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1 to 25 of 34  Show
  1. 1
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Category: Sequences.
    Tissue: Liver and Mammary tumor.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  2. 2
    "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-265 (ISOFORM 2).
    Category: Sequences.
    Strain: C57BL/6J.
    Tissue: Cerebellum.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 10625 and mapped to 43846 other entries.

  3. 3
    "APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development."
    Ma G., Li T., Price D.L., Wong P.C.
    J. Neurosci. 25:192-198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE.
    Category: Function, Pathology & Biotech, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 19 other entries.

  4. 4
    Cited for: FUNCTION, SUBUNIT.
    Category: Function, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 4 other entries.

  5. 5
    Category: Sequences.
    Source: MGI:2385110.

    This publication is cited by 16981 and mapped to 30126 other entries.

  6. 6
    "Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch."
    Lee S.-F., Shah S., Li H., Yu C., Han W., Yu G.
    J. Biol. Chem. 277:45013-45019(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: MGI:2385110.

    This publication is cited by 1 and mapped to 20 other entries.

  7. 7
    "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.
    Hayashizaki Y.
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:2385110.

    This publication is cited by 16984 and mapped to 41260 other entries.

  8. 8
    "Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney."
    Cheng H.T., Miner J.H., Lin M., Tansey M.G., Roth K., Kopan R.
    Development 130:5031-5042(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:2385110.

    This publication is mapped to 8 other entries.

  9. 9
    "Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes."
    Vetrivel K.S., Cheng H., Lin W., Sakurai T., Li T., Nukina N., Wong P.C., Xu H., Thinakaran G.
    J. Biol. Chem. 279:44945-44954(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: presenilin 1 (PS1)-derived fragments mature nicastrin APH-1 and PEN-2 associate with cholesterol-rich detergent insoluble membrane (DIM) domains of non-neuronal cells and neurons.
    Source: GeneRIF:226548.

    This publication is mapped to 25 other entries.

  10. 10
    "Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity."
    Hebert S.S., Serneels L., Dejaegere T., Horre K., Dabrowski M., Baert V., Annaert W., Hartmann D., De Strooper B.
    Neurobiol. Dis. 17:260-272(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:2385110.

    This publication is mapped to 22 other entries.

  11. 11
    Category: Pathology & Biotech.
    Source: MGI:2385110.

    This publication is mapped to 8 other entries.

  12. 12
    "Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components."
    Zhang Y.W., Luo W.J., Wang H., Lin P., Vetrivel K.S., Liao F., Li F., Wong P.C., Farquhar M.G., Thinakaran G., Xu H.
    J. Biol. Chem. 280:17020-17026(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Subcellular Location, Interaction.
    Annotation: Nct has a critical role in the stability and proper intracellular trafficking of other components of the PS1/ gamma-secretase complex but not in maintaining the association of PEN-2 APH-1 and full-length PS1.
    Source: GeneRIF:226548.

    This publication is mapped to 12 other entries.

  13. 13
    Category: Function, Subcellular Location.
    Source: MGI:2385110.

    This publication is mapped to 3 other entries.

  14. 14
    "BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system."
    Magdaleno S., Jensen P., Brumwell C.L., Seal A., Lehman K., Asbury A., Cheung T., Cornelius T., Batten D.M., Eden C., Norland S.M., Rice D.S., Dosooye N., Shakya S., Mehta P., Curran T.
    PLoS Biol. 4:e86-e86(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:2385110.

    This publication is mapped to 20511 other entries.

  15. 15
    "Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities."
    Li T., Wen H., Brayton C., Laird F.M., Ma G., Peng S., Placanica L., Wu T.C., Crain B.J., Price D.L., Eberhart C.G., Wong P.C.
    J. Neurosci. 27:10849-10859(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Source: MGI:2385110.

    This publication is mapped to 13 other entries.

  16. 16
    Category: Sequences.
    Source: MGI:2385110.

    This publication is mapped to 29565 other entries.

  17. 17
    "Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide."
    Tan J., Mao G., Cui M.Z., Lamb B., Sy M.S., Xu X.
    Neurobiol. Dis. 36:453-460(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Source: MGI:2385110.

    This publication is mapped to 32 other entries.

  18. 18
    "Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin."
    Zhao G., Liu Z., Ilagan M.X., Kopan R.
    J. Neurosci. 30:1648-1656(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Source: MGI:2385110.

    This publication is mapped to 29 other entries.

  19. 19
    "Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates."
    Chen A.C., Guo L.Y., Ostaszewski B.L., Selkoe D.J., LaVoie M.J.
    J. Biol. Chem. 285:11378-11391(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. [GeneRIF:226548].
    Source: GeneRIF:226548, MGI:2385110.

    This publication is mapped to 42 other entries.

  20. 20
    "Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase."
    Sanjo N., Katayama T., Hasegawa H., Jin H., Duthie M., Mount H.T., Mizusawa H., St George-Hyslop P., Fraser P.E.
    Neurosci. Lett. 483:53-56(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location, PTM / Processing.
    Source: MGI:2385110.

    This publication is mapped to 9 other entries.

  21. 21
    Category: Expression.
    Source: MGI:2385110.

    This publication is mapped to 50335 other entries.

  22. 22
    "Inhibitors of gamma-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates."
    Barthet G., Shioi J., Shao Z., Ren Y., Georgakopoulos A., Robakis N.K.
    FASEB J. 25:2937-2946(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:2385110.

    This publication is mapped to 22 other entries.

  23. 23
    "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:2385110.

    This publication is mapped to 57460 other entries.

  24. 24
    "Increased expression of PS1 is sufficient to elevate the level and activity of gamma-secretase in vivo."
    Li T., Li Y.M., Ahn K., Price D.L., Sisodia S.S., Wong P.C.
    PLoS ONE 6:e28179-e28179(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Upregulation of PS1/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.
    Source: GeneRIF:226548.

    This publication is mapped to 15 other entries.

  25. 25
    "Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both gamma-secretase assembly and substrate recruitment."
    Mao G., Cui M.Z., Li T., Jin Y., Xu X.
    J. Neurochem. 123:837-844(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pen-2 as well as nicastrin and Aph-1alpha is dispensable for presenilin endoproteolysis.
    Source: GeneRIF:226548.

    This publication is mapped to 9 other entries.

1 to 25 of 34  Show
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