name:
CatSper4
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3043288 Catsper4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66CytoplasmicSequence analysisAdd BLAST66
Transmembranei67 – 87Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini88 – 106ExtracellularSequence analysisAdd BLAST19
Transmembranei107 – 127Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini128 – 136CytoplasmicSequence analysis9
Transmembranei137 – 157Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini158ExtracellularSequence analysis1
Transmembranei159 – 173Helical; Name=Segment S4Sequence analysisAdd BLAST15
Topological domaini174 – 195CytoplasmicSequence analysisAdd BLAST22
Transmembranei196 – 216Helical; Name=Segment S5Add BLAST21
Topological domaini217 – 222ExtracellularSequence analysis6
Intramembranei223 – 243Helical; Pore-formingSequence analysisAdd BLAST21
Topological domaini244 – 260ExtracellularSequence analysisAdd BLAST17
Transmembranei261 – 281Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini282 – 442CytoplasmicSequence analysisAdd BLAST161

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs.2 Publications

Chemistry databases

GuidetoPHARMACOLOGYi391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956821 – 442Cation channel sperm-associated protein 4Add BLAST442

Proteomic databases

PaxDbiQ8BVN3
PRIDEiQ8BVN3

PTM databases

PhosphoSitePlusiQ8BVN3

Expressioni

Tissue specificityi

Testis-specific.2 Publications

Developmental stagei

Detected in hte testis during postnatal development at day 15. Restricted to the late-stage germline cells that line the seminiferous tubules.1 Publication

Gene expression databases

BgeeiENSMUSG00000048003 Expressed in 16 organ(s), highest expression level in testis
CleanExiMM_CATSPER4
ExpressionAtlasiQ8BVN3 baseline and differential

Interactioni

Subunit structurei

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1.Curated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Catsper1Q91ZR52EBI-15619199,EBI-15619083

Protein-protein interaction databases

BioGridi236869, 1 interactor
DIPiDIP-60803N
IntActiQ8BVN3, 1 interactor
STRINGi10090.ENSMUSP00000051694

Structurei

3D structure databases

ProteinModelPortaliQ8BVN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5Y Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000119325
HOGENOMiHOG000112053
HOVERGENiHBG102124
InParanoidiQ8BVN3
KOiK16892
OMAiMANIMAL
OrthoDBiEOG091G07AU
PhylomeDBiQ8BVN3
TreeFamiTF343841

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR028744 CatSper4
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF225 PTHR10037:SF225, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BVN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKHKWWQQ VENIDITHLG PKRKAYELLG RHEEQVLINR RDVMEKKDAW
60 70 80 90 100
DVQEFITQMY IKQLLRHPAF QLLLAFLLLS NAITIALRTN SYLGQKHYEL
110 120 130 140 150
FSTIDDIVLT ILICEVLLGW LNGFWIFWKD GWNILNFAIV FILFMGFFIK
160 170 180 190 200
QLDMVAITYP LRVLRLVHVC MAVEPLARII KVILQSMPDL ANVMALILFF
210 220 230 240 250
MLVFSVFGVT LFGAFVPKHF QNMGVALYTL FICITQDGWL DIYTDFQMDE
260 270 280 290 300
REYAMEVGGA IYFAVFITLG AFIGLNLFVV VVTTNLEQMM KTGEEEGHLN
310 320 330 340 350
IKFTETEEDE DWTDELPLVH CTEARKDTST VPKEPLVGGP LSNLTEKTCD
360 370 380 390 400
NFCLVLEAIQ ENLMEYKEIR EELNMIVEEV SSIRFNQEQQ NVILHKYTSK
410 420 430 440
SATFLSEPPE GANKQDLITA LVSREKVSDS NINMVNKHKF SH
Length:442
Mass (Da):51,130
Last modified:March 1, 2003 - v1
Checksum:iB4A41CAA47F0AE21
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3VNK5B3VNK5_MOUSE
Cation channel sperm-associated pro...
Catsper4
369Annotation score:
Z4YKD2Z4YKD2_MOUSE
Cation channel sperm-associated pro...
Catsper4
136Annotation score:

Sequence cautioni

The sequence CAM21941 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077145 mRNA Translation: BAC36641.1
AL627314 Genomic DNA Translation: CAM21940.1
AL627314 Genomic DNA Translation: CAM21941.1 Sequence problems.
BC108974 mRNA Translation: AAI08975.1
BC108975 mRNA Translation: AAI08976.1
CCDSiCCDS18766.1
RefSeqiNP_001123502.1, NM_001130030.1
NP_808534.1, NM_177866.4
UniGeneiMm.79072

Genome annotation databases

EnsembliENSMUST00000055892; ENSMUSP00000051694; ENSMUSG00000048003
GeneIDi329954
KEGGimmu:329954
UCSCiuc008veh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077145 mRNA Translation: BAC36641.1
AL627314 Genomic DNA Translation: CAM21940.1
AL627314 Genomic DNA Translation: CAM21941.1 Sequence problems.
BC108974 mRNA Translation: AAI08975.1
BC108975 mRNA Translation: AAI08976.1
CCDSiCCDS18766.1
RefSeqiNP_001123502.1, NM_001130030.1
NP_808534.1, NM_177866.4
UniGeneiMm.79072

3D structure databases

ProteinModelPortaliQ8BVN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236869, 1 interactor
DIPiDIP-60803N
IntActiQ8BVN3, 1 interactor
STRINGi10090.ENSMUSP00000051694

Chemistry databases

GuidetoPHARMACOLOGYi391

Protein family/group databases

TCDBi1.A.1.19.3 the voltage-gated ion channel (vic) superfamily

PTM databases

PhosphoSitePlusiQ8BVN3

Proteomic databases

PaxDbiQ8BVN3
PRIDEiQ8BVN3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055892; ENSMUSP00000051694; ENSMUSG00000048003
GeneIDi329954
KEGGimmu:329954
UCSCiuc008veh.2 mouse

Organism-specific databases

CTDi378807
MGIiMGI:3043288 Catsper4

Phylogenomic databases

eggNOGiENOG410II5Y Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000119325
HOGENOMiHOG000112053
HOVERGENiHBG102124
InParanoidiQ8BVN3
KOiK16892
OMAiMANIMAL
OrthoDBiEOG091G07AU
PhylomeDBiQ8BVN3
TreeFamiTF343841

Enzyme and pathway databases

ReactomeiR-MMU-1300642 Sperm Motility And Taxes

Miscellaneous databases

PROiPR:Q8BVN3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048003 Expressed in 16 organ(s), highest expression level in testis
CleanExiMM_CATSPER4
ExpressionAtlasiQ8BVN3 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR028744 CatSper4
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF225 PTHR10037:SF225, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTSR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BVN3
Secondary accession number(s): A2A9K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again