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Entry version 158 (02 Jun 2021)
Sequence version 2 (31 Oct 2006)
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Protein

Histone-lysine N-methyltransferase NSD2

Gene

Nsd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19483677, PubMed:32862441, PubMed:31636135).

Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:19483677).

Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (By similarity).

However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (PubMed:19483677).

By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:19483677, PubMed:31636135, PubMed:32862441, PubMed:23241889).

In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (PubMed:19483677).

During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (PubMed:19483677).

Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (By similarity).

During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (PubMed:31636135).

During B-cell development, required for the generation of the B1 lineage (PubMed:32862441).

During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (PubMed:32862441).

Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (PubMed:23241889).

By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (PubMed:23241889).

By similarity4 Publications

Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (By similarity).

Mono-, di- and tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2, H3K27me3) (PubMed:18172012).

Methylation of histone H3 at 'Lys-27' is controversial (By similarity).

May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:18172012).

By similarity1 Publication

Caution

Depending on the experimental set up and substrate used, NSD2 has been shown to mono-, di- or tri-methylate 'Lys-27', 'Lys-36' or 'Lys-79' of histone H3 and 'Lys-20' or 'Lys-44' of histone H4 (By similarity). However, dimethylation of nucleosomal histone H3 at 'Lys-36' (H3K36me2) is likely to be the physiological reaction catalyzed by NSD2 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1016Zinc 1By similarity1
Metal bindingi1018Zinc 1By similarity1
Metal bindingi1026Zinc 1By similarity1
Metal bindingi1026Zinc 2By similarity1
Metal bindingi1032Zinc 1By similarity1
Metal bindingi1041Zinc 2By similarity1
Metal bindingi1046Zinc 2By similarity1
Metal bindingi1052Zinc 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1075S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi1144Zinc 3By similarity1
Binding sitei1186S-adenosyl-L-methionineBy similarity1
Metal bindingi1191Zinc 3By similarity1
Binding sitei1192S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Metal bindingi1193Zinc 3By similarity1
Metal bindingi1198Zinc 3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi453 – 521HMG boxPROSITE-ProRule annotationAdd BLAST69
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri667 – 713PHD-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri714 – 770PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri831 – 875PHD-type 3PROSITE-ProRule annotationAdd BLAST45
Zinc fingeri1239 – 1286PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.357, 3474
2.1.1.359, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214841, PKMTs methylate histone lysines
R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571, Nonhomologous End-Joining (NHEJ)
R-MMU-5693607, Processing of DNA double-strand break ends
R-MMU-69473, G2/M DNA damage checkpoint

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase NSD2 (EC:2.1.1.3573 Publications)
Alternative name(s):
Multiple myeloma SET domain-containing protein
Short name:
MMSET
Nuclear SET domain-containing protein 2
Wolf-Hirschhorn syndrome candidate 1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nsd2
Synonyms:Kiaa1090, Whsc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1276574, Nsd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Offspring number is low at birth (PubMed:19483677). After birth, pups have growth retardation and die within 10 days (PubMed:19483677). At 15.5 dpc, levels of trimethylated 'Lys-36' on histone H3 are reduced (PubMed:19483677). At 18.5 dpc, embryos are smaller with midline fusion defects due to a lack of ossification centers and some have cleft palates (PubMed:19483677). Also have heart defects including atrial and ventricular septal defects (PubMed:19483677). Conditional knockout in CD4+ T-cells, reduces dimethylation of histone H3 at 'Lys-36' at the Bcl6 gene locus in response to T-cell activation which results in impaired Bcl6 expression (PubMed:31636135). Following immunization with ovalbumin antigen or sheep red blood cells, or infection with LCMV virus, follicular helper T (Tfh) cell differentiation and germinal center B cell response are reduced (PubMed:31636135). Also, following infection with LCMV virus, clearance of the virus is delayed (PubMed:31636135). No defect in T-cell development (PubMed:31636135).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1117F → A: Reduction in class switch recombination of the immunoglobulin heavy chain in B cells. 1 Publication1
Mutagenesisi1138R → A: No methyltransferase activity. 1 Publication1
Mutagenesisi1142H → G: No methyltransferase activity. 1 Publication1
Mutagenesisi1144C → A: No methyltransferase activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595201 – 1365Histone-lysine N-methyltransferase NSD2Add BLAST1365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110PhosphothreonineCombined sources1
Modified residuei114PhosphothreonineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei172PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei422PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BVE8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BVE8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8BVE8

PeptideAtlas

More...
PeptideAtlasi
Q8BVE8

PRoteomics IDEntifications database

More...
PRIDEi
Q8BVE8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
293976 [Q8BVE8-1]
293977 [Q8BVE8-2]
293978 [Q8BVE8-3]
293979 [Q8BVE8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BVE8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8BVE8

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q8BVE8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During B-cell development, expressed in early B2 cell progenitors (pre- and pro-B cells) with a decrease in expression at later stages.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed in early development (PubMed:9618163). Highly expressed in neuroepithelium at 10.5 dpc, and in the forebrain, midbrain, frontal facial region, jaw, heart but not in the endocardial cushion, and cartilage primordial at 14.5 dpc (PubMed:19483677).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in CD4+ T-cell in response to T-cell receptor (TCR) and CD28 stimulation (at protein level) (PubMed:31636135). Induced in B2-cells by IgM antibodies or lipopolysaccharide (LPS) stimulation (PubMed:32862441).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000057406, Expressed in manus and 285 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8BVE8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDAC1 (PubMed:19483677).

Interacts (via PHD-type zinc fingers 1, 2 and 3) with SALL1 (PubMed:19483677).

Interacts (via PHD-type 1, 2 and 3) with SALL4 (PubMed:19483677).

Interacts with NANOG (PubMed:19483677).

Interacts with OGT (PubMed:19483677).

Interacts (via HMG box) with NKX2-5 (PubMed:19483677).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
223605, 13 interactors

Database of interacting proteins

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DIPi
DIP-60452N

Protein interaction database and analysis system

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IntActi
Q8BVE8, 14 interactors

Molecular INTeraction database

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MINTi
Q8BVE8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058940

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BVE8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BVE8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini222 – 286PWWP 1PROSITE-ProRule annotationAdd BLAST65
Domaini880 – 942PWWP 2PROSITE-ProRule annotationAdd BLAST63
Domaini1011 – 1061AWSPROSITE-ProRule annotationAdd BLAST51
Domaini1063 – 1180SETPROSITE-ProRule annotationAdd BLAST118
Domaini1187 – 1203Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 169DisorderedSequence analysisAdd BLAST21
Regioni373 – 455DisorderedSequence analysisAdd BLAST83
Regioni513 – 567DisorderedSequence analysisAdd BLAST55
Regioni594 – 658DisorderedSequence analysisAdd BLAST65
Regioni1115 – 1118S-adenosyl-L-methionine bindingBy similarity4
Regioni1141 – 1142S-adenosyl-L-methionine bindingBy similarity2
Regioni1206 – 1232DisorderedSequence analysisAdd BLAST27
Regioni1329 – 1365DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi386 – 400Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi519 – 566Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi602 – 627Polar residuesSequence analysisAdd BLAST26
Compositional biasi642 – 656Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri667 – 713PHD-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri714 – 770PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri831 – 875PHD-type 3PROSITE-ProRule annotationAdd BLAST45
Zinc fingeri1239 – 1286PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1081, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157429

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_004494_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8BVE8

Identification of Orthologs from Complete Genome Data

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OMAi
EYVMVHR

Database of Orthologous Groups

More...
OrthoDBi
507784at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8BVE8

TreeFam database of animal gene trees

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TreeFami
TF329088

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.30.10, 1 hit
3.30.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006560, AWS_dom
IPR041306, C5HCH
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR003616, Post-SET_dom
IPR000313, PWWP_dom
IPR001214, SET_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

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Pfami
View protein in Pfam
PF17907, AWS, 1 hit
PF17982, C5HCH, 1 hit
PF00505, HMG_box, 1 hit
PF00855, PWWP, 2 hits
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00570, AWS, 1 hit
SM00398, HMG, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00293, PWWP, 2 hits
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095, SSF47095, 1 hit
SSF57903, SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51215, AWS, 1 hit
PS50118, HMG_BOX_2, 1 hit
PS50868, POST_SET, 1 hit
PS50812, PWWP, 2 hits
PS50280, SET, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BVE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFSIRKSPL SVQKVVKCMK MKQTPEILGS ANGKTQNCEV NHECSVFLSK
60 70 80 90 100
AQLSNSLQEG VMQKFNGHDA LPFLPAEKLK DLTSCVFNGE PGAHDTKLCF
110 120 130 140 150
EAQEVKGIGT PPNTTPIKNG SPEIKLKITK TYMNGKPLFE SSICGDGAAD
160 170 180 190 200
VSQSEENEQK SDNKTRRNRK RSIKYDSLLE QGLVEAALVS KISSPADKKI
210 220 230 240 250
PVKKESCPNT GRDRDLLLKY NVGDLVWSKV SGYPWWPCMV SADPLLHNHT
260 270 280 290 300
KLKGQKKSAR QYHVQFFGDA PERAWIFEKS LVAFEGEEQF EKLCQESAKQ
310 320 330 340 350
APTKAEKIKL LKPISGRLRA QWEMGIVQAE EAASMSIEER KAKFTFLYVG
360 370 380 390 400
DQLHLNPQVA KEAGIVTEPL GEMVDSSGAS EEAAVDPGSV REEDIPTKRR
410 420 430 440 450
RRTKRSSSAE NQEGDPGTDK STPPKMAEAE PKRGVGSPAG RKKSTGSAPR
460 470 480 490 500
SRKGDSAAQF LVFCQKHRDE VVAEHPDASG EEIEELLGSQ WSMLNEKQKA
510 520 530 540 550
RYNTKFSLMI SAQSEEDSGN GNGKKRSHTK RADDPAEDVD VEDAPRKRLR
560 570 580 590 600
ADKHSLRKRE TITDKTARTS SYKAIEAASS LKSQAATKNL SDACKPLKKR
610 620 630 640 650
NRASATASSA LGFNKSSSPS ASLTEHEVSD SPGDEPSESP YESADETQTE
660 670 680 690 700
ASVSSKKSER GMAAKKEYVC QLCEKTGSLL LCEGPCCGAF HLACLGLSRR
710 720 730 740 750
PEGRFTCTEC ASGIHSCFVC KESKMEVKRC VVNQCGKFYH EACVKKYPLT
760 770 780 790 800
VFESRGFRCP LHSCMSCHAS NPSNPRPSKG KMMRCVRCPV AYHGGDACLA
810 820 830 840 850
AGCSVIASNS IICTGHFTAR KGKRHHTHVN VSWCFVCSKG GSLLCCEACP
860 870 880 890 900
AAFHPDCLNI EMPDGSWFCN DCRAGKKLHF QDIIWVKLGN YRWWPAEVCH
910 920 930 940 950
PKNVPPNIQK MKHEIGEFPV FFFGSKDYYW THQARVFPYM EGDRGSRYQG
960 970 980 990 1000
VRGIGRVFKN ALQEAEARFN EVKLQREARE TQESERKPPP YKHIKVNKPY
1010 1020 1030 1040 1050
GKVQIYTADI SEIPKCNCKP TDENPCGSDS ECLNRMLMFE CHPQVCPAGE
1060 1070 1080 1090 1100
YCQNQCFTKR QYPETKIIKT DGKGWGLVAK RDIRKGEFVN EYVGELIDEE
1110 1120 1130 1140 1150
ECMARIKYAH ENDITHFYML TIDKDRIIDA GPKGNYSRFM NHSCQPNCET
1160 1170 1180 1190 1200
LKWTVNGDTR VGLFAVCDIP AGTELTFNYN LDCLGNEKTV CRCGASNCSG
1210 1220 1230 1240 1250
FLGDRPKTSA SLSSEEKGKK AKKKTRRRRA KGEGKRQSED ECFRCGDGGQ
1260 1270 1280 1290 1300
LVLCDRKFCT KAYHLSCLGL GKRPFGKWEC PWHHCDVCGK PSTSFCHLCP
1310 1320 1330 1340 1350
NSFCKEHQDG TAFRSTQDGQ SYCCEHDLRA DSSSSTKTEK PFPESLKSKG
1360
KRKKRRCWRR VTDGK
Length:1,365
Mass (Da):152,253
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8DC3F687D3EA2C2
GO
Isoform 2 (identifier: Q8BVE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-558: K → KQ

Show »
Length:1,366
Mass (Da):152,381
Checksum:i28858A53E6156DEF
GO
Isoform 3 (identifier: Q8BVE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-519: Missing.
     520-522: NGN → MGM
     558-558: K → KQ

Show »
Length:847
Mass (Da):95,042
Checksum:iEE0EF9742565F18D
GO
Isoform RE-IIBP1 Publication (identifier: Q8BVE8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-661: Missing.

Show »
Length:704
Mass (Da):79,633
Checksum:iDFB1AC7E5D1E7E4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3E4D3Z3E4_MOUSE
Histone-lysine N-methyltransferase ...
Nsd2 Whsc1
629Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3E0D3Z3E0_MOUSE
Histone-lysine N-methyltransferase ...
Nsd2 Whsc1
647Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Y765F6Y765_MOUSE
Histone-lysine N-methyltransferase ...
Nsd2 Whsc1
534Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S6G6F6S6G6_MOUSE
Histone-lysine N-methyltransferase ...
Nsd2 Whsc1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUM7A0A0J9YUM7_MOUSE
Histone-lysine N-methyltransferase ...
Nsd2 Whsc1
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z229D3Z229_MOUSE
Histone-lysine N-methyltransferase ...
Nsd2 Whsc1
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ACE75882 differs from that shown. Incorrectly indicated as originating from human.Curated
The sequence BAC37342 differs from that shown. Reason: Frameshift.Curated
The sequence BAC98097 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti757F → L in BAC37342 (PubMed:16141072).Curated1
Sequence conflicti1019K → T in ACE75882 (PubMed:18172012).Curated1
Sequence conflicti1345S → L in AAH53454 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0444201 – 661Missing in isoform RE-IIBP. 1 PublicationAdd BLAST661
Alternative sequenceiVSP_0214241 – 519Missing in isoform 3. 1 PublicationAdd BLAST519
Alternative sequenceiVSP_021425520 – 522NGN → MGM in isoform 3. 1 Publication3
Alternative sequenceiVSP_021426558K → KQ in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU733655 mRNA Translation: ACE75882.1 Sequence problems.
AK129287 mRNA Translation: BAC98097.1 Different initiation.
AC163329 Genomic DNA No translation available.
AK078622 mRNA Translation: BAC37342.1 Frameshift.
BC046473 mRNA Translation: AAH46473.1
BC053454 mRNA Translation: AAH53454.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51467.1 [Q8BVE8-2]
CCDS51468.1 [Q8BVE8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074571.2, NM_001081102.2 [Q8BVE8-2]
NP_780440.2, NM_175231.2 [Q8BVE8-1]
XP_006503721.1, XM_006503658.3 [Q8BVE8-2]
XP_006503722.1, XM_006503659.3 [Q8BVE8-2]
XP_006503723.1, XM_006503660.3 [Q8BVE8-1]
XP_017176079.1, XM_017320590.1 [Q8BVE8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000058096; ENSMUSP00000058940; ENSMUSG00000057406 [Q8BVE8-1]
ENSMUST00000066854; ENSMUSP00000067205; ENSMUSG00000057406 [Q8BVE8-2]
ENSMUST00000075812; ENSMUSP00000075210; ENSMUSG00000057406 [Q8BVE8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107823

UCSC genome browser

More...
UCSCi
uc008xbm.2, mouse [Q8BVE8-1]
uc012duw.1, mouse [Q8BVE8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU733655 mRNA Translation: ACE75882.1 Sequence problems.
AK129287 mRNA Translation: BAC98097.1 Different initiation.
AC163329 Genomic DNA No translation available.
AK078622 mRNA Translation: BAC37342.1 Frameshift.
BC046473 mRNA Translation: AAH46473.1
BC053454 mRNA Translation: AAH53454.1
CCDSiCCDS51467.1 [Q8BVE8-2]
CCDS51468.1 [Q8BVE8-1]
RefSeqiNP_001074571.2, NM_001081102.2 [Q8BVE8-2]
NP_780440.2, NM_175231.2 [Q8BVE8-1]
XP_006503721.1, XM_006503658.3 [Q8BVE8-2]
XP_006503722.1, XM_006503659.3 [Q8BVE8-2]
XP_006503723.1, XM_006503660.3 [Q8BVE8-1]
XP_017176079.1, XM_017320590.1 [Q8BVE8-2]

3D structure databases

SMRiQ8BVE8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi223605, 13 interactors
DIPiDIP-60452N
IntActiQ8BVE8, 14 interactors
MINTiQ8BVE8
STRINGi10090.ENSMUSP00000058940

PTM databases

iPTMnetiQ8BVE8
PhosphoSitePlusiQ8BVE8
SwissPalmiQ8BVE8

Proteomic databases

EPDiQ8BVE8
jPOSTiQ8BVE8
PaxDbiQ8BVE8
PeptideAtlasiQ8BVE8
PRIDEiQ8BVE8
ProteomicsDBi293976 [Q8BVE8-1]
293977 [Q8BVE8-2]
293978 [Q8BVE8-3]
293979 [Q8BVE8-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q8BVE8, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8608, 189 antibodies

Genome annotation databases

EnsembliENSMUST00000058096; ENSMUSP00000058940; ENSMUSG00000057406 [Q8BVE8-1]
ENSMUST00000066854; ENSMUSP00000067205; ENSMUSG00000057406 [Q8BVE8-2]
ENSMUST00000075812; ENSMUSP00000075210; ENSMUSG00000057406 [Q8BVE8-2]
GeneIDi107823
KEGGimmu:107823
UCSCiuc008xbm.2, mouse [Q8BVE8-1]
uc012duw.1, mouse [Q8BVE8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7468
MGIiMGI:1276574, Nsd2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1081, Eukaryota
GeneTreeiENSGT00940000157429
HOGENOMiCLU_004494_2_1_1
InParanoidiQ8BVE8
OMAiEYVMVHR
OrthoDBi507784at2759
PhylomeDBiQ8BVE8
TreeFamiTF329088

Enzyme and pathway databases

BRENDAi2.1.1.357, 3474
2.1.1.359, 3474
ReactomeiR-MMU-3214841, PKMTs methylate histone lysines
R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571, Nonhomologous End-Joining (NHEJ)
R-MMU-5693607, Processing of DNA double-strand break ends
R-MMU-69473, G2/M DNA damage checkpoint

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
107823, 8 hits in 54 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Whsc1, mouse

Protein Ontology

More...
PROi
PR:Q8BVE8
RNActiQ8BVE8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057406, Expressed in manus and 285 other tissues
GenevisibleiQ8BVE8, MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
3.30.40.10, 4 hits
InterProiView protein in InterPro
IPR006560, AWS_dom
IPR041306, C5HCH
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR003616, Post-SET_dom
IPR000313, PWWP_dom
IPR001214, SET_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF17907, AWS, 1 hit
PF17982, C5HCH, 1 hit
PF00505, HMG_box, 1 hit
PF00855, PWWP, 2 hits
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM00570, AWS, 1 hit
SM00398, HMG, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00293, PWWP, 2 hits
SM00317, SET, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
SSF57903, SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51215, AWS, 1 hit
PS50118, HMG_BOX_2, 1 hit
PS50868, POST_SET, 1 hit
PS50812, PWWP, 2 hits
PS50280, SET, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSD2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BVE8
Secondary accession number(s): B3VCH6
, Q6ZPY1, Q7TSF5, Q811F0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 2, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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